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Showing 1-23 of 23 results for "EZML" within Papers
Olga Barca-Mayo et al.
Glia, 68(6), 1131-1147 (2019-12-14)
Disruption of the circadian cycle is strongly associated with metabolic imbalance and reduced longevity in humans. Also, rodent models of circadian arrhythmia, such as the constitutive knockout of the clock gene Bmal1, leads to metabolic disturbances and early death. Although
Sanjin Zvonic et al.
Diabetes, 55(4), 962-970 (2006-03-29)
First described in the suprachiasmatic nucleus, circadian clocks have since been found in several peripheral tissues. Although obesity has been associated with dysregulated circadian expression profiles of leptin, adiponectin, and other fat-derived cytokines, there have been no comprehensive analyses of
Candela Caballero-Eraso et al.
The Journal of physiology, 597(1), 151-172 (2018-10-05)
Leptin is a potent respiratory stimulant. A long functional isoform of leptin receptor, LepRb , was detected in the carotid body (CB), a key peripheral hypoxia sensor. However, the effect of leptin on minute ventilation (VE ) and the hypoxic
Vincent E de Meijer et al.
PloS one, 6(9), e25587-e25587 (2011-10-08)
Hepatic steatosis is an established risk factor for complications following major hepatic resection. Pharmacological options to reverse steatosis prior to surgery, however, are lacking. We hypothesized that treatment with the pharmacologic tumor necrosis factor-α converting enzyme (TACE)-inhibitor Marimastat would reverse
Leptin signalling
Sweeney G
Cellular Signalling, 14(8), 655-663 (2002)
Effect of chronic and intermittent calorie restriction on serum adiponectin and leptin and mammary tumorigenesis.
Rogozina OP, Bonorden MJ, Seppanen CN, Grande JP, Cleary MP
Cancer Prevention Research (Philadelphia, Pa.) null
Exogenous insulin enhances humoural immune responses in short-day, but not long-day, Siberian hamsters (Phodopus sungorus).
Garcia NW, Greives TJ, Zysling DA, French SS, Chester EM, Demas GE
Proceedings. Biological Sciences / The Royal Society null
High-fat feeding alters the clock synchronization to light.
Jorge Mendoza, Paul Pevet, Etienne Challet
The Journal of Physiology null
Karthikeyani Chellappa et al.
Aging cell, 18(5), e13014-e13014 (2019-08-03)
The mechanistic target of rapamycin (mTOR) is an evolutionarily conserved protein kinase that regulates growth and metabolism. mTOR is found in two protein complexes, mTORC1 and mTORC2, that have distinct components and substrates and are both inhibited by rapamycin, a
Effects of castration on insulin levels and glucose tolerance in the mouse differ from those in man.
Takamitsu Inoue,Mahvash Zakikhani,Stephanie David,Carolyn Algire,Marie-Jose Blouin,Michael Pollak
Prostate null
Benjamin J Bivona et al.
American journal of physiology. Renal physiology, 300(3), F618-F625 (2010-12-15)
Diabetic nephropathy is a major cause of end-stage renal disease worldwide. The current studies were performed to determine the later stages of the progression of renal disease in type II diabetic mice (BKS; db/db). Methodology was developed for determining glomerular
Disruption of protein kinase A in mice enhances healthy aging.
Linda C Enns, John F Morton, Piper R Treuting, Mary J Emond, Norman S Wolf, G S McKnight et al.
Testing null
Zhong Q Wang et al.
Metabolism: clinical and experimental, 62(9), 1239-1249 (2013-05-25)
Nonalcoholic fatty liver disease (NAFLD) is a common liver disease which has no standard treatment. In this regard, we sought to evaluate the effects of extracts of Artemisia santolinaefolia (SANT) and Artemisia scoparia (SCO) on hepatic lipid deposition and cellular
Prostate cancer cell proliferation and angiogenesis in different obese mice models.
Ribeiro AM, Andrade S, Pinho F, Monteiro JD, Costa M, Lopes C, Aguas AP, Monteiro MP
International Journal of Experimental Pathology null
Peptide hormone isoforms: N-terminally branched PYY3-36 isoforms give improved lipid and fat-cell metabolism in diet-induced obese mice.
S?ren L Pedersen,Pottayil G Sasikumar,Shekar Chelur,Birgitte Holst,Andreas Artmann et al.
Journal of Peptide Science null
Night eating and obesity in the EP3R-deficient mouse.
Manuel Sanchez-Alavez, Izabella Klein, Sara E Brownell, Iustin V Tabarean et al.
Proceedings of the National Academy of Sciences of the USA null
Jun-Hui Choi et al.
Scientific reports, 10(1), 21102-21102 (2020-12-05)
Previous studies have suggested that vinegar intake can help to reduce body fat and hyperglycemia. Therefore, this study aimed to evaluate the anti-obesity efficacy of vinegar fermented using Cudrania tricuspidata fruits (CTFV) and its main phenolic constituents and to analyze
Reema P Vazirani et al.
Diabetes, 65(6), 1577-1589 (2016-05-22)
Insulin controls glucose uptake into adipose and muscle cells by regulating the amount of GLUT4 in the plasma membrane. The effect of insulin is to promote the translocation of intracellular GLUT4 to the plasma membrane. The small Rab GTPase, Rab10
Guo-Sheng Li et al.
Biological & pharmaceutical bulletin, 34(5), 644-654 (2011-05-03)
The diabetic "lipotoxicity" hypothesis presents that fat-induced visceral white adipose tissue insulin resistance plays a central role in the pathogenesis of type 2 diabetes. Berberine, a hypolipidemic agent, has been reported to have antidiabetic activities. The molecular mechanisms for this
Gina Moore et al.
Mechanisms of ageing and development, 129(4), 201-206 (2008-02-26)
Werner syndrome (WS) is an autosomal recessive progeroid syndrome caused by mutations in the Werner (Wrn) gene. WS patients have increased incidence of a number of chronic conditions including insulin resistance and type 2 diabetes. Since ingestion of foods that
Timothy M Griffin et al.
Arthritis and rheumatism, 60(10), 2935-2944 (2009-10-01)
To test the hypothesis that obesity resulting from deletion of the leptin gene or the leptin receptor gene results in increased knee osteoarthritis (OA), systemic inflammation, and altered subchondral bone morphology. Leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) female mice compared
Tamiris Lima Rachid et al.
Molecular and cellular endocrinology, 402, 86-94 (2015-01-13)
Browning is characterized by the formation of beige/brite fat depots in subcutaneous white adipose tissue (sWAT). This study aimed to examine whether the chronic activation of PPARalpha by fenofibrate could induce beige cell depots in the sWAT of diet-induced obese
Lin Xu et al.
The Journal of clinical investigation, 118(1), 272-280 (2007-12-22)
Leptin is a hormone that reduces excitability in some hypothalamic neurons via leptin receptor activation of the JAK2 and PI3K intracellular signaling pathways. We hypothesized that leptin receptor activation in other neuronal subtypes would have anticonvulsant activity and that intranasal
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