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Showing 1-30 of 316 results for "E9508" within Papers
Hong Gao et al.
Environmental toxicology and pharmacology, 37(3), 1079-1089 (2014-05-02)
The aim of this work was to investigate genomic DNA damage in human oral cavity cells after exposure to different tobacco product preparations (TPPs). The oral carcinoma cell line 101A, gingival epithelial cells HGEC, and gingival fibroblasts HGF were exposed
Young-Min Kim et al.
Biomaterials, 35(27), 7970-7977 (2014-06-22)
We developed a targetable micelleplex hydrogel as a new efficient systemic siRNA delivery material that functions as a targetable gene carrier, and a hydrogel capable of controlled release to overcome drawbacks of multiple administrations of systemic siRNA carriers due to
Matthew W Vetting et al.
Biochemistry, 54(3), 909-931 (2014-12-30)
The rate at which genome sequencing data is accruing demands enhanced methods for functional annotation and metabolism discovery. Solute binding proteins (SBPs) facilitate the transport of the first reactant in a metabolic pathway, thereby constraining the regions of chemical space
Sam Kafian et al.
Platelets, 26(5), 467-473 (2014-07-16)
High on-treatment platelet reactivity (HPR) to clopidogrel has been shown to increase the risk of cardiovascular events. Platelet-derived microvesicles (PMVs) may be prothrombotic and contribute to the risk of recurrent events observed in patients with HPR. However, PMVs may also
Lauriane N Roux et al.
Journal of applied toxicology : JAT, 35(5), 520-528 (2014-09-05)
Every year, 10 million workers are exposed to metalworking fluids (MWFs) that may be toxic. There are four types of MWFs: neat oils and three water-based MWFs (soluble oil, semisynthetic and synthetic), which are diluted with water and whose composition
Haibo Zhai et al.
Environmental science & technology, 49(13), 7571-7579 (2015-05-30)
This study employs a power plant modeling tool to explore the feasibility of reducing unit-level emission rates of CO2 by 30% by retrofitting carbon capture, utilization, and storage (CCUS) to existing U.S. coal-fired electric generating units (EGUs). Our goal is
Gabriel da Silva
The journal of physical chemistry. A, 116(45), 10980-10986 (2012-09-22)
The alkanolamine 2-aminoethanol (NH(2)CH(2)CH(2)OH), otherwise known as monoethanolamine (MEA), is a widely used solvent for carbon capture, yet relatively little is known about its atmospheric chemistry. The hydroxyl radical initiated oxidation of MEA is thought to predominantly form the α-aminoalkyl
Michael Waisberg et al.
PLoS pathogens, 10(9), e1004338-e1004338 (2014-09-12)
Invasion of mosquito salivary glands (SGs) by Plasmodium falciparum sporozoites is an essential step in the malaria life cycle. How infection modulates gene expression, and affects hematophagy remains unclear. Using Affimetrix chip microarray, we found that at least 43 genes
Werner J Geldenhuys et al.
Bioorganic & medicinal chemistry letters, 20(16), 4870-4877 (2010-07-20)
The high affinity neuronal choline transporter (CHT1) is responsible for the uptake of choline into the pre-synaptic terminal of cholinergic neurons. Considering our past experience with modeling the blood-brain barrier choline transporter (BBBCHT) as drug delivery vector to the CNS
Kiwamu Hyodo et al.
PLoS pathogens, 11(5), e1004909-e1004909 (2015-05-29)
Eukaryotic positive-strand RNA [(+)RNA] viruses are intracellular obligate parasites replicate using the membrane-bound replicase complexes that contain multiple viral and host components. To replicate, (+)RNA viruses exploit host resources and modify host metabolism and membrane organization. Phospholipase D (PLD) is
Patrick I Ferrell et al.
Stem cells (Dayton, Ohio), 33(4), 1130-1141 (2014-12-30)
Derivation of hematopoietic stem cells (HSCs) from human pluripotent stem cells remains a key goal for the fields of developmental biology and regenerative medicine. Here, we use a novel genetic reporter system to prospectively identify and isolate early hematopoietic cells
Neelam Khatri et al.
Biology direct, 7, 45-45 (2012-12-14)
Ethanolamine is used as an energy source by phylogenetically diverse bacteria including pathogens, by the concerted action of proteins from the eut-operon. Previous studies have revealed the presence of eutBC genes encoding ethanolamine-ammonia lyase, a key enzyme that breaks ethanolamine
Eliane N Miyaji et al.
Clinical and vaccine immunology : CVI, 22(2), 213-220 (2014-12-19)
Streptococcus pneumoniae has proteins that are attached to its surface by binding to phosphorylcholine of teichoic and lipoteichoic acids. These proteins are known as choline-binding proteins (CBPs). CBPs are an interesting alternative for the development of a cost-effective vaccine, and
Stefanie A Drieghe et al.
Clinical chemistry and laboratory medicine, 52(6), 861-867 (2014-01-09)
The measurement of C-reactive protein (CRP) concentrations has been of interest as a classical marker of acute phase response; in addition, it has been of particular interest in cardiovascular risk stratification where high-sensitive measurements are necessary. Since CRP is able
Jason M Hinzman et al.
Experimental neurology, 267, 243-253 (2015-03-31)
Spreading depolarizations (SD) are mass depolarizations of neurons and astrocytes that occur spontaneously in acute brain injury and mediate time-dependent lesion growth. Glutamate excitotoxicity has also been extensively studied as a mechanism of neuronal injury, although its relevance to in
Sheeja Jagadevan et al.
Journal of hazardous materials, 244-245, 394-402 (2013-01-01)
In metal machining processes, the regulation of heat generation and lubrication at the contact point are achieved by application of a fluid referred to as metalworking fluid (MWF). MWFs inevitably become operationally exhausted with age and intensive use, which leads
Label-Free Detection and Characterization of Heparin-Induced Thrombocytopenia (HIT)-like Antibodies.
Nida Zaman Khan et al.
ACS omega, 6(40), 25926-25939 (2021-10-19)
Heparin-induced thrombocytopenia (HIT) antibodies (Abs) can mediate and activate blood cells, forming blood clots. To detect HIT Abs, immunological assays with high sensitivity (≥95%) and fast response are widely used, but only about 50% of these tests are accurate as
Ingrid Hauser et al.
Applied biochemistry and biotechnology, 169(4), 1449-1458 (2013-01-15)
Large-scale amine-based CO(2) capture will generate waste containing large amounts of ammonia, in addition to contaminants such as the actual amine as well as degradation products thereof. Monoethanolamine (MEA) has been a dominant amine applied so far in this context.
Douglas L Huseby et al.
Journal of bacteriology, 195(12), 2864-2879 (2013-04-16)
Microcompartments are loose protein cages that encapsulate enzymes for particular bacterial metabolic pathways. These structures are thought to retain and perhaps concentrate pools of small, uncharged intermediates that would otherwise diffuse from the cell. In Salmonella enterica, a microcompartment encloses
Yang Sun et al.
Particle and fibre toxicology, 12, 4-4 (2015-04-19)
Nanoparticles have become a key technology in multiple industries. However, there are growing reports of the toxicity of nanomaterials to humans. In particular, nanomaterials have been linked to lung diseases. The molecular mechanisms of nanoparticle toxicity are largely unexplored. Acute
Jon Gil-Ranedo et al.
PLoS pathogens, 11(6), e1004920-e1004920 (2015-06-13)
It is unknown whether the mammalian cell cycle could impact the assembly of viruses maturing in the nucleus. We addressed this question using MVM, a reference member of the icosahedral ssDNA nuclear parvoviruses, which requires cell proliferation to infect by
Seigo Korematsu et al.
Vaccine, 32(48), 6345-6348 (2014-10-07)
Because the optic nerve is mainly comprised from phospholipids such as phosphatidylcholine, the association between optic neuritis, anti-phospholipids antibodies and vaccination was examined. Two female pediatric patients suddenly presented bilateral optic neuritis after administration of trivalent inactivated influenza vaccine. These
Cheng Wang et al.
Biosensors & bioelectronics, 71, 222-229 (2015-04-29)
This paper presents an aptameric graphene nanosensor for detection of small-molecule biomarkers. To address difficulties in direct detection of small molecules associated with their low molecular weight and electrical charge, we incorporate an aptamer-based competitive affinity assay in a graphene
A F Alkaim et al.
Environmental technology, 36(17), 2190-2197 (2015-03-03)
The photocatalytic production of molecular hydrogen (H2) from aqueous solutions of alkyl-alkanolamines (triethanolamine (tri-EOA), diethanolamine (di-EOA), ethanolamine (EOA), ethylamine (EA) and ethanol over Pt-loaded commercial (Sachtleben Hombikat UV100) nanoparticle titanium dioxide photocatalysts was studied. These photocatalysts were characterized using X-ray
Zhao Zhao et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 74, 216-224 (2014-12-03)
Blue light induced oxidative damage and ER stress are related to the pathogenesis of age-related macular degeneration (AMD). However, the mechanism of blue light-induced damage remained obscure. The objective of this work is to assess the photooxidative damage to retinal
Alicia K Au et al.
Biochimica et biophysica acta, 1852(9), 1902-1911 (2015-06-15)
Increased autophagy/mitophagy is thought to contribute to cerebellar dysfunction in Purkinje cell degeneration mice. Intriguingly, cerebellar Purkinje cells are highly vulnerable to hypoxia-ischemia (HI), related at least in part to their high metabolic activity. Whether or not excessive or supraphysiologic
Wookjin Choi et al.
Bioresource technology, 120, 295-299 (2012-07-10)
The influence of monoethanolamine (MEA) as a CO(2) absorbent on photoautotrophic culture of CO(2)-fixing microalgae was investigated. When 300 ppm MEA (4.92 mM) was added to blank culture medium, the dissolved inorganic carbon and the molar absorption ratio increased to
Estela Solanas et al.
Cells, tissues, organs, 200(5), 316-325 (2015-09-19)
The availability of fully functional human hepatocytes is critical for progress in human hepatocyte transplantation and the development of bioartificial livers and in vitro liver systems. However, the cell isolation process impairs the hepatocyte status and determines the number of
Shannon N Acker et al.
Pediatric research, 77(4), 511-519 (2015-01-13)
Pulmonary hypertension (PH) secondary to vascular remodeling contributes to poor outcomes in congenital diaphragmatic hernia (CDH), however mechanisms responsible are unknown. We hypothesized that pulmonary artery endothelial cell (PAEC) dysfunction contributes to smooth muscle cell (SMC) hyperplasia in experimental CDH.
Philippe Pierrat et al.
Langmuir : the ACS journal of surfaces and colloids, 31(45), 12362-12371 (2015-10-29)
Understanding the ionization behavior of lipid membranes is a key parameter for successful development of lipid-based drug delivery systems. Accurate determination of the ionization state of a titratable species incorporated in a lipid bilayer however requires special care. Herein we
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