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Showing 1-30 of 99 results for "F7252" within Papers
Yuan Fang Li et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 18(2), 177-181 (2002-03-05)
The interaction of Fast Green FCF (FCF) with proteins (including bovine serum albumin (BSA), human serum albumin (HSA), pepsin (Pep) and alpha-chymotrypsin (Chy), and lysozyme (Lys)) was characterized by enhanced resonance light-scattering (RLS) measurements using a common spectrofluorometer. The enhanced
Guoli Hu et al.
The American journal of pathology, 190(8), 1701-1712 (2020-05-18)
Interleukin 17A (IL-17A) is critical in the pathogenesis of autoimmune diseases through driving inflammatory cascades. However, the role of IL-17 in osteoarthritis (OA) is not well understood. Tumor necrosis factor-receptor-associated factor 3 (TRAF3) is a receptor proximal negative regulator of
Aimy Sebastian et al.
International journal of molecular sciences, 21(1) (2020-01-16)
Aging and injury are two major risk factors for osteoarthritis (OA). Yet, very little is known about how aging and injury interact and contribute to OA pathogenesis. In the present study, we examined age- and injury-related molecular changes in mouse
Elizabeth P Lackey et al.
Frontiers in systems neuroscience, 14, 7-7 (2020-03-03)
Purkinje cell microcircuits perform diverse functions using widespread inputs from the brain and spinal cord. The formation of these functional circuits depends on developmental programs and molecular pathways that organize mossy fiber afferents from different sources into a complex and
Michael J Ford et al.
Rapid communications in mass spectrometry : RCM, 18(12), 1303-1309 (2004-06-03)
A combined surface sampling probe/electrospray emitter coupled with an ion trap mass spectrometer was used for the direct read out of unmodified reversed-phase C18 thin-layer chromatography (TLC) plates. The operation of the surface sampling electrospray ionization interface in positive and
[Effects of various solvents on dentin permeability to dyes].
Y Ueta
Josai Shika Daigaku kiyo. The Bulletin of the Josai Dental University, 16(3), 777-797 (1987-01-01)
Rixin Zheng et al.
Annals of the New York Academy of Sciences, 1440(1), 54-66 (2018-12-24)
Growth differentiation factor 11 (GDF11), a secreted member of the transforming growth factor-β (TGF-β) superfamily, has been reported to have the capacity to reverse age-related pathologic changes and regulate organ regeneration after injury; however, the role of GDF11 in fracture
M R Fernández San Juan et al.
Ecotoxicology and environmental safety, 196, 110565-110565 (2020-04-10)
The aim of the present work was to study the effect of the pyrethroid cypermethrin (CYP) on the non-target freshwater snail Chilina parchappi. Initially, the sensitivity of adult snails to CYP was evaluated via the 96-h LC50 test. Then, snails
M Mourelle et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 36(12), 1471-1474 (1988-12-01)
We describe a simple, sensitive, and quantitative procedure for measurement of triglycerides and protein contents in formalin-fixed liver sections. The method can detect as little as 0.27 microgram of triglycerides per mg of protein. It is based on selective binding
Tatyana A Meyers et al.
Journal of molecular and cellular cardiology, 128, 51-61 (2019-01-22)
Duchenne muscular dystrophy (DMD) is an X-linked disease characterized by skeletal muscle degeneration and a significant cardiomyopathy secondary to cardiomyocyte damage and myocardial loss. The molecular basis of DMD lies in the absence of the protein dystrophin, which plays critical
Paul A Muller et al.
Science (New York, N.Y.), 370(6514), 314-321 (2020-08-29)
The gut microbiota affects tissue physiology, metabolism, and function of both the immune and nervous systems. We found that intrinsic enteric-associated neurons (iEANs) in mice are functionally adapted to the intestinal segment they occupy; ileal and colonic neurons are more
Miki Jishage et al.
Genes & development, 34(11-12), 767-784 (2020-05-10)
Liver regeneration and metabolism are highly interconnected. Here, we show that hepatocyte-specific ablation of RNA polymerase II (Pol II)-associated Gdown1 leads to down-regulation of highly expressed genes involved in plasma protein synthesis and metabolism, a concomitant cell cycle re-entry associated
Qi Sun et al.
eLife, 10 (2021-03-02)
Osteoarthritis, a highly prevalent degenerative joint disorder, is characterized by joint pain and disability. Available treatments fail to modify osteoarthritis progression and decrease joint pain effectively. Here, we show that intermittent parathyroid hormone (iPTH) attenuates osteoarthritis pain by inhibiting subchondral
Melanie E Mendez et al.
International journal of molecular sciences, 21(17) (2020-09-10)
Osteoarthritis (OA) is a painful and debilitating disease characterized by the chronic and progressive degradation of articular cartilage. Post-traumatic OA (PTOA) is a secondary form of OA that develops in ~50% of cases of severe articular injury. Inflammation and re-occurring
Samantha R Weaver et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 36(5), 986-999 (2021-01-13)
Endochondral ossification is tightly controlled by a coordinated network of signaling cascades including parathyroid hormone (PTH). Pleckstrin homology (PH) domain and leucine rich repeat phosphatase 1 (Phlpp1) affects endochondral ossification by suppressing chondrocyte proliferation in the growth plate, longitudinal bone
Astrid Deryckere et al.
eLife, 10 (2021-08-25)
Cephalopods have evolved nervous systems that parallel the complexity of mammalian brains in terms of neuronal numbers and richness in behavioral output. How the cephalopod brain develops has only been described at the morphological level, and it remains unclear where
Géraldine Meyer-Dilhet et al.
STAR protocols, 1(1), 100027-100027 (2020-07-21)
The cerebral cortex is composed of an exquisitely complex network of interconnected neurons supporting the higher cognitive functions of the brain. Here, we provide a fully detailed, step-by-step protocol to perform in utero cortical electroporation of plasmids, a simple surgical
Michael D Rainey et al.
Cell reports, 32(9), 108096-108096 (2020-09-03)
DNA replication initiates from multiple origins, and selective CDC7 kinase inhibitors (CDC7is) restrain cell proliferation by limiting origin firing. We have performed a CRISPR-Cas9 genome-wide screen to identify genes that, when lost, promote the proliferation of cells treated with sub-efficacious
L B Gilmore et al.
Journal of biochemical and biophysical methods, 5(1), 57-66 (1981-07-01)
The quantitation of proteins in polyacrylamide gels stained with Fast green FCF has been investigated using a modification of the elution technique originally described by Fenner et al. (Fenner, C., Traut, R.R., Mason, D.T. and Wikman-Coffelt, J. (1975) Anal. Biochem.
Veronica Ulici et al.
The American journal of pathology, 189(4), 868-885 (2019-01-22)
Mitogen-activated protein kinases, including c-Jun NH2-terminal kinase (JNK), play an important role in the development and function of a large variety of tissues. The skeletal phenotype of JNK1 and JNK2 double-knockout (dKO) mice (JNK1fl/flCol2-Cre/JNK2-/-) and control genotypes were analyzed at
Victoria Rozés-Salvador et al.
Frontiers in cell and developmental biology, 8, 550267-550267 (2020-10-06)
Neural development is a complex process that involves critical events, including cytoskeleton dynamics and selective trafficking of proteins to defined cellular destinations. In this regard, Smad Anchor for Receptor Activation (SARA) is an early endosome resident protein, where perform trafficking-
Lydia Wood et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(40), 12440-12448 (2009-10-09)
Rett syndrome, an autism spectrum disorder with prominent motor and cognitive features, results from mutations in the gene for methyl-CpG-binding protein 2 (MeCP2). Here, to identify cortical circuit abnormalities that are specifically associated with MeCP2 deficiency, we used glutamate uncaging
A M Thompson et al.
Molecular and cellular neurosciences, 109, 103554-103554 (2020-09-25)
The current study sought to characterize the pro-survival effects of erythropoietin (EPO) in a toxicant model of Parkinson's disease (PD). EPO treatment induced time-dependent elevations of antioxidant glutathione peroxidase (GPx) and anti-apoptotic factors (pAkt and pBad/Bad) within the striatum and
Long Ma et al.
International journal of molecular medicine, 47(3) (2021-01-16)
The present study aimed to investigate whether dihydroartemisinin (DHA) alleviates osteoarthritis (OA) in a mouse model of OA. Ten‑week‑old female C57BL/6j mice were used to establish OA models by anterior cruciate ligament transection (ACLT) and ovariectomized (OVX). DHA was then
A C Dhar et al.
Stain technology, 57(3), 151-155 (1982-05-01)
Fast green FCF was used to localize acidic nuclear proteins in sections of young flower buds of Limnophyton obtusifolium (L.) Miq. After extracting nucleic acids, the slides were stained at hydrogen ion concentrations ranging from pH 2.6 to 9.0. At
Aimy Sebastian et al.
Cells, 10(6) (2021-07-03)
Articular cartilage is a connective tissue lining the surfaces of synovial joints. When the cartilage severely wears down, it leads to osteoarthritis (OA), a debilitating disease that affects millions of people globally. The articular cartilage is composed of a dense
Melanie E Mendez et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 35(11), 2229-2241 (2020-06-22)
Osteoarthritis (OA) is a debilitating and painful disease characterized by the progressive loss of articular cartilage. Post-traumatic osteoarthritis (PTOA) is an injury-induced type of OA that persists in an asymptomatic phase for years before it becomes diagnosed in ~50% of
Xiakun Yuan et al.
Environmental toxicology and pharmacology, 32(2), 242-248 (2011-08-17)
The objective of the study was to assess the effect of ciprofloxacin antibiotic on the physiological or phenotypic characteristics of food-borne toxigenic Fusarium graminearum and F. avenaceum molds under in vitro conditions. In the presence of ciprofloxacin, Fusarium mycelia growth
Collin Challis et al.
Nature neuroscience, 23(3), 327-336 (2020-02-19)
Parkinson's disease is a synucleinopathy that is characterized by motor dysfunction, death of midbrain dopaminergic neurons and accumulation of α-synuclein (α-Syn) aggregates. Evidence suggests that α-Syn aggregation can originate in peripheral tissues and progress to the brain via autonomic fibers.
Zhou Han et al.
Science translational medicine, 12(558) (2020-08-28)
Dravet syndrome (DS) is an intractable developmental and epileptic encephalopathy caused largely by de novo variants in the SCN1A gene, resulting in haploinsufficiency of the voltage-gated sodium channel α subunit NaV1.1. Here, we used Targeted Augmentation of Nuclear Gene Output
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