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Showing 1-30 of 316 results for "E9508" within Papers
Hong Gao et al.
Environmental toxicology and pharmacology, 37(3), 1079-1089 (2014-05-02)
The aim of this work was to investigate genomic DNA damage in human oral cavity cells after exposure to different tobacco product preparations (TPPs). The oral carcinoma cell line 101A, gingival epithelial cells HGEC, and gingival fibroblasts HGF were exposed
Matthew W Vetting et al.
Biochemistry, 54(3), 909-931 (2014-12-30)
The rate at which genome sequencing data is accruing demands enhanced methods for functional annotation and metabolism discovery. Solute binding proteins (SBPs) facilitate the transport of the first reactant in a metabolic pathway, thereby constraining the regions of chemical space
Sam Kafian et al.
Platelets, 26(5), 467-473 (2014-07-16)
High on-treatment platelet reactivity (HPR) to clopidogrel has been shown to increase the risk of cardiovascular events. Platelet-derived microvesicles (PMVs) may be prothrombotic and contribute to the risk of recurrent events observed in patients with HPR. However, PMVs may also
Lauriane N Roux et al.
Journal of applied toxicology : JAT, 35(5), 520-528 (2014-09-05)
Every year, 10 million workers are exposed to metalworking fluids (MWFs) that may be toxic. There are four types of MWFs: neat oils and three water-based MWFs (soluble oil, semisynthetic and synthetic), which are diluted with water and whose composition
Zhao Zhao et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 74, 216-224 (2014-12-03)
Blue light induced oxidative damage and ER stress are related to the pathogenesis of age-related macular degeneration (AMD). However, the mechanism of blue light-induced damage remained obscure. The objective of this work is to assess the photooxidative damage to retinal
Wolfram Gronwald et al.
Kidney international, 79(11), 1244-1253 (2011-03-11)
Autosomal dominant polycystic kidney disease (ADPKD) is a frequent cause of kidney failure; however, urinary biomarkers for the disease are lacking. In a step towards identifying such markers, we used multidimensional-multinuclear nuclear magnetic resonance (NMR) spectroscopy with support vector machine-based
S H M Hedberg et al.
Pharmaceutical research, 32(12), 3975-3985 (2015-08-14)
Measurement of the second virial coefficient B22 for proteins using self-interaction chromatography (SIC) is becoming an increasingly important technique for studying their solution behaviour. In common with all physicochemical chromatographic methods, measuring the dead volume of the SIC packed column
Maria Pawula et al.
Talanta, 146, 823-830 (2015-12-24)
A surface plasmon resonance (SPR) sensor developed for the rapid, sensitive and specific detection of cardiac troponin T (cTnT) in serum samples is reported in this work. An extensive optimisation of assay parameters was conducted to achieve optimal detection strategy.
Eun Hye Jee et al.
Journal of chromatography. A, 1251, 232-235 (2012-07-10)
A2E, known to be involved in the pathogenesis of age-related macular degeneration (AMD), is one of the major compounds that accumulate as fluorescent pigments in retinal pigment epithelial (RPE) cells with age and in some retinal disorders. While the biomimetic
Estela Solanas et al.
Cells, tissues, organs, 200(5), 316-325 (2015-09-19)
The availability of fully functional human hepatocytes is critical for progress in human hepatocyte transplantation and the development of bioartificial livers and in vitro liver systems. However, the cell isolation process impairs the hepatocyte status and determines the number of
Thomas Van Blarcom et al.
Journal of molecular biology, 427(6 Pt B), 1513-1534 (2014-10-07)
The ability of antibodies to bind an antigen with a high degree of affinity and specificity has led them to become the largest and fastest growing class of therapeutic proteins. Clearly identifying the epitope at which they bind their cognate
Gabriel da Silva
The journal of physical chemistry. A, 116(45), 10980-10986 (2012-09-22)
The alkanolamine 2-aminoethanol (NH(2)CH(2)CH(2)OH), otherwise known as monoethanolamine (MEA), is a widely used solvent for carbon capture, yet relatively little is known about its atmospheric chemistry. The hydroxyl radical initiated oxidation of MEA is thought to predominantly form the α-aminoalkyl
Haibo Zhai et al.
Environmental science & technology, 49(13), 7571-7579 (2015-05-30)
This study employs a power plant modeling tool to explore the feasibility of reducing unit-level emission rates of CO2 by 30% by retrofitting carbon capture, utilization, and storage (CCUS) to existing U.S. coal-fired electric generating units (EGUs). Our goal is
Young-Min Kim et al.
Biomaterials, 35(27), 7970-7977 (2014-06-22)
We developed a targetable micelleplex hydrogel as a new efficient systemic siRNA delivery material that functions as a targetable gene carrier, and a hydrogel capable of controlled release to overcome drawbacks of multiple administrations of systemic siRNA carriers due to
I V Golubev et al.
Acta naturae, 6(3), 76-88 (2014-10-29)
Hydrophobization of alpha-helices is one of the general approaches used for improving the thermal stability of enzymes. A total of 11 serine residues located in alpha-helices have been found based on multiple alignments of the amino acid sequences of D-amino
Evelien A W Smits et al.
Journal of liposome research, 25(1), 46-57 (2014-07-02)
Besides the development of sample preparation methods for the determination of separate liposomal-encapsulated prednisolone phosphate and non-encapsulated prednisolone concentrations in murine plasma and blood, this article also presents the first description of an accurate sample preparation method for the determination
Maged W Helmy et al.
British journal of pharmacology, 172(17), 4291-4302 (2015-05-28)
Cyclosporine (CSA) and non-steroidal anti-inflammatory drugs (NSAIDs) are co-prescribed for some arthritic conditions. We tested the hypothesis that this combined regimen elicits exaggerated nephrotoxicity in rats via the up-regulation of endothelin (ET) receptor signalling. The effects of a 10 day
A Szkudlarek et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 152, 645-653 (2015-03-05)
Human serum albumin (HSA), transporting protein, is exposed during its life to numerous factors that cause its functions become impaired. One of the basic factors --glycation of HSA--occurs in diabetes and may affect HSA-drug binding. Accumulation of advanced glycation end-products
Dan Wang et al.
Clinica chimica acta; international journal of clinical chemistry, 438, 55-61 (2014-08-12)
Molecular binding characteristics of several thyroid stimulating hormone (TSH) antibodies were determined for the TSH antigen, along with its closely related endogenous interfering hormones, follicle stimulating hormone (FSH), luteinizing hormone (LH) and chorionic gonadotropin (CG). This data was compared to
Dong-Kee Kim et al.
Drug delivery, 22(3), 367-374 (2014-01-23)
Local delivery systems for treatment of intractable inner ear disorders have been attempted by many investigators. To evaluate the permeability and safety of a drug delivery system for the inner ear using a poly(2-hydroxyethyl aspartamide) (PHEA) polymersome. One-month-old male C57/BL6
Galith Abourbeh et al.
EJNMMI research, 5, 4-4 (2015-04-09)
Non-small cell lung carcinoma (NSCLC) represents approximately 80% of lung cancer cases, and over 60% of these tumors express the epidermal growth factor receptor (EGFR). Activating mutations in the tyrosine kinase (TK) domain of the EGFR are detected in 10%
Mihaela Puiu et al.
Sensors (Basel, Switzerland), 15(5), 10511-10525 (2015-05-08)
We report a Love wave surface acoustic wave (LW-SAW) immunosensor designed for the detection of high molecular weight targets in liquid samples, amenable also for low molecular targets in surface competition assays. We implemented a label-free interaction protocol similar to
James T Pearson et al.
Journal of neurophysiology, 114(1), 540-550 (2015-05-23)
Contrast, a fundamental feature of visual scenes, is encoded in a distributed manner by ∼ 20 retinal ganglion cell (RGC) types, which stream visual information to the brain. RGC types respond preferentially to positive (ON(pref)) or negative (OFF(pref)) contrast and
Michael Waisberg et al.
PLoS pathogens, 10(9), e1004338-e1004338 (2014-09-12)
Invasion of mosquito salivary glands (SGs) by Plasmodium falciparum sporozoites is an essential step in the malaria life cycle. How infection modulates gene expression, and affects hematophagy remains unclear. Using Affimetrix chip microarray, we found that at least 43 genes
Han Ju et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(9), 4040-4051 (2015-03-06)
The ability to process complex spatiotemporal information is a fundamental process underlying the behavior of all higher organisms. However, how the brain processes information in the temporal domain remains incompletely understood. We have explored the spatiotemporal information-processing capability of networks
Pavlina Lyskova et al.
Mycopathologia, 180(5-6), 407-419 (2015-08-21)
Trichophyton bullosum is a zoophilic dermatophyte from the Arthroderma benhamiae complex with a poorly known distribution. In this study, we report a case of dermatophytosis caused by T. bullosum in a 6-year-old male horse who had a skin lesion located
Eric S Kuebler et al.
Scientific reports, 5, 17718-17718 (2015-12-10)
Neuronal activity in vitro exhibits network bursts characterized by brief periods of increased spike rates. Recent work shows that a subpopulation of neurons reliably predicts the occurrence of network bursts. Here, we examined the role of burst predictors in cultures
Q Deng et al.
Journal of dairy science, 98(9), 6018-6028 (2015-07-21)
The objective of this investigation was to evaluate whether intravaginal infusion of lactic acid bacteria (LAB) around parturition could expedite involution rate of the uterus and improve reproductive performance of postpartum dairy cows. One hundred pregnant Holstein dairy cows were
Kathryn A Jewett et al.
The European journal of neuroscience, 42(4), 2078-2090 (2015-06-04)
We characterise sleep-like states in cultured neurons and glia during development in vitro as well as after electrical stimulation, the addition of tumor necrosis factor alpha (TNF), and the combination of TNF plus electrical stimulation. We also characterise optogenetic stimulation-induced
Andrew J Watkins et al.
Applied and environmental microbiology, 78(23), 8298-8303 (2012-09-25)
Choline (N,N,N-trimethylethanolamine), which is widely distributed in membrane lipids and is a component of sediment biota, has been shown to be utilized anaerobically by mixed prokaryote cultures to produce methane but not by pure cultures of methanogens. Here, we show
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