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Showing 1-30 of 79 results for "D4293" within Papers
Naoki Yamawaki et al.
Nature neuroscience, 22(4), 618-626 (2019-03-13)
Hippocampus, granular retrosplenial cortex (RSCg), and anterior thalamic nuclei (ATN) interact to mediate diverse cognitive functions. To identify cellular mechanisms underlying hippocampo-thalamo-retrosplenial interactions, we investigated the potential circuit suggested by projections to RSCg layer 1 (L1) from GABAergic CA1 neurons
Elizabeth E Smith et al.
Journal of tissue engineering and regenerative medicine, 11(12), 3326-3336 (2017-01-10)
A long-term goal is to bioengineer, fully functional, living teeth for regenerative medicine and dentistry applications. Biologically based replacement teeth would avoid insufficiencies of the currently used dental implants. Using natural tooth development as a guide, a model was fabricated
Lea L Weston et al.
Journal of neuroinflammation, 18(1), 161-161 (2021-07-20)
The presence of hyperphosphorylated microtubule-associated protein tau is strongly correlated with cognitive decline and neuroinflammation in Alzheimer's disease and related tauopathies. However, the role of inflammation and anti-inflammatory interventions in tauopathies is unclear. Our goal was to determine if removing
Expression of pluripotent stem cell markers in the human fetal testis
Kerr CL, et al.
Stem Cells, 26(2), 412-421 (2008)
Fangrui Ding et al.
Scientific reports, 11(1), 20650-20650 (2021-10-21)
Podocyte abnormalities are common mechanism driving the progression of glomerular diseases, which account for most chronic kidney diseases (CKDs). However, the role of podocyte in the mechanism of high-risk long-term CKD caused by prematurity has not been well clarified. In
Lixing W Reneker et al.
The British journal of ophthalmology, 104(7), 999-1004 (2019-10-06)
Meibomian gland dysfunction (MGD) is the most common form of evaporative dry eye disease, but its pathogenesis is poorly understood. This study examined the histopathological features of meibomian gland (MG) tissue from cadaver donors to identify potential pathogenic processes that
Hojin Kang et al.
Oncotarget, 8(30), 48603-48618 (2017-06-15)
Progressive dopaminergic neurodegeneration is responsible for the canonical motor deficits in Parkinson's disease (PD). The widely prescribed anti-diabetic medicine metformin is effective in preventing neurodegeneration in animal models; however, despite the significant potential of metformin for treating PD, the therapeutic
Claudio Cantù et al.
Science signaling, 10(465) (2017-02-09)
Wnt-stimulated β-catenin transcriptional regulation is necessary for the development of most organs, including teeth. Bcl9 and Bcl9l are tissue-specific transcriptional cofactors that cooperate with β-catenin. In the nucleus, Bcl9 and Bcl9l simultaneously bind β-catenin and the transcriptional activator Pygo2 to
Su Yang et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(8), 4411-4417 (2020-02-08)
Identification of repeat-associated non-AUG (RAN) translation in trinucleotide (CAG) repeat diseases has led to the emerging concept that CAG repeat diseases are caused by nonpolyglutamine products. Nonetheless, the in vivo contribution of RAN translation to the pathogenesis of CAG repeat
Adrian M Piliponsky et al.
Nature immunology, 20(2), 129-140 (2019-01-22)
Basophils are evolutionarily conserved in vertebrates, despite their small numbers and short life span, suggesting that they have beneficial roles in maintaining health. However, these roles are not fully defined. Here we demonstrate that basophil-deficient mice exhibit reduced bacterial clearance
Kathryn A Solka et al.
Histology and histopathology, 31(10), 1131-1141 (2016-03-01)
Progenitor cell differentiation into fibroblast-like synoviocytes (FLSs) and their ensuing phenotypic changes are incompletely explored. Synovial lining is composed of intimal macrophages and FLSs. FLSs have epithelioid morphology and directionally secrete components of synovial fluid, including lubricin. We stained human
Cheryl E G Leyns et al.
Nature neuroscience, 22(8), 1217-1222 (2019-06-27)
Variants in the triggering receptor expressed on myeloid cells 2 (TREM2) have been associated with increased risk for sporadic, late-onset Alzheimer's disease. Here we show that germline knockout of Trem2 or the TREM2R47H variant reduces microgliosis around amyloid-β plaques and
Anna Schildt et al.
Journal of Parkinson's disease, 9(1), 121-139 (2018-11-20)
Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic risk factor for Parkinson's disease (PD). While the corresponding pathogenic mechanisms remain largely unknown, LRRK2 has been implicated in the immune system. To assess whether LRRK2 mutations alter the
Bozhong Wang et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 131, 110690-110690 (2020-09-06)
Exercise training is beneficial for cardiac rehabilitation. Nevertheless, few study focused on the role of high-intensity interval training (HIIT) in cardiac repair. The current study aimed to elucidate the effect of HIIT on cardiac rehabilitation and the involved mechanisms after
Ruyi Zou et al.
Inflammation, 40(1), 100-105 (2016-10-09)
The transcriptional coactivator with PDZ-binding motif (TAZ) functions as a downstream regulatory target in the Hippo signaling pathway that plays various roles. We previously developed a cell-based assay and identified the TAZ activator IBS008738 as a potential therapeutic target for
Laura M Butkovich et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(39), 7559-7576 (2020-09-02)
Degeneration of locus ceruleus (LC) neurons and dysregulation of noradrenergic signaling are ubiquitous features of Parkinson's disease (PD). The LC is among the first brain regions affected by α-synuclein (asyn) pathology, yet how asyn affects these neurons remains unclear. LC-derived
Qing Cao et al.
Science advances, 6(50) (2020-12-11)
Epigenetic aberration is implicated in aging and neurodegeneration. Using postmortem tissues from patients with Alzheimer's disease (AD) and AD mouse models, we have found that the permissive histone mark H3K4me3 and its catalyzing enzymes are significantly elevated in the prefrontal
Linlin Zhang et al.
Clinical laboratory, 66(12) (2020-12-19)
Human common salivary protein 1 (CSP1) is one of a variety of molecules in saliva but its function remains to be determined. The gold standard method for diagnosis of diabetes mellitus (DM) is to check levels of glucose or HbA1C
Domenico Bucci et al.
Frontiers in neuroanatomy, 11, 98-98 (2017-11-23)
Catecholamine nuclei within the brainstem reticular formation (RF) play a pivotal role in a variety of brain functions. However, a systematic characterization of these nuclei in the very same experimental conditions is missing so far. Tyrosine hydroxylase (TH) immune-positive cells
Anita Cybulska-Klosowicz et al.
Acta neurobiologiae experimentalis, 77(2), 176-189 (2017-07-12)
Behavioral flexibility is subserved by the prefrontal cortex and the basal ganglia. Orbitofrontal cortex (OFC) and dorsomedial striatum (DMS) form a functional frontocorticostriatal circuit crucial for the mediation of flexibility during reversal learning via dopamine (DA) neurotransmission. The regulatory control
Ashley D Himes et al.
Developmental biology, 325(1), 151-161 (2008-11-11)
In the pituitary, the transition from proliferating progenitor cell into differentiated hormone producing cell is carefully regulated in a time-dependent and spatially-restricted manner. We report that two targets of Notch signaling, Hes1 and Prop1, are needed to maintain progenitors within
Minna Niittykoski et al.
Translational oncology, 10(5), 772-779 (2017-08-12)
Oncolytic adenoviruses show promise in targeting gliomas because they do not replicate in normal brain cells. However, clinical responses occur only in a subset of patients. One explanation could be the heterogenic expression level of virus receptors. Another contributing factor
Abhijeet Parkhe et al.
Neuroscience letters, 716, 134652-134652 (2019-11-30)
Parkinson's disease (PD) is a progressive, late-onset, and degenerative disorder that affects the central nervous system with an unknown etiology. Due to its incredible complexity in disease nature, many of the existing treatment approaches show a vain recovery in Parkinson's
Beverly Giam et al.
Clinical science (London, England : 1979), 134(20), 2755-2769 (2020-10-10)
Heart failure (HF) is associated with impaired L-arginine transport. In the present study, we tested the hypothesis that augmented L-arginine transport prevents the loss of kidney function in HF. Renal function was assessed in wildtype mice (WT), transgenic mice with
Anita Cybulska-Klosowicz et al.
Molecular and cellular neurosciences, 85, 82-92 (2017-09-20)
The executive control function of attention is regulated by the dopaminergic (DA) system. Dopamine transporter (DAT) likely plays a role in controlling the influence of DA on cognitive processes. We examined the effects of DAT depletion on cognitive processes related
Hyojung Kim et al.
Science signaling, 13(663) (2021-01-15)
Progressive degeneration of dopaminergic neurons characterizes Parkinson's disease (PD). This neuronal loss occurs through diverse mechanisms, including a form of programmed cell death dependent on poly(ADP-ribose) polymerase-1 (PARP1) called parthanatos. Deficient activity of the kinase Akt1 and aggregation of the
Alberto Parras et al.
Nature, 560(7719), 441-446 (2018-08-17)
Common genetic contributions to autism spectrum disorder (ASD) reside in risk gene variants that individually have minimal effect sizes. As environmental factors that perturb neurodevelopment also underlie idiopathic ASD, it is crucial to identify altered regulators that can orchestrate multiple
Michael C Puckette et al.
Journal of immunological methods, 487, 112873-112873 (2020-10-01)
This report covers the methodology for generation of stable heterohybridoma clones producing Foot-and-mouth disease virus (FMDV) reactive porcine monoclonal antibodies (mAbs). Swine received five inoculations of an inactivated O1 Manisa FMDV vaccine prior to the harvest of splenocytes. Due to
Ivó H Hernández et al.
Acta neuropathologica, 134(6), 839-850 (2017-09-02)
Activating transcription factor-5 (ATF5) is a stress-response transcription factor induced upon different cell stressors like fasting, amino-acid limitation, cadmium or arsenite. ATF5 is also induced, and promotes transcription of anti-apoptotic target genes like MCL1, during the unfolded protein response (UPR)
Abdu Mohamed et al.
International journal for parasitology, 50(10-11), 891-898 (2020-07-19)
The subpopulation of Atlantic cod, Gadus morhua, in the eastern part of the Baltic Sea has experienced a significant increase in infections with anisakid nematode larvae of the species Contracaecum osculatum sensu lato (s.l.) since the year 2000. The life
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