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Showing 1-30 of 471 results for "D7008" within Papers
Xiaofei Xu et al.
Endocrinology, 155(4), 1510-1519 (2014-01-31)
Uterine leiomyomas (fibroids) are a major public health problem. Current medical treatments with GnRH analogs do not provide long-term benefit. Thus, permanent shrinkage or inhibition of fibroid growth via medical means remains a challenge. The AKT pathway is a major
Lidia Garcia-Bonilla et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(44), 14783-14793 (2015-11-06)
The scavenger receptor CD36 is a critical factor initiating ischemic brain injury, but the cell type(s) expressing CD36 and responsible for its harmful effects remain unknown. Using bone marrow (BM) chimeras subjected to transient middle cerebral artery occlusion, we found
Lian Wang et al.
Molecular medicine reports, 9(2), 435-442 (2013-12-18)
Oxidative stress is becoming increasingly linked to the pathogenesis of abdominal aortic aneurysms (AAAs). The antioxidant activity of flavonoids has attracted attention for their possible role in the prevention of cardiovascular diseases. The purpose of this study was to determine
Dinesh M Tripathi et al.
American journal of physiology. Gastrointestinal and liver physiology, 309(5), G301-G309 (2015-07-04)
Increased hepatic vascular resistance is the primary factor in the development of portal hypertension. Metformin ameliorates vascular cells function in several vascular beds. Our study was aimed at evaluating the effects, and the underlying mechanisms, of metformin on hepatic and
Bernadette McEvoy et al.
The Journal of physiology, 593(23), 5167-5182 (2015-10-21)
The pancreatic β-cell has reduced antioxidant defences making it more susceptible to oxidative stress. In cystinosis, a lysosomal storage disorder, an altered redox state may contribute to cellular dysfunction. This rare disease is caused by an abnormal lysosomal cystine transporter
Hsuan-Shun Huang et al.
The Journal of pathology, 240(4), 484-494 (2016-10-30)
Fallopian tube fimbrial epithelium is considered to be the major site of origin of ovarian high-grade serous carcinoma, with p53 loss being the earliest and universal change. We previously reported that reactive oxygen species (ROS) in the ovulatory follicular fluids
Qian Sun et al.
American journal of physiology. Gastrointestinal and liver physiology, 308(9), G757-G766 (2015-03-15)
Hepatic zinc deficiency has been well documented in alcoholic patients, but the mechanisms by which zinc deficiency mediates cell death have not been well defined. The objectives of this study were to determine whether alcohol perturbs subcellular zinc homeostasis and
Ufuk Ozer et al.
Molecular pharmacology, 88(6), 970-981 (2015-10-08)
Thymidylate synthase (TYMS; EC 2.1.1.15) catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) by N(5),N(10)-methyhlenetetrahydrofolate, forming dTMP for the maintenance of DNA replication and repair. Inhibitors of TYMS have been widely used in the treatment of neoplastic disease. A number of
Seung Tae Lee et al.
Biochemical pharmacology, 94(4), 257-269 (2015-03-04)
The present study sought to determine the correlation between 2-methoxyestradiol (2-MeO-E2)-induced cell cycle arrest and 2-MeO-E2-induced apoptosis. Exposure of Jurkat T cell clone (JT/Neo) to 2-MeO-E2 (0.5-1.0 μM) caused G2/M arrest, Bak activation, Δψm loss, caspase-9 and -3 activation, PARP
Xiang Xiao et al.
Experimental cell research, 336(1), 58-65 (2015-06-24)
Angiotensin (Ang) II, the main effector of the renin-angiotensin system, has been implicated in the pathogenesis of vascular diseases. Ang-(1-7) binds to the G protein-coupled Mas receptor (MasR) and can exert vasoprotective effects. We investigated the effects and underlying mechanisms
Prakash Pragya et al.
PloS one, 9(2), e88181-e88181 (2014-02-08)
The evolutionarily conserved innate immune system plays critical role for maintaining the health of an organism. However, a number of environmental chemicals including metals are known to exert adverse effects on immune system. The present study assessed the in vivo
Hong Pan et al.
PloS one, 9(12), e114186-e114186 (2014-12-04)
Retinal ischemia-reperfusion (I/R) injury induces oxidative stress, leukocyte infiltration, and neuronal cell death. Sulforaphane (SF), which can be obtained in cruciferous vegetables such as broccoli, exerts protective effects in response to oxidative stress in various tissues. These effects can be
Peng Wang et al.
Oncotarget, 6(25), 21148-21158 (2015-05-29)
The oncogenic K-Ras can transform various mammalian cells and plays a critical role in development of pancreatic cancer. MicroRNAs (miRNA) have been shown to contribute to tumorigenic progression. However, the nature of miRNAs involved in K-Ras transformation remains to be
Cristina Manguan-Garcia et al.
PloS one, 9(7), e101424-e101424 (2014-07-06)
The predominant X-linked form of Dyskeratosis congenita results from mutations in DKC1, which encodes dyskerin, a protein required for ribosomal RNA modification that is also a component of the telomerase complex. We have previously found that expression of an internal
Laure Campillo-Gimenez et al.
The Journal of allergy and clinical immunology, 134(5), 1142-1152 (2014-07-22)
Despite control of HIV infection under antiretroviral therapy (ART), immune T-cell activation persists in patients with controlled HIV infection, who are at higher risk of inflammatory diseases than the general population. PMNs play a key role in host defenses against
Bo Ra You et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36(3), 2087-2095 (2014-11-14)
PX-12 (1-methylpropyl 2-imidazolyl disulfide) as a thioredoxin (Trx) inhibitor has an anti-tumor effect. However, there is no report about the toxicological effect of PX-12 on lung cancer cells. Here, we investigated the anti-growth effects of PX-12 on Calu-6 lung cancer
Gabriela Braga Rodrigues et al.
Journal of photochemistry and photobiology. B, Biology, 209, 111942-111942 (2020-07-06)
Antimicrobial photodynamic treatment (APDT) has emerged as an effective therapy against pathogenic fungi with both acquired and intrinsic resistance to commonly used antifungal agents. Success of APDT depends on the availability of effective photosensitizers capable of acting on different fungal
Ming Kang et al.
Journal of virology, 88(21), 12541-12550 (2014-08-22)
Superoxide dismutases (SODs) are metalloproteins that protect organisms from toxic reactive oxygen species by catalyzing the conversion of superoxide anion to hydrogen peroxide and molecular oxygen. Chlorovirus PBCV-1 encodes a 187-amino-acid protein that resembles a Cu-Zn SOD with all of
Morihiko Maeda et al.
PloS one, 10(4), e0123169-e0123169 (2015-04-17)
Impaired glucose tolerance characterized by postprandial hyperglycemia, which occurs frequently in elderly persons and represents an important preliminary step in diabetes mellitus, poses an independent risk factor for the development of atherosclerosis. Endothelial cellular senescence is reported to precede atherosclerosis.
Carolina Luna et al.
Investigative ophthalmology & visual science, 62(1), 2-2 (2021-01-05)
To test the effect of different sodium channel blockers on the electrical activity of corneal nociceptors in intact and surgically injured corneas. In anesthetized guinea pigs, a 4-mm diameter corneal flap was performed in one eye at a midstromal depth
Yi Han et al.
PloS one, 7(11), e50402-e50402 (2012-12-05)
Previous studies indicated that estrogen could improve endothelial function. However, whether estrogen protects vascular complications of diabetes has yet to be clarified. The study was designed to investigate the action of 17ß-estradiol on vascular endothelium in streptozotocin (STZ)-induced diabetic rats.
Yucong Xue et al.
Pharmacology research & perspectives, 9(5), e00852-e00852 (2021-08-15)
Myocardial ischemia (MI) remains the leading cause of mortality worldwide. Therefore, it is urgent to seek the treatment to protect the heart. [8]-Gingerol (8-Gin), one of the most active ingredients in ginger, has antioxidant, cardiotonic, and cardiovascular protective properties. The
Kumar Sachin Singh et al.
Nature, 589(7843), 597-602 (2020-12-29)
Isoprenoids are vital for all organisms, in which they maintain membrane stability and support core functions such as respiration1. IspH, an enzyme in the methyl erythritol phosphate pathway of isoprenoid synthesis, is essential for Gram-negative bacteria, mycobacteria and apicomplexans2,3. Its
Vincenzo La Mura et al.
Journal of hepatology, 61(6), 1321-1327 (2014-07-20)
Sepsis is associated with microvascular dysfunction, which contributes to organ failure. Intrahepatic endothelial dysfunction occurs after exposure to lipopolysaccharide (LPS). The upregulation of inducible nitric oxide synthase (iNOS) has been shown to contribute to systemic vascular dysfunction after LPS administration.
Alexander V Ivanov et al.
Viruses, 7(6), 2745-2770 (2015-06-04)
Hepatitis C virus (HCV) infection is accompanied by the induction of oxidative stress, mediated by several virus proteins, the most prominent being the nucleocapsid protein (HCV core). Here, using the truncated forms of HCV core, we have delineated several mechanisms
Robert W Button et al.
The Journal of biological chemistry, 292(33), 13599-13614 (2017-07-05)
Autophagy comprises the processes of autophagosome synthesis and lysosomal degradation. In certain stress conditions, increased autophagosome synthesis may be associated with decreased lysosomal activity, which may result in reduced processing of the excessive autophagosomes by the rate-limiting lysosomal activity. Thus
20-HETE increases superoxide production and activates NAPDH oxidase in pulmonary artery endothelial cells.
Medhora M, et al.
American Journal of Physiology. Lung Cellular and Molecular Physiology, 294, L902-L911 (2008)
Amalia Icreverzi et al.
Cell cycle (Georgetown, Tex.), 11(3), 554-568 (2012-02-02)
Drosophila cyclinD (CycD) is the single fly ortholog of the mammalian cyclin D1 and promotes both cell cycle progression and cellular growth. However, little is known about how CycD promotes cell growth. We show here that CycD/Cdk4 hyperactivity leads to
Limei Liu et al.
Biochemical and biophysical research communications, 458(4), 796-801 (2015-02-18)
Activation of endoplasmic reticulum (ER) stress in endothelial cells leads to increased oxidative stress and often results in cell death, which has been implicated in hypertension. The present study investigated the effects of berberine, a botanical alkaloid purified from Coptidis
Gang Wang et al.
PloS one, 10(7), e0132046-e0132046 (2015-07-02)
Microwaves are used in one method of physical therapy and can increase muscle tissue temperature which is useful for improving muscle, tendon and bone injuries. In the study, we sought to determine whether titanium alloy internal fixations influence apoptosis in
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