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Showing 1-30 of 1071 results for "F2456" within Papers
Noura Al-Jameil et al.
Medicine, 96(42), e8320-e8320 (2017-10-20)
Alpha-1 antitrypsin (AAT) is an acute phase protein produced in hepatocytes. Its deficiency affects the lungs and liver. A case-control study was carried out to determine the prevalence of 2 common deficiency alleles, PI*S and PI*Z, for alpha-1 antitrypsin deficiency
Seyeon Oh et al.
Marine drugs, 18(8) (2020-07-31)
Hyperlipidemia induces vascular smooth muscle cell (VSMC) proliferation and phenotype switching from contractile to synthetic. This process is involved in arterial remodeling via the chemokine ligand 5 (CCL5)/chemokine receptor 5 (CCR5) pathway. Arterial remodeling is related to atherosclerosis or intimal
Sridhar Bammidi et al.
Current neurovascular research, 16(3), 187-193 (2019-07-02)
Retinal degeneration and related eye disorders have limited treatment interventions. Since stem cell therapy has shown promising results, ciliary epithelium (CE) derived stem cells could be a better choice given the fact that cells from eye niche can better integrate
Timothy C Chang et al.
Journal of visualized experiments : JoVE, (71)(71), e4409-e4409 (2013-01-29)
Probe-based confocal laser endomicroscopy (CLE) is an emerging optical imaging technology that enables real-time in vivo microscopy of mucosal surfaces during standard endoscopy. With applications currently in the respiratory and gastrointestinal tracts, CLE has also been explored in the urinary
Minae An et al.
Cardiovascular research, 113(10), 1137-1147 (2017-04-22)
Autophagy is essential to maintain tissue homeostasis, particularly in long-lived cells such as cardiomyocytes. Whereas many studies support the importance of autophagy in the mechanisms underlying obesity-related cardiac dysfunction, the role of autophagy in cardiac lipid metabolism remains unclear. In
Maurice Pasternak et al.
Oncotarget, 8(12), 19631-19644 (2017-01-28)
High-frequency ultrasound (~20 MHz) techniques were investigated using in vitro and ex vivo models to determine whether alterations in chromatin structure are responsible for ultrasound backscatter changes in biological samples. Acute myeloid leukemia (AML) cells and their isolated nuclei were
Brandon Y H Chan et al.
Cardiovascular research, 117(1), 188-200 (2020-01-30)
Heart failure is a major complication in cancer treatment due to the cardiotoxic effects of anticancer drugs, especially from the anthracyclines such as doxorubicin (DXR). DXR enhances oxidative stress and stimulates matrix metalloproteinase-2 (MMP-2) in cardiomyocytes. We investigated whether MMP
B A Henry et al.
Journal of animal science, 93(5), 2083-2093 (2015-05-29)
Body weight and adiposity are determined by the balance between energy intake, energy expenditure, and nutrient deposition. We have identified differences in appetite-regulating peptides in sheep selectively bred to be either lean or fat, wherein gene expression for orexin and
Gang Liu et al.
The Journal of thoracic and cardiovascular surgery, 160(2), e55-e66 (2020-07-22)
This study aims to evaluate the protective effects of progesterone on white matter injury and brain immaturity in neonatal rats with chronic hypoxia. Three-day old Sprague-Dawley rats were randomly divided into 3 groups: (1) control (n = 48), rats were exposed to
Annina Balsiger et al.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 49(4), 893-901 (2018-12-29)
Over a 2-yr period, four Goeldi's monkeys ( Callimico goeldii) died in a private zoo due to infections with the spirurid nematode Pterygodermatites nycticebi. Therapeutic measures with different anthelmintics were not successful. Due to the severe consequences caused by these
Chih-Wei Chiang et al.
International journal of molecular sciences, 16(10), 23318-23336 (2015-10-02)
Regenerative medicine is increasingly important in clinical practice. Ligamentum flava (LF) are typically removed during spine-related surgeries. LF may be a source of cells for spinal fusion that is conducted using tissue engineering techniques. In this investigation, LF cells of
F Chen et al.
Osteoarthritis and cartilage, 28(8), 1121-1132 (2020-05-30)
This study investigated whether melatonin alleviates intervertebral disc degeneration (IVDD) by promoting autophagy through inhibiting the NF-κB signaling pathway. Magnetic resonance imaging (MRI), hematoxylin and eosin (H&E) staining and Safranin-O staining were used to measure disc degeneration in rat needle
Bisera Stepanovska et al.
International journal of molecular sciences, 21(4) (2020-02-20)
Sphingosine 1-phosphate (S1P) is a key bioactive lipid that regulates a myriad of physiological and pathophysiological processes, including endothelial barrier function, vascular tone, vascular inflammation, and angiogenesis. Various S1P receptor subtypes have been suggested to be involved in the regulation
Y Harada et al.
Bone & joint research, 3(12), 328-334 (2014-12-06)
To investigate the appropriate dose and interval for the administration of triamcinolone acetonide (TA) in treating tendinopathy to avoid adverse effects such as tendon degeneration and rupture. Human rotator cuff-derived cells were cultured using three media: regular medium (control), regular
Yukishige Kimura et al.
Journal of diabetes investigation, 10(4), 933-946 (2019-01-22)
Type 2 diabetes mellitus is a risk factor of acute kidney injury after myocardial infarction (MI), a form of cardiorenal syndrome. Recent clinical trials have shown that a sodium-glucose cotransporter 2 (SGLT2) inhibitor improved both cardiac and renal outcomes in patients with
Carolin Dippmann et al.
Clinical epigenetics, 12(1), 171-171 (2020-11-13)
High-risk human papillomavirus (hrHPV)-based screening is becoming increasingly important, either by supplementing or replacing the traditional cytology-based cervical Pap smear. However, hrHPV screening lacks specificity, because it cannot differentiate between transient virus infection and clinically relevant hrHPV-induced disease. Therefore, reliable
Chih-Chieh Hsu et al.
Thrombosis and haemostasis, 119(5), 786-796 (2019-02-08)
The mechanisms or host factors involved in septic thrombus or vegetation formation in Staphylococcus aureus-induced infective endocarditis (IE) are unclear. Using an experimental endocarditis rat model, here we demonstrated that S. aureus HG001-induced vegetation was composed of bacterial floes encased
Delivery of adipose-derived stem cells in poloxamer hydrogel improves peripheral nerve regeneration.
Kassandra O Allbright et al.
Muscle & nerve, 58(2), 251-260 (2018-02-07)
Peripheral nerve damage is associated with high long-term morbidity. Because of beneficial secretome, immunomodulatory effects, and ease of clinical translation, transplantation with adipose-derived stem cells (ASC) represents a promising therapeutic modality. Effect of ASC delivery in poloxamer hydrogel was assessed
Martín García-Flores et al.
Journal of agricultural and food chemistry, 63(3), 1042-1052 (2015-01-15)
In comparison to the exponential increase of genotyping methods, phenotyping strategies are lagging behind in agricultural sciences. Genetic improvement depends upon the abundance of quantitative phenotypic data and the statistical partitioning of variance into environmental, genetic, and random effects. A
Katarzyna Brach et al.
Langmuir : the ACS journal of surfaces and colloids, 33(36), 8993-8999 (2017-08-13)
We report on two-photon excitation properties of small silver-doped gold nanoclusters (AuAgNCs) and on their three-dimensional arrangement in a hybrid system composed of DNA liquid crystals (LCs) and AuAgNCs. UV-vis and fluorescence spectroscopy, transmission electron microscopy (TEM), and multiphoton excitation
Sangeetha Kumaravel et al.
Inorganic chemistry, 59(19), 14501-14512 (2020-09-15)
An advanced approach with DNA-mediated bismuth tungstate (Bi2WO6) one-dimensional (1-D) nanochain assemblies for hydrogen production with 5-fold enhanced photoelectrochemical (PEC) water splitting reaction is presented. The creation of new surface states upon DNA modification mediates the electron transfer in a
Beatrice Beck-Schimmer et al.
Anesthesia and analgesia, 127(4), 1058-1065 (2018-09-15)
Randomized controlled trials (RCTs) data demonstrate that sevoflurane postconditioning improves clinical outcomes of liver resection with inflow occlusion, presumably due to hepatocyte protection from ischemic injury. However, mechanisms remain unclear. This study examines liver biopsy samples obtained in an RCT
Patricia Altea-Manzano et al.
EMBO reports, 21(10), e50635-e50635 (2020-09-24)
Nutrients are indispensable resources that provide the macromolecular building blocks and energy requirements for sustaining cell growth and survival. Cancer cells require several key nutrients to fulfill their changing metabolic needs as they progress through stages of development. Moreover, both
Mahmoud A Ali et al.
BMC veterinary research, 16(1), 458-458 (2020-11-25)
Dehydration has deleterious effects in many species, but camels tolerate long periods of water deprivation without serious health compromise. The kidney plays crucial role in water conservation, however, some reports point to elevated kidney function tests in dehydrated camels. In
Ning Ning et al.
Journal of Cancer, 11(7), 1679-1692 (2020-03-21)
Melanoma is the most aggressive and treatment-resistant form of skin cancer. Curcumol is a Chinese medicinal herb traditionally used as a cancer remedy. However, the molecular mechanisms underlying the anticancer activity of curcumol in melanoma remains largely unknown. In the
Kimberley M Heinhuis et al.
Cancers, 12(6) (2020-05-31)
Sarcoma is a heterogeneous group of rare malignancies arising from mesenchymal tissues. Recurrence rates are high and methods for early detection by blood-based biomarkers do not exist. Hence, development of blood-based liquid biopsies as disease recurrence monitoring biomarkers would be
Yu Han et al.
Nucleic acids research, 42(13), e103-e103 (2014-05-13)
Imaging of protein-protein and RNA-protein interactions in vivo, especially in live animals, is still challenging. Here we developed far-red mNeptune-based bimolecular fluorescence complementation (BiFC) and trimolecular fluorescence complementation (TriFC) systems with excitation and emission above 600 nm in the 'tissue
Yichen Ge et al.
ACS applied materials & interfaces, 11(31), 27588-27597 (2019-07-13)
Recently, many researchers have reported that DNA nanostructures, such as tetrahedral framework nucleic acids (tFNAs), have great potential to be useful tools in clinical and laboratory applications due to their programmable shapes, functional sites, and biological responses. However, finite endocytosis
V Ramesh et al.
The Journal of infectious diseases, 221(4), 608-617 (2019-12-20)
No satisfactory canonical treatment is available for post-kala-azar dermal leishmaniasis (PKDL), clinical sequela of visceral leishmaniasis. Confined treatment options and substantial increase in relapse rate after miltefosine (MIL) treatment warrant the need to adapt resilient combination therapies. In this study
Isaac A Klein et al.
Science (New York, N.Y.), 368(6497), 1386-1392 (2020-06-20)
The nucleus contains diverse phase-separated condensates that compartmentalize and concentrate biomolecules with distinct physicochemical properties. Here, we investigated whether condensates concentrate small-molecule cancer therapeutics such that their pharmacodynamic properties are altered. We found that antineoplastic drugs become concentrated in specific
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