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Showing 1-30 of 217 results for "F6057" within Papers
Yue-Yi Yao et al.
Brain research, 1717, 190-203 (2019-04-27)
Microglia contribute to the regulation of neuroinflammation and play an important role in the pathogenesis of brain disorders. Thus, regulation of neuroinflammation triggered by activation of microglia has become a promising therapeutic strategy. Here, we investigated the beneficial effects of
Yansong Zhao et al.
Brain research bulletin, 150, 168-178 (2019-06-04)
To assess the possible neuroprotective effects of melatonin against brain white matter damage via the Toll-like receptor 4 (TLR4)/ nuclear factor-kappa B (NF-κB) signaling pathway in focal cerebral ischemic rats. Fifty-four Sprague-Dawley rats were randomly divided into the Sham, middle
Francesca Grisan et al.
Cell death and differentiation, 28(8), 2436-2449 (2021-03-21)
Autophagy is a highly regulated degradative process crucial for maintaining cell homeostasis. This important catabolic mechanism can be nonspecific, but usually occurs with fine spatial selectivity (compartmentalization), engaging only specific subcellular sites. While the molecular machines driving autophagy are well
Baixuan He et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(10), 13361-13375 (2020-08-28)
Radiotherapy is one of the most effective treatments for head and neck tumors. However, delayed radiation-induced brain necrosis (RN) remains a serious issue due to the lack of satisfying prevention and effective treatment. The pathological role of radiation in the
Yi Zhou et al.
Laboratory investigation; a journal of technical methods and pathology, 101(4), 477-489 (2020-10-03)
Odd-skipped related 1 (Osr1) is a novel tumor suppressor gene in several cancer cell lines. Non-alcoholic steatohepatitis (NASH) is considered as a high-risk factor for hepatocellular carcinoma (HCC). This study is aimed to investigate the novel role of Osr1 in
Yingjun Min et al.
Frontiers in cellular neuroscience, 14, 244-244 (2020-09-10)
Neonatal brain injury, especially severe injury induced by hypoxia-ischemia (HI), causes mortality and long-term neurological impairments. Our previous study demonstrated activation of CD11b+ myeloid cells, including residential microglial cells (MGs) and infiltrating monocyte-derived macrophages (MDMs) in a murine model of
Shivapriya Shivakumar et al.
BioMed research international, 2018, 7627329-7627329 (2018-12-07)
Dry eye disease (DED) is a multifactorial ocular surface disorder affecting millions of individuals worldwide. Inflammation has been associated with dry eye and anti-inflammatory drugs are now being targeted as the alternate therapeutic approach for dry eye condition. In this
Marek Hampl et al.
Frontiers in cell and developmental biology, 8, 572-572 (2020-08-28)
Secondary palate development is characterized by the formation of two palatal shelves on the maxillary prominences, which fuse in the midline in mammalian embryos. However, in reptilian species, such as turtles, crocodilians, and lizards, the palatal shelves of the secondary
Yun Zhou et al.
Neurochemistry international, 123, 22-33 (2018-07-28)
Glutamate-ammonia ligase (glutamine synthetase; Glul) is enriched in astrocytes and serves as the primary enzyme for ammonia detoxification and glutamate inactivation in the brain. Loss of astroglial Glul is reported in hippocampi of epileptic patients, but the mechanism by which
Hendrika A Segeren et al.
Cell reports, 33(9), 108449-108449 (2020-12-03)
E2F transcription factors control the expression of cell-cycle genes. Cancers often demonstrate enhanced E2F target gene expression, which can be explained by increased percentages of replicating cells. However, we demonstrate in human cancer biopsy specimens that individual neoplastic cells display
Zhen-Ye Zhang et al.
Journal of vascular research, 57(1), 24-33 (2019-11-13)
Glucose fluctuations may be responsible for, or further the onset of arterial hypertension, but the exact mechanisms remain unclear. The purpose of this study was to investigate the mechanisms behind and related to aortic fibrosis and aortic stiffening induced by
Emel Dikicioglu et al.
Journal of cutaneous pathology, 30(7), 430-436 (2003-07-16)
Long-term preservation of immunofluorescence is important for re-examinations. We investigated whether the storage of direct immunofluorescent (DIF)-positive slides at room temperature was reliable in daily practice. One hundred and twenty-five DIF-positive slides from the skin of 52 patients were evaluated.
Kang Zhang et al.
Frontiers in pharmacology, 8, 302-302 (2017-06-13)
The sigma-1 receptor is a 223 amino acids molecular chaperone with a single transmembrane domain. It is resident to eukaryotic mitochondrial-associated endoplasmic reticulum and plasma membranes. By chaperone-mediated interactions with ion channels, G-protein coupled receptors and cell-signaling molecules, the sigma-1
Derek M Waldner et al.
Translational vision science & technology, 8(4), 1-1 (2019-07-12)
The posthatching chicken is a valuable animal model for research, but molecular tools needed for altering its gene expression are not yet available. Our purpose here was to adapt the adeno-associated viral (AAV) vector method, used widely in mammalian studies
Huai-Chun Yang et al.
World journal of stem cells, 12(2), 152-167 (2020-03-19)
Human-derived mesenchymal stromal cells have been shown to improve cognitive function following experimental stroke. The activity of exosomes has been verified to be comparable to the therapeutic effects of mesenchymal stromal cells. However, the effects of exosomes derived from human
Paula G Miller et al.
Biotechnology and bioengineering, 113(10), 2213-2227 (2016-04-14)
We describe a human "Body-on-a-chip" device (or microphysiological system) that could be used to emulate drug distribution, metabolism, and action in the body. It is based upon a physiologically based pharmacokinetic-pharmacodynamic (PBPK-PD) model, where multiple chambers representing different organs are
Gloria B Kim et al.
Bioactive materials, 5(3), 624-635 (2020-05-15)
Glioblastoma (GBM), the deadliest form of brain cancer, presents long-standing problems due to its localization. Chimeric antigen receptor (CAR) T cell immunotherapy has emerged as a powerful strategy to treat cancer. IL-13-receptor-α2 (IL13Rα2), present in over 75% of GBMs, has
Paras Sehgal et al.
The EMBO journal, 40(15), e107134-e107134 (2021-06-29)
Long non-coding RNAs (lncRNAs) are emerging as key regulators of endothelial cell function. Here, we investigated the role of a novel vascular endothelial-associated lncRNA (VEAL2) in regulating endothelial permeability. Precise editing of veal2 loci in zebrafish (veal2gib005Δ8/+ ) induced cranial
Zhen Zhang et al.
Bioengineering & translational medicine, 6(1), e10189-e10189 (2021-02-04)
The round window of the cochlea provides an ideal route for delivering medicines and gene therapy reagents that can cross the round window membrane (RWM) into the inner ear. Recombinant adeno-associated viruses (rAAVs) have several advantages and are recommended as
Katrin A Becker et al.
Journal of neurochemistry, 154(6), 662-672 (2020-02-15)
A major dose-limiting side effect of docetaxel chemotherapy is peripheral neuropathy. Patients' symptoms include pain, numbness, tingling and burning sensations, and motor weakness in the extremities. The molecular mechanism is currently not understood, and there are no treatments available. Previously
Kyung-Eon Lee et al.
Microbiome, 8(1), 107-107 (2020-07-17)
In a pilot study, we found that feces transplantation from elderly individuals to mice significantly caused cognitive impairment. Paenalcaligenes hominis and Escherichia coli are increasingly detected in the feces of elderly adults and aged mice. Therefore, we isolated Paenalcaligenes hominis
Brijesh K Garg et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 65(9), 499-512 (2017-08-02)
Alpha7 nicotinic acetylcholine receptors (α7 nAChRs) are important drug targets in neurological disorders and inflammation, making their detection and localization by validated antibodies highly desirable. However, tests in knockout animals raised questions about specificity of antibodies to mouse α7 nAChRs.
Carla Maria Figueiredo de Carvalho Miranda et al.
Journal of equine veterinary science, 90, 102962-102962 (2020-06-15)
Equine represents an attractive animal model for musculoskeletal tissue diseases, exhibiting much similarity to the injuries that occur in humans. Cell therapy and tissue bioengineering have been widely used as a therapeutic alternative by regenerative medicine in musculoskeletal diseases. Thus
Xinhua Li et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(5), 6741-6756 (2020-04-01)
The intervertebral disc degeneration (IVDD)-related diseases occur in more than 90% of the population older than 50 years. Owing to the lack of understanding of the cellular mechanisms involved in IVDD formation effective treatment options are still unavailable. Primary cilia are
Jinman Chen et al.
Nature communications, 11(1), 3159-3159 (2020-06-24)
Extravasated erythrocytes in cerebrospinal fluid (CSF) critically contribute to the pathogenesis of subarachnoid hemorrhage (SAH). Meningeal lymphatics have been reported to drain macromolecules and immune cells from CSF into cervical lymph nodes (CLNs). However, whether meningeal lymphatics are involved in
Bhavik Anil Patel et al.
Scientific reports, 7, 42754-42754 (2017-02-16)
Treatment for chronic constipation in older people is challenging and the condition has a major impact on quality of life. A lack of understanding about the causes of this condition has hampered the development of effective treatments. 5-HT is an
A I Costa et al.
Materials science & engineering. C, Materials for biological applications, 120, 111735-111735 (2021-02-07)
One of the main problems that remain in the implant industry is poor osseointegration due to bioinertness of implants. In order to promote bioactivity, calcium (Ca), phosphorus (P) and strontium (Sr) were incorporated into a TiO2 porous layer produced by
Jerzy Wiater et al.
International journal of molecular sciences, 22(18) (2021-09-29)
Pig-to-human xenotransplantation seems to be the response to the contemporary shortage of tissue/organ donors. Unfortunately, the phylogenetic distance between pig and human implies hyperacute xenograft rejection. In this study, we tested the hypothesis that combining expression of human α1,2-fucosyltransferase (hFUT2)
Pedro Marques et al.
Endocrine-related cancer, 26(12), 853-865 (2019-10-24)
Tumour-associated fibroblasts (TAFs) are key elements of the tumour microenvironment, but their role in pituitary neuroendocrine tumours (PitNETs) has been little explored. We hypothesised that TAF-derived cytokines may play a role in tumour aggressiveness and that their release can be
Beatriz A Ibarra et al.
Journal of developmental biology, 9(3) (2021-07-03)
Wnt signaling regulates cell fate decisions in diverse contexts during development, and loss of Wnt signaling in the cranial mesenchyme results in a robust and binary cell fate switch from cranial bone to ectopic cartilage. The Extracellular signal-regulated protein kinase
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