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Showing 1-30 of 2411 results for "F4274" within Papers
Koichiro Nozaki et al.
PloS one, 9(10), e111019-e111019 (2014-10-25)
The specific mechanisms how lung cancer cells harboring epidermal growth factor receptor (EGFR) activating mutations can survive treatment with EGFR-tyrosine kinase inhibitors (TKIs) until they eventually acquire treatment-resistance genetic mutations are unclear. The phenotypic diversity of cancer cells caused by
Anke Hannemann et al.
The Journal of physiology, 592(18), 4039-4049 (2014-07-13)
The heterocyclic aldehyde 5-hydroxymethyl-2-furfural (5HMF) interacts allosterically with the abnormal form of haemoglobin (Hb), HbS, in red blood cells (RBCs) from patients with sickle cell disease (SCD), thereby increasing oxygen affinity and decreasing HbS polymerization and RBC sickling during hypoxia.
Themistoklis Spyridopoulos et al.
Journal of reconstructive microsurgery, 31(7), 516-526 (2015-07-01)
Dental pulp stem cells (DPSCs) present an exciting new tool in the field of peripheral nerve regeneration due to their close embryonic origin. In this study, we examined their potential in pigs, using biodegradable collagen conduits filled with DPSCs. To
Wen-Qing Shang et al.
Oncology reports, 34(6), 3007-3016 (2015-09-24)
Receptor activator for nuclear factor κB ligand (RANKL) is a member of the tumor necrosis factor (TNF) family. The interaction between RANKL and its receptor RANK plays an important role in the development and function of diverse tissues. However, the
Teresa Chiacchio et al.
The Journal of infection, 69(6), 533-545 (2014-07-01)
Polyfunctional T-cells associate with chronic viral infection control while their involvement in tuberculosis (TB) is unclear. We evaluated TB-specific polyfunctional T-cell response and memory status in antiretroviral treatment (ART)-naïve HIV-infected patients from a low TB-endemic country. We prospectively enrolled HIV-infected
Seon-Yeong Lee et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(7), 1768-1778 (2014-03-20)
Intravenous immunoglobulin (IVIG) is used as a therapeutic agent in various autoimmune diseases. The aims of this study were to investigate the therapeutic effects of IVIG on collagen-induced arthritis (CIA) and identify the mechanism responsible for any therapeutic effects. IVIG
Margo C Honeyman et al.
PloS one, 9(9), e106560-e106560 (2014-09-03)
Rotavirus is a ubiquitous double-stranded RNA virus responsible for most cases of infantile gastroenteritis. It infects pancreatic islets in vitro and is implicated as a trigger of autoimmune destruction of islet beta cells leading to type 1 diabetes, but pancreatic
Yufeng Jiang et al.
Molecular and cellular biochemistry, 406(1-2), 255-262 (2015-05-15)
Mitogen-activated protein kinase (MAPK) pathway-dependent linker phosphorylation of Smad2/3 and subsequent formation of Smad2/3/4 complex and its nuclear translocation are crucial for dysregulated transforming growth factor beta (TGF)-β/Smad signaling in liver fibrosis. Abrogation of this critical step of TGF-β/Smad signaling
Hao Zheng et al.
Pharmaceutical research, 32(6), 2038-2050 (2014-12-24)
Present study aimed at exploring advantages/disadvantages of amino acid modified trimethylated chitosan in conquering multiple gene delivery obstacles and thus providing comprehensive understandings for improved transfection efficiency. Arginine, cysteine, and histidine modified trimethyl chitosan were synthesized and employed to self-assemble
Francisco Alberto García-Vázquez et al.
Theriogenology, 84(4), 566-574 (2015-05-23)
Once deposited in the female reproductive system, sperm begin their competition and undergo a selection to reach the site of fertilization. Little is known about the special characteristics of sperm that reach the oviduct and are able to fertilize, with
Xudong Yu et al.
Materials science & engineering. C, Materials for biological applications, 39, 73-77 (2014-05-28)
In the present work, a new kind of fluorescein-based chemosensor L was designed and synthesized to selectively recognize Ca(2+) or Mg(2+) over other competing ions. The chemosensor showed "off-on" fluorescent and color changes upon the addition of Ca(2+) and Mg(2+).
Wen-Wu Li et al.
Pain, 155(11), 2377-2389 (2014-09-15)
Complex regional pain syndrome (CRPS) is a painful, disabling, chronic condition whose etiology remains poorly understood. The recent suggestion that immunological mechanisms may underlie CRPS provides an entirely novel framework in which to study the condition and consider new approaches
Wei Zhao et al.
Journal of virology, 88(15), 8397-8406 (2014-05-16)
Infectious laryngotracheitis (ILT) is a highly contagious acute respiratory disease of chickens caused by infectious laryngotracheitis virus (ILTV). The disease is controlled mainly through biosecurity and vaccination with live attenuated strains of ILTV and vectored vaccines based on turkey herpesvirus
Yuan-Ji Day et al.
Pain, 155(7), 1293-1302 (2014-04-12)
Interleukin-17 (IL-17) is involved in a wide range of inflammatory disorders and in recruitment of inflammatory cells to injury sites. A recent study of IL-17 knock-out mice revealed that IL-17 contributes to neuroinflammation and neuropathic pain after peripheral nerve injury.
Jun Ho Jeon et al.
Molecular immunology, 65(1), 168-176 (2015-02-11)
Binding of allergen to IgE on basophils positively affects allergic inflammation by releasing inflammatory mediators. Recently, basophils were shown to express pattern-recognition receptors, such as toll-like receptors (TLRs), for recognizing microbe-associated molecular patterns (MAMPs) that are independent of allergen-IgE binding.
Jiraporn Jirakkakul et al.
FEMS microbiology letters, 362(2), 1-8 (2015-02-12)
Iron is an essential element for life. However, the iron overload can be toxic. Here, we investigated the significant increase of tenellin and iron-tenellin complex production in ferricrocin-deficient mutants of Beauveria bassiana. Our chemical analysis indicated that the ferricrocin-deficient mutants
Athanasios E Raptis et al.
American journal of hypertension, 28(1), 22-29 (2014-07-06)
The aim of this study was to investigate the effects of aliskiren on vascular function and endothelial progenitor cells (EPCs) in patients with type 2 diabetes and essential hypertension. The study enrolled type 2 diabetic patients aged >50 years under
I Grulova et al.
Scientific reports, 5, 13702-13702 (2015-09-09)
Spinal cord injury (SCI) has been implicated in neural cell loss and consequently functional motor and sensory impairment. In this study, we propose an alginate-based neurobridge enriched with/without trophic growth factors (GFs) that can be utilized as a therapeutic approach
Sheri L Pollock et al.
Leukemia & lymphoma, 55(6), 1383-1387 (2013-08-10)
The t(5;17) variant of acute promyelocytic leukemia (APL) fuses the nucleophosmin (NPM) gene at 5q35 with the retinoic acid receptor alpha (RARA) at 17q12-22. We have previously shown that leukemic cells express both NPM-RAR and RAR- NPM reciprocal translocation products.
Arinder Kohli et al.
PloS one, 9(5), e98077-e98077 (2014-05-27)
The majority of HIV-1 infections worldwide are acquired via mucosal surfaces. However, unlike the vaginal mucosa, the issue of whether the oral mucosa can act as a portal of entry for HIV-1 infection remains controversial. To address potential differences with
Maja Antunovic et al.
Anti-cancer drugs, 26(2), 180-186 (2014-10-04)
Effective treatment methods for human leukemia are under development, but so far none of them have been found to be completely satisfactory. It was recently reported that palladium complexes have significant anticancer activity as well as lower toxicity compared with
Hyo Jung Choi et al.
PloS one, 10(6), e0129761-e0129761 (2015-06-20)
The first identification of swine-originated influenza A/CA/04/2009 (pH1N1) as the cause of an outbreak of human influenza accelerated efforts to develop vaccines to prevent and control influenza viruses. The current norm in many countries is to prepare influenza vaccines using
Seon-Hee Kim et al.
Parasitology, 142(9), 1228-1238 (2015-06-04)
Despite recent reports regarding the biology of cytosine methylation in Schistosoma mansoni, the impact of the regulatory machinery remains unclear in diverse platyhelminthes. This ambiguity is reinforced by discoveries of DNA methyltransferase 2 (DNMT2)-only organisms and the substrate specificity of
Jing Li et al.
Molecular medicine reports, 12(3), 4572-4577 (2015-06-18)
Berberine (BBR) has been suggested as a potential candidate anticancer agent due to its high anticancer activity and multiple mechanisms. In the present study, the inhibitory effect of BBR on hepatocellular carcinoma (HCC) via the suppression of the arachidonic acid
Saad Y Salim et al.
Inflammatory bowel diseases, 20(7), 1129-1138 (2014-05-27)
Epidemiological associations between early-life air pollution exposure and increased risk of inflammatory bowel diseases have been shown. Our aim was to determine if exposure to airborne particulate matter (PM(10)) during the neonatal period would alter colitis in the interleukin (IL)-10(-/-)
Andrew J Kinloch et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(12), 3359-3370 (2014-10-14)
In lupus nephritis (LN), severe tubulointerstitial inflammation (TII) predicts progression to renal failure. Severe TII is associated with tertiary lymphoid neogenesis and in situ antigen-driven clonal B cell selection. The autoantigen(s) driving in situ B cell selection in TII are
Ying Dai et al.
PloS one, 9(10), e109856-e109856 (2014-10-22)
Cell fate and function can be regulated and reprogrammed by intrinsic genetic program, extrinsic factors and niche microenvironment. Direct reprogramming has shown many advantages in the field of cellular reprogramming. Here we tried the possibility to generate corneal endothelia (CE)
Yuta Yoshizaki et al.
Biomaterials, 35(28), 8186-8196 (2014-06-28)
Cationic lipid-incorporated liposomes modified with pH-sensitive polymers were prepared by introducing 3, 5-didodecyloxybenzamidine as a cationic lipid to egg yolk phosphatidylcholine liposomes modified with 3-methylglutarylated hyperbranched poly(glycidol) (MGlu-HPG) as a pH-sensitive polymer. These liposomes were stable at neutral pH, but
Ana Soraia Mendo et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 20(6), 935-948 (2015-06-17)
Several copper complexes have been assessed as anti-tumor agents against cancer cells. In this work, a copper compound [Cu(H2O){OS(CH3)2}L](NO3)2 incorporating the ligand 4'-phenyl-terpyridine antiproliferative activity against human colorectal, hepatocellular carcinomas and breast adenocarcinoma cell lines was determined, demonstrating high cytotoxicity.
Zheng Zachory Wei et al.
Cell transplantation, 24(3), 391-402 (2015-02-04)
Neonatal stroke is a major cause of mortality and long-term morbidity in infants and children. Currently, very limited therapeutic strategies are available to protect the developing brain against ischemic damage and promote brain repairs for pediatric patients. Moreover, children who
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