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Showing 31-60 of 6326 results for "E2385" within Papers
Samantha K Schmitt et al.
Advanced healthcare materials, 4(10), 1555-1564 (2015-05-23)
Human mesenchymal stem cells (hMSCs) are a widely available and clinically relevant cell type with a host of applications in regenerative medicine. Current clinical expansion methods can lead to selective changes in hMSC phenotype potentially resulting from relatively undefined cell
Karpagavalli Ramji et al.
Journal of biomaterials applications, 29(3), 411-422 (2014-04-09)
Electrospun fibers with an average fiber diameter in the nanometer range were prepared from soy protein isolate to develop scaffolds for tissue engineering applications. Poly(ethylene oxide) was added to facilitate fiber formation. The influence of processing parameters such as applied
Luka Mihajlovic et al.
Phytochemistry, 109, 125-132 (2014-12-04)
Phenolic composition of Ambrosia artemisiifolia L. pollen and sub-pollen particles (SPP) aqueous extracts was determined, using a novel extraction procedure. Total phenolic and flavonoid content was determined, as well as the antioxidative properties of the extract. Main components of water-soluble
Maria J Matos et al.
Bioorganic chemistry, 61, 1-6 (2015-06-05)
With the aim of finding new adenosine receptor (AR) ligands presenting the 3-amidocoumarin scaffold, a study focusing on the discovery of new chemical entities was carried out. The synthesized compounds 1-8 were evaluated in radioligand binding (A1, A2A and A3)
Jasreen K Sekhon et al.
Bioresource technology, 192, 451-460 (2015-06-17)
Enzyme-assisted aqueous extraction processing (EAEP) is an environmentally-friendly alternative to solvent and mechanical oil extraction methods, and can achieve ∼ 97% oil recovery from soybeans. The present study utilized soy skim (protein rich) and insoluble fiber (IF; carbohydrate rich), both
Emily E Noble et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 307(6), R737-R745 (2014-07-06)
Central oxytocin reduces food intake and increases energy expenditure. The ventromedial hypothalamic nucleus (VMN) is associated with energy balance and contains a high density of oxytocin receptors. We hypothesized that oxytocin in the VMN is a negative regulator of energy
Rajesh Madhu et al.
ACS applied materials & interfaces, 7(29), 15812-15820 (2015-07-01)
Herein, we report the preparation of Pongam seed shells-derived activated carbon and cobalt oxide (∼2-10 nm) nanocomposite (PSAC/Co3O4) by using a general and facile synthesis strategy. The as-synthesized PSAC/Co3O4 samples were characterized by a variety of physicochemical techniques. The PSAC/Co3O4-modified
Yong Li et al.
Molecular medicine reports, 12(1), 1328-1334 (2015-03-31)
The mechanisms underlying lung cancer radioresistance remain to be fully elucidated. The DNA repair pathway is a predominant target of radiotherapy, which is considered to be involved in the acquired radioresistance of cancer cells. The present study aimed to establish
Huimin Yang et al.
Nature communications, 6, 6478-6478 (2015-04-04)
Generally, transition metal catalysts are essential for the reductive hydrogen atom transfer reaction, which is also known as the transfer hydrogenation reaction or the borrowing-hydrogen reaction. It has been reported that graphene can be an active catalyst in ethylene and
Hannes Beims et al.
Applied and environmental microbiology, 81(16), 5411-5419 (2015-06-07)
Paenibacillus larvae is the causative agent of American foulbrood (AFB), the most serious honey bee brood bacterial disease. We isolated and characterized P. larvae-directed bacteriophages and developed criteria for safe phage therapy. Whole-genome analysis of a highly lytic virus of
Qiaozhen Yu et al.
Journal of biomedical materials research. Part A, 103(2), 721-729 (2014-05-16)
An axially aligned three-dimensional (3-D) fibrous scaffold was fabricated with regenerated spider silk protein (RSSP)/poly (l-lactic acid) (PLLA) through electrospinning and post treatment. The morphology, mechanical and degradation properties of the scaffold were controlled through the weight ratio of RSSP
Victoria A Blaho et al.
Nature, 523(7560), 342-346 (2015-06-09)
Lipid mediators influence immunity in myriad ways. For example, circulating sphingosine-1-phosphate (S1P) is a key regulator of lymphocyte egress. Although the majority of plasma S1P is bound to apolipoprotein M (ApoM) in the high-density lipoprotein (HDL) particle, the immunological functions
Jing Chen et al.
Molecular medicine reports, 12(2), 2487-2494 (2015-05-06)
A disintegrin and metallopeptidase with thrombospondin motif type 1 (ADAMTS1) is a metalloproteinase with antiangiogenic activity. It was previously observed that the mRNA and protein levels of ADAMTS1 are downregulated in primary gastric tumors. The aim of the present study
Huiping Zhang et al.
Human genetics, 133(11), 1383-1394 (2014-07-31)
Chronic alcohol consumption may induce gene expression alterations in brain reward regions such as the prefrontal cortex (PFC), modulating the risk of alcohol use disorders (AUDs). Transcriptome profiles of 23 AUD cases and 23 matched controls (16 pairs of males
Chih-Ya Cheng et al.
Experimental neurology, 267, 143-151 (2015-03-18)
Mutations in the gene of RAB18, a member of Ras superfamily of small G-proteins, cause Warburg Micro Syndrome (WARBM) which is characterized by defective neurodevelopmental and ophthalmological phenotypes. Despite loss of Rab18 had been reported to induce disruption of the
Bin Xu et al.
Journal of pharmaceutical and biomedical analysis, 114, 447-454 (2015-07-03)
A new method based on a Direct Analysis in Real Time (DART) ionization source coupled with triple quadrupole tandem mass spectrometry has been developed for rapid qualitative and quantitative analyses of 1-deoxynojirimycin (DNJ) in mulberry leaves. Two ions produced from
Wenyi Sun et al.
PloS one, 10(5), e0125976-e0125976 (2015-05-15)
Oral squamous cell carcinoma (OSCC) comprises a subset of head and neck squamous cell carcinoma (HNSCC) with poor therapeutic outcomes and high glycolytic dependency. Neoadjuvant chemotherapy regimens of docetaxel, cisplatin and 5-fluorouracil (TPF) are currently accepted as standard regimens for
Dafna Kanny et al.
MMWR. Morbidity and mortality weekly report, 63(53), 1238-1242 (2015-01-13)
Alcohol poisoning is typically caused by binge drinking at high intensity (i.e., consuming a very large amount of alcohol during an episode of binge drinking). Approximately 38 million U.S. adults report binge drinking an average of four times per month
Lalita Wattanachanya et al.
Experimental cell research, 333(2), 289-302 (2015-02-24)
G protein-coupled receptor (GPCR) signaling in osteoblasts (OBs) is an important regulator of bone formation. We previously described a mouse model expressing Rs1, an engineered constitutively active Gs-coupled GPCR, under the control of the 2.3 kb Col I promoter. These
Jara Majuelos-Melguizo et al.
Oncotarget, 6(7), 4790-4803 (2015-01-13)
Glioblastoma multiforme (GBM) is the most common primary brain tumour in adults and one of the most aggressive cancers. PARP-1 is a nuclear protein involved in multiple facets of DNA repair and transcriptional regulation. In this study we dissected the
Jinzi Zheng et al.
Biomaterials, 67, 160-168 (2015-07-29)
Intraoperative imaging technologies including computed tomography and fluorescence optical imaging are becoming routine tools in the cancer surgery operating room. They constitute an enabling platform for high performance surgical resections that assure local control while minimizing morbidity. New contrast agents
Jeongyub Kim et al.
Stem cells and development, 24(3), 284-295 (2014-09-18)
There is a growing body of evidence that small subpopulations of cells with stem cell-like characteristics within most solid tumors are responsible for the malignancy of aggressive cancer cells and that targeting these cells might be a good therapeutic strategy
Liming Zhang et al.
Biotechnology for biofuels, 7(1), 494-494 (2015-01-22)
Reducing the cost of producing cellulosic ethanol is essential for the industrialization of biorefinery. Several processes are currently under investigation, but few of these techniques are entirely satisfactory in terms of competitive cost or environmental impact. In this study, a
Marlies De Boeck et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 786-788, 151-157 (2015-07-28)
As part of the Japanese Center for the Validation of Alternative Methods (JaCVAM)-initiated international validation study of in vivo rat alkaline comet assay (comet assay), p-phenylenediamine dihydrochloride (PPD), o-phenylphenol sodium salt (OPP), and 2,4-diaminotoluene (2,4-DAT), were analyzed in this laboratory
Charles S Elmore et al.
Journal of labelled compounds & radiopharmaceuticals, 57(5), 342-349 (2014-04-05)
In support of a program to develop an alpha 7 agonist as a treatment for Alzheimer's disease, three drug candidates, 1, 2, and 3, were prepared in labeled forms. Compound 1 was prepared in C-14 labeled form by lithiation of
Shanshan Cheng et al.
The international journal of biochemistry & cell biology, 57, 186-196 (2014-12-03)
Impairment in the microRNA (miRNA) network causes a number of neurodegenerative diseases. Endoribonuclease Dicer is a key RNase to produce mature miRNAs. It has been shown that Dicer is important for the maintenance of excitatory neuron survival during early postnatal
Franca Raucci et al.
Theriogenology, 84(5), 732-742 (2015-06-04)
Primordial germ cells (PGCs) are the precursors of differentiated germ cells. Located in the epiblast of a stage X (EG&K) embryo, the PGCs translocate anteriorly to the germinal crescent and migrate, within 48 to 56 hours of development, through the
William J Chapin et al.
Pharmacogenetics and genomics, 25(3), 126-133 (2015-01-08)
Despite of the common usage of glucocorticoids (GCs), a significant portion of asthma patients exhibit GC insensitivity. This could be mediated by diverse mechanisms, including genomics. Recent work has suggested that measuring changes in gene expression may provide more predictive
Nicholas P Vitko et al.
mBio, 6(2) (2015-04-09)
Staphylococcus aureus is a prolific human pathogen capable of causing severe invasive disease with a myriad of presentations. The ability of S. aureus to cause infection is strongly linked with its capacity to overcome the effects of innate immunity, whether
Kuo-Chin Huang et al.
BMC musculoskeletal disorders, 16, 355-355 (2015-11-18)
Prolonged bisphosphonate treatment might suppress bone remodeling to the extent that normal bone repair is impaired. While this adverse side effect is usually ascribed to the negative effects of bisphosphonates on osteoclast survival and function, these effects on osteoblasts are
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