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Showing 1-30 of 40 results for "ECM508" within Papers
Yao Kong et al.
Oncology letters, 19(4), 2832-2838 (2020-03-29)
The present study aimed to investigate the involvement of long intergenic non-coding RNA for kinase activation (LINK-A) long non-coding RNA (lncRNA) in osteosarcoma. Plasma levels of LINK-A lncRNA and transforming growth factor β1 (TGF-β1) were measured by reverse transcription-quantitative polymerase
Presenilin 1/gamma-secretase is associated with cadmium-induced E-cadherin cleavage and COX-2 gene expression in T47D breast cancer cells.
Chang Seok Park,Ohn Soon Kim,Sang-Moon Yun,Sangmee A Jo,Inho Jo,Young Ho Koh
Toxicological Sciences null
Yang Wang et al.
Artificial cells, nanomedicine, and biotechnology, 47(1), 1050-1056 (2019-04-04)
Osteoblast has been found to exert indispensable functions during fracture healing. This study aimed to investigate the effects of kaempferol, a natural flavonoid compound, on osteoblast proliferation, migration and differentiation, as well as possible molecular mechanisms. qRT-PCR was performed to
M Shafiq et al.
European cells & materials, 30, 282-302 (2015-11-29)
In situ tissue regeneration holds great promise for regenerative medicine and tissue engineering applications. However, to achieve control over long-term and localised presence of biomolecules, certain barriers must be overcome. The aim of this study was to develop electrospun scaffolds
Zhenghua Fei et al.
Frontiers in oncology, 12, 916246-916246 (2022-07-19)
The long-term prognosis of HCC (hepatocellular carcinoma) with metastasis remains extremely poor. CircRNAs are promising as critical biological markers in identifying disease mechanisms and developing new effective treatments. However, the role of the aberrant expression of circRNAs in HCC progression
Meghnad Joshi et al.
Stem cells translational medicine, 4(1), 21-30 (2014-12-05)
Effective repopulation of the liver is essential for successful clinical hepatocyte transplantation. The objective was to improve repopulation of the liver with human hepatocytes using chemokines. We used flow cytometry and immunohistochemistry assays to identify commonly expressed chemokine receptors on
Marie-Nicole Theodoraki et al.
Oncoscience, 5(3-4), 75-87 (2018-06-02)
Photodynamic therapy (PDT) is a palliative treatment option for head and neck squamous cell carcinoma (HNSCC) patients which induces local inflammation and alters tumor cell morphology. We show that exosomes in plasma of HNSCC patients undergoing PDT reprogram tumor cells
Siti Nur Ain Roesley et al.
Cell cycle (Georgetown, Tex.), 15(1), 137-151 (2016-01-16)
Expression of Breast Cancer Metastasis Suppressor 1 (BRMS1) reduces the incidence of metastasis in many human cancers, without affecting tumorigenesis. BRMS1 carries out this function through several mechanisms, including regulation of gene expression by binding to the mSin3/histone deacetylase (HDAC)
Martha Douglas-Escobar et al.
PloS one, 7(12), e51706-e51706 (2012-12-20)
Hypoxic ischemic encephalopathy (HIE) affects 2-3 per 1000 full-term neonates. Up to 75% of newborns with severe HIE die or have severe neurological handicaps. Stem cell therapy offers the potential to replace HIE-damaged cells and enhances the autoregeneration process. Our
Jiani Wang et al.
Molecular therapy oncolytics, 12, 195-203 (2019-03-09)
The antimicrobial peptide cathelicidin inhibits development of colitis-associated colon cancer. However, the role of cathelicidin in colon cancer metastasis remains unknown. We hypothesized that cathelicidin is effective in inhibiting colon cancer metastasis. Human colon cancer HT-29 cells were injected intravenously
Do Young Park et al.
Artificial organs, 44(4), E136-E149 (2019-10-30)
Cartilage extracellular matrix contains antiadhesive and antiangiogenic molecules such as chondromodulin-1, thrombospondin-1, and endostatin. We have aimed to develop a cross-linked cartilage acellular matrix (CAM) barrier for peritendinous adhesion prevention. CAM film was fabricated using decellularized porcine cartilage tissue powder
Ghaneya Al-Khadairi et al.
Journal of translational medicine, 17(1), 9-9 (2019-01-04)
The triple negative breast cancer (TNBC) paradox marks a major challenge in the treatment-decision making process. TNBC patients generally respond better to neoadjuvant chemotherapy compared to other breast cancer patients; however, they have a substantial higher risk of disease recurrence.
Hon Wai Koon et al.
The American journal of pathology, 177(5), 2300-2309 (2010-10-05)
Substance P (SP) and the neurokinin-1 receptor (NK-1R) are involved in the development of colitis and mucosal healing after colonic inflammation. We studied whether SP modulates colonic fibrosis by using a chronic model of trinitrobenzenesulfonic acid (TNBS)-induced colitis in wild-type
Luis Rodriguez-Menocal et al.
Stem cells translational medicine, 1(3), 221-229 (2012-12-01)
Chronic wounds continue to be a major cause of morbidity for patients and an economic burden on the health care system. Novel therapeutic approaches to improved wound healing will need, however, to address cellular changes induced by a number of
Yoshito Nagano et al.
Cell cycle (Georgetown, Tex.), 10(15), 2592-2602 (2011-07-08)
p27(kip1) has been implicated in cell cycle regulation, functioning as an inhibitor of cyclin-dependent kinase activity. In addition, p27 was also shown to affect cell migration, with accumulation of cytoplasmic p27 associated with tumor invasiveness. However, the mechanism underlying p27
Plasma rich in growth factors (PRGF-Endoret) stimulates proliferation and migration of primary keratocytes and conjunctival fibroblasts and inhibits and reverts style=background-c
Anitua E, Sanchez M, Merayo-Lloves J, De la Fuente M, Muruzabal F, Orive G
Investigative Ophthalmology & Visual Science null
Chia-Hung Hsu et al.
Disease markers, 2022, 8446629-8446629 (2022-07-30)
Despite therapeutic advancements, metastasis remains a major cause in breast cancer-specific mortality. Breast cancer cells are susceptible to oxidative damage and exhibit high levels of oxidative stress, including protein damage, DNA damage, and lipid peroxidation. Some breast cancer risk factors
Thupten Tsering et al.
Cancers, 12(10) (2020-10-15)
Extracellular vesicles (EVs) carry molecules derived from donor cells and are able to alter the properties of recipient cells. They are important players during the genesis and progression of tumors. Uveal melanoma (UM) is the most common primary intraocular tumor
Amirah Abdul Rahman et al.
Frontiers in pharmacology, 13, 844199-844199 (2022-04-09)
Emerging reports have shown therapeutic potential of hydroxychavicol (HC) and epigallocatechin-3-gallate (EGCG) against cancer cells, however high concentrations are required to achieve the anticancer activity. We reported the synergy of low combination doses of EGCG+HC in glioma cell lines 1321N1
Sabena M Conley et al.
Frontiers in cell and developmental biology, 8, 197-197 (2020-04-11)
Chronic inflammatory conditions like obesity may adversely impact the biological functions underlying the regenerative potential of mesenchymal stromal/stem cells (MSC). Obesity can impair MSC function by inducing cellular senescence, a growth-arrest program that transitions cells to a pro-inflammatory state. However
Xiang-Cui Guo et al.
Aging, 11(5), 1333-1341 (2019-03-12)
The outgrowth and metastasis of cervical cancer (CC) contribute to its malignancy. Pituitary Tumor Transforming Gene 1 (PTTG1) is upregulated in many types of cancer, and enhances tumor cell growth and metastasis. However, the activation and regulation of PTTG1 in
Sarra El-Soussi et al.
Frontiers in pediatrics, 9, 693145-693145 (2021-08-24)
Neuroblastoma is the most common extracranial nervous system tumor in children. It presents with a spectrum of clinical prognostic measures ranging from benign growths that regress spontaneously to highly malignant, treatment evasive tumors affiliated with increased mortality rates. MYCN amplification
Y Meng et al.
Cell transplantation, 27(10), 1495-1503 (2018-09-07)
Mesenchymal stem cells (MSCs) constitute an important repair system, but may be impaired by exposure to cardiovascular risk factors. Consequently, adipose tissue-derived MSCs from pigs with the metabolic syndrome (MetS) show decreased vitality. A growing number of microRNAs (miRNAs) are
Patty C H Cai et al.
Oncotarget, 5(17), 7549-7562 (2014-10-04)
Transforming growth factor (TGF)-β-activating kinase 1 (TAK1) is a serine/threonine kinase which is frequently associated with human cancer progression. However, its functional role in tumorigenesis is still controversial. Here, we report that TAK1 enhances the oncogenic capacity of ovarian cancer
Gábor Bögel et al.
The Journal of biological chemistry, 287(37), 31321-31329 (2012-07-26)
Mutations in the SH3PXD2B gene coding for the Tks4 protein are responsible for the autosomal recessive Frank-ter Haar syndrome. Tks4, a substrate of Src tyrosine kinase, is implicated in the regulation of podosome formation. Here, we report a novel role
Amirah Abdul Rahman et al.
Journal of physiology and biochemistry, 75(4), 499-517 (2019-08-16)
Gamma-tocotrienol (GTT) and hydroxychavicol (HC) exhibit anticancer activity in glioma cancer cells, where the combination of GTT + HC was shown to be more effective than single agent. The aim of this study was to determine the effect of GTT
Giorgia Nardone et al.
Nature communications, 8, 15321-15321 (2017-05-16)
Hippo effectors YAP/TAZ act as on-off mechanosensing switches by sensing modifications in extracellular matrix (ECM) composition and mechanics. The regulation of their activity has been described by a hierarchical model in which elements of Hippo pathway are under the control
Hon-Wai Koon et al.
The American journal of pathology, 173(2), 400-410 (2008-07-05)
Substance P (SP) regulates important intestinal functions, such as mucosal permeability, motility, chloride secretion, and inflammation via the neurokinin-1 receptor (NK-1R). Previous reports showed that vascularization and expression of angiogenic factors are evident in the colonic mucosa of rats with
Ahmed Saad et al.
Stem cell research & therapy, 7(1), 128-128 (2016-09-11)
Adipose-derived MSC (AMSCs) possess angiogenic and immunomodulatory properties that may modulate kidney regeneration. Whether these properties are retained in older patients with atherosclerotic vascular disease is poorly understood. Hypoxic conditions are known to modify properties and growth characteristics of AMSCs.
Elizebeth C Turner et al.
The Journal of biological chemistry, 286(17), 15440-15457 (2011-03-02)
In humans, thromboxane (TX) A(2) signals through the TPα and TPβ isoforms of the TXA(2) receptor or TP. Here, the RhoA effector protein kinase C-related kinase (PRK) 1 was identified as an interactant of both TPα and ΤPβ involving common
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