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靶蛋白降解_化学合成方法_蛋白降解剂-默克生命科学
默克分享，靶蛋白降解（TPD）是一种新颖的药物研发策略，利用小分子“劫持”细胞的降解过程，从细胞中降解问题蛋白。
Accelerating Protein Degrader Discovery with IAP
Plate of 80 ligands against E3 ligase IAP designed by ComInnex; allows creation of bifunctional targeted protein degraders or molecular glues.
Degrader Building Blocks with IAP In Silico-Derived Ligands
Targeted protein degradation reduces disease-relevant proteins in cells using small molecules, hijacking endogenous proteolysis systems.
Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.
Targeted Protein Degradation Partners
Webinar explores advances in chemical building blocks for protein degradation, including warheads, linkers, and ligands.
Targeted Protein Degradation and Drug Discovery
In this webinar, the technologies and compounds that induce targeted protein degradation will be covered.
Targeted Protein Degradation
Targeted protein degradation (TPD) is an emerging drug discovery strategy that uses small-molecules, such as proteolysis-targeting chimeras (PROTACs), to eradicate targeted proteins linked to disease from cells.
Solutions for "Undruggable" Protein Targets
This webinar specifically highlights high-throughput, affinity-based screening with DNA-encoded libraries and more.
PROTAC Synthesis Kits for Targeted Protein Degradation
Discover QuicTPD™ Acid/Amine Screening Sets for rapid, high-throughput PROTAC® synthesis, streamlining targeted protein degradation research.