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Peptide synthesis

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Overcoming Aggregation in Solid-phase Peptide Synthesis
The ease of assembly of a given peptide sequence is hard to predict, which makes peptide synthesis challenging. Review methods and reagents for avoiding aggregation in solid-phase peptide synthesis.
Peptide Resin Loading Protocols
Review methods and resins for attaching amino acids and peptides, including Merrifield, trityl-based, and hydroxymethyl-functionalized resins. Resin-immobilized peptides can be used for various downstream applications.
Protocols for the Fmoc SPPS of Cysteine-containing Peptides
Overcome challenges in synthesis and disulfide bond formation with protocols for Fmoc solid-phase peptide synthesis of peptides with cysteine and methionine.
Solvent Systems for Thin-layer Chromatography of Novabiochem Products
A guide to create solvent systems used for the thin-layer chromatography assay of Novabiochem products.
Building Blocks for Introducing Post-translational Modified Amino Acids
We provide an overview of our available reagents, together with recommendations and details of their use for synthesis of peptides containing post-translationally modified amino acids.
Boc Resin Cleavage and Deprotection
The most popular reagent for cleavage of peptides from Boc-based resins is anhydrous HF. Of all the cleavage procedures HF appears to be the most versatile and least harmful to a wide variety of peptides synthesized on Boc-based resins.
Fmoc Resin Cleavage and Deprotection
Fmoc resin cleavage and deprotection follows the difficult task of detaching the peptide from the resin support and removing all the side-chain protecting groups of the amino acid residues to yield the desired peptide.