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Showing 31-60 of 108 results for "D3314" within Papers
X L Yang et al.
Advances in contraception : the official journal of the Society for the Advancement of Contraception, 4(4), 319-326 (1988-12-01)
8 pregnant women (below 49 days of amenorrhea) were administered 600 mg RU486 orally in a single dosage, and 1 mg PG-05 as a vaginal suppository 48 h afterwards. The plasma beta-hCG, progesterone, 17 beta-estradiol and PGFM (13,14-dihydro-15-keto-PGF2 alpha) were
Avraham Ashkenazi et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 26(11), 4628-4636 (2012-08-09)
Understanding the structural organization of lipids in the cell and viral membranes is essential for elucidating mechanisms of viral fusion that lead to entry of enveloped viruses into their host cells. The HIV lipidome shows a remarkable enrichment in dihydrosphingomyelin
Graham Brogden et al.
Biomolecules, 9(9) (2019-09-11)
Sphingolipids are an important group of lipids that play crucial roles in living cells, facilitating cell recognition, signal transduction and endocytosis. The concentration of sphingosine and some of its derivatives like sphinganine may serve as a biomarker for the diagnosis
Guangguo Tan et al.
Scientific reports, 7, 46176-46176 (2017-04-07)
To address the shortcomings of cystoscopy and urine cytology for detecting and grading bladder cancer (BC), ultrahigh performance liquid chromatography (UHPLC) coupled with Q-TOF mass spectrometry in conjunction with univariate and multivariate statistical analyses was employed as an alternative method
B Bouchon et al.
Biochemical and biophysical research communications, 143(3), 827-831 (1987-03-30)
The glycosphingolipids of isolated human thyrocytes have been analyzed. As compared to the total thyroid gland, the pattern of gangliosides was found to be similar, whereas the neutral glycolipid profile was quite different, with glucosylceramide as the major glycosphingolipid of
Anthony S Don et al.
The Journal of biological chemistry, 282(21), 15833-15842 (2007-04-03)
The clinical immunosuppressant FTY720 is a sphingosine analogue that, once phosphorylated by sphingosine kinase 2 (Sphk2), is an agonist of multiple receptor subtypes for sphingosine 1-phosphate. Short exposures to FTY720 afford long term protection in lymphoproliferative and autoimmune disease models
N Flamand et al.
Journal of chromatography. B, Biomedical applications, 656(1), 65-71 (1994-06-03)
Conditions were established for the in vivo determination of free long-chain bases (phytosphingosine, sphingosine and sphinganine) in human stratum corneum layers by reversed-phase HPLC analysis of adhesive-tape strippings. Long-chain bases were first extracted from individual strippings with pure methanol in
F Andreolini et al.
Clinical chemistry, 31(10), 1698-1702 (1985-10-01)
We report a method for measuring estriol and its intact conjugates in urine, serum, and amniotic fluid. A single assay can be done within about 50 min, eight samples assayed in less than 5 h. A 70-microL urine sample is
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the
C Rodriguez-Lafrasse et al.
Biochimica et biophysica acta, 1226(2), 138-144 (1994-05-25)
The 20-fold increase of free sphingoid bases found in liver from a murine model of Niemann-Pick type C (NPC) combined to the NPC-like phenotype induced by addition of sphinganine to normal fibroblast cultures prompted us to investigate the potential involvement
G Cano-Sancho et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 28(8), 1055-1065 (2011-06-07)
Fumonisins occur mainly in maize and they produce alterations on sphingolipid metabolism, unbalancing the sphinganine (Sa)/sphingosine (So) ratio. This alteration has been proposed as a biomarker of fumonisin exposure. The objective of this study was to establish the urinary and
H A Khan et al.
Clinical and experimental medicine, 6(3), 134-137 (2006-10-25)
Fasting blood glucose (FBG) and serum fructosamine are simple and commonly used tests for monitoring diabetes mellitus. Unfortunately, both these parameters are associated with high error rates and therefore used with caution in high-risk populations. Setting high cut-off values for
Eun Hyun Ahn et al.
International journal of oncology, 54(2), 655-664 (2018-11-30)
The overall goal of the present study was to evaluate the chemotherapeutic and cancer‑protective properties of D‑erythro‑sphingosine (sphingosine) and C2‑ceramide using a human breast epithelial cell (HBEC) culture system, which represents multiple‑stages of breast carcinogenesis. The HBEC model includes Type I HBECs
Yakir Guri et al.
Cancer cell, 32(6), 807-823 (2017-12-13)
Dysregulated mammalian target of rapamycin (mTOR) promotes cancer, but underlying mechanisms are poorly understood. We describe an mTOR-driven mouse model that displays hepatosteatosis progressing to hepatocellular carcinoma (HCC). Longitudinal proteomic, lipidomics, and metabolomic analyses revealed that hepatic mTORC2 promotes de
Xiaoyun Li et al.
Science China. Life sciences, 62(3), 333-348 (2019-03-23)
Traditionally, herbal medicine is consumed by drinking decoctions produced by boiling herbs with water. The functional components of the decoction are heat stable. Small RNAs (sRNAs) were reported as a new class of functional components in decoctions. However, the mechanisms
D J Bibel et al.
Clinical and experimental dermatology, 20(5), 395-400 (1995-09-01)
Sphingosine and sphinganine, free sphingolipids of the stratum corneum, are, in vitro, strongly inhibitory for both bacteria and fungi. Whether or not they are suitable, indeed active, in vivo was examined: (i) on human volunteers, first as a preventative antiseptic
Jorge L Garaicoa et al.
Journal of prosthodontics : official journal of the American College of Prosthodontists, 27(8), 755-762 (2016-11-22)
Several complications may arise in patients wearing complete prosthetic appliances, including denture-associated infections and mucosal stomatitis due to Candida species. This study evaluated the activity of anti-Candida agents in denture adhesive and the cytotoxicities of these preparations for primary human
Hiroshi Deguchi et al.
The Journal of biological chemistry, 279(13), 12036-12042 (2004-01-15)
Sphingolipids contribute to modulation of two opposing cell processes, cell growth and apoptotic cell death; ceramide and sphingosine promote the latter and sphingosine-1-phosphate triggers the former. Thrombin, a pro-inflammatory protease that is regulated by the blood coagulation cascade, exerts similar
Yoon Jung Yang et al.
Biomedical chromatography : BMC, 17(4), 219-225 (2003-07-02)
Using column-switching liquid chromatography/tandem mass spectrometry (LC-MS/MS), we developed an improved analytical method of urinary estriol glucuronides. This new method is derived predominantly from maternal and fetal precursors in pregnancy. We used in the following procedure: first, we filtered urine
Mariana Saucedo-García et al.
The New phytologist, 191(4), 943-957 (2011-05-04)
Long chain bases (LCBs) are sphingolipid intermediates acting as second messengers in programmed cell death (PCD) in plants. Most of the molecular and cellular features of this signaling function remain unknown. We induced PCD conditions in Arabidopsis thaliana seedlings and
João Henrique T M Fabri et al.
Current protein & peptide science, 21(3), 265-283 (2019-07-10)
The cell wall (CW) and plasma membrane are fundamental structures that define cell shape and support different cellular functions. In pathogenic fungi, such as Aspegillus fumigatus, they not only play structural roles but are also important for virulence and immune
Emma M Dangerfield et al.
Chembiochem : a European journal of chemical biology, 13(9), 1349-1356 (2012-05-29)
The immunomodulatory glycolipid α-galactosylceramide (α-GalCer) binds to CD1d and exhibits potent activity as a ligand for invariant CD1d-restricted natural killer-like T cells (iNKT cells). Structural analogues of α-GalCer have been synthesised to determine which components are required for CD1d presentation
One-step lipid extraction for plasma lipidomics analysis by liquid chromatography mass spectrometry.
Yoshinori Satomi et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1063, 93-100 (2017-08-30)
In the past decade, various lipidomics methodologies have been developed using mass spectrometry based analytical technologies, enabling wide coverage lipid detection in a quantitative manner. Hence, lipidomics has become a widely-accepted approach for biomarker discovery and mechanism elucidation in both
Elizabeth L Johnson et al.
Nature communications, 11(1), 2471-2471 (2020-05-20)
Gut microbes are linked to host metabolism, but specific mechanisms remain to be uncovered. Ceramides, a type of sphingolipid (SL), have been implicated in the development of a range of metabolic disorders from insulin resistance (IR) to hepatic steatosis. SLs
M Książek et al.
Scandinavian journal of medicine & science in sports, 28(1), 57-64 (2017-05-12)
Sphingosine-1-phosphate (S1P) is a bioactive lysosphingolipid that is found in relatively high concentration in human plasma. Erythrocytes, endothelial cells, and activated platelets are the main sources of circulating S1P. The majority of plasma S1P is transported bound to high-density lipoprotein
Po-Chin Huang et al.
Human reproduction (Oxford, England), 22(10), 2715-2722 (2007-08-21)
Maternal hypothyroidism during pregnancy can cause adverse effects in the fetus. Scientific evidence has shown that probable thyroid-like function of some phthalates in vitro and in vivo, and phthalates exposure, can begin in utero. This study investigated the association between
I Castanon et al.
Nature communications, 11(1), 3317-3317 (2020-07-06)
Oriented cell division is a fundamental mechanism to control asymmetric stem cell division, neural tube elongation and body axis extension, among other processes. During zebrafish gastrulation, when the body axis extends, dorsal epiblast cells display divisions that are robustly oriented
Sören Stahlberg et al.
Langmuir : the ACS journal of surfaces and colloids, 31(17), 4906-4915 (2015-04-15)
We investigated equimolar mixtures of ceramides with lignoceric acid and cholesterol as models for the human stratum corneum by differential scanning calorimetry and (2)H solid-state NMR spectroscopy. Our reference system consisted of lignoceroyl sphingosine (Cer[NS24]), which represents one of the
Jing Yuan et al.
Nature chemical biology, 5(10), 765-771 (2009-09-08)
Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279 bioactive chemicals. Hundreds of compounds were
A Zimber et al.
International journal of cancer, 59(1), 71-77 (1994-10-01)
We have tested the effect of several bile acids on the proliferation and differentiation of the HL60 human promyelocytic leukemia cell line in vitro. Deoxycholate, chenodeoxycholate and lithocholic acid caused dose-dependent inhibition of cell proliferation and induction of differentiation along
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