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Showing 1-30 of 471 results for "D7008" within Papers
Feng Liu-Smith et al.
Methods in molecular biology (Clifton, N.J.) (2016-04-12)
Redox homeostasis plays multiple roles in essentially all aspects of cellular function, and hence, reliable methods for measuring cellular or tissue redox status are key elements in understanding the redox related signal pathways. However, in the free radical biology field
Potential importance of transition metals in the induction of DNA damage by sperm preparation media.
R J Aitken et al.
Human reproduction (Oxford, England), 29(10), 2136-2147 (2014-08-22)
What are the mechanisms by which the preparation of spermatozoa on discontinuous density gradients leads to an increase in oxidative DNA damage? The colloidal silicon solutions that are commonly used to prepare human spermatozoa for assisted reproduction technology (ART) purposes
Atsuko Nakayama et al.
PloS one, 10(9), e0137106-e0137106 (2015-09-04)
Oxidative stress has been implicated in cardiac remodeling (cardiac fibrosis and hypertrophy), which impairs cardiac function and metabolism; therefore, it is anticipated antioxidative compounds will have protective properties against cardiac remodeling. Luteolin (3',4',5,7-tetrahydroxyflavone), a widely distributed flavonoid found in many
Jinyao Jiang et al.
Redox biology, 36, 101638-101638 (2020-08-31)
Increased pulmonary vascular permeability due to endothelial cell (EC) barrier dysfunction is a major pathological feature of acute respiratory distress syndrome/acute lung injury (ARDS/ALI), which is a devastating critical illness with high incidence and excessive mortality. Activation of NADPH oxidase
Chang Hyun Byon et al.
Atherosclerosis, 241(2), 313-321 (2015-06-13)
Inflammation of vascular smooth muscle cells (VSMC) is intimately linked to atherosclerosis and other vascular inflammatory disease. Thioredoxin interacting protein (Txnip) is a key regulator of cellular sulfhydryl redox and a mediator of inflammasome activation. The goals of the present
Jacqueline Chor-Wing Tam et al.
Journal of diabetes and its complications, 28(4), 436-447 (2014-04-16)
Diabetic foot ulcer is closely associated with peripheral vascular disease. Enhancement of tissue oxidative stress, reduction of nitric oxide (NO) and angiogenic growth factors, and abnormal matrix metalloproteinase (MMP) activity are pathophysiological factors in post-ischemic neovascularization and diabetic wound healing.
Narayana Pineda-Ramírez et al.
Molecular neurobiology, 57(2), 1055-1069 (2019-11-02)
During cerebral ischemia, oxygen and glucose levels decrease, producing many consequences such as the generation of reactive oxygen species, tissue injury, and the general metabolism collapse. Resveratrol triggers signaling dependent on the protein kinase activated by adenosine monophosphate (AMPK), the
Ryuji Kato et al.
European journal of pharmacology, 765, 7-14 (2015-08-16)
Ezetimibe is as an inhibitor of NPC1L1 protein, which has a key role in cholesterol absorption. The aim of this study was to evaluate the influence of ezetimibe on the plasma lipid profile, atherosclerotic lesions, and cardiomyocyte ultrastructure in an
Zhongyuan He et al.
Cell death & disease, 9(5), 505-505 (2018-05-05)
Increasing evidence indicates that dysregulation of microRNAs (miRNAs) plays a crucial role in human malignancies. Here, we showed that microRNA-422a (miR-422a) expression was dramatically downregulated in gastric cancer (GC) samples and cell lines compared with normal controls, and that its
Joseph M Kulinski et al.
Virology, 483, 264-274 (2015-05-24)
Gammaherpesviruses are cancer-associated pathogens that establish life-long infection in most adults. Insufficiency of Ataxia-Telangiectasia mutated (ATM) kinase leads to a poor control of chronic gammaherpesvirus infection via an unknown mechanism that likely involves a suboptimal antiviral response. In contrast to
Smriti Shukla et al.
Pesticide biochemistry and physiology, 123, 74-86 (2015-08-13)
Oxidative stress is a key factor in Parkinson's disease (PD) pathogenesis. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and impaired mitochondrion regulate oxidative stress-mediated maneb (MB)- and paraquat (PQ)-induced Parkinsonism. However, their contribution in the MB- and PQ-induced toxicity in polymorphonuclear
Emile B Gordon et al.
mBio, 6(3), e00725-e00725 (2015-06-04)
Malaria is an infectious disease caused by parasites of several Plasmodium spp. Cerebral malaria (CM) is a common form of severe malaria resulting in nearly 700,000 deaths each year in Africa alone. At present, there is no adjunctive therapy for
Jingyang Feng et al.
Ophthalmic research, 52(4), 224-233 (2014-11-18)
Age-related lipofuscin N-retinylidene-N-retinylethanolamine (A2E) accumulated in human retinal pigment epithelium (RPE) cells confers susceptibility to blue light-mediated damage, which represents one pathogenesis of age-related macular degeneration. This study investigated the expression of 2 best-characterized endoplasmic reticulum (ER) stress markers, glucose-related
Bo Ra You et al.
Molecular medicine reports, 11(2), 1428-1434 (2014-11-06)
Auranofin (Au), an inhibitor of thioredoxin reductase, is a known anti‑cancer drug. In the present study, the anti‑growth effect of Au on HeLa cervical cancer cells was examined in association with levels of reactive oxygen species (ROS) and glutathione (GSH).
Jaimee C Eckers et al.
International journal of radiation oncology, biology, physics, 87(3), 619-625 (2013-10-01)
Radiation is a common mode of cancer therapy whose outcome is often limited because of normal tissue toxicity. We have shown previously that the accumulation of radiation-induced late reactive oxygen species (ROS) precedes cell death, suggesting that metabolic oxidative stress
Yongjun Zhong et al.
Microbial cell factories, 13, 163-163 (2014-11-27)
The yeast Pichia pastoris (P. pastoris) has become a popular 'cell factory' for producing heterologous proteins, but production widely varies among proteins. Cultivation temperature is frequently reported to significantly affect protein production; however, the underlying mechanisms of this effect remain
Shanshan W Howland et al.
PLoS pathogens, 11(6), e1004963-e1004963 (2015-06-06)
In the murine model of cerebral malaria caused by P. berghei ANKA (PbA), parasite-specific CD8+ T cells directly induce pathology and have long been hypothesized to kill brain endothelial cells that have internalized PbA antigen. We previously reported that brain
Priyanka Bapat et al.
International journal of molecular sciences, 22(9) (2021-05-01)
Her/2+ breast cancer accounts for ~25% mortality in women and overexpression of Her/2 leads to cell growth and tumor progression. Trastuzumab (Tz) with Taxane is the preferred treatment for Her/2+ patients. However, Tz responsive patients often develop resistance to Tz
Yi Zhou et al.
Experimental and therapeutic medicine, 22(6), 1380-1380 (2021-10-16)
Hepatic ischemia-reperfusion injury (HIRI) is caused by blood flow recovery following ischemia. Baicalein (BAI), a natural antioxidant used in traditional Chinese medicine, eliminates excessive free radicals and protects the structure of the cell membrane. However, its protective mechanism against HIRI
Narayana Pineda-Ramírez et al.
Antioxidants (Basel, Switzerland), 9(3) (2020-04-05)
This study aimed to compare the antioxidant activities of extracts obtained from three plant families and evaluate their therapeutic effect on strokes. Ethanol extracts were obtained from either the leaf or the aerial parts of plants of the families Annonaceae
Baomei Xia et al.
Frontiers in pharmacology, 11, 577062-577062 (2020-11-03)
α-Cyperone (Cy) is a major active compound of Cyperus rotundus that has various pharmacological activities. But whether Cy possesses antidepressant effect is unknown. In this study, we exposed mice to chronic unpredictable mild stress (CUMS) with or without intervention with
Hongfeng Chen et al.
PLoS genetics, 16(10), e1009046-e1009046 (2020-10-17)
The Ccr4-Not complex functions as an effector of multiple signaling pathways that control gene transcription and mRNA turnover. Consequently, Ccr4-Not contributes to a diverse array of processes, which includes a significant role in cell metabolism. Yet a mechanistic understanding of
Sheng Jin et al.
Oxidative medicine and cellular longevity, 2015, 758358-758358 (2015-06-17)
Aims. To examine whether hydrogen sulfide (H2S) generation changed in ageing diabetic mouse hearts. Results. Compared to mice that were fed tap water only, mice that were fed 30% fructose solution for 15 months exhibited typical characteristics of a severe
Hydrogen sulfide accelerates the recovery of kidney tubules after renal ischemia/reperfusion injury.
Sang Jun Han et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 30(9), 1497-1506 (2015-07-05)
Progression of acute kidney injury to chronic kidney disease (CKD) is associated with inadequate recovery of damaged kidney. Hydrogen sulfide (H2S) regulates a variety of cellular signals involved in cell death, differentiation and proliferation. This study aimed to identify the
Hui Gao et al.
Regulatory toxicology and pharmacology : RTP, 73(2), 587-594 (2015-09-13)
3-methyl-2-quinoxalin benzenevinylketo-1, 4-dioxide (Quinocetone, QCT) has been broadly used to treat dysentery and promote animal growth in food producing animals. However, its potential toxicity could not been neglected as parts of safety assessment according to the acceptable guidelines for QCT
Junhui Zhang et al.
Cell death & disease, 10(3), 234-234 (2019-03-10)
BNIP3 is an atypical BH3-only member of the Bcl-2 family with pro-death, pro-autophagic, and cytoprotective functions, depending on the type of stress and cellular context. Recently, we demonstrated that BNIP3 stimulates the migration of epidermal keratinocytes under hypoxia. In the
Naoto Terami et al.
PloS one, 9(6), e100777-e100777 (2014-06-25)
Inhibition of sodium glucose cotransporter 2 (SGLT2) has been reported as a new therapeutic strategy for treating diabetes. However, the effect of SGLT2 inhibitors on the kidney is unknown. In addition, whether SGLT2 inhibitors have an anti-inflammatory or antioxidative stress
Quercetin reduces oxidative stress and inhibits activation of c-Jun N-terminal kinase/activator protein-1 signaling in an experimental mouse model of abdominal aortic aneurysm.
Wang L, et al.
Molecular Medicine Reports, 9, 435-442 (2014)
X-R Liu et al.
European review for medical and pharmacological sciences, 19(21), 4068-4075 (2015-11-26)
To investigate the possible pathway involved in hydrogen peroxide (H2O2) induced apoptosis in U251 glioma cells. The cultured U251 glioma cells were used in this study. The cells were divided into three groups: control group (untreated glioma cells), H2O2 group
José George F Albuquerque et al.
BMC complementary and alternative medicine, 17(1), 376-376 (2017-07-30)
In northeastern Brazil, grape pomace has become a potential alternative byproduct because of the recover phenolic compounds from the vinification process. Comparative analyses were performed between lyophilized extract of grape skins from pomace, described as fermented (FGS), and fresh, unfermented
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