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Showing 1-30 of 4916 results for "d5879" within Papers
M Shahidullah et al.
Experimental eye research, 140, 85-93 (2015-09-01)
The bulk of the lens consists of tightly packed fiber cells. Because mature lens fibers lack mitochondria and other organelles, lens homeostasis relies on a monolayer of epithelial cells at the anterior surface. The detection of various signaling pathways in
C Hochfellner et al.
Journal of applied microbiology, 118(4), 864-872 (2015-01-22)
The interaction of quinolone and indoloquinazoline alkaloids concerning their antimycobacterial activity was studied. The antimycobacterial and modulating activity of evodiamine (1), rutaecarpine (2) and evocarpine (3) was tested on mycobacteria including three multidrug-resistant (MDR) clinical isolates of Mycobacterium tuberculosis. Antagonistic
Susanna Pietropaolo et al.
Neuropharmacology, 89, 368-374 (2014-08-16)
Huntington's disease (HD) is a devastating neurodegenerative disease characterized by a progressive decline in motor abilities, as well as in cognitive and social behaviors. Most of these behavioral deficits are recapitulated in the R6/1 transgenic mouse, which can therefore be
Jin Lu et al.
Phytochemistry, 104, 79-88 (2014-05-27)
Ten lathyrane-type diterpenoids named Euphorbia Factor L12-L21 (1-10) and twelve known diterpenoids (11-22) were isolated from seeds of Euphorbia lathyris. The structures of these compounds were determined by extensive spectroscopic (UV, IR, HRESIMS, 1D and 2D NMR) analyses. In addition
Zhengxiao Ouyang et al.
Biochemical pharmacology, 90(3), 276-287 (2014-06-21)
Osteoclast-induced bone resorption and wear-particle-induced osteolysis leads to prosthetic loosening, one of the most common causes of joint implant failure, resulting in revision surgery. Thus, inhibition of osteoclastic bone resorption, which further prevents wear particle-induced osteolysis, is a potential treatment
Andreas Üllen et al.
Biochemical pharmacology, 93(4), 470-481 (2015-01-13)
Hypochlorous acid added as reagent or generated by the myeloperoxidase (MPO)-H2O2-Cl(-) system oxidatively modifies brain ether-phospholipids (plasmalogens). This reaction generates a sn2-acyl-lysophospholipid and chlorinated fatty aldehydes. 2-Chlorohexadecanal (2-ClHDA), a prototypic member of chlorinated long-chain fatty aldehydes, has potent neurotoxic potential
Asuka Yuda et al.
Journal of cellular physiology, 230(1), 150-159 (2014-06-07)
Appropriate mechanical loading during occlusion and mastication play an important role in maintaining the homeostasis of periodontal ligament (PDL) tissue. Connective tissue growth factor (CTGF/CCN2), a matricellular protein, is known to upregulate extracellular matrix production, including collagen in PDL tissue.
Feng-Hua Yuan et al.
Journal of cellular physiology, 234(10), 17839-17853 (2019-04-12)
Sepsis is a systemic inflammatory response that may be induced by trauma, infection, surgery, and burns. With the aim of discovering novel treatment targets for sepsis, this current study was conducted to investigate the effect and potential mechanism by which
Riki Okita et al.
Oncology reports, 34(6), 2864-2870 (2015-10-28)
EGFR/HER2 are frequently expressed in MPM tissues, however, no studies have shown the clinical benefit of using EGFR/HER2-targeting drugs in patients with malignant pleural mesothelioma (MPM). It was reported that the tyrosine kinase inhibitor (TKI) lapatinib enhanced trastuzumab-mediated antibody-dependent cellular
M Melusova et al.
Neoplasma, 61(6), 690-699 (2014-10-25)
For several thousand years natural products were successfully used to treat a variety of diseases and to maintain health in humans, but until now it is not fully known what causes these medicinal effects. In our study we assessed the cytotoxic
Nicole P Bowles et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(1), 285-290 (2014-12-24)
Glucocorticoids are known to promote the development of metabolic syndrome through the modulation of both feeding pathways and metabolic processes; however, the precise mechanisms of these effects are not well-understood. Recent evidence shows that glucocorticoids possess the ability to increase
Krista A Mitchnick et al.
The European journal of neuroscience, 41(6), 773-786 (2015-02-03)
Epigenetic mechanisms are increasingly acknowledged as major players in memory formation. Specifically, DNA methylation is necessary for the formation of long-term memory in various brain regions, including the hippocampus (HPC); however, its role in the perirhinal cortex (PRh), a structure
Tapan P Patel et al.
Journal of neuroscience methods, 243, 26-38 (2015-01-30)
Recent advances in genetically engineered calcium and membrane potential indicators provide the potential to estimate the activation dynamics of individual neurons within larger, mesoscale networks (100s-1000+neurons). However, a fully integrated automated workflow for the analysis and visualization of neural microcircuits
Hong Wang et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(6), 5417-5425 (2014-02-13)
UNC5H4 is a newly identified member of the UNC5H receptor family. Previously, we have demonstrated that UNC5H4 expression is significantly higher in favorable neuroblastomas than in unfavorable ones, and higher UNC5H4 level is correlated with longer survival time. However, the
Dmitry G Semenov et al.
Neurochemical research, 40(11), 2200-2210 (2015-09-01)
The study assessed involvement of Ca(2+) signaling mediated by the metabotropic glutamate receptors mGluR1/5 in brain tolerance induced by hypoxic preconditioning. Acute slices of rat piriform cortex were tested 1 day after exposure of adult rats to mild hypobaric hypoxia
Shenshen Zhang et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 68, 239-246 (2014-04-08)
Ganoderma atrum polysaccharide (PSG-1) has been commonly suggested as a candidate for prevention and therapy of cancer. We investigated the antitumor effect and the underlying molecular mechanisms of PSG-1. The results showed that PSG-1 inhibited tumor growth and resulted in
G Horvath et al.
Journal of molecular neuroscience : MN, 54(3), 320-330 (2014-05-31)
Pituitary adenylate cyclase activating polypeptide (PACAP) is an endogenous neuropeptide having a widespread distribution both in the nervous system and peripheral organs including the female reproductive system. Both the peptide and its receptors have been shown in the placenta but
Frithjof Lohmann et al.
Biochimica et biophysica acta, 1842(7), 945-958 (2014-03-04)
Podocytes are terminally differentiated cells of the glomerular filtration barrier that react with hypertrophy in the course of injury such as in membranous nephropathy (MGN). The neuronal deubiquitinase ubiquitin C-terminal hydrolase L1 (UCH-L1) is expressed and activated in podocytes of
Caihong Liu et al.
Journal of cancer research and clinical oncology, 141(3), 431-441 (2014-09-24)
microRNAs (miRNAs) have been documented playing a critical role in cancer development and progression. In this study, we investigated the role of miR-548l in non-small cell lung cancer (NSCLC) migration and invasion. microRNAs microarray analysis was used to detect the
Fangjia Lu et al.
Journal of controlled release : official journal of the Controlled Release Society, 204, 51-59 (2015-03-10)
The use of nanoparticles for delivery of vaccine antigens and as vaccine adjuvants is appealing because their size allows efficient uptake by dendritic cells and their biological properties can be tailored to the desired function. Here, we report the effect
Marcel Kuhny et al.
Cell communication and signaling : CCS, 12, 40-40 (2014-09-04)
Mast cells (MCs) are major contributors to an inflammatory milieu. One of the most potent drivers of inflammation is the cytokine IL-1β, which is produced in the cytoplasm in response to danger signals like LPS. Several controlling mechanisms have been
S R Deshpande et al.
Indian journal of pharmaceutical sciences, 77(1), 24-33 (2015-03-15)
A series of novel 3, 4-methylenedioxybenzene scaffold incorporated 1,3,5-trisubstituted-2-pyrazoline derivatives was synthesised as potent antitubercular agents via chalcone intermediates by reaction with hydrazines. The structures of the compounds were confirmed by IR, 1HNMR, 13CNMR and mass spectral data. The novel
Tiong Chai Seah et al.
International journal of toxicology, 34(5), 454-468 (2015-08-14)
A cell-based assay to measure cytochrome P450 3A4 (CYP3A4) induction was developed to screen for potential CYP3A4 inducers. This 96-well format assay utilizes HepG2 cells transfected with a gene construct of CYP3A4 proximal promoter linked to green fluorescence protein (GFP)
Shoude Zhang et al.
BMC cancer, 14, 689-689 (2014-09-23)
Hypericum japonicum Thunb. ex Murray is widely used as an herbal medicine for the treatment of hepatitis and tumours in China. However, the molecular mechanisms of its effects are unclear. Our previous research showed that extracts of H. japonicum can
Samaneh Solati Sarvandi et al.
Iranian journal of basic medical sciences, 18(1), 89-97 (2015-03-27)
Mesenchyme is a type of undifferentiated loose connective tissue that is derived mostly from mesoderm. Recently, mesenchymal stem cells (MSCs), as adult stem cells (ASCs) able to divide into a variety of different cells, are of utmost importance for stem
Guang-Bi Jin et al.
European journal of immunology, 44(6), 1685-1698 (2014-02-13)
The aryl hydrocarbon receptor (AHR) has garnered considerable attention as a modulator of CD4(+) cell lineage development and function. It also regulates antiviral CD8(+) T-cell responses, but via indirect mechanisms that have yet to be determined. Here, we show that
Eun-Seok Park et al.
Journal of ethnopharmacology, 153(3), 552-560 (2014-03-13)
Many studies have emphasized that flavonoids, found in various fruits, vegetables, and seeds, as well as tea and red wine, have potential health-promoting and disease-preventing effects. Rhamnetin is a flavonoid that exhibits antioxidant capabilities. However, little is known about its
Cong Zhou et al.
BMC cancer, 15, 889-889 (2015-11-12)
Ovarian cancer is a possibly lethal gynecological malignancy and this study utilized phage display technology to screen and identify peptides that specifically bind to ovarian cancer cells and explored the effects of these peptides on ovarian cancer cells in vitro
Meng Yang et al.
Experimental biology and medicine (Maywood, N.J.), 240(12), 1717-1727 (2015-06-13)
Liver X receptors are in the nuclear receptor superfamily and are contained in the regulation of lipid and cholesterol metabolism. Besides, liver X receptors are considered crucial regulators of the inflammatory response and innate immunity. The current study evaluates the
Karrie Marren
The Physician and sportsmedicine, 39(3), 75-82 (2011-10-28)
Dimethyl sulfoxide (DMSO) is a molecule with a long history in pharmaceutics and is now well established as a penetration enhancer in topical pharmaceutical formulations. It is currently used for this purpose in diclofenac sodium topical solution (approved in the
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