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Showing 1-30 of 32 results for "F5007" within Papers
C Pujades et al.
The Biochemical journal, 313 ( Pt 3), 899-908 (1996-02-01)
Here we describe experiments in which we mutated four of the six integrin alpha 4 subunit cysteine residues that are not present in most other integrin alpha subunits that lack an I domain. In four different types of ligand binding
M J Humphries et al.
The Journal of biological chemistry, 262(14), 6886-6892 (1987-05-15)
The principal region of the human plasma fibronectin molecule mediating the adhesion of melanoma cells appears to be the alternatively spliced type III connecting segment (IIICS (Humphries, M. J., Akiyama, S. K., Komoriya, A., Olden, K., and Yamada, K. M.
H Fujita et al.
Experimental cell research, 217(2), 484-489 (1995-04-01)
A 29-kDa monomeric dispase-digestive fragment of human plasma fibronectin has been purified by heparin affinity chromatography. The NH2-terminal sequence was determined as Ala1687-Val-Thr-Thr-Ile-Pro-Ala-Pro. By mass spectrometry the molecular weight was determined to be 30,241.9 with standard deviation of 3.9 amu.
M J Humphries et al.
The Journal of cell biology, 106(4), 1289-1297 (1988-04-01)
Fibronectin contains at least two domains that support cell adhesion. One is the central cell-binding domain that is recognized by a variety of cell types, including fibroblasts. The second, originally identified by its ability to support melanoma cell adhesion, is
G Bazzoni et al.
The Journal of biological chemistry, 273(12), 6670-6678 (1998-04-18)
Here we show striking differences in conformational regulation among beta1 integrins. Upon manganese stimulation, a beta1 epitope defined by monoclonal antibody (mAb) 9EG7 was induced strongly (on alpha4beta1), moderately (on alpha5beta1), weakly (on alpha2beta1), or was scarcely detectable (on alpha6beta1
A P Martín et al.
Journal of cutaneous pathology, 29(6), 347-353 (2002-07-24)
Allergic contact dermatitis (ACD) is a common human dermatosis in which not all the mechanisms involved in its pathogenesis have been elucidated. To study the expression of CS-1 fibronectin, TARC and Th1-associated chemokine receptors in biopsies from allergic patch test
Jooeun Bae et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 18(17), 4850-4860 (2012-07-04)
The efficacy of peptide vaccines may be enhanced by stimulating immune cells with multiple peptides derived from distinct tumor-associated antigens. We have evaluated the heteroclitic XBP1-US(184-192) (YISPWILAV), heteroclitic XBP1-SP(367-375) (YLFPQLISV), native CD138(260-268) (GLVGLIFAV), and native CS1(239-247) (SLFVLGLFL) peptides, which have
A Komoriya et al.
The Journal of biological chemistry, 266(23), 15075-15079 (1991-08-15)
Fibronectin contains at least two major domains that support cell adhesion. One is the central cell-binding domain that is recognized by a variety of cell types via the integrin alpha 5 beta 1. The second, originally identified by its ability
Elzbieta Gubała et al.
Endokrynologia Polska, 56(5), 752-757 (2006-07-04)
In our study we present chosen elements of microarray analysis of gene expression profile in papillary thyroid cancer. The study group included 16 papillary thyroid cancer tissues and 16 corresponding normal tissues. Samples were analyzed on high density oligonucleotide microarrays
M Muñoz et al.
The Biochemical journal, 327 ( Pt 3), 727-733 (1998-05-15)
The integrin VLA-4 (alpha4 beta1) is a receptor for fibronectin and vascular cell-adhesion molecule 1 (VCAM-1). Four functionally different epitopes, designated A, B1, B2 and C, have previously been defined on the alpha4 subunit. Using K562 alpha4 mutant transfectants we
S Miyamoto et al.
Annals of the New York Academy of Sciences, 857, 119-129 (1999-01-26)
Fibronectin and integrins play crucial roles in a variety of morphogenetic processes, in which they mediate cell adhesion, migration, and signal transduction. They induce hierarchical transmembrane organization of cytoskeletal and signaling molecules into multimolecular complexes of more than 30 proteins.
Pachiyappan Kamarajan et al.
BMC cancer, 10, 330-330 (2010-06-29)
The alternatively spliced V region or type III connecting segment III (IIICS) of fibronectin is important in early development, wound healing, and tumorigenesis, however, its role in oral cancer has not been fully investigated. Thus, we investigated the role of
M D Stegall et al.
Transplantation, 71(11), 1549-1555 (2001-07-04)
Adhesion molecules are involved in multiple steps of the continuum of allograft rejection. We studied the effects of blockade of the interactions between alpha4 integrin and its ligands, vascular cell adhesion molecule-1 (VCAM-1) and fibronectin, on allograft survival. Streptozotocin-induced diabetic
S Molossi et al.
The Journal of clinical investigation, 95(6), 2601-2610 (1995-06-01)
Graft arteriopathy, a leading cause of cardiac allograft failure, is associated with increased intimal smooth muscle cells, inflammatory cells, and accumulation of extracellular matrix. We hypothesized that cellular fibronectin plays a pivotal role in the progression of the allograft arteriopathy
Kayoko Motojima et al.
Endocrine journal, 55(2), 373-379 (2008-04-02)
To compare the effects of postprandial hypertriglyceridemia and postprandial hyperglycemia on monocyte adhesion to endothelial cells, we investigated the effects of twice-daily standard diet (5% fat) and high-fat diet (30% fat) for 3 weeks on monocyte adhesion to endothelial cells
D Haworth et al.
British journal of pharmacology, 126(8), 1751-1760 (1999-06-18)
1. Small, N- to C-terminal cyclized peptides containing the leucyl-aspartyl-valine (LDV) motif from fibronectin connecting segment-1 (CS-1) have been investigated for their effects on the adhesion of human T-lymphoblastic leukaemia cells (MOLT-4) to human plasma fibronectin in vitro mediated by
Wen Xiong et al.
Journal of visualized experiments : JoVE, (33)(33), doi:10-doi:10 (2009-11-20)
Mouse embryonic stem (ES) cells are conventionally cultured with Leukemia Inhibitory Factor (LIF) to maintain self-renewal.(1) However, LIF is expensive and activation of the LIF/JAK/STAT3 pathway is not absolutely required to maintain the self-renewal state.(2) The SC1 small molecule may
C Moore et al.
Transplantation proceedings, 37(1), 432-434 (2005-04-06)
We investigated the effects of the connecting segment-1 (CS1) peptide, which blocks fibronectin (FN)-alpha4beta1 integrin interactions upon cell signaling, leukocyte migration, and secretion of proinflammatory cytokines, in a well-established steatotic rat liver model using ex vivo cold ischemia followed by
Junya Kuroda
Nihon rinsho. Japanese journal of clinical medicine, 73(1), 119-123 (2015-01-30)
Multiple myeloma (MM) remains mostly incurable despite the recent progress in the treatment strategy. One of novel fields for anti-MM therapeutic strategy is the development of immunotherapy using monoclonal antibodies (MoAbs) against myeloma-specific antigens. This article focuses on the basic
S J Chakravorty et al.
The American journal of pathology, 154(2), 503-514 (1999-02-23)
Renal inflammatory conditions are characterized by mononuclear cell recruitment to sites of inflammation. We have developed a modified Stamper-Woodruff assay system to analyze mechanisms of functional T cell adhesion to cryostat sections of renal biopsy material from patients with vasculitic
Kosuke Azuma et al.
Arteriosclerosis, thrombosis, and vascular biology, 26(10), 2275-2280 (2006-08-05)
The aim of this study was to elucidate the effect of repetitive fluctuations in blood glucose concentrations on monocyte adhesion to the aortic endothelium. Nonobese type 2 diabetes, Goto-Kakizaki (GK) rats were fed twice daily to induce repetitive postprandial glucose
I N Jongewaard et al.
Cell adhesion and communication, 3(6), 487-495 (1996-04-01)
The type III connecting segment (IIICS) within fibronectin is the major binding site for the integrin alpha 4 beta 1. Most integrin ligands have an essential acidic residue within their integrin binding site, in IIICS this residue is hypothesized to
D L Boyle et al.
Cellular immunology, 200(1), 1-7 (2000-03-16)
VLA-4 is a critical adhesion molecule that regulates mononuclear cell trafficking to sites of inflammation. VCAM-1 is a primary ligand of VLA-4, although alternatively spliced fibronectin (FN) containing the CS1 region (CS1 FN) also binds to VLA-4. CS1 FN is
Y Huo et al.
Circulation research, 87(2), 153-159 (2000-07-25)
Atherosclerotic lesion development seems to be inflammatory in nature and involves the recruitment of monocytes to the vessel wall. In this study, we investigated the role of vascular cell adhesion molecule-1 (VCAM-1) and fibronectin (FN) connecting segment-1 containing the amino
C F Craddock et al.
British journal of haematology, 97(1), 15-21 (1997-04-01)
In vitro the integrin VLA4 mediates the adhesion of haemopoietic progenitors to bone marrow stroma through an interaction with its ligands VCAM-1 and the CS1 moiety of fibronectin. The VLA4/VCAM-1 pathway has been implicated in haemopoietic trafficking in vivo since
C Moore et al.
Transplantation proceedings, 37(4), 1682-1683 (2005-05-28)
We investigated the effects of the connecting segment-1 (CS1) peptide, which blocks fibronectin (FN)-alpha4beta1 integrin interactions, upon recipient survival and extent of tissue injury in a well-established rat liver model of ex vivo 24-hour cold ischemia followed by isotransplantation. In
Haoyun Duan et al.
Experimental eye research, 100, 52-58 (2012-05-09)
This study was designed to demonstrate the effects of pluripotin on the proliferation, senescence and colony formation efficiency of rabbit limbal epithelial cells (RLECs) in vitro. Rabbit primary limbal epithelial cells were harvested and cultured in the presence of pluripotin.
P Vanderslice et al.
Journal of immunology (Baltimore, Md. : 1950), 158(4), 1710-1718 (1997-02-15)
The alpha 4 integrins mediate leukocyte adhesion to specific counter-receptors, including vascular cell adhesion molecule-1 (VCAM-1), the fibronectin splice variant containing connecting segment 1 (CS1), and mucosal addressin cell adhesion molecule-1. A series of cyclized peptides based on the LDV
Joakim Huber et al.
Arteriosclerosis, thrombosis, and vascular biology, 22(4), 581-586 (2002-04-16)
Oxidation products of cholesteryl esters have been shown to be present in oxidized low density lipoprotein and in atherosclerotic lesions. Monocyte adhesion to the endothelium is an initiating crucial event in atherogenesis. Here, we show that in vitro oxidized cholesteryl
P T Shih et al.
The Journal of clinical investigation, 103(5), 613-625 (1999-03-13)
We have shown previously that treatment of human aortic endothelial cells (HAECs) with minimally modified low-density lipoprotein (MM-LDL) induces monocyte but not neutrophil binding. This monocyte binding was not mediated by endothelial E-selectin, P-selectin, vascular cell adhesion molecule-I, or intercellular
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