D9516

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Inhibitors of folic acid synthesis in the treatment of experimental Pneumocystis carinii pneumonia.

P D Walzer et al.

Antimicrobial agents and chemotherapy, 32(1), 96-103 (1988-01-01)

Inhibitors of folic acid synthesis were compared alone and in different combinations in the therapy of pneumocystosis in immunosuppressed rats. Sulfonamides (sulfamethoxazole, sulfadiazine, and sulfadoxine) and sulfones (dapsone) used alone were very active against Pneumocystis carinii, as judged by histologic

Mutagenicity of the coccidiostat diaveridine in the Salmonella/mammalian microsome assay.

H Yoshimura

Mutation research, 261(2), 149-152 (1991-10-01)

The coccidiostat diaveridine was tested for mutagenicity in the Salmonella/microsome assay with tester strains TA100 and TA98. This compound was not mutagenic in either tester strain in the presence and absence of rat S9 mix, but was found to be

A new antiinflammatory agent (EGIS-5645) without gastrointestinal side-effect.

G Gigler et al.

Agents and actions. Supplements, 32, 39-43 (1991-01-01)

The compound EGIS-5645 is a potent antipyretic agent possessing analgesic and antiinflammatory properties. The drug is active in antiinflammatory models such as carrageenin oedema and adjuvant arthritis. EGIS-5645 shows practically no gastro-ulcerogenic effect. The molecule does not inhibit either prostaglandin

Determination of residual diaveridine and sulfaquinoxaline in Hen's egg, chicken plasma and tissues by high-performance liquid chromatography.

T Sakano et al.

Chemical & pharmaceutical bulletin, 29(8), 2290-2295 (1981-08-01)

Mutagenic activity and mutational specificity of antiprotozoal drugs with and without nitrite treatment.

Tomoko Ono-Ogata et al.

Environmental and molecular mutagenesis, 39(1), 43-48 (2002-01-29)

We examined the mutagenic activities of six antiprotozoal drugs (three diaminopyrimidine compounds [pyrimethamine, diaveridine, and trimethoprim] and three 8-aminoquinoline derivatives [primaquine, pentaquine, and pamaquine]) in Escherichia coli WP2uvrA/pKM101 and Salmonella typhimurium TA100 and TA98 with and without nitrite treatment. The

Residue Reviews: Residues of Pesticides and Other Contaminants in the Total Environment (2012)

Demonstration of synergistic effects of sulfonamides and dihydrofolate reductase/thymidylate synthase inhibitors against Neospora caninum tachyzoites in cultured cells, and characterization of mutants resistant to pyrimethamine.

D S Lindsay et al.

American journal of veterinary research, 57(1), 68-72 (1996-01-01)

To examine the efficacies of combinations of 7 sulfonamides and 5 dihydrofolate reductase/thymidylate synthase (DHFR/TS) inhibitors against tachyzoites of Neospora caninum in cultured cells. Mutant tachyzoites that were resistant to pyrimethamine were produced and examined for resistance to other DHFR/TS

[Effect of sulfaquinoxaline and diaveridine on leucocytozoon infection in chickens].

A Tanabe et al.

Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 86(6), 411-415 (1985-12-01)

The preventive effect of sulfaquinoxaline and diaveridine in combination against leucocytozoon infection in White Leghorn female chickens was tested in a field trial. The experiment was initiated when the animals were 120 days old, and it lasted for 10 weeks.

[Polarographic determination of diaveridine in biological samples].

P Tömpe et al.

Acta pharmaceutica Hungarica, 60(1), 23-29 (1990-01-01)

Differential pulse polarographic method was applied for determination of diaveridine in plasma, whole blood and isolated organs (liver, spleen, kidney, thymus). Deproteinization of homogenized blood and organs had been carried out on Extrelut column and then concentration of diaveridine was

Characterization of in vitro metabolites of trimethoprim and diaveridine in pig liver microsomes by liquid chromatography combined with hybrid ion trap/time-of-flight mass spectrometry.

Zhao-Ying Liu et al.

Biomedical chromatography : BMC, 26(9), 1101-1108 (2011-12-14)

Trimethoprim (TMP) and diaveridine (DVD) are used in combination with sulfonamides and sulfaquinoxlaine as an effective antibacterial agent and antiprotozoal agent, respectively, in humans and animals. To gain a better understanding of the metabolism of TMP and DVD in the

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