CN
Search Within
G0450000
Applied Filters:
Keyword:'G0450000'
Showing 1-30 of 544 results for "G0450000" within Papers
J Michael Wells et al.
American journal of respiratory and critical care medicine, 190(1), 51-61 (2014-05-31)
Chronic neutrophilic inflammation is a hallmark in the pathogenesis of chronic obstructive pulmonary disease (COPD) and persists after cigarette smoking has stopped. Mechanisms involved in this ongoing inflammatory response have not been delineated. We investigated changes to the leukotriene A4
Luoxiu Huang et al.
Journal of neuroscience research, 92(12), 1767-1774 (2014-07-22)
Retinal ganglion cells (RGCs), which are the sole output neurons of the retina, express N-methyl-D-aspartate receptors (NMDARs), rendering these cells susceptible to glutamate excitotoxicity, with implications for loss of normal RGC excitatory responses in disorders such as glaucoma and diabetic
Hollie Burrell-Saward et al.
The Journal of antimicrobial chemotherapy, 70(2), 510-517 (2014-10-10)
To optimize the Trypanosoma brucei brucei GVR35 VSL-2 bioluminescent strain as an innovative drug evaluation model for late-stage human African trypanosomiasis. An IVIS® Lumina II imaging system was used to detect bioluminescent T. b. brucei GVR35 parasites in mice to
Zuo Tong How et al.
Journal of chromatography. A, 1370, 135-146 (2014-12-03)
This paper reports a new analytical method for the analysis of 18 amino acids in natural waters using solid-phase extraction (SPE) followed by liquid chromatography-electrospray tandem mass spectrometry (LC-MS/MS) operated in multiple reaction monitoring mode. Two different preconcentration methods, solid-phase
Jia-Xuan Qiu et al.
Drug design, development and therapy, 9, 349-417 (2015-01-23)
Plumbagin (PLB) has exhibited a potent anticancer effect in preclinical studies, but the molecular interactome remains elusive. This study aimed to compare the quantitative proteomic responses to PLB treatment in human prostate cancer PC-3 and DU145 cells using the approach
Kevin S Jones et al.
PloS one, 9(10), e109303-e109303 (2014-10-08)
The dysfunction of parvalbumin-positive, fast-spiking interneurons (FSI) is considered a primary contributor to the pathophysiology of schizophrenia (SZ), but deficits in FSI physiology have not been explicitly characterized. We show for the first time, that a widely-employed model of schizophrenia
Amy A Boaro et al.
FEMS microbiology ecology, 90(3), 802-815 (2014-10-08)
Integrated 'omics have been used on pure cultures and co-cultures, yet they have not been applied to complex microbial communities to examine questions of perturbation response. In this study, we used integrated 'omics to measure the perturbation response of a
Olgary Figueroa-Santiago et al.
Infection and immunity, 82(12), 5005-5012 (2014-09-17)
The liver fluke Fasciola hepatica is a highly evolved parasite that uses sophisticated mechanisms to evade the host immune response. The immunosuppressive capabilities of the parasite have been associated with antigens secreted through the parasite's tegument, called excretory-secretory products (ESPs).
Xiaoyan Lin et al.
Nucleic acids research, 43(1), 446-460 (2014-12-19)
The replication enzyme of RNA viruses must preferentially recognize their RNAs in an environment that contains an abundance of cellular RNAs. The factors responsible for specific RNA recognition are not well understood, in part because viral RNA synthesis takes place
Eva F G Naninck et al.
Hippocampus, 25(3), 309-328 (2014-10-02)
Early life stress (ES) increases vulnerability to psychopathology and impairs cognition in adulthood. These ES-induced deficits are associated with lasting changes in hippocampal plasticity. Detailed information on the neurobiological basis, the onset, and progression of such changes and their sex-specificity
Mallappa K Kolar et al.
Stem cells and development, 23(14), 1659-1674 (2014-05-08)
Spinal cord injury triggers a cascade of degenerative changes leading to cell death and cavitation. Severed axons fail to regenerate across the scar tissue and are only capable of limited sprouting. In this study, we investigated the effects of adult
Jaleh Varshosaz et al.
Pharmaceutical development and technology, 20(2), 183-196 (2013-11-14)
Haloperidol (Hal) is a ligand that can target sigma 2 receptors over-expressed in non-small cell lung cancer. Hal targeted nanoparticles of bovine serum albumin (BSA) were prepared for pulmonary delivery of doxorubicin (DOX). The conjugation was confirmed by Fourier transform
Maria G A Hägglund et al.
Journal of molecular biology, 427(6 Pt B), 1495-1512 (2014-12-03)
Glutamine transporters are important for regulating levels of glutamate and GABA in the brain. To date, six members of the SLC38 family (SNATs) have been characterized and functionally subdivided them into System A (SNAT1, SNAT2 and SNAT4) and System N
Hong Ji et al.
PloS one, 9(10), e110314-e110314 (2014-10-21)
Secreted microRNAs (miRNAs) enclosed within extracellular vesicles (EVs) play a pivotal role in intercellular communication by regulating recipient cell gene expression and affecting target cell function. Here, we report the isolation of three distinct EV subtypes from the human colon
L A Ruocco et al.
Amino acids, 47(3), 637-650 (2015-01-18)
The Disrupted-in-schizophrenia 1 (DISC1) gene is involved in vulnerability to neuropsychiatric disorders. Naples high-excitability (NHE) rat model neuropsychiatric problems characterized by an unbalanced mesocortical dopamine system. Here, we assessed behavioral and neurochemical effects of immunization against multimeric rat DISC1 protein
Sung Huhn Kim et al.
PloS one, 9(10), e111039-e111039 (2014-10-21)
Meniere's disease is an inner ear disorder that can manifest as fluctuating vertigo, sensorineural hearing loss, tinnitus, and aural fullness. However, the pathologic mechanism of Meniere's disease is still unclear. In this study, we evaluated autoimmunity as a potential cause
Ajaz A Ganai et al.
Chemico-biological interactions, 214, 33-40 (2014-02-26)
Glycine propionyl l-carnitine (GPLC) is a propionyl ester of carnitine that includes an additional glycine component. The present study evaluated hepatoprotective effect of GPLC in d-Galactosamine (d-GalN) induced fulminant hepatic failure. Rats were intraperitonially administered d-GalN (700mg/kgBW). GPLC was given
Chao Deng et al.
Psychiatry research, 225(3), 347-354 (2015-01-13)
Neuregulin-1 (NRG1) and ErbB4 genes have been identified as candidate genes for schizophrenia. Post-mortem studies indicated that NRG1-ErbB4 signalling is impaired in schizophrenia subjects. This study investigated whether short- or long-term antipsychotic treatment has different effects on the expression of
Davide Bressanello et al.
Journal of chromatography. A, 1361, 265-276 (2014-08-28)
This study investigates the potential of a parallel dual secondary column-dual detection two-dimensional comprehensive GC platform (GC×2GC-MS/FID) for metabolic profiling and fingerprinting of mouse urine. Samples were obtained from a murine model that mimics a typical unhealthy Western diet featuring
Christian M Karsten et al.
Journal of immunology (Baltimore, Md. : 1950), 194(4), 1841-1855 (2015-01-16)
Many of the biological properties of C5a are mediated through activation of its receptor (C5aR1), the expression of which has been demonstrated convincingly on myeloid cells, such as neutrophils, monocytes, and macrophages. In contrast, conflicting results exist regarding C5aR1 expression
Ligia M Antunes-Correa et al.
American journal of physiology. Heart and circulatory physiology, 307(11), H1655-H1666 (2014-10-12)
Previous studies have demonstrated that muscle mechanoreflex and metaboreflex controls are altered in heart failure (HF), which seems to be due to changes in cyclooxygenase (COX) pathway and changes in receptors on afferent neurons, including transient receptor potential vanilloid type-1
Florian Mayer et al.
Journal of neurophysiology, 112(11), 2901-2915 (2014-09-05)
Neurons in the medial nucleus of the trapezoid body (MNTB) are well known for their prominent excitatory inputs, mediated by the calyx of Held. Less attention has been paid to the prominent inhibitory inputs that MNTB neurons also receive. Because
Kazushige Morishita et al.
Cell structure and function, 39(2), 113-124 (2014-10-15)
The dedicator of cytokinesis (DOCK) family proteins that are conserved in a wide variety of species are known as DOCK1-DOCK11 in mammals. The Sponge (Spg) is a Drosophila counterpart to the mammalian DOCK3. Specific knockdown of spg by pannir-GAL4 or
Brian M De Borba et al.
Journal of chromatography. A, 1369, 131-137 (2014-12-03)
An ion chromatography (IC) method was developed for the simultaneous determination of total nitrogen and total phosphorus after alkaline persulfate digestion. This study takes advantage of advances in construction of high-resolution, high-capacity anion-exchange columns that can better tolerate the matrices
Elaheh Gheybi et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(11), 11489-11497 (2014-08-17)
Breast cancer is the most common cancer among women in the world. One of the approaches for diagnosis of breast cancer is detection of its tumor-associated markers. Mucin 1 (MUC1), a tumor-associated antigen, is a transmembrane glycoprotein expressed by normal
Jenna M Puccini et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(13), 5271-5283 (2015-04-04)
Leucine-rich repeat kinase 2 (LRRK2) is the single most common genetic cause of both familial and sporadic Parkinson's disease (PD), both of which share pathogenetic and neurologic similarities with human immunodeficiency virus 1 (HIV-1)-associated neurocognitive disorders (HAND). Pathologic LRRK2 activity
Zai Ahmad et al.
PloS one, 10(3), e0119834-e0119834 (2015-03-19)
Medulloblastoma (MB) is the most common malignant pediatric brain tumor. While the pathways that are deregulated in MB remain to be fully characterized, amplification and/or overexpression of the MYCN gene, which is has a critical role in cerebellar development as
Nicholas A Dillon et al.
Antimicrobial agents and chemotherapy, 58(12), 7258-7263 (2014-09-24)
Pyrazinamide (PZA) is a first-line tuberculosis drug that inhibits the growth of Mycobacterium tuberculosis via an as yet undefined mechanism. An M. tuberculosis laboratory strain that was auxotrophic for pantothenate was found to be insensitive to PZA and to the
Johana Musso et al.
Analytical and bioanalytical chemistry, 407(5), 1285-1294 (2014-12-20)
Detection of protein biomarkers is of major interest in proteomics. This work reports the analysis of protein biomarkers directly from a biological fluid, human saliva, by surface plasmon resonance imaging coupled to mass spectrometry (SPRi-MS), using a functionalized biochip in
Vittorio Caggiano et al.
PloS one, 9(6), e100865-e100865 (2014-06-26)
Inhibitory neurons in the adult mammalian spinal cord are known to locally modulate afferent feedback--from muscle proprioceptors and from skin receptors--to pattern motor activity for locomotion and postural control. Here, using optogenetic tools, we explored how the same population of
Page 1 of 19