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Showing 1-30 of 211 results for "E4884" within Papers
Matej Adámik et al.
Biochemical and biophysical research communications, 456(1), 29-34 (2014-12-03)
Site-specific DNA recognition and binding activity belong to common attributes of all three members of tumor suppressor p53 family proteins: p53, p63 and p73. It was previously shown that heavy metals can affect p53 conformation, sequence-specific binding and suppress p53
Priyam Singh et al.
Frontiers in pharmacology, 13, 901710-901710 (2022-07-06)
Background: The current gold-standard therapies for chronic obstructive pulmonary disease (COPD) lack disease-modifying potential and exert adverse side effects. Moreover, COPD patients are at a higher risk of severe outcomes if they get infected by severe acute respiratory syndrome coronavirus
Determination of vanadium in groundwater samples with an improved kinetic spectrophotometric method.
Esra Bağda
Environmental technology, 35(9-12), 1165-1174 (2014-04-08)
A kinetic catalytic method has been developed for the determination of vanadium based on its catalytic effect on the redox reaction of azorubin S and bromate in the presence of a sulphuric and nitric acid mixture. The reaction is monitored
Theodore A Craig et al.
Biochemical and biophysical research communications, 433(4), 508-512 (2013-03-26)
The EF-hand protein, DREAM/KChIP3 (henceforth referred to as DREAM), regulates apoptosis by incompletely understood mechanisms. We demonstrate that in the presence of Ca2+, DREAM interacts with hexokinase I, a protein known to bind mitochondria and regulate apoptosis. A mutant DREAM
Mingqiang Li et al.
Biomaterials, 51, 161-172 (2015-03-17)
As a synergistic drug combination, doxorubicin-loaded cisplatin crosslinked polysaccharide-based nanoparticles (Dex-SA-DOX-CDDP) have demonstrated enhanced antitumor efficacy and reduced systemic toxicity via optimized biodistribution, controlled drug release, prolonged blood circulation, and improved tolerability, compared to the non-crosslinked nanoparticles or free doxorubicin.
Lili Ma et al.
Molecular medicine reports, 12(2), 2529-2538 (2015-05-09)
Premature ovarian failure (POF) is an ovarian defect characterized by the premature depletion of ovarian follicles in individuals <40 years old, and is a major cause of infertility in females. Genetic factors are considered to be responsible for the development
Douglas S Rehder et al.
mAbs, 11(1), 145-152 (2018-10-27)
While characterizing a therapeutic IgG4 monoclonal antibody (mAb), we observed a variant with a mass 1177 Da larger than the predominant mAb form that could not be ascribed to previously described modifications. Through successive rounds of experimentation, we localized the mass addition
Naoko Ohashi et al.
The American journal of emergency medicine, 31(7), 1157-1157 (2013-05-25)
EDTA-dependent pseudothrombocytopenia (EDTA-PTCP) is a phenomenon that occurs in vitro when EDTA reacts with harvested blood. EDTA-dependent pseudothrombocytopenia usually does not indicate thrombocytopenia in vivo. Here, we report the first case of EDTA-PTCP complicated by eosinophilic pneumonia. A 70-year-old man
Gaofeng Wang et al.
Cell host & microbe, 29(5), 777-791 (2021-04-03)
Environmental factors that enhance regeneration are largely unknown. The immune system and microbiome are attributed roles in repairing and regenerating structure but their precise interplay is unclear. Here, we assessed the function of skin bacteria in wound healing and wound-induced
Iman Tahmasbian et al.
Environmental monitoring and assessment, 185(11), 8847-8860 (2013-05-21)
The application of electrical fields and chelating agents is an innovative hybrid technology used for the decontamination of soil polluted by heavy metals. The effects of four center-oriented electrical fields and chelating agents on active fractions of lead and zinc
Kerensa Broersen et al.
Protein engineering, design & selection : PEDS, 24(9), 743-750 (2011-05-14)
We provide a validated and rapid protocol for the solubilization of amyloid β-peptide (Aβ). This procedure involves sequential solubilization using structure-breaking organic solvents hexafluoroisopropanol and DMSO followed by column purification. The low solubility and tendency of Aβ to aggregate considerably
Rene L Suleiman et al.
Current protocols, 2(1), e327-e327 (2022-01-28)
Entamoeba histolytica is a parasitic protozoan and the causative agent of amoebiasis in humans. Amoebiasis has a high incidence of disease, resulting in ∼67,900 deaths per year, and it poses a tremendous burden of morbidity and mortality in children. Despite
Jose Manuel Vagace et al.
Journal of clinical pathology, 66(9), 811-814 (2013-06-01)
We investigated the case of a 14-year-old girl with an ethylenediaminetetraacetic acid (EDTA)-dependent haemagglutination detected by macrocytosis, which was only evident by an abnormal red blood cell (RBC) population in the histogram. Investigations included haemograms with different anticoagulants and experimental
Carolina Kato Prado et al.
Food additives & contaminants. Part B, Surveillance, 8(2), 81-84 (2014-09-24)
The aim of this study was to investigate the presence of tetracycline residues in pasteurised cow's milk using high-performance liquid chromatography coupled with UV/VIS detection to determine the exposure of Brazilian's population to antibiotic residues. One hundred samples collected from
Catherine W Macharia-Mutie et al.
Public health nutrition, 16(9), 1605-1613 (2012-12-12)
Simulating the probable impact of grain amaranth and highly absorbable, low-Fe micronutrient powder (MNP) on Fe status in a potential target population is an essential step in choosing and developing an appropriate actual intervention. We simulated the potential effect of
Concerns about reliability in the Trial to Assess Chelation Therapy (TACT).
Steven E Nissen
JAMA, 309(12), 1293-1294 (2013-03-28)
S N Kozlov et al.
Zhurnal mikrobiologii, epidemiologii, i immunobiologii, (2)(2), 3-12 (2013-06-29)
Detection ofproteases in outer membranes (OM) of ompT+ and ompT- Vibrio cholerae strains of O1 and O139 serogroups. Specific sterile preparations of OM were obtained by lysis of live V. cholerae cells by 4.5 M urea solution with subsequent differential
S de Vries et al.
Poultry science, 93(8), 2010-2017 (2014-06-17)
Marker methodologies to measure ileal and total tract digestibilities of diets varying in content and degradability of dietary fiber in broiler chickens were evaluated. Chromium sesquioxide (Cr2O3) and cobalt-ethylenediamine tetraacetic acid (Co-EDTA) were used as markers of solid and soluble
Gervasio A Lamas et al.
American heart journal, 168(1), 37-44 (2014-06-24)
Disodium ethylenediaminetetraacetic acid (EDTA) reduced adverse cardiac outcomes in a factorial trial also testing oral vitamins. This report describes the intent-to-treat comparison of the 4 factorial groups overall and in patients with diabetes. This was a double-blind, placebo-controlled, 2 ×
Anke M Smits et al.
Nature protocols, 4(2), 232-243 (2009-02-07)
To date, there is no suitable in vitro model to study human adult cardiac cell biology. Although embryonic stem cells are able to differentiate into cardiomyocytes in vitro, the efficiency of this process is very low. Other methods to differentiate
Octavian Bucur et al.
Frontiers in medicine, 5, 322-322 (2018-12-07)
Kidney glomerular diseases, such as the minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS), and other nephrotic syndromes, are typically diagnosed or confirmed via electron microscopy. Although optical microscopy has been a vital tool to examine clinical specimens for
Soham Gupta et al.
Frontiers in immunology, 11, 437-437 (2020-04-01)
The hijacking of cellular function through expression of proteins that interfere with the activity of cellular enzymes and regulatory complexes is a common strategy used by viruses to remodel the cell environment in favor of their own replication and spread.
Byeong-Won Kim et al.
Autophagy, 14(12), 2104-2116 (2018-08-08)
The initiation of macroautophagy/autophagy is tightly regulated by the upstream ULK1 kinase complex, which affects many downstream factors including the PtdIns3K complex. The phosphorylation of the right position at the right time on downstream molecules is governed by proper complex
Salah Al Zadjali et al.
International journal of clinical and experimental medicine, 8(5), 7160-7167 (2015-07-30)
Lead is a widely-spread environmental pollutant and a commonly-used industrial chemical that can cause multisystemic adverse health effects. However, the effects of lead exposure on diabetic animals have not been reported so far. The aim of this study is to
Luminita David et al.
Colloids and surfaces. B, Biointerfaces, 122, 767-777 (2014-09-02)
This research aimed at reporting the synthesis, characterization and evaluation of the anti-inflammatory effects of some new biomaterials based on silver nanoparticles and polyphenols rich natural extracts. A fast and eco-friendly extracellular biosynthesis of silver nanoparticles (AgNPs), using European black
Serena Duchi et al.
Materials (Basel, Switzerland), 12(4) (2019-02-23)
Cartilage defects and diseases remain major clinical issues in orthopaedics. Biomanufacturing is now a tangible option for the delivery of bioscaffolds capable of regenerating the deficient cartilage tissue. However, several limitations of in vitro and experimental animal models pose serious
Robert M Beaty et al.
Methods in molecular biology (Clifton, N.J.), 360, 57-89 (2006-12-19)
Pancreatic cancer is a lethal disease and rational strategies for early detection and targeted therapies are urgently required to alleviate the dismal prognosis of this neoplasm. The use of global RNA and protein expression-profiling technologies, such as DNA microarrays, serial
J X F Sim et al.
Journal of applied microbiology, 127(1), 99-108 (2019-05-06)
The antimicrobial activity of cinnamon essential oil and cinnamaldehyde against bacterial and fungal pathogens associated with canine otitis externa, as well as the effect of their combination with EDTA were investigated. Antimicrobial susceptibility testing was performed using the broth microdilution
Ilya B Zavodnik et al.
Life sciences, 92(23), 1110-1117 (2013-05-07)
The present study was designed for further evaluation of the biochemical mechanism of hepatic mitochondrial dysfunction under oxidative damages induced by organic hydroperoxide, tert-butyl hydroperoxide (tBHP), for estimation of the molecular targets impaired during oxidative stress, and for investigation of
[Alternative medicine sensation. Surprisingly effective: chelates and multivitamins in coronary heart disease].
Dirk Einecke
MMW Fortschritte der Medizin, 155(6), 23-23 (2013-05-25)
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