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Showing 1-30 of 36 results for "D3418" within Papers
Ingrid Torregroza et al.
PloS one, 7(10), e46844-e46844 (2012-10-12)
Using the zebrafish model we describe a previously unrecognized requirement for the transcription factor gata4 controlling embryonic angiogenesis. The development of a vascular plexus in the embryonic tail, the caudal hematopoietic tissue (CHT), fails in embryos depleted of gata4. Rather
Falk Schrödl et al.
Investigative ophthalmology & visual science, 44(9), 3705-3712 (2003-08-27)
The chemical coding of intrinsic choroidal neurons (ICNs) has features in common with extrinsic fibers (e.g., from the pterygopalatine ganglion) making it impossible to assess whether a neuronal nitric oxide synthase (nNOS)/vasoactive intestinal polypeptide (VIP)-immunoreactive nerve fiber is of intrinsic
Frank C Hendriks et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 23(26), 6305-6314 (2017-02-22)
A micro-spectroscopic method has been developed to probe the accessibility of zeolite crystals using a series of fluorescent 4-(4-diethylaminostyryl)-1-methylpyridinium iodide (DAMPI) probes of increasing molecular size. Staining large zeolite crystals with MFI (ZSM-5) topology and subsequent mapping of the resulting
Ian De Proost et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 23(4), 1153-1160 (2008-12-04)
Pulmonary neuroepithelial bodies (NEBs) are densely innervated groups of complex sensory airway receptors involved in the regulation of breathing. Together with their surrounding Clara-like cells, they exhibit stem cell potential through their capacity to regenerate depopulated areas of the epithelium
H Hilbig et al.
Neuroreport, 5(4), 477-480 (1994-01-12)
Five different populations of interlayer neurones (ILNs) can be described after DiI/Di-ASP tracing in rat superior colliculus (SC). All of these labelled neurones preferentially lay in the rostro-medial part of the SC. Most of them are located in the stratum
J A Dybowski et al.
Brain research, 842(1), 62-72 (1999-10-20)
The effects of intraocular (i.o.) administration of the alkaloid colchicine on visual recovery following axotomy of the goldfish optic nerve were investigated. Under the experimental conditions used, control goldfish recovered vision, measured behaviorally, within 5-7 weeks of retro-orbital optic nerve
Anna Pistocchi et al.
BMC developmental biology, 9, 58-58 (2009-12-02)
The lateral line system in zebrafish is composed of a series of organs called neuromasts, which are distributed over the body surface. Neuromasts contain clusters of hair cells, surrounded by accessory cells. In this report we describe zebrafish prox1 mRNA
Shih-Wei Chou et al.
Nature communications, 8(1), 2234-2234 (2017-12-23)
Detection of water motion by the lateral line relies on mechanotransduction complexes at stereocilia tips. This sensory system is comprised of neuromasts, patches of hair cells with stereociliary bundles arranged with morphological mirror symmetry that are mechanically responsive to two
L Chen et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 14(2), 796-808 (1994-02-01)
Remodeling of the synaptic extracellular matrix (ECM) and its dynamic relationship with nerve terminal plasticity have been demonstrated in normal frog neuromuscular junctions (NMJs) in vivo (Chen et al., 1991). Our previous work has led to a hypothesis that extension
Amanda K Powers et al.
Symmetry, 12(12) (2021-02-23)
A key challenge in contemporary biology is connecting genotypic variation to phenotypic diversity. Quantitative genetics provides a powerful technique for identifying regions of the genome that covary with phenotypic variation. Here, we present a quantitative trait loci (QTL) analysis of
Zongwei Chen et al.
Human molecular genetics, 29(12), 2004-2021 (2020-03-14)
Perception of sound is initiated by mechanically gated ion channels at the tips of stereocilia. Mature mammalian auditory hair cells require transmembrane channel-like 1 (TMC1) for mechanotransduction, and mutations of the cognate genetic sequences result in dominant or recessive heritable
M J Marques et al.
Journal of anatomy, 192 ( Pt 3), 425-430 (1998-08-04)
The mammalian neuromuscular junction has been extensively studied by different methods to understand better the biological aspects of its normal development, ageing and pathological conditions, such as disorders of neuromuscular transmission. In the present report, a new technique is described
M Hanani et al.
Journal of pediatric surgery, 28(7), 939-941 (1993-07-01)
A simple and reliable method is described for staining the nerve plexuses of the human gastrointestinal tract in whole-mounts. The staining does not require fixation and consists of a single step of 6 to 10 minutes incubation in a solution
V A Campanucci et al.
Neuroscience, 132(2), 437-451 (2005-04-02)
In this study we use nystatin perforated-patch and conventional whole-cell recording to characterize the biophysical properties of neuronal nitric oxide synthase (nNOS)-expressing paraganglion neurons from the rat glossopharyngeal nerve (GPN), that are thought to provide NO-mediated efferent inhibition of carotid
Line Verckist et al.
Respiratory research, 19(1), 207-207 (2018-10-28)
The microenvironment (ME) of neuroepithelial bodies (NEBs) harbors densely innervated groups of pulmonary neuroendocrine cells that are covered by Clara-like cells (CLCs) and is believed to be important during development and for adult airway epithelial repair after severe injury. Yet
Lukas Anneser et al.
Nature, 588(7839), 653-657 (2020-12-04)
Species that depend on membership in social groups for survival exhibit changes in neuronal gene expression and behaviour when they face restricted social interactions or isolation1-3. Here we show that, across the lifespan of zebrafish (Danio rerio), social isolation specifically
Narsing A Rao et al.
Investigative ophthalmology & visual science, 44(1), 22-31 (2002-12-31)
To devise methods for unequivocal identification of activated retinal microglia in experimental autoimmune uveoretinitis (EAU) and to investigate their role in the development of EAU. A group of Lewis rats underwent optic nerve axotomy with the application of N-4-(4-didecylaminostyryl)-N methylpyridinium
Rosie Dawkins et al.
Journal of neurophysiology, 93(5), 2541-2551 (2004-12-24)
Cholinergic efferent fibers modify hair cell responses to mechanical stimulation. It is hypothesized that calcium entering the hair cell through a nicotinic receptor activates a small-conductance (SK), calcium-activated potassium channel to hyperpolarize the hair cell. The calcium signal may be
Y Kasai et al.
The Journal of physiology, 504 ( Pt 2), 349-357 (1997-11-20)
1. We visualized intracellular Ca2+ concentration ([Ca2+]i) changes, using fluo-3 as an indicator, of individual vascular smooth muscle cells and endothelial cells within intact rat tail arteries by confocal microscopy. 2. Using a piezo-driven objective, we focused on endothelial and
Elizabeth A Bolan et al.
Molecular pharmacology, 71(5), 1222-1232 (2007-02-03)
The dopamine transporter (DAT) terminates dopamine (DA) neurotransmission by reuptake of DA into presynaptic neurons. Regulation of DA uptake by D(2) dopamine receptors (D(2)R) has been reported. The high affinity of DA and other DAT substrates for the D(2)R, however
Randy D Blakely et al.
Molecular pharmacology, 71(5), 1206-1208 (2007-03-03)
Mounting evidence supports the idea that neurotransmitter transporters are subject to many forms of post-translational regulation typically associated with receptors and ion channels, including receptor and kinase-mediated changes in transporter phosphorylation, cell surface trafficking, and/or catalytic activation. Although hints of
Margot A B Schwalbe et al.
The Journal of experimental biology, 219(Pt 7), 1050-1059 (2016-04-01)
The mechanosensory lateral line system of fishes detects water motions within a few body lengths of the source. Several types of artificial stimuli have been used to probe lateral line function in the laboratory, but few studies have investigated the
Julie Jung et al.
The Journal of experimental biology, 223(Pt 24) (2020-11-15)
Mechanosensory-cued hatching (MCH) is widespread, diverse and important for survival in many animals. From flatworms and insects to frogs and turtles, embryos use mechanosensory cues and signals to inform hatching timing, yet mechanisms mediating mechanosensing in ovo are largely unknown.
P Kurdyak et al.
The Journal of comparative neurology, 350(3), 463-472 (1994-12-15)
Morphological and physiological characteristics of the two major motor axons supplying the commonly studied ventral longitudinal muscle fibers (6 and 7) of third-instar Drosophila melanogaster larvae were investigated. The innervating terminals of the two motor axons differ in the size
Sung W Choi et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(12), 4524-4534 (2011-03-25)
Dopaminergic neurons of the substantia nigra pars compacta are defective in Parkinson's disease, but the specificity of this dysfunction is not understood. One hypothesis is that mitochondrial bioenergetic capacity is intrinsically lower in striatal dopaminergic presynaptic nerve varicosities, making them
Manali Mukherjee et al.
International journal of pharmaceutics, 426(1-2), 7-14 (2012-01-24)
A physiologically pertinent in vitro model is urgently needed for probing interactions between inhaled drugs and the organic cation transporters (OCT) in the bronchial epithelium. This study evaluated OCT expression, functionality, inhibition by common inhaled drugs and impact on formoterol
Daizo Morikane et al.
Molecules (Basel, Switzerland), 25(17) (2020-09-04)
In recent decades, zebrafish (Danio rerio) has become a widely used vertebrate animal model for studying development and human diseases. However, studies on skin medication using zebrafish are rare. Here, we developed a novel protocol for percutaneous absorption of molecules
T R Cushway et al.
Microsurgery, 17(8), 444-448 (1996-01-01)
Fibre-optic technology combined with confocality produces a microscope capable of optical thin sectioning. In this original study, tibial nerves have been stained in a rat model with a vital dye, 4-(4-diethylaminostyryl)-N-methylpyridinium iodide, and analysed by fibre-optic confocal microscopy to produce
Reno C Reyes et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(39), 9682-9691 (2008-09-26)
Vesicular glutamate release from astrocytes depends on mobilization of free Ca(2+) from the endoplasmic reticulum (ER), and extracellular space to elevate cytosolic Ca(2+) (Ca(2+)(cyt)). Although mitochondria in neurons, and other secretory cells, have been shown to sequester free Ca(2+) and
I Pintelon et al.
Cell and tissue research, 321(1), 21-33 (2005-05-20)
Pulmonary neuroepithelial bodies (NEBs) are extensively innervated organoid groups of neuroendocrine cells that lie in the epithelium of intrapulmonary airways. Our present understanding of the morphology of NEBs is comprehensive, but direct physiological studies have so far been challenging because
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