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Showing 1-30 of 198 results for "D5905" within Papers
Mariana A Woudwyk et al.
Experimental parasitology, 156, 32-36 (2015-06-02)
Bovine tritrichomonosis is a sexually transmitted disease caused by the protozoon Tritrichomonas foetus and characterised by embryonic-death and abortion. During pregnancy, the processes of cell proliferation and death play a crucial role for blastocyst implantation and the subsequent maintenance of
R L Cramp et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 185, 107-114 (2015-04-15)
While there is a considerable body of work describing osmoregulation by elasmobranchs in brackish and saltwater, far fewer studies have investigated osmoregulation in hypersaline waters. We examined osmo- and ionoregulatory function and plasticity in juvenile brown-banded bamboo sharks, Chiloscyllium punctatum
Timothy J Break et al.
Science (New York, N.Y.), 371(6526) (2021-01-16)
Human monogenic disorders have revealed the critical contribution of type 17 responses in mucosal fungal surveillance. We unexpectedly found that in certain settings, enhanced type 1 immunity rather than defective type 17 responses can promote mucosal fungal infection susceptibility. Notably
Gonzalo Pérez-Arana et al.
Histology and histopathology, 30(4), 479-487 (2014-11-15)
Several surgical techniques are used nowadays as a severe treatment for obesity and diabetes mellitus type 2. These techniques are aggressive due to drastic changes in the nutrient flow and non-reversible modifications on the digestive tube. In this paper we
Jose Luis Slon-Campos et al.
Nature immunology, 20(10), 1291-1298 (2019-09-04)
Infections with dengue virus (DENV) and Zika virus (ZIKV) can induce cross-reactive antibody responses. Two immunodominant epitopes-one to precursor membrane protein and one to the fusion loop epitope on envelope (E) protein-are recognized by cross-reactive antibodies1-3 that are not only
Leonardo Della Salda et al.
Veterinary and comparative oncology, 17(3), 298-307 (2019-02-16)
Nectin-4 is an E-cadherin-based adherens junction protein of normal epithelial cells, as well as a potent mediator of anchorage-independent cancer colony formation. It is considered a tumour-associated histological and serological marker in various human cancers. The transcription factor p63 is
Rui Zhang et al.
Oncology reports, 32(1), 286-292 (2014-05-21)
Evidence suggests that Pin2/TRF1-interacting protein X1 (PinX1) inhibits telomerase activity in many types of cancer cells. G-patch is a motif in the PinX1 protein; however, the function of G-patch in colorectal cancer cells has not been definitively elucidated. The present
Mónica Romera-Hernández et al.
Cell reports, 30(1), 37-45 (2020-01-09)
Tissue repair requires temporal control of progenitor cell proliferation and differentiation to replenish damaged cells. In response to acute insult, group 3 innate lymphoid cells (ILC3s) regulate intestinal stem cell maintenance and subsequent tissue repair. ILC3-derived IL-22 is important for
Yoon-Jung Choy et al.
Journal of chemical neuroanatomy, 66-67, 10-18 (2015-04-11)
Neuroinflammation is an early event and important contributor to the pathobiology of neurodegenerative diseases. Neuroglia, especially microglia, are a major central nervous system population that can modulate neuroinflammation. To determine potential key molecules in this process, we employed microarray analysis
Serge Corbeil et al.
Journal of virological methods, 211, 43-50 (2014-12-03)
An in situ hybridization protocol for detecting mRNAs of ostreid herpesvirus type 1 (OsHV-1) which infects Pacific oysters, Crassostrea gigas, was developed. Three RNA probes were synthesized by cloning three partial OsHV-1 genes into plasmids using three specific primer pairs
Rui-Fang Li et al.
Experimental and therapeutic medicine, 9(3), 697-706 (2015-02-11)
Treatments for leukemia remain unsatisfactory. Conventional chemotherapy agents that aim to kill tumor cells may also damage normal cells and thus result in severe side-effects. Naringenin, a natural polyphenolic compound with antioxidant effects, has been revealed to have significant antitumor
Kai-Ping Chang et al.
Scientific reports, 5, 11689-11689 (2015-07-04)
The profiling of cancer cell secretomes is considered to be a good strategy for identifying cancer-related biomarkers, but few studies have focused on identifying low-molecular-mass (LMr) proteins (<15 kDa) in cancer cell secretomes. Here, we used tricine-SDS-gel-assisted fractionation and LC-MS/MS
Jacqueline Atsuko Tida et al.
Acupuncture in medicine : journal of the British Medical Acupuncture Society, 36(6), 386-393 (2018-08-26)
Acupuncture has been associated with improved cerebral circulation, analgesia, neuromodulatory function and neurogenesis. In particular, acupuncture at ST36 has been widely used in several central nervous system (CNS) disorders, including neurodegenerative diseases. However, its effects on hydrocephalus have not been
Valentin Becker et al.
World journal of gastroenterology, 21(3), 982-987 (2015-01-28)
To determine the laryngeal H+K+-ATPase and pharyngeal pH in patients with laryngopharyngeal reflux (LPR)-symptoms as well as to assess the symptom scores during PPI therapy. Endoscopy was performed to exclude neoplasia and to collect biopsies from the posterior cricoid area
Sanchari Datta et al.
The Journal of cell biology, 218(4), 1335-1351 (2019-02-16)
Lipid droplets (LDs) are nutrient reservoirs used by cells to maintain homeostasis. Nascent droplets form on the endoplasmic reticulum (ER) and grow following an influx of exogenous fatty acids (FAs). The budding of LDs requires extensive ER-LD crosstalk, but how
Z-Y Zhang et al.
Transplantation proceedings, 46(5), 1594-1600 (2014-06-18)
Activated hepatic stellate cells (HSCs) possess strong immune inhibitory activity. The present study highlighted the protective role of HSCs in islet transplantation. Recipients were randomly divided into 4 groups: a diabetic group, an HSC-alone group, an islet-alone transplant group, and
Diana Alarcón-Arís et al.
EBioMedicine, 59, 102944-102944 (2020-08-19)
Progressive neuronal death in monoaminergic nuclei and widespread accumulation of α-synuclein are neuropathological hallmarks of Parkinson's disease (PD). Given that α-synuclein may be an early mediator of the pathological cascade that ultimately leads to neurodegeneration, decreased α-synuclein synthesis will abate
Hung-Chih Hsu et al.
Journal of cancer research and clinical oncology, 141(1), 11-21 (2014-07-26)
Lysine-specific demethylase 1 (LSD1) was highly expressed in several malignancies and had been implicated in pathological processes of cancer cells. However, the role of LSD1 in colorectal cancer (CRC) carcinogenesis, prognosis and treatment remains uncharacterized. In this study, we examined
Jason Chesney et al.
Oncotarget, 5(16), 6670-6686 (2014-08-15)
Fructose-2,6-bisphosphate (F2,6BP) is a shunt product of glycolysis that allosterically activates 6-phosphofructo-1-kinase (PFK-1) resulting in increased glucose uptake and glycolytic flux to lactate. The F2,6BP concentration is dictated by four bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFKFB1-4) with distinct kinase:phosphatase activities. PFKFB4 is over-expressed
Hui Yi Chew et al.
Cell, 180(5), 895-914 (2020-03-07)
A safe and controlled manipulation of endocytosis in vivo may have disruptive therapeutic potential. Here, we demonstrate that the anti-emetic/anti-psychotic prochlorperazine can be repurposed to reversibly inhibit the in vivo endocytosis of membrane proteins targeted by therapeutic monoclonal antibodies, as directly demonstrated
Tayana Silva de Carvalho et al.
Molecular neurobiology, 58(4), 1491-1503 (2020-11-18)
Calorie restriction confers post-ischemic neuroprotection, when administered in a defined time window before ischemic stroke. How a hypocaloric diet influences stroke recovery when initiated after stroke has not been investigated. Male C57BL6/j mice were exposed to transient intraluminal middle cerebral
A R Tejeda-Martínez et al.
Behavioural neurology, 2021, 6651492-6651492 (2021-04-10)
Symptoms of depressive disorders such as anhedonia and despair can be a product of an aberrant adaptation to stress conditions. Chronic unpredictable stress model (CUS) can generate an increase in the activity of the hypothalamic-pituitary-adrenal axis (HPA) and induce a
Regulation of Hepatic Metabolism: Intra- and Intercellular Compartmentation (2012)
Barbro Ekstrand-Hammarström et al.
Biomaterials, 51, 58-68 (2015-03-17)
There is a compelling need to understand and assess the toxicity of industrially produced nanoparticles (NPs). In order to appreciate the long-term effects of NPs, sensitive human-based screening tests that comprehensively map the NP properties are needed to detect possible
Sujin Park et al.
Histochemistry and cell biology, 153(2), 89-99 (2019-11-14)
Autophagy is a degradative cellular process that can be both non-selective and selective and begins with the formation of a unique smooth double-membrane phagophore which wraps around a portion of the cytoplasm. Excess and damaged organelles and cytoplasmic protein aggregates
Sandra Barata-Antunes et al.
International journal of molecular sciences, 21(10) (2020-05-20)
Parkinson's disease (PD) is the second most common age-related neurodegenerative disorder. The neurodegeneration leading to incapacitating motor abnormalities mainly occurs in the nigrostriatal pathway due to the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Several animal
Alexey A Konev et al.
Clinical biochemistry, 48(12), 774-780 (2015-05-31)
Recent findings show that circulating N- and C-terminal fragments of IGF-binding protein-4 (NT-IGFBP-4 and CT-IGFBP-4) can be utilized as biomarkers for cardiac risk assessment in acute coronary syndrome (ACS) patients. The fragments are thought to be the products of pregnancy-associated
Janneke E Jaspers et al.
Cancer research, 75(4), 732-741 (2014-12-17)
Pan- or multidrug resistance is a central problem in clinical oncology. Here, we use a genetically engineered mouse model of BRCA2-associated hereditary breast cancer to study drug resistance to several types of chemotherapy and PARP inhibition. We found that multidrug
Tayana Silva de Carvalho et al.
Molecular neurobiology, 56(12), 8477-8488 (2019-07-02)
Food composition influences stroke risk, but its effects on ischemic injury and neurological deficits are poorly examined. While severe reduction of protein content was found to aggravate neurological impairment and brain injury as a consequence of combined energy-protein malnutrition, moderate
Emilio Varea et al.
Frontiers in neuroscience, 5, 17-17 (2011-03-19)
Neuronal production persists during adulthood in the dentate gyrus and the olfactory bulb, where substantial numbers of immature neurons can be found. These cells can also be found in the paleocortex layer II of adult rodents, but in this case
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