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Showing 1-30 of 237 results for "F3879" within Papers
Justin C Luo et al.
Scientific reports, 10(1), 13144-13144 (2020-08-06)
We introduce laser cavitation rheology (LCR) as a minimally-invasive optical method to characterize mechanical properties within the interior of biological and synthetic aqueous soft materials at high strain-rates. We utilized time-resolved photography to measure cavitation bubble dynamics generated by the
Dao Lin et al.
iScience, 24(9), 102977-102977 (2021-09-07)
The effective utility of physiologically active molecules is crucial in numerous biological processes. However, the regulation of enzyme functions through active substances remains challenging at present. Here, glutathione (GSH), produced in cells, was used to modulate the catalytic activity of
Aleksandra Golenia et al.
Neurologia i neurochirurgia polska, 47(2), 152-156 (2013-05-08)
Ischaemic stroke is considered to be multifactorial and interactions between environmental and genetic factors play an important role. Although vascular risk factors are well known, the genetic ones are still undiscovered. In the present study, we assessed the significance of
Zhimin Song et al.
Biochemical pharmacology, 178, 114088-114088 (2020-06-13)
Phagocytes, especially neutrophils, can produce reactive oxygen species (ROS), through the activation of the NADPH oxidase (NOX2). Although this enzyme is crucial for host-pathogen defense, ROS production by neutrophils can be harmful in several pathologies such as cardiovascular diseases or
Kazuma Takahashi et al.
Acta veterinaria Scandinavica, 55, 70-70 (2013-09-24)
Horse fibrinogen has been identified as a plasma specific ferritin-binding protein. There are two ways in the binding of ferritin-binding protein with ferritin: one is direct binding and the other is indirect binding which is heme-mediated. The aim of this
Jerro Saidykhan et al.
Analytical chemistry, 93(41), 14007-14013 (2021-10-08)
Fibrinogen concentration is a major determinant of both clotting and bleeding risk. Clotting and bleeding disorders cause extensive morbidity and mortality, particularly in resource-poor and emergency settings. This is exacerbated by a lack of timely intervention informed by measurement of
Julien Carvelli et al.
Nature, 588(7836), 146-150 (2020-07-30)
Coronavirus disease 2019 (COVID-19) is a disease caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has resulted in a pandemic1. The C5a complement factor and its receptor C5aR1 (also known as CD88) have a key role
Comparison of mesenchymal stem cells from bone marrow, umbilical cord blood, and umbilical cord tissue in regeneration of a full-thickness tendon defect in vitro and in vivo.
Yea, et al.
Biochemistry and Biophysics Reports, 34, 101486-101486 (2023)
Alessia Pisanu et al.
iScience, 25(5), 104297-104297 (2022-05-20)
Functional three-dimensional (3D) engineered cardiac tissue (ECT) models are essential for effective drug screening and biological studies. Application of physiological cues mimicking those typical of the native myocardium is known to promote the cardiac maturation and functionality in vitro. Commercially available
Ke Zhang et al.
Biomicrofluidics, 16(4), 044101-044101 (2022-07-19)
The vascular structure of the tumor microenvironment (TME) plays an essential role in the process of metastasis. In vitro microvascular structures that can be maintained for a long time will greatly promote metastasis research. In this study, we constructed a
Pauline Brevet et al.
Frontiers in immunology, 12, 733511-733511 (2021-10-26)
To identify the targets recognized by anti-carbamylated protein antibodies (anti-CarP) in patients with early Rheumatoid Arthritis (RA), to study the cross-reactivity between anti-CarP and anti-citrullinated protein antibodies (ACPA) and to evaluate their prognostic value. 331 patients (184 RA and 147
Joseph Philip et al.
Laboratory medicine, 45(2), 111-115 (2014-05-30)
To compare the coagulation-factor profile of cryoprecipitate produced from fresh frozen plasma from whole blood (WB) stored for 24 hours at room temperature (24CP) with that of standard cryoprecipitate (CP). We collected 80 units of WB from healthy volunteers, of
Jordan Debono et al.
Toxicology letters, 316, 35-48 (2019-09-12)
Snake envenomation globally is attributed to an ever-increasing human population encroaching into snake territories. Responsible for many bites in Asia is the widespread genus Trimeresurus. While bites lead to haemorrhage, only a few species have had their venoms examined in
Brian L Mejak et al.
The journal of extra-corporeal technology, 45(2), 107-111 (2013-08-13)
The timing of blood product administration after cardiopulmonary bypass (CPB) may influence the amount of postoperative transfusion and chest tube output. We performed a retrospective study of a novel technique of administering blood products during modified ultrafiltration (MUF) in congenital
Kacey Ronaldson-Bouchard et al.
Nature biomedical engineering, 6(4), 351-371 (2022-04-29)
Engineered tissues can be used to model human pathophysiology and test the efficacy and safety of drugs. Yet, to model whole-body physiology and systemic diseases, engineered tissues with preserved phenotypes need to physiologically communicate. Here we report the development and
Fatemeh Navaee et al.
International journal of molecular sciences, 24(3) (2023-02-12)
Biochemical and biophysical properties instruct cardiac tissue morphogenesis. Here, we are reporting on a blend of cardiac decellularized extracellular matrix (dECM) from porcine ventricular tissue and fibrinogen that is suitable for investigations employing an in vitro 3D cardiac cell culture
Meriem Ameziani et al.
The protein journal, 39(5), 574-590 (2020-09-23)
The current report focuses on purification, structural and functional characterization of Cerastategrin from Cerastes cerastes venom, a novel basic disintegrin (pI 8.36) with 128 amino acid residues and a molecular weight of 13 835.25 Da measured by MALDI-MSMS. The 3D structure
Yutian Zhang et al.
Journal of molecular cell biology, 14(3) (2022-03-22)
The nuclear envelope comprises the outer nuclear membrane, inner nuclear membrane (INM), and nucleopore. Although ∼60 INM proteins have been identified, only a few of them have been well characterized, revealing their crucial roles. Our group focused on the INM
Sukhbir Singh Badhal et al.
Tropical gastroenterology : official journal of the Digestive Diseases Foundation, 33(3), 193-199 (2013-04-23)
This study was conducted to assess the predictive value of coagulation abnormalities in determining disease severity and prognosis of acute pancreatitis (AP). Patients of AP and 25 healthy volunteers were included in this prospective observational study. The final outcomes were
Andrew C Hickey et al.
The American journal of tropical medicine and hygiene, 89(6), 1043-1057 (2013-09-26)
Dengue virus (DENV) is considered to be the most important arthropod-borne viral disease and causes more than 100 million human infections annually. To further characterize primary DENV infection in vivo, rhesus macaques were infected with DENV-1, DENV-2, DENV-3, or DENV-4
Tian Tian et al.
Nucleic acids research, 45(5), 2283-2293 (2017-01-25)
Supramolecular chemistry addresses intermolecular forces and consequently promises great flexibility and precision. Biological systems are often the inspirations for supramolecular research. The G-quadruplex (G4) belongs to one of the most important secondary structures in nucleic acids. Until recently, the supramolecular
Ana R Almeida et al.
Journal of biomedical materials research. Part A, 108(4), 851-862 (2019-12-18)
Fibrinogen (Fg) is a pro-inflammatory protein with pro-healing properties. Previous work showed that fibrinogen 3D scaffolds (Fg-3D) promote bone regeneration, but the cellular players were not identified. Osteoclasts are bone resorbing cells that promote bone remodeling in close crosstalk with
Ryota Nomura et al.
Infection and immunity, 82(12), 5223-5234 (2014-10-08)
Streptococcus mutans, a pathogen responsible for dental caries, is occasionally isolated from the blood of patients with bacteremia and infective endocarditis (IE). Our previous study demonstrated that serotype k-specific bacterial DNA is frequently detected in S. mutans-positive heart valve specimens
John B Holcomb et al.
The journal of trauma and acute care surgery, 75(1 Suppl 1), S31-S39 (2013-08-15)
There are few clinical data to guide the use of cryoprecipitate in severely injured trauma patients. Cryoprecipitate is a rich source of fibrinogen and has been associated with improved survival in animal as well as limited human studies. Our objectives
Jay V Karri et al.
The Journal of surgical research, 190(2), 655-661 (2014-03-08)
Fibrinogen is the first coagulation factor to reach critical levels during hemorrhage. Consequently, reestablishing normal fibrinogen levels is necessary to achieve adequate hemostasis. Fibrinogen is supplemented through administration of fresh frozen plasma, cryoprecipitate, or human fibrinogen concentrate, RiaSTAP. RiaSTAP is
Minghua Jiang et al.
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, 31(2), 134-139 (2014-04-09)
To analyze clinical manifestation and genetic mutations in 8 Chinese pedigrees featuring hereditary dysfibrinogenemia. Prothrombin time(PT), activated partial thromboplastin time(APTT), thrombin time(TT), calibration of plasma protamine sulfate against TT, fibrinogen (Fg) activity, coagulation factors II, V, VII, VIII, IX, X
Jordan Debono et al.
Toxicology in vitro : an international journal published in association with BIBRA, 58, 195-206 (2019-04-02)
Envenomations by Asian pitvipers can induce multiple clinical complications resulting from coagulopathic and neuropathic effects. While intense research has been undertaken for some species, functional coagulopathic effects have been neglected. As these species' venoms affect the blood coagulation cascade we
Tilde Andersson et al.
Frontiers in cellular and infection microbiology, 10, 571578-571578 (2020-12-18)
Stapylococcus aureus is a common infectious agent in e.g. sepsis, associated with both high mortality rates and severe long-term effects. The cytolytic protein α-hemolysin has repeatedly been shown to enhance the virulence of S. aureus. Combined with an unhindered spread
C C Clawson et al.
The American journal of pathology, 98(1), 197-211 (1980-01-01)
Platelets from a patient with congenital afibrinogenemia (CA) were tested in their native plasma for reactivity in vitro to Staphylococcus aureus 502A. Previous studies of the interactions between normal human platelets and this organism have shown rapid irreversible aggregation responses
Karin I Pappelbaum et al.
Circulation, 128(1), 50-59 (2013-05-31)
During pathogenesis of infective endocarditis, Staphylococcus aureus adherence often occurs without identifiable preexisting heart disease. However, molecular mechanisms mediating initial bacterial adhesion to morphologically intact endocardium are largely unknown. Perfusion of activated human endothelial cells with fluorescent bacteria under high-shear-rate
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