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Showing 1-30 of 682 results for "D65100" within Papers
Özge Erdemli et al.
Journal of biomaterials applications, 29(4), 524-542 (2014-05-24)
Anti-tumor necrosis factor α (TNFα) drugs such as etanercept (ETN) have been mostly used in systemic treatment of rheumatoid arthritis. To eliminate the side effects in long-term treatments and to achieve a local sustained anti-inflammatory effect, a controlled drug delivery
Eshwar Jagerdeo et al.
Journal of analytical toxicology, 39(2), 83-88 (2014-11-30)
The abuse of gamma-hydroxybutyric acid (GHB) and its suspicion in cases of suspected drug-facilitated sexual assault is of keen interest to forensic toxicology laboratories. This paper reports an extraction, separation and detection procedure for GHB in hair utilizing a combination
Lu Zhang et al.
Colloids and surfaces. B, Biointerfaces, 122, 260-269 (2014-07-25)
In order to enhance the antitumor effects of doxorubicin (DOX), a novel micellar vector with high DOX loading and tumor targeting function based on folate-conjugated amphiphilic copolymer folate-poly(ethylene glycol)-poly(d,l-lactide)-β-cyclodextrin (FA-PEL-CD) was constructed. Cytotoxicity and cellular uptake experiments were performed in
Qing Lan et al.
Carcinogenesis, 36(1), 160-167 (2014-11-14)
Formaldehyde (FA) is an economically important industrial chemical to which millions of people worldwide are exposed environmentally and occupationally. Recently, the International Agency for Cancer Research concluded that there is sufficient evidence that FA causes leukemia, particularly myeloid leukemia. To
Fan Meng et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 71, 12-24 (2015-02-18)
Curcumin (CUR) was used as a poorly soluble drug whereas polyvinyl pyrrolidone K90 (PVP), Eudragit EPO (EPO), hydroxypropyl methylcellulose E5 (HPMC) and polyethylene glycol 8000 (PEG) were used as hydrophilic polymers. CUR polymer miscibility was evaluated by solubility parameter, melting
Jakub Vysloužil et al.
Acta pharmaceutica (Zagreb, Croatia), 64(4), 403-417 (2014-12-23)
The main objective of this study was to evaluate the influence of the formulation and process parameters on PLGA microparticles containing a practically insoluble model drug (ibuprofen) prepared by the o/w solvent evaporation method. Multivariate data analysis was used. The
Olaf Wagner et al.
International journal of molecular sciences, 16(9), 20183-20194 (2015-09-08)
Perfluoroalkyl-functionalized, hyperbranched polyglycerols that produce stable microbubbles are integrated into a microfluidic emulsion to create porous microspheres. In a previously-presented work a dendrimer with a perfluorinated shell was used. By replacing this dendrimer core with a hyperbranched core and evaluating
Bilal Yilmaz et al.
Journal of chromatographic science, 52(7), 584-589 (2013-06-25)
A simple high-performance liquid chromatography method has been developed for the determination of naproxen in human plasma. The method was validated on an Ace C18 column using ultraviolet detection. The mobile phase consisted of 20 mM phosphate buffer (pH 7)
Maryam Maghsoodi et al.
Drug development and industrial pharmacy, 40(11), 1468-1475 (2013-08-14)
Spherical crystallization is a process of formation of agglomerates of crystals held together by binder liquid. This research focused on understanding the effect of type of solvents used as binder liquid on the agglomeration of crystals. Carbamazepine and ethanol/water were
Yun Hu et al.
Acta biomaterialia, 28, 149-159 (2015-10-03)
Lipid-polymer hybrid nanoparticles (NPs), consisting of a polymeric core and a lipid shell, have been intensively examined as delivery systems for cancer drugs, imaging agents, and vaccines. For applications in vaccine particularly, the hybrid NPs need to be able to
Monika Gibis et al.
Journal of food science, 80(11), C2430-C2439 (2015-10-08)
The impact of precursors such as creatine, creatinine, and glucose on the formation of mutagenic/carcinogenic heterocyclic amines (HAs) were studied in patties of 9 different animal species equally heat treated with a double-plate contact grill. All grilled patties of the
Yu-Xin Xu et al.
Journal of lipid research, 56(2), 266-276 (2014-12-22)
Perlecan is a major heparan sulfate (HS) proteoglycan in the arterial wall. Previous studies have linked it to atherosclerosis. Perlecan contains a core protein and three HS side chains. Its core protein has five domains (DI-DV) with disparate structures and
Sylvain Merel et al.
Chemosphere, 127, 238-245 (2015-03-10)
N,N-diethyl-m-toluamide (DEET), the active component of many insect repellents, is among the most frequently detected compounds in aqueous environments with concentrations reported in the ng L(-1) to μg L(-1) range. However, DEET is often detected in blanks and reported concentrations
Christopher R Behrens et al.
Molecular pharmaceutics, 12(11), 3986-3998 (2015-09-24)
Conventional antibody-drug conjugates (ADCs) are heterogeneous mixtures of chemically distinct molecules that vary in both drugs/antibody (DAR) and conjugation sites. Suboptimal properties of heterogeneous ADCs have led to new site-specific conjugation methods for improving ADC homogeneity. Most site-specific methods require
Darina Lankova et al.
Analytica chimica acta, 854, 61-69 (2014-12-07)
In the present study, a novel analytical approach for the simultaneous determination of 27 brominated flame retardants (BFRs), namely polybrominated diphenyl ethers (PBDEs), isomers of hexabromocyclododecane (HBCD), tetrabromobisphenol A (TBBPA) and several novel BFRs (NBFRs), together with 18 perfluoroalkyl substances
Zulin Zhang et al.
Journal of separation science, 37(24), 3699-3705 (2014-10-02)
A simple and rapid method was developed for the simultaneous analysis of nine different pesticides in water samples by gas chromatography with mass spectrometry. A number of parameters that may affect the recovery of pesticides, such as the type of
Sarah E Rothenberg et al.
Environmental pollution (Barking, Essex : 1987), 196, 125-133 (2014-12-03)
The rice ingestion rate in Madagascar is among the highest globally; however studies concerning metal(loid) concentrations in Madagascar rice are lacking. For Madagascar unpolished rice (n = 51 landraces), levels of toxic elements (e.g., total mercury, methylmercury, arsenic and cadmium)
Mette Thing et al.
Journal of pharmaceutical sciences, 103(12), 4021-4029 (2014-10-31)
Long-acting nonsteroidal anti-inflammatory drug formulations for intra-articular injection might be effective in the management of joint pain and inflammation associated sports injuries and osteoarthritis. In this study, a prodrug-based delivery system was evaluated. The synthesized diclofenac ester prodrug, a weak
Attractors in Sequence Space: Peptide Morphing by Directed Simulated Evolution.
Jan A Hiss et al.
Molecular informatics, 34(11-12), 709-714 (2016-01-19)
Mauricio Mora-Pale et al.
Biotechnology and bioengineering, 112(12), 2417-2428 (2015-06-26)
Plant polyphenols are known to have varying antimicrobial potencies, including direct antibacterial activity, synergism with antibiotics and suppression of bacterial virulence. We performed the in vitro oligomerization of resveratrol catalyzed by soybean peroxidase, and the two isomers (resveratrol-trans-dihydrodimer and pallidol)
Jian Kang et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 62, 141-147 (2014-06-08)
A novel method has been developed to protect Recombinant Human Growth Hormone (rhGH) in poly (lactic-co-glycolic acid) (PLGA) microspheres using an aqueous phase/aqueous phase emulsion and S/O/W multi-emulsion method. This method develops a novel rhGH sustained-release system, which is based
Xiuhong Wu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 989, 98-103 (2015-03-31)
We investigated the metabolic fate of gentianine after oral administration to Wistar rats for the first time. Liquid chromatography/ion trap mass spectrometry detected four metabolites secogentianoxide, gentiandiol, gentianepoxide and gentianoxide in rat plasma together with the original compound gentianine. The
Bettina Gohlke et al.
Hormone research in paediatrics, 84(5), 331-337 (2015-10-07)
Events during foetal or early extrauterine life may affect bodily structure and/or functions and even pave the way for adult diseases. To find whether extremely low birth weight (ELBW) infants differ from healthy controls regarding the excretion of steroid metabolites.
Qing Lin et al.
Oncology reports, 32(6), 2405-2410 (2014-09-19)
Tumor treatment requires a long-term regimen of chemotherapy, and both surgical tumor resection and radiation therapy are also used. The present study aimed to develop a novel method for 5-fluorouracil (5-FU)-loaded microspheres which enhance the therapeutic effects of chemotherapy, the
Gui-Peng Tian et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 70(12), 1934-1940 (2014-12-19)
1,4-Dioxane is a probable human carcinogenic and refractory substance that is widely detected in aquatic environments. Traditional wastewater treatment processes, including activated sludge, cannot remove 1,4-dioxane. Removing 1,4-dioxane with a reaction kinetic constant of 0.32 L/(mol·s) by using ozone, a
Victor V Zubkov et al.
The Journal of chemical physics, 137(7), 074705-074705 (2012-08-28)
The method for prediction of structural properties of ultrathin liquid layers has been developed on the base of the atomistic molecular dynamics (AMD) and the density functional theory (DFT). A comparative analysis of ultrathin dichloromethane layer density profiles on three
Smriti Sharma et al.
Journal of AOAC International, 97(4), 1183-1188 (2014-08-26)
An analytical method to quantify imidacloprid and its metabolites in sugarcane leaves and soil using HPLC has been developed. The samples were extracted with acetonitrile + water (80 + 20, v/v), soil samples partitioned with dichloromethane, and leaf samples with
Ana Masiá et al.
Journal of chromatography. A, 1378, 19-31 (2015-01-13)
Pressurized liquid extraction (PLE) and Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS) extraction methods were optimized for the simultaneous determination of 50 pesticides in sediment, soils and sewage sludge. For QuEChERS development, several buffers and dispersive solid-phase extraction clean-up
Agnieszka Kucharska et al.
The Science of the total environment, 505, 1062-1071 (2014-12-03)
In this study, we investigated the hypothesis whether externally adsorbed and internally deposited flame retardants (FRs) in hair could be distinguished. To this extent, hair samples collected from one volunteer were exposed under controlled conditions to phosphate FR (PFR) and
Prachi Kakkar et al.
Materials science & engineering. C, Materials for biological applications, 45, 343-347 (2014-12-11)
Keratin has gained much attention in the recent past as a biomaterial for wound healing owing to its biocompatibility, biodegradability, intrinsic biological activity and presence of cellular binding motifs. In this paper, a novel biomimetic scaffold containing keratin, chitosan and
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