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Showing 1-30 of 2411 results for "F4274" within Papers
Francisco Alberto García-Vázquez et al.
Theriogenology, 84(4), 566-574 (2015-05-23)
Once deposited in the female reproductive system, sperm begin their competition and undergo a selection to reach the site of fertilization. Little is known about the special characteristics of sperm that reach the oviduct and are able to fertilize, with
Xudong Yu et al.
Materials science & engineering. C, Materials for biological applications, 39, 73-77 (2014-05-28)
In the present work, a new kind of fluorescein-based chemosensor L was designed and synthesized to selectively recognize Ca(2+) or Mg(2+) over other competing ions. The chemosensor showed "off-on" fluorescent and color changes upon the addition of Ca(2+) and Mg(2+).
Wen-Wu Li et al.
Pain, 155(11), 2377-2389 (2014-09-15)
Complex regional pain syndrome (CRPS) is a painful, disabling, chronic condition whose etiology remains poorly understood. The recent suggestion that immunological mechanisms may underlie CRPS provides an entirely novel framework in which to study the condition and consider new approaches
Sheri L Pollock et al.
Leukemia & lymphoma, 55(6), 1383-1387 (2013-08-10)
The t(5;17) variant of acute promyelocytic leukemia (APL) fuses the nucleophosmin (NPM) gene at 5q35 with the retinoic acid receptor alpha (RARA) at 17q12-22. We have previously shown that leukemic cells express both NPM-RAR and RAR- NPM reciprocal translocation products.
Arinder Kohli et al.
PloS one, 9(5), e98077-e98077 (2014-05-27)
The majority of HIV-1 infections worldwide are acquired via mucosal surfaces. However, unlike the vaginal mucosa, the issue of whether the oral mucosa can act as a portal of entry for HIV-1 infection remains controversial. To address potential differences with
Maja Antunovic et al.
Anti-cancer drugs, 26(2), 180-186 (2014-10-04)
Effective treatment methods for human leukemia are under development, but so far none of them have been found to be completely satisfactory. It was recently reported that palladium complexes have significant anticancer activity as well as lower toxicity compared with
Keiko Kaneko et al.
FEBS letters, 589(4), 447-454 (2015-01-17)
Hyaluronan (HA), one of the major structural extracellular components in cartilage, regulates cellular responses via receptors such as CD44. However, the direct effects of HA on osteoblastic differentiation has not been studied in detail. Here, we investigated the effects of
Yosuke Maeda et al.
Journal of virology, 89(1), 502-511 (2014-10-24)
Interaction of the envelope glycoprotein (Env) of human T-lymphotropic virus 1 (HTLV-1) with the glucose transporter type 1 (GLUT1) expressed in target cells is essential for viral entry. This study found that the expression level of GLUT1 in virus-producing 293T
Raushan K Singh et al.
The Journal of biological chemistry, 290(10), 6607-6619 (2015-01-22)
We reported previously that an N-acylthiourea derivative (TM-2-51) serves as a potent and isozyme-selective activator for human histone deacetylase 8 (HDAC8). To probe the molecular mechanism of the enzyme activation, we performed a detailed account of the steady-state kinetics, thermodynamics
Shao-can Tang et al.
Journal of the neurological sciences, 348(1-2), 174-180 (2014-12-17)
Progressive multiple sclerosis (MS) is an immune-mediated demyelinating disease in which both imbalanced T helper (Th) subsets and aberrant cytokine profiles have been found. Interleukin-27 (IL-27), a cytokine with pro-inflammatory and anti-inflammatory effects, plays pleiotropic roles in immunomodulation. In the
Thomas M Bodenstine et al.
Molecular cancer research : MCR, 12(10), 1480-1491 (2014-09-27)
Patients with metastatic disease face high rates of mortality with a paucity of therapeutic options. Protein-based therapeutics provide advantages over traditional chemotherapy through increased specificity, decreased immune impairment, and more direct means of delivery. However, development is often hindered because
Ke Yuan et al.
The American journal of pathology, 185(1), 69-84 (2014-12-03)
Pericytes are perivascular cells localized to capillaries that promote vessel maturation, and their absence can contribute to vessel loss. Whether impaired endothelial-pericyte interaction contributes to small vessel loss in pulmonary arterial hypertension (PAH) is unclear. Using 3G5-specific, immunoglobulin G-coated magnetic
Tae Ho Kim et al.
Journal of biomaterials science. Polymer edition, 26(5), 322-337 (2015-01-20)
Growth factors (GFs) (basic fibroblast growth factor (bFGF) and/or nerve growth factor (NGF))-immobilized polycaprolactone (PCL)/Pluronic F127 microspheres were prepared using an isolated particulate-melting method and the sequential binding of heparin and GFs onto the microspheres. The GFs immobilized on the
Yanli Zhang et al.
Molecular medicine reports, 11(2), 1366-1371 (2014-11-06)
Stimulation of Toll‑like receptor 9 (TLR9) has been associated with invasion in various types of cancer cell in vitro. The present study aimed to evaluate the expression of TLR9 in MGC803 gastric cancer cells and investigate the effect of a
Till Scheuer et al.
Glia, 63(10), 1825-1839 (2015-05-13)
According to recent research, brain injury after premature birth often includes impaired growth of the cerebellum. However, causes of cerebellar injury in this population are poorly understood. In this study, we analyzed whether postnatal hyperoxia perturbs white matter development of
Shatha G Felemban et al.
Chemical research in toxicology, 28(11), 2179-2191 (2015-10-16)
At present, little is known about the effect(s) of organophosphorous compounds (OPs) on cardiomyocytes. In this study, we have investigated the effects of phenyl saligenin phosphate (PSP), two organophosphorothioate insecticides (diazinon and chlorpyrifos), and their acutely toxic metabolites (diazoxon and
Sunyi Ye et al.
Molecular medicine reports, 9(5), 1998-2002 (2014-03-15)
Ischemia reperfusion injury (IRI) occurs in almost every liver surgery and is associated with the reduction of the liver blood flow. Ischemia impairs liver function and can even cause liver failure following surgery. The present study aimed to identify a
Jing Zhu et al.
Molecular medicine reports, 11(5), 3800-3807 (2015-01-22)
The present study aimed to investigate the effects of topical application of sphingosine 1‑phosphate receptor 1 (S1P1) on allogeneic corneal transplantation in mice. A total of 45 BALB/c mice received corneal grafts from C57BL/6 donors. The recipients were randomly divided
Diahann T S L Jansen et al.
Arthritis research & therapy, 17, 220-220 (2015-08-21)
Abatacept is a fusion protein of human cytotoxic T-lymphocyte-associated protein (CTLA)-4 and the Fc portion of human immunoglobulin G1 (IgG1). It is believed to be effective in the treatment of rheumatoid arthritis by inhibiting costimulation of T cells via blocking
István Molnár et al.
Annals of botany, 116(2), 189-200 (2015-06-06)
Aegilops markgrafii (CC) and its natural hybrids Ae. triuncialis (U(t)U(t)C(t)C(t)) and Ae. cylindrica (D(c)D(c)C(c)C(c)) represent a rich reservoir of useful genes for improvement of bread wheat (Triticum aestivum), but the limited information available on their genome structure and the shortage
Ayuko Sato et al.
Journal of virology, 88(23), 13699-13708 (2014-09-19)
Protective immunity against genital pathogens causing chronic infections, such as herpes simplex virus 2 (HSV-2) or human immunodeficiency virus, requires the induction of cell-mediated immune responses locally in the genital tract. Intranasal immunization with a thymidine kinase-deficient (TK(-)) mutant of
Jun-Li Liu et al.
Molecular medicine reports, 12(3), 3979-3985 (2015-05-29)
Determining the molecular phenotype is a key to understanding and predicting the metastatic potential and the prognosis for patients with lung cancer. Our previous study demonstrated that increased expression of cyclin‑dependent kinase 5 (CDK5) in patients with non‑small cell lung
Wei Li et al.
Biochemical and biophysical research communications, 467(4), 1076-1082 (2015-10-04)
The objective of this study was to investigate the effects of urotensin II (UII) treatment on the proliferation and collagen synthesis of cultured rat pulmonary arterial smooth muscle cells (PASMCs) and to explore whether these effects are mediated by mitogen-activated
Shinya Toyokuni et al.
Pathology international, 65(8), 415-419 (2015-06-18)
Sunlight exposure and aging are two major factors in the deterioration of skin function. In the present study, we used eighty formalin-fixed human skin samples from sun-exposed and unexposed areas from old and young individuals to evaluate the presence of
M W Laschke et al.
European cells & materials, 29, 190-200 (2015-03-22)
Adipose tissue-derived microvascular fragments represent promising vascularisation units for implanted tissue constructs. However, their reassembly into functional microvascular networks takes several days, during which the cells inside the implants are exposed to hypoxia. In the present study, we analysed whether
Seon-Hee Kim et al.
Parasitology, 142(9), 1228-1238 (2015-06-04)
Despite recent reports regarding the biology of cytosine methylation in Schistosoma mansoni, the impact of the regulatory machinery remains unclear in diverse platyhelminthes. This ambiguity is reinforced by discoveries of DNA methyltransferase 2 (DNMT2)-only organisms and the substrate specificity of
Hyo Jung Choi et al.
PloS one, 10(6), e0129761-e0129761 (2015-06-20)
The first identification of swine-originated influenza A/CA/04/2009 (pH1N1) as the cause of an outbreak of human influenza accelerated efforts to develop vaccines to prevent and control influenza viruses. The current norm in many countries is to prepare influenza vaccines using
Themistoklis Spyridopoulos et al.
Journal of reconstructive microsurgery, 31(7), 516-526 (2015-07-01)
Dental pulp stem cells (DPSCs) present an exciting new tool in the field of peripheral nerve regeneration due to their close embryonic origin. In this study, we examined their potential in pigs, using biodegradable collagen conduits filled with DPSCs. To
Ying Dai et al.
PloS one, 9(10), e109856-e109856 (2014-10-22)
Cell fate and function can be regulated and reprogrammed by intrinsic genetic program, extrinsic factors and niche microenvironment. Direct reprogramming has shown many advantages in the field of cellular reprogramming. Here we tried the possibility to generate corneal endothelia (CE)
X Zeng et al.
European journal of pain (London, England), 18(9), 1323-1332 (2014-03-26)
Adrenomedullin (AM) belongs to the calcitonin gene-related peptide (CGRP) family. Our previous studies show that chronic exposure to morphine increases spinal AM bioactivity, contributing to the development and maintenance of morphine tolerance. This study investigated the possible involvement of AM
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