G013

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Showing 1-15 of 15 results for "G013" within Papers

The Role of Spinal GABAB Receptors in Cancer-Induced Bone Pain in Rats.

Ya-Qun Zhou et al.

The journal of pain, 18(8), 933-946 (2017-03-23)

Cancer-induced bone pain (CIBP) remains a major challenge in advanced cancer patients because of our lack of understanding of its mechanisms. Previous studies have shown the vital role of γ-aminobutyric acid B receptors (GABABRs) in regulating nociception and various neuropathic

GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals.

Pradeep Bhandari et al.

eLife, 10 (2021-04-30)

The synaptic connection from medial habenula (MHb) to interpeduncular nucleus (IPN) is critical for emotion-related behaviors and uniquely expresses R-type Ca2+ channels (Cav2.3) and auxiliary GABAB receptor (GBR) subunits, the K+-channel tetramerization domain-containing proteins (KCTDs). Activation of GBRs facilitates or

The GABA(B) receptor positive modulator BHF177 attenuated anxiety, but not conditioned fear, in rats.

Xia Li et al.

Neuropharmacology, 97, 357-364 (2015-05-24)

GABAB (γ-aminobutyric acid B) receptors may be a therapeutic target for anxiety disorders. Here we characterized the effects of the GABAB receptor positive allosteric modulator (PAM) BHF177 on conditioned and unconditioned physiological responses to threat in the light-enhanced startle (LES)

The indirect γ-aminobutyric acid (GABA) receptor agonist gabaculine-induced loss of the righting reflex may inhibit the descending analgesic pathway.

Yuya Ogawa et al.

Pharmacology, biochemistry, and behavior, 198, 173034-173034 (2020-09-11)

In the spinal cord, γ-aminobutyric acid (GABA) interneurons play an essential role in antinociception. However, not all actions of GABA favor antinociception at the supraspinal level. We previously reported that gabaculine, which increases endogenous GABA in the synaptic clefts, induces

Analgesic properties of the novel compound M43068 in rat models of acute and neuropathic pain.

Yasushige Akada et al.

European journal of pharmacology, 523(1-3), 46-53 (2005-10-18)

We investigated the effects of 2-(4-hydroxybenzoyl)amino-2-methylpropionic acid (M43068), a novel analgesic agent, in rat models of acute and neuropathic pain. Oral M43068 (10-100 mg/kg) suppressed only the late phase of formalin-induced nociceptive behaviors. In the neuropathic pain model, oral M43068

Effects of phaclofen and the enantiomers of baclofen on cardiovascular responses to intrathecal administration of L- and D-baclofen in the rat.

Y G Hong et al.

European journal of pharmacology, 196(3), 267-275 (1991-04-24)

In a previous study it was found that i.t. administration of L-baclofen decreased arterial pressure and heart rate while D-baclofen differentially increased arterial pressure. The objective of the present study was to determine which of these effects was blocked by

Alleviation by GABA

Toshihiko Kinjo et al.

Neurochemical research, 43(1), 70-79 (2017-06-14)

Mitochondrial permeability transition pore (PTP) is supposed to at least in part participate in molecular mechanisms underlying the neurotoxicity seen after overactivation of N-methyl-D-aspartate (NMDA) receptor (NMDAR) in neurons. In this study, we have evaluated whether activation of GABA

Direct inhibition of hypothalamic proopiomelanocortin neurons by dynorphin A is mediated by the μ-opioid receptor.

Reagan L Pennock et al.

The Journal of physiology, 592(19), 4247-4256 (2014-08-03)

It has recently been shown that dynorphin A (Dyn A), an endogenous agonist of the κ-opioid receptor (KOR), directly inhibits proopiomelanocortin (POMC) neurons in the hypothalamus through activation of G-protein-coupled inwardly rectifying K(+) channels (GIRKs). This effect has been proposed

Stimulation of accumbal GABAB receptors inhibits delta1- and delta2-opioid receptor-mediated dopamine efflux in the nucleus accumbens of freely moving rats.

Yuriko Watanabe et al.

European journal of pharmacology, 837, 88-95 (2018-08-08)

The nucleus accumbens contains delta-opioid receptors that may decrease inhibitory neurotransmission. As GABAB receptors inhibit dopamine release, decrease in activation of GABAB receptors may be a mediator of delta-opioid receptor-induced accumbal dopamine efflux. If so, accumbal dopamine efflux induced by

Synthesis of both enantiomers of baclofen using (R)-and (S)-N-phenylpantolactam as chiral auxiliaries

Camps P, et al.

Tetrahedron Asymmetry, 15(13) (2004)

Effects of Propofol on Electrical Synaptic Strength in Coupling Reticular Thalamic GABAergic Parvalbumin-Expressing Neurons.

Yu Zhang et al.

Frontiers in neuroscience, 14, 364-364 (2020-05-16)

Electrical synapses between neurons exhibit a high degree of plasticity, which makes critical contributions to neuronal communication. The GABAergic parvalbumin-expressing (PV+) neurons in the thalamic reticular nucleus (TRN) interact with each other through electrical and chemical synapses. Plasticity of electrical

Intracerebral Baclofen Administration Decreases Amphetamine-Induced Behavior and Neuropeptide Gene Expression in the Striatum

Wenxia Z, et al.

Neuropsychopharmacology, 880?890-880?890 (2004)

An efficient synthesis of (R)-and (S)-baclofen via desymmetrization

Ji L, et al.

Tetrahedron Letters, 50(45), 6166-6168 (2009)

3-(p-Chlorophenyl)-4-aminobutanoic acid--resolution into enantiomers and pharmacological activity.

B Witczuk et al.

Polish journal of pharmacology and pharmacy, 32(2), 187-196 (1980-03-01)

Racemic 3-(p-chlorophenyl)-4-aminobutanoic acid was resolved into enantiomers and their absolute configuration determined. Pharmacological activity of hydrochlorides of the racemic acid and its enantiomers has been determined. The R(+) enantiomer was found to be 4.2-9.2-fold as effective as the S(-) one

Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations.

E Falch et al.

Journal of neurochemistry, 47(3), 898-903 (1986-09-01)

The affinities of a number of analogues of gamma-aminobutyric acid (GABA) for GABAA and GABAB receptor sites and GABA uptake were studied using rat brain membrane preparations. Studies on the (S)-(+)- and (R)-(-)-isomers of baclofen, 3-hydroxy-4-aminobutyric acid (3-OH-GABA), and 4,5-dihydromuscimol

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