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Showing 1-30 of 198 results for "D5905" within Papers
Ewa Tomaszewska et al.
Journal of clinical medicine, 10(21) (2021-11-14)
A metabolite of leucine, ß-hydroxy-ß-methylbutyrate (HMB), used as a dietary supplement effects muscle tissue gain and bone tissue quality. Since there are no studies on the effects of HMB during pregnancy yet, the aim of the current study was to
Grethe M Olsen et al.
Frontiers in systems neuroscience, 13, 38-38 (2019-09-10)
Recent investigations of the rat posterior parietal cortex (PPC) suggest that this region plays a central role in action control together with the frontal cortical areas. Posterior parietal-frontal cortical connections have been described in rats, but little is known about
Gregory Charles Nordmann et al.
Scientific reports, 10(1), 915-915 (2020-01-24)
The transcription factor ZENK is an immediate early gene that has been employed as a surrogate marker to map neuronal activity in the brain. It has been used in a wide variety of species, however, commercially available antibodies have limited
Elena Pomari et al.
Molecules (Basel, Switzerland), 20(5), 8409-8428 (2015-05-15)
Rhodiola rosea (Rro) has been reported to have various pharmacological properties, including anti-fatigue, anti-stress and anti-inflammatory activity. It is also known to improve glucose and lipid metabolism, but the effects of Rhodiola rosea on adipocyte differentiation and metabolism are not
Ronny Bayer et al.
Drug and alcohol dependence, 156, 139-149 (2015-09-30)
Adult neurogenesis has been shown to occur throughout life and different brain pathologies were demonstrated to be associated with altered neurogenesis. Here, an impact of heroin addiction on neurogenesis in humans is hypothesised. Post mortem hippocampal specimens of drug addicts
Lindsey B Kuiper et al.
Frontiers in behavioral neuroscience, 14, 87-87 (2020-07-17)
Individual variance in vulnerability to develop addictions is influenced by social factors. Specifically, drug-taking in a sexual context appears to enhance further drug-seeking behavior in human users, as these users identify the effects of drugs to enhance sexual pleasure as
Sara Sanz-Blasco et al.
Molecular neurobiology, 55(6), 5125-5136 (2017-08-26)
Dopamine replacement therapy with L-DOPA is the treatment of choice for Parkinson's disease; however, its long-term use is frequently associated with L-DOPA-induced dyskinesia (LID). Many molecules have been implicated in the development of LID, and several of these have been
Jian Zhang et al.
Oncology reports, 33(1), 103-110 (2014-10-22)
Programmed cell death 2 (PDCD2) is a highly conserved nuclear protein, and aberrant PDCD2 expression alters cell apoptosis. The present study aimed to investigate PDCD2 expression in gastric cancer. Tissue specimens from 34 gastric cancer patients were collected for analysis
Mohammad AlWahsh et al.
EXCLI journal, 18, 51-62 (2019-04-09)
Repeated administration of hepatotoxicants is usually accompanied by liver fibrosis. However, the difference in response as a result of repeated exposures of acetaminophen (APAP) compared to a single dose is not well-studied. Therefore, in the current study, the liver response
Taku Fujimura et al.
Dermatology (Basel, Switzerland), 230(3), 250-255 (2015-02-14)
Continuous intra-arterial administration of peplomycin (PEP) through a tumor-feeding artery using an intravascular indwelling catheter is one of the best treatments for cutaneous squamous cell carcinoma (SCC) on cosmetic areas. Although this reagent is useful for the treatment of SCC
Yuzi Luo et al.
Journal of virological methods, 222, 22-27 (2015-05-26)
Classical swine fever (CSF), caused by classical swine fever virus (CSFV), is a devastating disease of swine worldwide. Although a mandatory vaccination with the modified live vaccine C-strain has been implemented in China for decades, CSF remains a serious threat
Ajai Tripathi et al.
Annals of clinical and translational neurology, 8(6), 1279-1291 (2021-05-13)
Multiple sclerosis (MS) is an inflammatory, demyelinating and neurodegenerative disease of the central nervous system (CNS). Though MS was initially considered to be a white matter demyelinating disease, myelin loss in cortical gray matter has been reported in all disease
Guo-Qing Song et al.
Oncology reports, 33(2), 669-674 (2014-11-26)
Breast cancer is the leading cause of cancer-related death in women. Kisspeptin-10 (KP-10) is a shorter fragment of KISS1. In the present study, we demonstrated the antitumor effects of KP-10 on human breast cancer cell lines, MDA-MB-231 and MDA-MB-157, both
David J Pearton et al.
Developmental biology, 392(2), 344-357 (2014-05-27)
In mice the transcription factor Elf5 is necessary for correct trophoblast development. Upon knockdown of Elf5, TS cells display neither a decrease in proliferation nor an increase in cell death but rather an increased propensity to differentiate. Such cells rapidly
Maria de Fátima Martins et al.
Acta histochemica, 121(2), 119-124 (2018-11-19)
Mammalian lung development is a complex process that is partially accomplished during the postnatal period. Surface carbohydrates are crucial in many biological and pathological phenomena and are key partners during development. The outer surface of lung epithelial cells, which is
Nami Yamashita et al.
Clinical breast cancer, 15(6), 498-504 (2015-07-22)
Triple-negative breast cancer (TNBC) has many similarities with basal-like breast cancer. Additionally, TNBCs are associated with Breast cancer susceptibility gene I (BRCA1) functional loss, which leads to impaired homologous recombination-mediated DNA repair. Although somatic mutations in BRCA1 rarely occur in
Beeran Meghpara et al.
Archives of ophthalmology (Chicago, Ill. : 1960), 127(8), 1029-1035 (2009-08-12)
To examine histopathologic and immunohistochemical features of human corneal buttons from patients who developed keratoglobus. Nine corneal buttons were obtained during penetrating keratoplasty from patients with keratoglobus. Histologic features were examined using hematoxylin-eosin-stained sections. Immunohistochemical staining for alpha1-proteinase inhibitor, Sp1
Tadateru Iwayama et al.
Journal of cardiology, 63(5), 344-349 (2013-11-16)
Epicardial adipose tissue (EAT) surrounding the heart may contribute to the development of coronary artery disease (CAD) through its local secretion of adipocytokines. Although the quantity of EAT is associated with obesity and metabolic syndrome, the role of EAT in
Mihika Gangolli et al.
Journal of neurotrauma, 36(5), 735-755 (2018-08-24)
Due to the unmet need for a means to study chronic traumatic encephalopathy (CTE) in vivo, there have been numerous efforts to develop an animal model of this progressive tauopathy. However, there is currently no consensus in the field on
Jean-Baptiste Faure et al.
Epilepsia, 55(5), 644-653 (2014-03-14)
Temporal lobe epilepsy is a relatively frequent, invalidating, and often refractory neurologic disorder. It is associated with cognitive impairments that affect memory and executive functions. In the rat lithium-pilocarpine temporal lobe epilepsy model, memory impairment and anxiety disorder are classically
Vladimirs Pilipenko et al.
European journal of pharmacology, 881, 173290-173290 (2020-06-25)
The earliest hallmarks of sporadic Alzheimer's disease (sAD) are impaired glucose metabolism, chronic neuroinflammation, diminished synaptic plasticity and subsequent cognitive decline. The safest antidiabetic drug metformin has shown both glucose metabolism-improving and cognition-enhancing action in type 2 diabetes patients and
Carla D Cisternas et al.
Molecular and cellular endocrinology, 414, 99-110 (2015-08-02)
Aromatase, which converts testosterone in estradiol, is involved in the generation of brain sex dimorphisms. Here we used the "four core genotypes" mouse model, in which the effect of gonadal sex and sex chromosome complement is dissociated, to determine if
C Ingvorsen et al.
International journal of obesity (2005), 38(10), 1282-1289 (2014-05-03)
Maternal obesity is associated with increased risk of metabolic dysfunction in the offspring. It is not clear whether it is the metabolic changes or chronic low-grade inflammation in the obese state that causes this metabolic programming. We therefore investigated whether
Sarah E Barnes et al.
Journal of neuroinflammation, 18(1), 199-199 (2021-09-14)
Patients with chronic inflammatory disorders such as inflammatory bowel disease frequently experience neurological complications including epilepsy, depression, attention deficit disorders, migraines, and dementia. However, the mechanistic basis for these associations is unknown. Given that many patients are unresponsive to existing
Edgar Dahl et al.
BMC cancer, 9, 410-410 (2009-11-26)
Y-box binding protein-1 (YB-1) is the prototypic member of the cold shock protein family that fulfills numerous cellular functions. In the nucleus YB-1 protein orchestrates transcription of proliferation-related genes, whereas in the cytoplasm it associates with mRNA and directs translation.
Tassanee Lerksuthirat et al.
PloS one, 10(3), e0118547-e0118547 (2015-03-21)
Pythium insidiosum is a unique oomycete that can infect humans and animals. Patients with a P. insidiosum infection (pythiosis) have high rates of morbidity and mortality. The pathogen resists conventional antifungal drugs. Information on the biology and pathogenesis of P.
Elisa Gecchele et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 960, 34-42 (2014-05-03)
The 65-kDa isoform of human glutamic acid decarboxylase (hGAD65) is a major autoantigen in autoimmune diabetes. The heterologous production of hGAD65 for diagnostic and therapeutic applications is hampered by low upstream productivity and the absence of a robust and efficient
Hongrui Liu et al.
Materials science & engineering. C, Materials for biological applications, 53, 83-94 (2015-06-05)
Stromal cell-derived factor-1 (SDF-1) recruits adult stem/progenitor cells via its specific receptor, C-X-C motif receptor 4 (CXCR4), to promote heart, kidney and tendon regeneration, but little is known about the effects of SDF-1 on bone regeneration in periodontal diseases. The
Alba Timón-Gómez et al.
STAR protocols, 1(2) (2020-10-01)
By using negatively charged Coomassie brilliant blue G-250 dye to induce a charge shift on proteins, blue native polyacrylamide gel electrophoresis (BN-PAGE) allows resolution of enzymatically active multiprotein complexes extracted from cellular or subcellular lysates while retaining their native conformation.
Jessica S Jarmasz et al.
Clinical epigenetics, 11(1), 5-5 (2019-01-13)
Epigenetic (including DNA and histone) modifications occur in a variety of neurological disorders. If epigenetic features of brain autopsy material are to be studied, it is critical to understand the post-mortem stability of the modifications. Pig and mouse brain tissue
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