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Showing 1-30 of 41 results for "E24859" within Papers
Ravi Kant et al.
Molecular and cellular biochemistry, 312(1-2), 25-31 (2008-02-15)
Remote preconditioning is a unique phenomenon in which brief episodes of ischemia and reperfusion to remote organ protect the target organ against sustained ischemia-reperfusion (I/R)-induced injury. Protective effects of remote renal preconditioning (RRPC) are well established in heart, but their
L M Andersson et al.
Biochimica et biophysica acta, 1268(1), 27-34 (1995-07-20)
Fibroblasts degrade about 15% of newly synthesised collagen within the cell before it can be secreted. When the helical structure of collagen is disrupted, about 30% is degraded intracellularly. To determine if collagen degradation occurs in a pre-lysosomal compartment, the
Yuting Li et al.
Food chemistry, 317, 126454-126454 (2020-03-01)
The reaction efficiency of o-benzoquinones with amines (L-lysine, Nα-acetyl-L-lysine, glycine, L-methionine and L-arginine), thiols (L-cysteine and Nα-acetyl-L-cysteine) and protein (bovine serum albumin) were determined at pH 5.0, 7.0 and 8.0 and scan rate of 10, 50 and 100 mV/s by cyclic
Claudia Grajeda-Iglesias et al.
Food chemistry, 194, 749-757 (2015-10-17)
Hibiscus sabdariffa L. is a worldwide consumed plant, principally after infusion of its dried sepals and calyces, which are usually discarded. Nevertheless, they represent a potential source of natural bioactive compounds, e.g. polyphenols, which could add value to this under-exploited
Yanpeng Gao et al.
Water research, 176, 115745-115745 (2020-04-03)
Widespread occurrence of emerging organic contaminants (EOCs) in water have been explicitly associated with adverse effects on human health, therefore representing a major risk to public health. Especially the increased toxicity is frequently observed during the photodegradation of EOCs in
Su Jin Kang et al.
International journal of molecular sciences, 16(10), 24219-24242 (2015-10-17)
Plants rich in antioxidant substances may be useful for preventing skin aging. Pomegranates, containing flavonoids and other polyphenolic compounds, are widely consumed due to their beneficial properties. We examined the underlying mechanisms of dried pomegranate concentrate powder (PCP) on melanin
Tanveer Ahmad et al.
American journal of respiratory cell and molecular biology, 47(1), 1-10 (2012-02-09)
Oxygen-sensing prolyl-hydroxylase (PHD)-2 negatively regulates hypoxia-inducible factor (HIF)1-α and suppresses the hypoxic response. Hypoxia signaling is thought to be proinflammatory but also attenuates cellular injury and apoptosis. Although increased hypoxic response has been noted in asthma, its functional relevance is
James M May et al.
Archives of biochemistry and biophysics, 500(2), 162-168 (2010-06-01)
Ascorbic acid improves endothelial barrier function by decreasing the permeability of endothelial cells cultured on semi-porous membrane filters. This decrease was not due to enhanced collagen synthesis and was mimicked by the collagen synthesis inhibitor ethyl-3,4-dihydroxybenzoic acid (EDHB). Since EDHB
Maria-Ioanna Stavropoulou et al.
Molecules (Basel, Switzerland), 26(2) (2021-01-21)
Chemical composition of propolis depends on the plant source and thus on the geographic and climatic characteristics of the site of collection. The aim of this study was to investigate the chemical profile of Greek and Chinese propolis extracts from
Christina Warnecke et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 17(9), 1186-1188 (2003-04-24)
Hypoxia-inducible transcription factors (HIF) mediate complex adaptations to reduced oxygen supply, including neoangiogenesis. Regulation of HIF occurs mainly through oxygen-dependent destruction of its alpha subunit. In the presence of oxygen, two HIFalpha prolyl residues undergo enzymatic hydroxylation, which is required
Jian Wang et al.
FEBS letters, 529(2-3), 309-312 (2002-10-10)
Ethyl-3,4-dihydroxybenzoate (EDHB) is commonly utilized as a substrate analog and competitive inhibitor of prolyl 4-hydroxylases. These iron-dependent enzymes have received a lot of attention for their involvement in crucial biochemical pathways such as collagen maturation and oxygen sensing. Since EDHB
Zhi Zhong et al.
American journal of physiology. Gastrointestinal and liver physiology, 295(4), G823-G832 (2008-09-06)
The mitochondrial permeability transition (MPT) plays an important role in hepatocyte death caused by ischemia-reperfusion (IR). This study investigated whether activation of the cellular oxygen-sensing signal cascade by prolyl hydroxylase inhibitors (PHI) protects against the MPT after hepatic IR. Ethyl
Michael J Fallon et al.
Metabolism: clinical and experimental, 57(8), 1148-1154 (2008-07-22)
The presence of Fe(II) alpha-ketoglutarate hydroxylases in rat and human pancreatic islets and INS-1 832/13 cells was demonstrated with the reverse transcriptase polymerase chain reaction (PHD1, 2, and 3; lysyl hydroxylases 1, 2, and 3; and phytanoyl-coenzyme A hydroxylase were
Maria Luiza Zeraik et al.
PloS one, 9(10), e110277-e110277 (2014-10-24)
Pro-oxidant effects of phenolic compounds are usually correlated to the one-electron redox potential of the phenoxyl radicals. Here we demonstrated that, besides their oxidizability, hydrophobicity can also be a decisive factor. We found that esterification of protocatechuic acid (P0) provoked
Regina G Daré et al.
International journal of pharmaceutics, 582, 119336-119336 (2020-04-19)
Excessive exposure to solar radiation induces injurious effects on human skin. Our previous study evidenced that protocatechuic acid (P0) and ethyl protocatechuate (P2) act against photodamage and photoaging. The present study aimed to develop solid lipid nanoparticles (SLNs) and nanostructured
Milind M Muley et al.
Life sciences, 93(1), 51-57 (2013-06-08)
The neuroprotective activities of silymarin, piracetam and protocatechuic acid ethyl ester (PCA) on cerebral global ischemic/reperfusion were evaluated in a rat model. A midline ventral incision was made in the throat region. The right and left common carotid arteries were
H Kondo et al.
In vitro cellular & developmental biology. Animal, 29A(12), 929-935 (1993-12-01)
Human fetal skin fibroblasts (TIG-3S) were found to migrate into a denuded area in a cell monolayer when cultured in both serum-depleted and serum-supplemented media, unlike adult-donor skin fibroblasts which migrated well only when cultured in serum-supplemented medium. Therefore, a
H Kasiganesan et al.
Acta physiologica (Oxford, England), 190(2), 163-169 (2007-03-31)
Recently a family of O(2)-dependent prolyl hydroxylase domain-containing enzymes (PHD) has been identified as a cellular oxygen-sensing mechanism. Reduced prolyl hydroxylase activity initiates a signalling cascade that includes the accumulation, as well as the activation, of hypoxia-inducible factor (HIF-1alpha). In
Marine Lambert et al.
Molecules (Basel, Switzerland), 20(5), 7890-7914 (2015-05-06)
A rapid, sensitive and selective analysis method using Ultra High Performance Liquid Chromatography coupled to triple-quadrupole Mass Spectrometry (UHPLC-QqQ-MS) has been developed for the quantification of polyphenols in rosé wines. The compound detection being based on specific MS transitions in
Lutz Kiep
ALTEX, 22(3), 135-141 (2005-09-28)
It is well known that in vitro preparations of the chick embryo can functionalise and conjugate selected model substances. Based on this biochemical knowledge an ex vivo model was developed to study xenobiotic metabolism in the incubated hen's egg. The
Ikuyo Nakajima et al.
Differentiation; research in biological diversity, 70(2-3), 84-91 (2002-06-22)
Ethyl-3,4-dihydroxybenzoate (EDHB), a specific inhibitor of collagen synthesis, was used to study the role of collagen in the differentiation of bovine intramuscular preadipocytes (BIP). Triglyceride (TG) accumulation levels of BIP cells were dose-dependently inhibited by EDHB and were reduced to
David J Lomb et al.
Journal of neurochemistry, 103(5), 1897-1906 (2007-09-01)
Nerve growth factor (NGF) serves a critical survival-promoting function for developing sympathetic neurons. Following removal of NGF, sympathetic neurons undergo apoptosis characterized by the activation of c-Jun N-terminal kinases (JNKs), up-regulation of BH3-only proteins including BcL-2-interacting mediator of cell death
Pascale Sulser et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(2), 2344-2358 (2020-01-08)
Pharmacologic HIF hydroxylase inhibitors (HIs) are effective for the treatment of anemia in chronic kidney disease patients and may also be beneficial for the treatment of diseases such as chronic inflammation and ischemia-reperfusion injury. The selectivities of many HIs for
Jonathan M Harnoss et al.
Annals of surgery, 265(4), 782-791 (2017-03-08)
We sought to assess whether pharmacological inhibition of hypoxia-inducible transcription factor (HIF)-prolyl hydroxylase enzymes (PHD1, PHD2, and PHD3) is a suitable strategy to stimulate liver regeneration after partial hepatectomy for colorectal liver metastases (CRLM). Liver regeneration occurs in a hypoxic
S Saika et al.
Ophthalmic research, 27(6), 335-346 (1995-01-01)
We examined the effect of a prolyl hydroxylase inhibitor, ethyl-3,4-dihydroxybenzoate (E-DHB), on collagen production, proliferation, and spreading by cultured rabbit keratocytes and subconjunctival fibroblasts. Proliferating cells were incubated with or without E-DHB, and were examined by phase-contrast microscopy and proliferation
Susana Soares et al.
Journal of agricultural and food chemistry, 66(33), 8814-8823 (2018-07-31)
Polyphenols may contribute directly to plant-based foodstuffs flavor, in particular to astringency and bitterness. In this work, the bitterness of a small library of polyphenols from different classes [procyanidin dimers type B, ellagitannins (punicalagin, castalagin, and vescalagin) and phenolic acid
S A Fisher et al.
Journal of molecular and cellular cardiology, 26(6), 721-731 (1994-06-01)
The extra-cellular matrix has been demonstrated to play an important role in the differentiation of a number of cell types in vitro. The purpose of this study was to establish the role of ECM collagen synthesis in regulating growth and
Irena Sytařová et al.
Food chemistry, 310, 125784-125784 (2019-12-10)
Bioactive compounds demonstrating antioxidant activity were analyzed in berries and leaves of nine cultivars of sea buckthorn (Hippophaë rhamnoides L.) of various ripening times. Total polyphenols were ranging between 0.70-3.62 g GAE.kg-1 (berries) and 1.88-3.72 g GAE.kg-1 (leaves). Leaves were significantly richer source
Sebastian Philipp et al.
American journal of physiology. Heart and circulatory physiology, 290(1), H450-H457 (2005-09-13)
Protection from a prolyl hydroxylase domain-containing enzyme (PHD) inhibitor, desferoxamine (DFO), was recently reported to be dependent on production of reactive oxygen species (ROS). Ischemic preconditioning triggers the protected state by stimulating nitric oxide (NO) production to open mitochondrial ATP-sensitive
Vijayalakshmi Sridharan et al.
American journal of physiology. Cell physiology, 292(2), C719-C728 (2006-10-20)
The cellular oxygen sensor is a family of oxygen-dependent proline hydroxylase domain (PHD)-containing enzymes, whose reduction of activity initiate a hypoxic signal cascade. In these studies, prolyl hydroxylase inhibitors (PHIs) were used to activate the PHD-signaling pathway in cardiomyocytes. PHI-pretreatment
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