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Showing 1-30 of 237 results for "F3879" within Papers
Sri Ram Krishna Vedula et al.
Nature materials, 13(1), 87-96 (2013-12-03)
The ability of skin to act as a barrier is primarily determined by the efficiency of skin cells to maintain and restore its continuity and integrity. In fact, during wound healing keratinocytes migrate collectively to maintain their cohesion despite heterogeneities
E Renard et al.
European cells & materials, 40, 74-87 (2020-08-21)
Current pulpotomy is limited in its ability to induce regeneration of the dental-pulp (DP) complex. Hydrogels are reported to be well-suited for tissue engineering and are unlikely to induce an inflammatory response that might damage the remaining tissue. The present
Ramzi A Ajjan et al.
Blood, 122(1), 134-142 (2013-05-24)
Diabetes is associated with hypofibrinolysis by mechanisms that are only partially understood. We investigated the effects of in vivo plasminogen glycation on fibrinolysis, plasmin generation, protein proteolytic activity, and plasminogen-fibrin interactions. Plasma was collected from healthy controls and individuals with
Investigating and Resolving Cardiotoxicity Induced by COVID-19 Treatments using Human Pluripotent Stem Cell-Derived Cardiomyocytes and Engineered Heart Tissues.
Xu, et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 9, e2203388-e2203388 (2022)
Maria Koivisto et al.
Scientific reports, 12(1), 13459-13459 (2022-08-06)
Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC) are widely used in in vitro biomedical research and testing. However, fully matured, adult cardiomyocyte characteristics have not been achieved. To improve the maturity and physiological relevance of hiPSC-derived cardiomyocytes, we
Yu Liu et al.
Scientific reports, 5, 17215-17215 (2015-11-26)
Staphylococcus aureus causes a wide range of infectious diseases. Treatment of these infections has become increasingly difficult due to the widespread emergence of antibiotic-resistant strains; therefore, it is essential to explore effective alternatives to antibiotics. A secreted protein of S.
Peter Urbanellis et al.
Immunology, 144(1), 91-106 (2014-07-06)
Therapies that promote tolerance in solid organ transplantation will improve patient outcomes by eliminating the need for long-term immunosuppression. To investigate mechanisms of rapamycin-induced tolerance, C3H/HeJ mice were heterotopically transplanted with MHC-mismatched hearts from BALB/cJ mice and were monitored for
V L Vida et al.
The Journal of cardiovascular surgery, 55(3), 401-406 (2014-04-24)
The aim of this study was to evaluate the efficacy and cost-effectiveness of fibrinogen/thrombin-coated collagen patch (FTCCP)(TachoSil®) during intraoperative hemostasis in patients with congenital heart disease, who required a reoperation during childhood. We reviewed data on the intraoperative blood product
Quiz page: a familial glomerulopathy.
Alexandre Cez et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 63(4), A17-A20 (2014-03-29)
Maxime Ducret et al.
Dental materials : official publication of the Academy of Dental Materials, 35(4), 523-533 (2019-02-05)
Regenerating a functional dental pulp in the pulpectomized root canal has been recently proposed as a novel therapeutic strategy in dentistry. To reach this goal, designing an appropriate scaffold able to prevent the growth of residual endodontic bacteria, while supporting
Yanhua Wang et al.
Molecular pharmacology, 92(3), 285-296 (2017-07-01)
Smad4, a key transcription factor in the transforming growth factor-
Hua Shen et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 40(12), 2754-2762 (2022-02-26)
Intrasynovial flexor tendon lacerations of the hand are clinically problematic, typically requiring operative repair and extensive rehabilitation. The small-molecule connective tissue growth factor (CTGF) mimics, oxotremorine M (Oxo-M) and 4-PPBP maleate (4-PPBP), have been shown to improve tendon healing in
Bernd Uhl et al.
Arteriosclerosis, thrombosis, and vascular biology, 34(7), 1495-1504 (2014-04-26)
Neutrophil infiltration of the postischemic tissue considerably contributes to organ dysfunction on ischemia/reperfusion injury. Beyond its established role in fibrinolysis, tissue-type plasminogen activator (tPA) has recently been implicated in nonfibrinolytic processes. The role of this serine protease in the recruitment
In reply.
Cristina Solomon et al.
Transfusion, 53(5), 1138-1140 (2013-05-11)
Nino Muradashvili et al.
American journal of physiology. Cell physiology, 307(2), C169-C179 (2014-05-16)
Inflammation-induced vascular endothelial dysfunction can allow plasma proteins to cross the vascular wall, causing edema. Proteins may traverse the vascular wall through two main pathways, the paracellular and transcellular transport pathways. Paracellular transport involves changes in endothelial cell junction proteins
Vance G Nielsen et al.
Anesthesia and analgesia, 118(5), 919-924 (2014-01-15)
Patients with brain tumors suffer significant thrombotic morbidity and mortality. In addition to increased thrombin generation via tumor release of tissue factor-bearing microparticles and hyperfibrinogenemia, brain tumors and surrounding normal brain likely generate endogenous carbon monoxide (CO) via the hemeoxygenase-1
Federico Traldi et al.
International journal of molecular sciences, 24(3) (2023-02-12)
Biomedical applications of nanoparticles require a fundamental understanding of their interactions and behavior with biological interfaces. Protein corona formation can alter the morphology and properties of nanomaterials, and knowledge of the interfacial behavior of the complexes, using in situ analytical
John B Holcomb et al.
The journal of trauma and acute care surgery, 75(1 Suppl 1), S31-S39 (2013-08-15)
There are few clinical data to guide the use of cryoprecipitate in severely injured trauma patients. Cryoprecipitate is a rich source of fibrinogen and has been associated with improved survival in animal as well as limited human studies. Our objectives
Ryota Nomura et al.
Infection and immunity, 82(12), 5223-5234 (2014-10-08)
Streptococcus mutans, a pathogen responsible for dental caries, is occasionally isolated from the blood of patients with bacteremia and infective endocarditis (IE). Our previous study demonstrated that serotype k-specific bacterial DNA is frequently detected in S. mutans-positive heart valve specimens
Ana R Almeida et al.
Journal of biomedical materials research. Part A, 108(4), 851-862 (2019-12-18)
Fibrinogen (Fg) is a pro-inflammatory protein with pro-healing properties. Previous work showed that fibrinogen 3D scaffolds (Fg-3D) promote bone regeneration, but the cellular players were not identified. Osteoclasts are bone resorbing cells that promote bone remodeling in close crosstalk with
Sara Zeugmann et al.
Psychiatria Danubina, 25(3), 227-235 (2013-09-21)
An increasing body of research considers the immunological effects of major depression. It remains an open question, whether depression itself acts in an immunomodulatory fashion or whether other factors related to depression result in these immunological effects. Regardless, major depression
Matthew J Healey et al.
The Analyst, 145(7), 2595-2601 (2020-02-18)
Prion diseases are a group of fatal transmissible neurological conditions caused by the change in conformation of intrinsic cellular prion protein (PrPC). We present a rapid assay using aptamers and resistive pulse sensing, RPS, to extract and quantify PrPC from
Irina Afonina et al.
mBio, 11(5) (2020-10-22)
Enterococcus faecalis is an opportunistic pathogen, which can cause multidrug-resistant life-threatening infections. Gaining a complete understanding of enterococcal pathogenesis is a crucial step in identifying a strategy to effectively treat enterococcal infections. However, bacterial pathogenesis is a complex process often
Marc Delpech et al.
Bulletin de l'Academie nationale de medecine, 196(7), 1309-1318 (2013-07-03)
Familial amyloid polyneuropathies (FAP) are among the most frequent hereditary amyloidoses. These are serious, most often fatal diseases with autosomal dominant inheritance. FAP can be caused by mutations in four genes, namely those encoding transthyretin, Al-apoliprotein, gelsolin, and beta-2 microglobulin.
Loes E M Kistemaker et al.
American journal of physiology. Lung cellular and molecular physiology, 308(1), L96-103 (2014-11-09)
Anticholinergics, blocking the muscarinic M3 receptor, are effective bronchodilators for patients with chronic obstructive pulmonary disease. Recent evidence from M(3) receptor-deficient mice (M(3)R(-/-)) indicates that M3 receptors also regulate neutrophilic inflammation in response to cigarette smoke (CS). M(3) receptors are
Jonathan J Morrison et al.
JAMA surgery, 148(3), 218-225 (2013-05-15)
To quantify the impact of fibrinogen-containing cryoprecipitate in addition to the antifibrinolytic tranexamic acid on survival in combat injured. Retrospective observational study comparing the mortality of 4 groups: tranexamic acid only, cryoprecipitate only, tranexamic acid and cryoprecipitate, and neither tranexamic
Lihong Huang et al.
Biochemistry, 53(49), 7824-7834 (2014-11-25)
We have developed new procedures to examine the early steps in fibrin polymerization. First, we isolated fibrinogen monomers from plasma fibrinogen by gel filtration. Polymerization of fibrinogen monomers differed from that of plasma fibrinogen. The formation of protofibrils was slower
H Kara et al.
Acta clinica Belgica, 69(4), 240-245 (2014-07-12)
The D-dimer level, fibrinogen level, and D-dimer/fibrinogen ratio are used in the diagnosis of pulmonary embolism, but results vary. We evaluated these parameters in the diagnosis of pulmonary embolism in emergency clinic patients. In this prospective study, 200 patients (pulmonary
Shanmugavel Chinnathambi et al.
Nanomaterials (Basel, Switzerland), 10(11) (2020-11-19)
A better understanding of the compatibility of water-soluble semiconductor quantum dots (QDs) upon contact with the bloodstream is important for biological applications, including biomarkers working in the first therapeutic spectral window for deep tissue imaging. Herein, we investigated the conformational
C C Clawson et al.
The American journal of pathology, 98(1), 197-211 (1980-01-01)
Platelets from a patient with congenital afibrinogenemia (CA) were tested in their native plasma for reactivity in vitro to Staphylococcus aureus 502A. Previous studies of the interactions between normal human platelets and this organism have shown rapid irreversible aggregation responses
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