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Showing 1-30 of 6326 results for "e2385" within Papers
Marina Komrakova et al.
Calcified tissue international, 97(4), 391-401 (2015-06-19)
The following questions were addressed: whether therapy with strontium ranelate (SR) should be continued or interrupted if the fractures occur during SR treatment and whether SR could be applied directly after fracture to improve bone healing. Sprague-Dawley rats (3 month
Dongxia Hou et al.
PloS one, 10(11), e0142442-e0142442 (2015-11-12)
Trophoblasts (TR) are specialized cells of the placenta and play an important role in embryo implantation. The in vitro culture of trophoblasts provided an important tool to investigate the mechanisms of implantation. In the present study, porcine trophoblast cells were
Joo Youn Oh et al.
Investigative ophthalmology & visual science, 55(11), 7628-7635 (2014-11-06)
Mesenchymal stem/stromal cells (MSCs) facilitate the regeneration of injured tissue. Our group has previously shown that human MSCs (hMSCs) or hMSC-derived factors suppress excessive inflammatory response in the cornea following chemical injury in vivo. We here investigated direct effects of
T Hosoya et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 26(8), 1112-1121 (2014-05-17)
Transient receptor potential channel melastatin 8 (TRPM8) is activated by cold temperatures and cooling agents (menthol and icilin). Recent studies showed TRPM8 is expressed in visceral organs and peripheral sensory pathways. However, the role of TRPM8 in visceral hyperalgesia is
Ilan Shimon et al.
European journal of endocrinology, 172(6), 707-713 (2015-03-21)
Patients with acromegaly usually harbor macroadenomas measuring between 10 and 30 mm in maximal diameter. Giant (adenoma size ≥40 mm) GH-secreting pituitary tumors are rarely encountered and the aim of this study is to analyze different methods for managing them. We have
Kyung Mi Lim et al.
Molecular medicine reports, 12(2), 2650-2660 (2015-05-09)
Dermal papilla (DP) cells function as important regulators of the hair growth cycle. The loss of these cells is a primary cause of diseases characterized by hair loss, including alopecia, and evidence has revealed significantly increased levels of reactive oxygen
Russell J H Ryan et al.
Cancer discovery, 5(10), 1058-1071 (2015-08-01)
B-cell lymphomas frequently contain genomic rearrangements that lead to oncogene activation by heterologous distal regulatory elements. We used a novel approach called "pinpointing enhancer-associated rearrangements by chromatin immunoprecipitation," or PEAR-ChIP, to simultaneously map enhancer activity and proximal rearrangements in lymphoma
B S Margulies et al.
Bone, 79, 121-130 (2015-06-09)
Ewing's sarcoma of bone is a primary childhood malignancy of bone that is treated with X-radiation therapy in combination with surgical excision and chemotherapy. To better study Ewing's sarcoma of bone we developed a novel model of primary Ewing's sarcoma
Qiao Zhao et al.
Phytochemistry, 112, 170-178 (2014-08-12)
Pinoresinol reductase (PrR) catalyzes the conversion of the lignan (-)-pinoresinol to (-)-lariciresinol in Arabidopsis thaliana, where it is encoded by two genes, PrR1 and PrR2, that appear to act redundantly. PrR1 is highly expressed in lignified inflorescence stem tissue, whereas
Alexander P Scott et al.
Steroids, 88, 26-35 (2014-06-15)
Interpretation of plasma cortisol levels in wild-caught fish is confounded by the stress of capture. Measurement of cortisol metabolites in fish bile could provide a method for assessing the stress level of wild fish because the time-lag for metabolism, conjugation
Liberty François-Moutal et al.
Pain, 156(7), 1247-1264 (2015-03-19)
Targeting proteins within the N-type voltage-gated calcium channel (CaV2.2) complex has proven to be an effective strategy for developing novel pain therapeutics. We describe a novel peptide aptamer derived from the collapsin response mediator protein 2 (CRMP2), a CaV2.2-regulatory protein.
Pedro L Sánchez et al.
Biomaterials, 61, 279-289 (2015-05-26)
The best definitive treatment option for end-stage heart failure currently is transplantation, which is limited by donor availability and immunorejection. Generating an autologous bioartificial heart could overcome these limitations. Here, we have decellularized a human heart, preserving its 3-dimensional architecture
Waldemar Hauf et al.
Applied and environmental microbiology, 81(13), 4411-4422 (2015-04-26)
Cyanobacteria are photoautotrophic microorganisms which fix atmospheric carbon dioxide via the Calvin-Benson cycle to produce carbon backbones for primary metabolism. Fixed carbon can also be stored as intracellular glycogen, and in some cyanobacterial species like Synechocystis sp. strain PCC 6803
Bin Zhou et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(31), 11143-11151 (2015-06-23)
We report an efficient approach to the synthesis of AgSbS2 nanocrystals (NCs) by colloidal chemistry. The size of the AgSbS2 NCs can be tuned from 5.3 to 58.3 nm with narrow size distributions by selection of appropriate precursors and fine control
S Bascil et al.
Bratislavske lekarske listy, 115(9), 588-592 (2014-10-17)
Acromegaly is a complex syndrome which influences the connective tissue and bone metabolism. Although the effects of excess growth hormone on bone tissue are well known, its effect on periodontal tissue is an enigma. A total of 23 acromegalic patients
Ignacio Gonzalez Segura et al.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 44(3), 178-184 (2014-07-30)
Prevention and early diagnosis have the greatest potential for public health and are the most effective method in the long-term to control oral cancer. The aim was to apply PAP staining together with AgNOR staining and morphometric analysis in oral
Julie M Quach et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(5), 886-897 (2014-11-25)
Skeletal-related events resulting from accelerated bone loss are common complications in patients treated for a range of cancers. However, the mechanisms and rate of bone loss after myelosuppression are unclear. We, therefore, investigated this in mice and humans. We treated
Guoqing Wang et al.
Neuropeptides, 54, 79-83 (2015-09-10)
Exogenous administration of prolactin-releasing peptide (PrRP) exerts anorexigenic effects in rats while causing orexigenic effects in chicks. While the central mechanism mediating PrRP's effect on food intake in rodents is somewhat understood, in chicks information is lacking. Therefore, this study
Tawut Rudtanatip et al.
Fish & shellfish immunology, 47(1), 231-238 (2015-09-13)
Previous studies demonstrated that sulfated galactans (SG) from Gracilaria fisheri (G. fisheri) exhibit immunostimulant activity in shrimp. The present study was conducted to test the hypothesis that SG stimulates signaling molecules of the immune response of shrimp by binding to
Mirko Basen et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(49), 17618-17623 (2014-11-05)
Bioethanol production is achieved by only two metabolic pathways and only at moderate temperatures. Herein a fundamentally different synthetic pathway for bioalcohol production at 70 °C was constructed by insertion of the gene for bacterial alcohol dehydrogenase (AdhA) into the
Min Jung Kim et al.
Experimental biology and medicine (Maywood, N.J.), 240(4), 477-487 (2014-09-27)
Since Korean mistletoe (Viscum album) has been used for alleviating metabolic diseases, it may also prevent the impairment of energy, glucose, lipid, and bone metabolisms in an estrogen-deficient animal model. We determined that long-term consumption of Korean mistletoe water extract
Lei Wu et al.
Small (Weinheim an der Bergstrasse, Germany), 11(23), 2798-2806 (2015-02-18)
A surface enhanced Raman scattering (SERS)-assisted 3D barcode chip has been developed for high-throughput biosensing. The 3D barcode is realized through joint 2D spatial encoding with the Raman spectroscopic encoding, which stores the SERS fingerprint information in the format of
Onju Ham et al.
Cell transplantation, 24(7), 1329-1341 (2014-05-16)
Mesenchymal stem cells (MSCs) have the potential to repair and regenerate ischemic heart tissue; however, the poor viability of transplanted MSCs in the ischemic region is a major obstacle to their therapeutic use. This cell death is caused by Fas
Nidhi Nath et al.
Journal of immunological methods, 426, 95-103 (2015-09-01)
Antibodies labeled with small molecules such as fluorophore, biotin or drugs play an important role in various areas of biological research, drug discovery and diagnostics. However, the majority of current methods for labeling antibodies is solution-based and has several limitations
Zhe-Yi Hu et al.
Clinical pharmacokinetics, 53(9), 825-836 (2014-08-12)
Human carboxylesterase-1 (CES1) is an enzyme that is primarily expressed in the liver, where it plays an important role in the metabolism of many commonly used medications. Ethanol (alcohol)-mediated inhibition of CES1 and loss-of-function polymorphisms in the CES1 gene can
Hong-Sook Bae et al.
Natural product communications, 10(6), 963-968 (2015-07-23)
This study examined the anthocyanin composition and antioxidant activity of various berries cultivated in Korea: blueberry, crowberry, Korean black raspberry, mulberry, and strawberry. The anthocyanins in berries were identified by high-performance liquid chromatography (HPLC) analysis, and each component was quantitatively
Swati Pund et al.
International journal of pharmaceutics, 487(1-2), 148-156 (2015-04-15)
The present study is a mechanistic validation of 'proof of concept' of effective topical delivery of leflunomide (LFD) nanoemulgel for localized efficient treatment of psoriatic lesions as well as melanoma affected skin regions. Hyperproliferation of keratinocytes in psoriasis and symbiotic
Antonella Spagnoletti et al.
Molecular and cellular endocrinology, 412, 56-64 (2015-06-02)
Bisphenol A (BPA) and para-Nonylphenol (p-NP) are chemicals of industrial origin which may influence human reproductive health. The effects of these substances in the prenatal life is an important topic that is receiving greater attention in the developed countries. In
Paula Urquhart et al.
Journal of lipid research, 56(8), 1419-1433 (2015-06-03)
Arachidonoyl ethanolamine (anandamide) and pros-taglandin ethanolamines (prostamides) are biologically active derivatives of arachidonic acid. Although available through different precursor phospholipids, there is considerable overlap between the biosynthetic pathways of arachidonic acid-derived eicosanoids and anandamide-derived prostamides. Prostamides exhibit physiological actions and
Shan Yu et al.
Cell research, 25(12), 1352-1367 (2015-11-28)
Biofilms are surface-associated communities of microorganism embedded in extracellular matrix. Exopolysaccharide is a critical component in the extracellular matrix that maintains biofilm architecture and protects resident biofilm bacteria from antimicrobials and host immune attack. However, self-produced factors that target the
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