E2425000

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Showing 1-30 of 33 results for "E2425000" within Papers

Analysis of endocrine disrupters and related compounds in sediments and sewage sludge using on-line turbulent flow chromatography-liquid chromatography-tandem mass spectrometry.

Marina Gorga et al.

Journal of chromatography. A, 1352, 29-37 (2014-06-10)

A novel fully automated method based on dual column switching using turbulent flow chromatography followed by liquid chromatography coupled to tandem mass spectrometry (TFC-LC-MS/MS) was applied for the determination of endocrine disruptors (EDCs) and related compounds in sediment and sewage

Potential estrogenic effect(s) of parabens at the prepubertal stage of a postnatal female rat model.

Thuy T B Vo et al.

Reproductive toxicology (Elmsford, N.Y.), 29(3), 306-316 (2010-02-06)

In this study, a female pubertal assay on the effects of parabens, including methyl-, ethyl-, propyl-, isopropyl-, butyl-, and isobutylparaben, was performed in a female Sprague-Dawley rat model during the juvenile-peripubertal period. The rats were orally treated with these parabens

Simultaneous analysis of antioxidants and preservatives in cosmetics by supercritical fluid extraction combined with liquid chromatography-mass spectrometry.

Maw-Rong Lee et al.

Journal of chromatography. A, 1120(1-2), 244-251 (2006-03-04)

This study evaluated supercritical fluid extraction (SFE) combined with liquid chromatography-mass spectrometry (LC-MS) to determine trace preservatives and antioxidants including methylparaben (MP), ethylparaben (EP), propylparaben (PP), butylparaben (BP), butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), alpha-tocopherol (alpha-t) and alpha-tocopherol acetate (alpha-ta)

Molecular dissection of the role of two methyltransferases in the biosynthesis of phenolglycolipids and phthiocerol dimycoserosate in the Mycobacterium tuberculosis complex.

Esther Pérez et al.

The Journal of biological chemistry, 279(41), 42584-42592 (2004-08-05)

A few mycobacterial species, most of which are pathogenic for humans, produce dimycocerosates of phthiocerol (DIM) and of glycosylated phenolphthiocerol, also called phenolglycolipid (PGL), two groups of molecules shown to be important virulence factors. The biosynthesis of these molecules is

Determination of ethyl-p-hydroxybenzoate in sow pancreatic juice by reversed-phase high-performance liquid chromatography.

R Di Giovannandre et al.

Journal of chromatography. B, Biomedical sciences and applications, 751(2), 365-369 (2001-03-10)

We have developed a high-performance liquid chromatographic-UV-Vis-diode-array detection (HPLC-DAD) method for the determination of ethyl-p-hydroxybenzoate, a hydrolytic degradation product of the synthetic protease inhibitor, gabexate-mesilate ethyl-p-(6-guanidinohexanoyloxy) benzoate methanesulfonate (GM) (FOY) in sow pancreatic juice. Methyl-p-hydroxybenzoate (I) was used as the

The preservatives ethyl-, propyl- and butylparaben are oestrogenic in an in vivo fish assay.

K L Pedersen et al.

Pharmacology & toxicology, 86(3), 110-113 (2001-02-07)

The widely used phenolic preservatives ethylparaben, propylparaben, butylparaben and their common metabolite p-hydroxybenzoic acid were tested for their ability to evoke an oestrogenic response in vivo. Yolk protein induction in sexually immature rainbow trout was used as an oestrogen-specific endpoint

Simplified matrix solid phase dispersion procedure for the determination of parabens and benzophenone-ultraviolet filters in human placental tissue samples.

F Vela-Soria et al.

Journal of chromatography. A, 1371, 39-47 (2014-12-03)

In recent decades, the industrial development has resulted in the appearance of a large amount of new chemicals that are able to produce disorders in the human endocrine system. These substances, so-called endocrine disrupting chemicals (EDCs), include many families of

Determination and separation of bisphenol A, phthalate metabolites and structural isomers of parabens in human urine with conventional high-pressure liquid chromatography combined with electrospray ionisation tandem mass spectrometry.

Antonis Myridakis et al.

Analytical and bioanalytical chemistry, 407(9), 2509-2518 (2015-02-04)

Phthalates, bisphenol A (BPA) and parabens (PBs), organic chemicals widely used in everyday products, are considered to be endocrine disruptors. We propose a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination of seven phthalate metabolites, six PBs and BPA

Estimation of preservative concentrations in foods and their daily intake based on official inspection results in Japan in fiscal year 1998.

H Ishiwata et al.

Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan, 42(6), 404-412 (2002-03-06)

The mean concentration and daily intake of five preservatives were estimated based on the results of an analysis of 89,927 samples of food obtained in official inspections by Japanese local governments in fiscal year 1998. The mean concentration of benzoic

Morphometric analysis of mice uteri treated with the preservatives methyl, ethyl, propyl, and butylparaben.

C Lemini et al.

Toxicology and industrial health, 20(6-10), 123-132 (2005-06-09)

The alkyl esters of p-hydroxybenzoic acid (PHBA) known as parabens (Pbens) are widely used as preservatives in food, pharmaceuticals, and cosmetics. Several in vivo and in vitro studies have shown these compounds to be estrogenic. Here, for the first time

Alkyl protocatechuates as novel urinary biomarkers of exposure to p-hydroxybenzoic acid esters (parabens).

Lei Wang et al.

Environment international, 59, 27-32 (2013-06-12)

Human exposure to p-hydroxybenzoic acid esters (parabens) is a concern, owing to adverse health effects of these compounds. Parabens are metabolized and eliminated from the human bodies within a few hours of exposure. In this study, for the first time

[Quantitative determination of ethyl-p-hydroxybenzoate in resins extracted from Dracaena cochinchinensis with two technologies].

Yue-ying Song et al.

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 29(4), 323-325 (2005-02-15)

Quantitative determination was made of ethyl-p-hydroxybenzoate in Dracaena cochinchinensis extracted with two technologies. The sample was resolved with methanol and isolated by TLC, purged with methanol. Tge sample solution was chroma to graphed on a C18 column with acetonitrile-1% acetic

[Chemical constituents of rhizoma imperatae and their anti-complementary activity].

Li-Na Fu et al.

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 33(12), 1871-1874 (2011-05-10)

To study the chemical constituents of Rhizoma Imperatae and their anti-complementary activity. By the hemolysis test, the petroleum extraction, ethyl acetate extraction, n-butanol extraction and the water extraction was tested for anti-complementary activity. Compounds were isolated and purified by silica

Estimation of the effects of longitudinal temperature gradients caused by frictional heating on the solute retention using fully porous and superficially porous sub-2μm materials.

Szabolcs Fekete et al.

Journal of chromatography. A, 1359, 124-130 (2014-07-30)

In this study, the retention changes induced by frictional heating were evaluated for model small compounds (150-190Da) and a small protein, namely insulin (5.7kDa). For this purpose, the effect of longitudinal temperature gradient caused by frictional heating was experimentally dissociated

Relating solubility data of parabens in liquid PEG 400 to the behaviour of PEG 4000-parabens solid dispersions.

Johan Unga et al.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 73(2), 260-268 (2009-06-11)

The solid state behaviour of polyethylene glycol 4000 (PEG 4000) and dispersions of a homologous series of parabens (methyl- (MP), ethyl- (EP), propyl- (PP) and butyl- (BP)) were examined and compared to the paraben solubility in liquid PEG 400. Dispersions

Diffusion of preservatives from topical dosage forms: a comparative study.

Elisabetta Esposito et al.

Journal of cosmetic science, 54(3), 239-250 (2003-07-15)

A study of the diffusion of parabens from topical formulations is presented here. In particular, four different topical formulations, namely, a water-in-oil emulsion, an oil-in-water emulsion, and two hydrophilic gels (Pemulen gel and Carbopol gel) were produced, containing a mixture

Urinary concentrations of four parabens in the U.S. population: NHANES 2005-2006.

Antonia M Calafat et al.

Environmental health perspectives, 118(5), 679-685 (2010-01-09)

Parabens are widely used as antimicrobial preservatives in cosmetics, -pharmaceuticals, and food and beverage processing. We assessed exposure to methyl, ethyl, propyl, and butyl parabens in a representative sample of persons >or= 6 years of age in the U.S. general

Metabolic bioactivation and toxicity of ethyl 4-hydroxybenzoate in human SK-MEL-28 melanoma cells.

Nikhil M Vad et al.

Journal of pharmaceutical sciences, 97(5), 1934-1945 (2007-09-12)

The metabolism and toxicity of ethyl 4-hydroxybenzoate (4-HEB) were investigated in vitro using tyrosinase enzyme, a melanoma molecular target, and CYP2E1 induced rat liver microsomes, and in human SK-MEL-28 melanoma cells. The results were compared to 4-hydroxyanisole (4-HA). At 90

Metabolism of parabens (4-hydroxybenzoic acid esters) by hepatic esterases and UDP-glucuronosyltransferases in man.

Suzanne Abbas et al.

Drug metabolism and pharmacokinetics, 25(6), 568-577 (2010-10-12)

Parabens (alkyl esters of 4-hydroxybenzoic acid) are widely used as preservatives in drugs, cosmetic products, and foodstuffs. Safety concerns have recently increased due to the potential health risks associated to exposure to large amounts of these substances. Biotransformation of parabens

Influence of crystal structure on the tableting properties of n-alkyl 4-hydroxybenzoate esters (parabens).

Yushi Feng et al.

Journal of pharmaceutical sciences, 96(12), 3324-3333 (2007-06-02)

Certain crystallographic features, such as the existence of slip planes, can greatly facilitate the ability of crystals to deform plastically. An investigation of the relationship between the slip planes and the tableting performance of the crystals of methyl, ethyl, n-propyl

Hydrolysis of a series of parabens by skin microsomes and cytosol from human and minipigs and in whole skin in short-term culture.

Christopher Jewell et al.

Toxicology and applied pharmacology, 225(2), 221-228 (2007-09-25)

Parabens are esters of 4-hydroxybenzoic acid and used as anti-microbial agents in a wide variety of toiletries, cosmetics and pharmaceuticals. It is of interest to understand the dermal absorption and hydrolysis of parabens, and to evaluate their disposition after dermal

The effect of ethanol on the simultaneous transport and metabolism of methyl p-hydroxybenzoate in excised skin of Yucatan micropig.

S Y Oh et al.

International journal of pharmaceutics, 236(1-2), 35-42 (2002-03-14)

The effects of ethanol on the simultaneous transport and metabolism of methyl p-hydroxybenzoate (HBM) were investigated in the skin of Yucatan micropig in vitro. It was found that transesterification occurred in the permeation studies involving ethanol. This was confirmed by

Lack of spermatotoxic effects of methyl and ethyl esters of p-hydroxybenzoic acid in rats.

Shinshi Oishi

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 42(11), 1845-1849 (2004-09-08)

Parabens are alkyl esters of p-hydroxybenzoic acid widely used as preservatives in foodstuffs, cosmetics toiletries and pharmaceuticals. These compounds are known to exert a weak estrogenic activity in estrogen receptor assays in vitro. In addition butyl and propyl parabens show

High efficiency polyethylene glycol diacrylate monoliths for reversed-phase capillary liquid chromatography of small molecules.

Pankaj Aggarwal et al.

Journal of chromatography. A, 1364, 96-106 (2014-09-07)

Highly cross-linked monolithic networks (i.e., polyethylene glycol diacrylate, PEGDA) synthesized from monomers containing varying ethylene oxide chain lengths were fabricated inside fused silica capillary columns for use in liquid chromatography (LC) of small molecules. Tergitol was used as a surfactant

Ultra-preconcentration and determination of selected pharmaceutical and personal care products in different water matrices by solid-phase extraction combined with dispersive liquid-liquid microextraction prior to ultra high pressure liquid chromatography tandem mass spectrometry analysis.

Rita Celano et al.

Journal of chromatography. A, 1355, 26-35 (2014-06-19)

Pharmaceutical and personal care products (PPCPs) are one of the most important classes of emerging contaminants. The potential of ecological and environmental impacts associated with PPCPs are of particular concern because they continually penetrate the aquatic environment. This work describes

Use of a capillary tube for collecting an extraction solvent lighter than water after dispersive liquid-liquid microextraction and its application in the determination of parabens in different samples by gas chromatography--flame ionization detection.

M A Farajzadeh et al.

Talanta, 81(4-5), 1360-1367 (2010-05-06)

In this study a new dispersive liquid-liquid microextraction (DLLME) method is presented on the basis of a safe organic solvent, octanol, which is lighter than water. The proposed method is used for the extraction and pre-concentration of some preservatives including

Direct rapid analysis of multiple PPCPs in municipal wastewater using ultrahigh performance liquid chromatography-tandem mass spectrometry without SPE pre-concentration.

Ke Yu et al.

Analytica chimica acta, 738, 59-68 (2012-07-14)

Ultrahigh performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) was utilized to develop a rapid, sensitive and reliable method without solid phase extraction (SPE) pre-concentration for trace analysis of 11 pharmaceuticals and personal care products (PPCPs) in inﬂuent and efﬂuent from municipal

Ethyl-paraben and nicotinamide mixtures: apparent solubility, thermal behavior and X-ray structure of the 1:1 co-crystal.

S Nicoli et al.

Journal of pharmaceutical sciences, 97(11), 4830-4839 (2008-03-05)

This work aims at investigating the nicotinamide (NA)-ethyl-paraben (EP) binary system both in solution and in the solid state. In particular, the apparent EP solubility in water was studied in the presence of different NA concentrations (between 0.28 and 1.64

Mixture effects at very low doses with combinations of anti-androgenic pesticides, antioxidants, industrial pollutant and chemicals used in personal care products.

Frances Orton et al.

Toxicology and applied pharmacology, 278(3), 201-208 (2013-09-24)

Many xenobiotics have been identified as in vitro androgen receptor (AR) antagonists, but information about their ability to produce combined effects at low concentrations is missing. Such data can reveal whether joint effects at the receptor are induced at low

Assessment of principal parabens used in cosmetics after their passage through human epidermis-dermis layers (ex-vivo study).

Sawsan El Hussein et al.

Experimental dermatology, 16(10), 830-836 (2007-09-12)

Concern is continuously raised about the safety of parabens which are present in most of the cosmetic preparations. In this investigation, methyl-, ethyl-, propyl- and butyl paraben (MP, EP, PP, BP), in a commercial cosmetic lotion, were deposited on human

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