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Showing 1-30 of 568 results for "DUO92001" within Papers
Seo-Young An et al.
Imaging science in dentistry, 48(2), 97-101 (2018-07-03)
This study evaluated the radiopacity of contemporary luting cements using conventional and digital radiography. Disc specimens (N=24, n=6 per group, ø7 mm×1 mm) were prepared using 4 resin-based luting cements (Duolink, Multilink N, Panavia F 2.0, and U-cem). The specimens
P von Morgen et al.
Oncogene, 36(34), 4943-4950 (2017-04-25)
The MRN (MRE11-RAD50-NBS1) complex is essential for repair of DNA double-strand breaks and stalled replication forks. Mutations of the MRN complex subunit MRE11 cause the hereditary cancer-susceptibility disease ataxia-telangiectasia-like disorder (ATLD). Here we show that MRE11 directly interacts with PIH1D1
Chao Liu et al.
The Journal of biological chemistry, 290(19), 12048-12057 (2015-03-15)
Amyloid precursor protein (APP) is commonly associated with Alzheimer disease, but its physiological function remains unknown. Nav1.6 is a key determinant of neuronal excitability in vivo. Because mouse models of gain of function and loss of function of APP and
Aleksandra R Dukic et al.
The Biochemical journal, 475(2), 455-476 (2017-12-21)
A limited number of human cells can fuse to form multinucleated syncytia. In the differentiation of human placenta, mononuclear cytotrophoblasts fuse to form an endocrinologically active, non-proliferative, multinucleated syncytium. This syncytium covers the placenta and manages the exchange of nutrients
Jeong-Hwan Yoon et al.
Nature communications, 6, 7600-7600 (2015-07-22)
Transforming growth factor-β (TGF-β) and interleukin-6 (IL-6) are the pivotal cytokines to induce IL-17-producing CD4(+) T helper cells (TH17); yet their signalling network remains largely unknown. Here we show that the highly homologous TGF-β receptor-regulated Smads (R-Smads): Smad2 and Smad3
Jagadeesh Janjanam et al.
The Journal of biological chemistry, 293(9), 3088-3103 (2018-01-13)
Restenosis arises after vascular injury and is characterized by arterial wall thickening and decreased arterial lumen space. Vascular injury induces the production of thrombin, which in addition to its role in blood clotting acts as a mitogenic and chemotactic factor.
Josef Novák et al.
Cytokine, 133, 155141-155141 (2020-07-03)
Interleukin-1α (IL-1α) and Annexin A2 (AnxA2) are pleiotropic molecules with both intracellular and extracellular roles. They share several characteristics including unconventional secretion aided by S100 proteins, anchoring of the externalized proteins at the outer surface of the plasma membrane and
Kai Gao et al.
Shanghai kou qiang yi xue = Shanghai journal of stomatology, 20(3), 256-259 (2011-07-23)
To test and compare the marginal leakage of radicular dentin cemented with three resin cements. Nine extracted maxillary incisors after endodontically treated were divided into 3 groups(n=3).Fiber posts were inserted using three resin cements: One-Step Plus/DuoLink (OD),ParaCore Automix (PA) and
Adham Elsayed et al.
The journal of adhesive dentistry, 19(3), 221-228 (2017-06-10)
To test the bond strength and durability after artificial aging of so-called universal primers and universal multimode adhesives to lithium disilicate or zirconia ceramics. A total of 240 ceramic plates, divided into two groups, were produced and conditioned: 120 acid-etched
Benoit Miotto et al.
Nucleic acids research, 46(9), 4392-4404 (2018-03-01)
Reactive oxygen species (ROS) are a byproduct of cell metabolism, and can also arise from environmental sources, such as toxins or radiation. Depending on dose and context, ROS have both beneficial and deleterious roles in mammalian development and disease, therefore
James D Phelan et al.
Nature, 560(7718), 387-391 (2018-06-22)
B cell receptor (BCR) signalling has emerged as a therapeutic target in B cell lymphomas, but inhibiting this pathway in diffuse large B cell lymphoma (DLBCL) has benefited only a subset of patients1. Gene expression profiling identified two major subtypes
Laëtitia Gorisse et al.
The Biochemical journal, 475(19), 3073-3086 (2018-09-07)
Axl is a tyrosine kinase receptor that is important for hematopoiesis, the innate immune response, platelet aggregation, engulfment of apoptotic cells and cell survival. Binding of growth arrest-specific protein 6 (Gas6) activates Axl signaling, but the mechanism of inactivation of
Tomohisa Toda et al.
Cell stem cell, 21(5), 618-634 (2017-09-19)
Neural progenitor cells (NeuPCs) possess a unique nuclear architecture that changes during differentiation. Nucleoporins are linked with cell-type-specific gene regulation, coupling physical changes in nuclear structure to transcriptional output; but, whether and how they coordinate with key fate-determining transcription factors
Hyun Mu Shin et al.
PLoS pathogens, 13(8), e1006544-e1006544 (2017-08-23)
Virus infections induce CD8+ T cell responses comprised of a large population of terminal effector cells and a smaller subset of long-lived memory cells. The transcription factors regulating the relative expansion versus the long-term survival potential of anti-viral CD8+ T
Shensi Shen et al.
STAR protocols, 2(3), 100621-100621 (2021-07-06)
The eukaryotic translation initiation complex eIF4F plays an important role in gene expression. The methods that are used to monitor the formation of the eIF4F complex are usually indirect and provide no information on its subcellular localization. This protocol describes
Ana Paula R V Pedreira et al.
Dental materials : official publication of the Academy of Dental Materials, 25(7), 868-876 (2009-02-17)
To analyze the microhardness of four dual-cure resin cements used for cementing fiber-reinforced posts under the following conditions: after 7 days of storage in water, after additional 24h of immersion in 75% ethanol, and after 3 months of storage in
Ahmed M Fahmy et al.
PloS one, 13(10), e0205189-e0205189 (2018-10-05)
Hepatitis C virus (HCV) infection is known to induce autophagosome accumulation as observed by the typical punctate cytoplasmic distribution of LC3B-II in infected cells. Previously, we showed that viral RNA-dependent RNA polymerase (NS5B) interacts with ATG5, a major component of
Ahmad F Alghanem et al.
Angiogenesis, 20(3), 341-358 (2017-03-09)
Regulator of calcineurin 1 (RCAN1) is an endogenous inhibitor of the calcineurin pathway in cells. It is expressed as two isoforms in vertebrates: RCAN1.1 is constitutively expressed in most tissues, whereas transcription of RCAN1.4 is induced by several stimuli that
Charles Lu et al.
PloS one, 7(4), e34833-e34833 (2012-05-05)
Tumor suppressor gene TUSC2/FUS1 (TUSC2) is frequently inactivated early in lung cancer development. TUSC2 mediates apoptosis in cancer cells but not normal cells by upregulation of the intrinsic apoptotic pathway. No drug strategies currently exist targeting loss-of-function genetic abnormalities. We
Saara Hämälistö et al.
Nature communications, 11(1), 229-229 (2020-01-15)
Lysosomes are membrane-surrounded cytoplasmic organelles filled with a powerful cocktail of hydrolases. Besides degrading cellular constituents inside the lysosomal lumen, lysosomal hydrolases promote tissue remodeling when delivered to the extracellular space and cell death when released to the cytosol. Here
Jong-Ho Cha et al.
Molecular cell, 71(4), 606-620 (2018-08-18)
Metformin has been reported to possess antitumor activity and maintain high cytotoxic T lymphocyte (CTL) immune surveillance. However, the functions and detailed mechanisms of metformin's role in cancer immunity are not fully understood. Here, we show that metformin increases CTL
Paulina Sosicka et al.
Biochimica et biophysica acta. Molecular cell research, 1864(5), 825-838 (2017-02-09)
SLC35A4 has been classified in the SLC35A subfamily based on amino acid sequence homology. Most of the proteins belonging to the SLC35 family act as transporters of nucleotide sugars. In this study, the subcellular localization of endogenous SLC35A4 was determined
Rajendra Kumar Gurumurthy et al.
Science signaling, 3(113), ra21-ra21 (2010-03-18)
Chlamydiae are obligate intracellular bacterial pathogens that have a major effect on human health. Because of their intimate association with their host, chlamydiae depend on various host cell functions for their survival. Here, we present an RNA-interference-based screen in human
Makoto Hirano et al.
Glycobiology, 22(1), 84-95 (2011-08-13)
Ischemia/reperfusion (I/R) is an important cause of acute renal failure. Recent studies have shown that the complement system mediated by the mannan-binding protein (MBP), which is a C-type serum lectin recognizing mannose, fucose and N-acetylglucosamine residues, plays a critical role
Marion Pauly et al.
Biochimica et biophysica acta. Molecular basis of disease, 1863(9), 2229-2239 (2017-06-20)
Besides its role in calcium (Ca2+) homeostasis, the sarco-endoplamic reticulum (SR/ER) controls protein folding and is tethered to mitochondria. Under pathophysiological conditions the unfolded protein response (UPR) is associated with disturbance in SR/ER-mitochondria crosstalk. Here, we investigated whether ER stress
Jianquan Li et al.
Scientific reports, 7, 41072-41072 (2017-01-24)
The mitotic checkpoint complex (MCC) is formed from two sub-complexes of CDC20-MAD2 and BUBR1-BUB3, and current models suggest that it is generated exclusively by the kinetochores after nuclear envelope breakdown (NEBD). However, neither sub-complex has been visualised in vivo, and
Björn Koos et al.
The Journal of physiology, 596(7), 1227-1241 (2018-01-26)
Na+ conducting hypertonicity-induced cation channels (HICCs) are key players in the volume restoration of osmotically shrunken cells and, under isotonic conditions, considered as mediators of proliferation - thereby opposing apoptosis. In an siRNA screen of ion channels and transporters in
Wen-Hao Yang et al.
Cancer research, 78(14), 3761-3768 (2018-05-24)
Programmed death-ligand 1 (PD-L1) is a well-known immune checkpoint protein that helps cancer cells evade immune response. Anti-PD-L1 immune therapy has been approved for the treatment of several advanced human cancers. Therefore, further understanding of the regulatory mechanisms of PD-L1
Liang Chen et al.
The journal of adhesive dentistry, 15(4), 325-331 (2013-03-28)
To evaluate the effect of the hydrophilicity of adhesives on the compatibility between one-bottle simplified adhesives and a dual-curing resin cement. Three experimental and two commercial adhesives (All-Bond Universal, OptiBond Allin- One) with the same or similar pH and various
Yan Yih Goh et al.
The American journal of pathology, 177(6), 2791-2803 (2010-10-19)
Adipose tissue secretes adipocytokines for energy homeostasis, but recent evidence indicates that some adipocytokines also have a profound local impact on wound healing. Upon skin injury, keratinocytes use various signaling molecules to promote reepithelialization for efficient wound closure. In this
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