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Showing 1-30 of 435 results for "G0923" within Papers
Diego Jarquin et al.
Frontiers in genetics, 10, 1294-1294 (2020-02-11)
Genomic selection (GS) is an emerging methodology that helps select superior lines among experimental cultivars in plant breeding programs. It offers the opportunity to increase the productivity of cultivars by delivering increased genetic gains and reducing the breeding cycles. This
Kim Heang Ly et al.
Arthritis research & therapy, 16(6), 487-487 (2014-11-25)
Giant cell arteritis (GCA) is characterized by intimal hyperplasia leading to ischaemic manifestations that involve large vessels. Neurotrophins (NTs) and their receptors (NTRs) are protein factors for growth, differentiation and survival of neurons. They are also involved in the migration
Peng Jiang et al.
Xenobiotica; the fate of foreign compounds in biological systems, 50(6), 670-676 (2019-11-22)
This study aimed to observe the influence of Sophora flavescens alcohol extract (SFAE) on hepatic metabolic profiling in rats to explore the possible mechanism of hepatotoxicity induced by S. flavescens.Male Sprague-Dawley rats were randomly divided into three groups (n = 6 in
Sung Hwa Shin et al.
PloS one, 10(6), e0127784-e0127784 (2015-06-09)
Uncoordinated 51-like kinase 2 (ULK2), a member of the serine/threonine kinase family, plays an essential role in the regulation of autophagy in mammalian cells. Given the role of autophagy in normal cellular homeostasis and in multiple diseases, improved mechanistic insight
Heinz Fischer et al.
Frontiers in immunology, 11, 939-939 (2020-06-24)
Zoonotic infections are an imminent threat to human health. Pangolins were recently identified as carriers and intermediate hosts of coronaviruses. Previous research has shown that infection with coronaviruses activates an innate immune response upon sensing of viral RNA by interferon-induced
Wulong Liang et al.
Journal of biosciences, 42(1), 43-56 (2017-02-24)
The Golgi apparatus and its resident proteins are utilized and regulated by viruses to facilitate their proliferation. In this study, we investigated Classical swine fever virus (CSFV) proliferation when the function of the Golgi was disturbed. Golgi function was disturbed
Tik-Chee Cheng et al.
American journal of physiology. Heart and circulatory physiology, 319(6), H1459-H1473 (2020-10-17)
Although women are more susceptible to pulmonary arterial hypertension (PAH) than men, their right ventricular (RV) function is better preserved. Estrogen receptor-α (ERα) has been identified as a likely mediator for estrogen protection in the RV. However, the role of
Artur Zajkowicz et al.
Cellular signalling, 27(9), 1677-1687 (2015-05-20)
The p53 tumor suppressor protein is a transcription factor activated by phosphorylation of its N-terminus. MDM2, encoded by a p53-activated gene, acts as a negative-feedback regulator of p53 by promoting p53 degradation. Moreover, MDM2 inhibits p53 by binding to and
Subin Park et al.
Behavioral and brain functions : BBF, 10, 43-43 (2014-11-27)
We aimed to determine whether early parenting is associated with externalizing and internalizing symptoms in children with attention-deficit hyperactivity disorder (ADHD) and whether such an association is affected by the brain-derived neurotrophic factor (BDNF) val66met polymorphism. The participants included 92
Farhad Islami et al.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 17(3), 429-439 (2018-06-15)
There is limited information on contemporary incidence rates and trends, by race, ethnicity, and age, for major subtypes of esophageal and gastric cancer in the United States. We examined the most recent nationwide incidence data for esophageal squamous cell carcinoma
Simone Guedes Calderano et al.
Nucleic acids research, 43(5), 2655-2665 (2015-02-19)
Eukaryotic genome duplication relies on origins of replication, distributed over multiple chromosomes, to initiate DNA replication. A recent genome-wide analysis of Trypanosoma brucei, the etiological agent of sleeping sickness, localized its replication origins to the boundaries of multigenic transcription units.
Michaela Jung et al.
Scientific reports, 6, 21950-21950 (2016-02-26)
Renal ischemia-reperfusion injury triggers an inflammatory response associated to infiltrating macrophages which determines the further outcome of disease. Brown Norway rats are known to show endogenous resistance to ischemia-induced renal damage. By contrast, Sprague Dawley rats exhibit a higher susceptibility
Lijun Hou et al.
Environmental science & technology, 49(1), 326-333 (2014-12-20)
Denitrification is an important pathway of nitrogen removal and nitrous oxide (N2O) production in estuarine and coastal ecosystems, and plays a significant role in counteracting aquatic eutrophication induced by excessive nitrogen loads. Estuarine and coastal environments also suffer from increasing
Hilary C Martin et al.
Molecular biology and evolution, 35(5), 1238-1252 (2018-04-25)
The platypus is an egg-laying mammal which, alongside the echidna, occupies a unique place in the mammalian phylogenetic tree. Despite widespread interest in its unusual biology, little is known about its population structure or recent evolutionary history. To provide new
Balázs Kalapos et al.
Scientific reports, 9(1), 4094-4094 (2019-03-13)
Mitogen-activated protein kinase (MAPK) pathways are central cellular signalling mechanisms in all eukaryotes. They are key regulators of the cell cycle and stress responses, yet evolution of MAPK families took markedly different paths in the animal and plant kingdoms. Instead
Yang Yang et al.
Oncology letters, 13(5), 3151-3158 (2017-05-20)
Colorectal cancer (CRC) is the third most common cancer worldwide and its treatment remains a challenge. Effective control of cell survival and proliferation is critical in the prevention of oncogenesis and successful treatment of cancer. Long non-coding RNAs (lncRNAs) have
Lijuan Zhao et al.
Diabetes research and clinical practice, 169, 108418-108418 (2020-09-07)
Studies have shown that destruction of the intestinal barrier in type 2 diabetes (T2D) leads to increased absorption of macromolecules from intestinal. We previously exhibited that short-chain fatty acids (SCFAs) and bile acids (BAs) were significantly decreased in faeces of
Federica Mangili et al.
Frontiers in endocrinology, 11, 611752-611752 (2021-03-06)
The actin binding protein filamin A (FLNA) is required for somatostatin receptor 2 (SSTR2) and dopamine receptor 2 (DRD2) expression and signaling in GH- and PRL-secreting PitNETs, respectively, playing a role in tumor responsiveness to somatostatin receptors ligands and dopaminergic
Catherine A Sánchez et al.
Oncotarget, 7(4), 3993-4008 (2015-12-18)
The different prostate cancer (PCa) cell populations (bulk and cancer stem cells, CSCs) release exosomes that contain miRNAs that could modify the local or premetastatic niche. The analysis of the differential expression of miRNAs in exosomes allows evaluating the differential
Tocilizumab increased sustained glucocorticoid-free remission from giant cell arteritis.
Nataliya Milman
Annals of internal medicine, 167(12), JC63-JC63 (2017-12-20)
Anton Kuzmenko et al.
Nature, 587(7835), 632-637 (2020-07-31)
Members of the conserved Argonaute protein family use small RNA guides to locate their mRNA targets and regulate gene expression and suppress mobile genetic elements in eukaryotes1,2. Argonautes are also present in many bacterial and archaeal species3-5. Unlike eukaryotic proteins
Pieter H Nienhuis et al.
Seminars in arthritis and rheumatism, 50(4), 616-623 (2020-06-06)
Assessing cranial artery inflammation plays an important role in the diagnosis of cranial giant cell arteritis (C-GCA). However, current diagnostic tests are limited. The use of fluorine-18-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT imaging is an established tool for assessing large
Andre L Samson et al.
Nature communications, 11(1), 3151-3151 (2020-06-21)
Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory necroptotic cell death program. RIPK3-mediated phosphorylation is thought to initiate MLKL oligomerization, membrane translocation and membrane disruption, although the precise choreography of events is incompletely understood. Here, we
Wuyi Wang et al.
Frontiers in human neuroscience, 12, 151-151 (2018-05-22)
In a study of the stop signal task (SST) we employed Bayesian modeling to compute the estimated likelihood of stop signal or P(Stop) trial by trial and identified regional processes of conflict anticipation and response slowing. A higher P(Stop) is
Will Draper et al.
Nature communications, 8, 14838-14838 (2017-03-23)
Bacterial chemoreceptors organize into large clusters at the cell poles. Despite a wealth of structural and biochemical information on the system's components, it is not clear how chemoreceptor clusters are reliably targeted to the cell pole. Here, we quantify the
David Gómez-Ríos et al.
Microorganisms, 8(9) (2020-08-23)
Streptomyces clavuligerus is a filamentous Gram-positive bacterial producer of the β-lactamase inhibitor clavulanic acid. Antibiotics biosynthesis in the Streptomyces genus is usually triggered by nutritional and environmental perturbations. In this work, a new genome scale metabolic network of Streptomyces clavuligerus
Guohao Wang et al.
Nature communications, 11(1), 220-220 (2020-01-12)
Cancer stem cells (CSCs) may be responsible for treatment resistance, tumor metastasis, and disease recurrence. Here we demonstrate that the Arf1-mediated lipid metabolism sustains cells enriched with CSCs and its ablation induces anti-tumor immune responses in mice. Notably, Arf1 ablation
Ying Xu et al.
Journal of diabetes and its complications, 29(8), 976-983 (2015-08-25)
With intensive investigations recently, autophagy is hoped to be a potential therapeutic target to prevent or alleviate diabetic nephropathy (DN). Our previous study revealed that lipotoxicity participated in epithelial-to-mesenchymal transition (EMT) of proximal tubular epithelial cells (PTECs) under diabetic conditions.
Grégory Pugnet et al.
The Journal of rheumatology, 42(2), 316-322 (2014-12-17)
To investigate the potential association between statin use and giant cell arteritis (GCA) course. Using the French National Health Insurance system, we included patients with incident GCA from the Midi-Pyrenees region, southern France, from January 2005 to December 2008 and
Sien Hu et al.
NeuroImage, 119, 286-295 (2015-06-23)
Previous studies have examined the neural correlates of proactive control using a variety of behavioral paradigms; however, the neural network relating the control process to its behavioral consequence remains unclear. Here, we applied a dynamic Bayesian model to a large
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