Search Within
DUO92001
Applied Filters:
Keyword:'DUO92001'
Showing 1-30 of 568 results for "DUO92001" within Papers
Benoit Miotto et al.
Nucleic acids research, 46(9), 4392-4404 (2018-03-01)
Reactive oxygen species (ROS) are a byproduct of cell metabolism, and can also arise from environmental sources, such as toxins or radiation. Depending on dose and context, ROS have both beneficial and deleterious roles in mammalian development and disease, therefore
Lena Larsson et al.
Journal of periodontology, 82(9), 1376-1382 (2011-02-12)
Interleukin (IL)-10 is an important cytokine in immune regulation, and the -1087 IL-10 single nucleotide polymorphism (SNP) is associated with chronic periodontitis. The binding of the transcription factor Sp1 to the -1087 position in the IL-10 promoter upregulates IL-10 gene
Aaron Provence et al.
The Journal of pharmacology and experimental therapeutics, 364(1), 131-144 (2017-11-01)
Voltage-gated KV7 channels (KV7.1 to KV7.5) are important regulators of the cell membrane potential in detrusor smooth muscle (DSM) of the urinary bladder. This study sought to further the current knowledge of KV7 channel function at the molecular, cellular, and
Saara Hämälistö et al.
Nature communications, 11(1), 229-229 (2020-01-15)
Lysosomes are membrane-surrounded cytoplasmic organelles filled with a powerful cocktail of hydrolases. Besides degrading cellular constituents inside the lysosomal lumen, lysosomal hydrolases promote tissue remodeling when delivered to the extracellular space and cell death when released to the cytosol. Here
Jong-Ho Cha et al.
Molecular cell, 71(4), 606-620 (2018-08-18)
Metformin has been reported to possess antitumor activity and maintain high cytotoxic T lymphocyte (CTL) immune surveillance. However, the functions and detailed mechanisms of metformin's role in cancer immunity are not fully understood. Here, we show that metformin increases CTL
M A Bobrich et al.
Journal of obesity, 2013, 476240-476240 (2013-03-28)
Our previous experiments revealed an association of PTPIP51 (protein tyrosine phosphatase interacting protein 51) with the insulin signalling pathway through PTP1B and 14-3-3beta. We aimed to clarify the role of PTPIP51 in adipocyte metabolism. Four groups of ten C57Bl/6 mice
Chun-Shan Liu et al.
Scientific reports, 7(1), 4613-4613 (2017-07-06)
JAK2 activation is crucial for cytokine receptor signal transduction and leukemogenesis. However, the underlying processes that lead to full activation of JAK2 are unclear. Here, we report a positive role for ubiquitination of JAK2 during GM-CSF-induced activation. Upon GM-CSF stimulation
Jonathan Ausman et al.
Cell death & disease, 9(3), 298-298 (2018-02-22)
Mitochondria are in a constant balance of fusing and dividing in response to cellular cues. Fusion creates healthy mitochondria, whereas fission results in removal of non-functional organelles. Changes in mitochondrial dynamics typify several human diseases. However, the contribution of mitochondrial
Ahmed M Fahmy et al.
PloS one, 13(10), e0205189-e0205189 (2018-10-05)
Hepatitis C virus (HCV) infection is known to induce autophagosome accumulation as observed by the typical punctate cytoplasmic distribution of LC3B-II in infected cells. Previously, we showed that viral RNA-dependent RNA polymerase (NS5B) interacts with ATG5, a major component of
Charles Lu et al.
PloS one, 7(4), e34833-e34833 (2012-05-05)
Tumor suppressor gene TUSC2/FUS1 (TUSC2) is frequently inactivated early in lung cancer development. TUSC2 mediates apoptosis in cancer cells but not normal cells by upregulation of the intrinsic apoptotic pathway. No drug strategies currently exist targeting loss-of-function genetic abnormalities. We
Jagadeesh Janjanam et al.
The Journal of biological chemistry, 293(9), 3088-3103 (2018-01-13)
Restenosis arises after vascular injury and is characterized by arterial wall thickening and decreased arterial lumen space. Vascular injury induces the production of thrombin, which in addition to its role in blood clotting acts as a mitogenic and chemotactic factor.
Qiangmin Zhang et al.
iScience, 24(7), 102770-102770 (2021-07-01)
SARS-CoV-2 is responsible for the global COVID-19 pandemic. Angiotensin converting enzyme 2 (ACE2) is the membrane-delimited receptor for SARS-CoV-2. Lung, intestine, and kidney, major sites of viral infection, express ACE2 that harbors an intracellular, carboxy-terminal PDZ-recognition motif. These organs prominently
Björn Koos et al.
The Journal of physiology, 596(7), 1227-1241 (2018-01-26)
Na+ conducting hypertonicity-induced cation channels (HICCs) are key players in the volume restoration of osmotically shrunken cells and, under isotonic conditions, considered as mediators of proliferation - thereby opposing apoptosis. In an siRNA screen of ion channels and transporters in
Fernanda Tranchesi Sadek et al.
Journal of endodontics, 32(12), 1174-1177 (2006-12-19)
This study examined the contribution of testing time on the interfacial strengths of fiber posts to radicular dentin. Twenty-five fiber posts were luted to root segments with resin cements and a zinc phosphate cement. Immediately upon setting of the materials
Laura C Hautala et al.
Laboratory investigation; a journal of technical methods and pathology, 100(7), 1014-1025 (2020-03-25)
Glycodelin is a major glycoprotein expressed in reproductive tissues, like secretory and decidualized endometrium. It has several reproduction related functions that are dependent on specific glycosylation, but it has also been found to drive differentiation of endometrial carcinoma cells toward
Isopeptide and ester bond ubiquitination both regulate degradation of the human dopamine receptor 4.
Jennifer C Peeler et al.
The Journal of biological chemistry, 292(52), 21623-21630 (2017-11-05)
How an optimal level of human dopamine D4 receptor (hD4R) is maintained in synaptic membranes is not known. We show here that hD4R is ubiquitinated in primary neurons. We go on to show that ubiquitin is attached to hD4R through
Chien-Hui Weng et al.
Oncogene (2018-08-17)
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) is a major advance in treating NSCLC with EGFR-activating mutations. However, acquired resistance, due partially to secondary mutations limits their use. Here we report that NSCLC cells with acquired resistance to
Aleksandra R Dukic et al.
The Biochemical journal, 475(2), 455-476 (2017-12-21)
A limited number of human cells can fuse to form multinucleated syncytia. In the differentiation of human placenta, mononuclear cytotrophoblasts fuse to form an endocrinologically active, non-proliferative, multinucleated syncytium. This syncytium covers the placenta and manages the exchange of nutrients
Jeong-Hwan Yoon et al.
Nature communications, 6, 7600-7600 (2015-07-22)
Transforming growth factor-β (TGF-β) and interleukin-6 (IL-6) are the pivotal cytokines to induce IL-17-producing CD4(+) T helper cells (TH17); yet their signalling network remains largely unknown. Here we show that the highly homologous TGF-β receptor-regulated Smads (R-Smads): Smad2 and Smad3
Chao Liu et al.
The Journal of biological chemistry, 290(19), 12048-12057 (2015-03-15)
Amyloid precursor protein (APP) is commonly associated with Alzheimer disease, but its physiological function remains unknown. Nav1.6 is a key determinant of neuronal excitability in vivo. Because mouse models of gain of function and loss of function of APP and
Marion Pauly et al.
Biochimica et biophysica acta. Molecular basis of disease, 1863(9), 2229-2239 (2017-06-20)
Besides its role in calcium (Ca2+) homeostasis, the sarco-endoplamic reticulum (SR/ER) controls protein folding and is tethered to mitochondria. Under pathophysiological conditions the unfolded protein response (UPR) is associated with disturbance in SR/ER-mitochondria crosstalk. Here, we investigated whether ER stress
Jianquan Li et al.
Scientific reports, 7, 41072-41072 (2017-01-24)
The mitotic checkpoint complex (MCC) is formed from two sub-complexes of CDC20-MAD2 and BUBR1-BUB3, and current models suggest that it is generated exclusively by the kinetochores after nuclear envelope breakdown (NEBD). However, neither sub-complex has been visualised in vivo, and
Wen-Hao Yang et al.
Cancer research, 78(14), 3761-3768 (2018-05-24)
Programmed death-ligand 1 (PD-L1) is a well-known immune checkpoint protein that helps cancer cells evade immune response. Anti-PD-L1 immune therapy has been approved for the treatment of several advanced human cancers. Therefore, further understanding of the regulatory mechanisms of PD-L1
J Matthew Rhett et al.
The Journal of membrane biology, 245(7), 411-422 (2012-07-20)
Gap junctions (GJs) are aggregates of channels that provide for direct cytoplasmic connection between cells. Importantly, this connection is thought responsible for cell-to-cell transfer of the cardiac action potential. The GJ channels of ventricular myocytes are composed of connexin43 (Cx43).
Rémi Lasserre et al.
The Journal of cell biology, 195(5), 839-853 (2011-11-23)
Antigen recognition within immunological synapses triggers and sustains T cell activation by nucleating protein microclusters that gather T cell receptors (TCRs), kinases, and adaptors. Dissipation of these microclusters results in signal termination, but how this process is regulated is unclear.
Costanza Giampietro et al.
Scientific reports, 7, 43669-43669 (2017-03-04)
Intraneural accumulation of misfolded proteins is a common feature of several neurodegenerative pathologies including Alzheimer's and Parkinson's diseases, and Familial Encephalopathy with Neuroserpin Inclusion Bodies (FENIB). FENIB is a rare disease due to a point mutation in neuroserpin which accelerates
Hyun Mu Shin et al.
PLoS pathogens, 13(8), e1006544-e1006544 (2017-08-23)
Virus infections induce CD8+ T cell responses comprised of a large population of terminal effector cells and a smaller subset of long-lived memory cells. The transcription factors regulating the relative expansion versus the long-term survival potential of anti-viral CD8+ T
Shensi Shen et al.
STAR protocols, 2(3), 100621-100621 (2021-07-06)
The eukaryotic translation initiation complex eIF4F plays an important role in gene expression. The methods that are used to monitor the formation of the eIF4F complex are usually indirect and provide no information on its subcellular localization. This protocol describes
Ana Paula R V Pedreira et al.
Dental materials : official publication of the Academy of Dental Materials, 25(7), 868-876 (2009-02-17)
To analyze the microhardness of four dual-cure resin cements used for cementing fiber-reinforced posts under the following conditions: after 7 days of storage in water, after additional 24h of immersion in 75% ethanol, and after 3 months of storage in
Joanna Stanicka et al.
Oncogene, 37(23), 3131-3150 (2018-03-16)
IGF-1 receptor (IGF-1R) and integrin cooperative signaling promotes cancer cell survival, proliferation, and motility, but whether this influences cancer progression and therapy responses is largely unknown. Here we investigated the non-receptor tyrosine adhesion kinase FES-related (FER), following its identification as
Page 1 of 19