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Showing 1-30 of 435 results for "G0923" within Papers
Xiaoyan Bao et al.
Journal of nanobiotechnology, 18(1), 67-67 (2020-04-30)
Exenatide is an insulinotropic peptide drug for type 2 diabetes treatment with low risk of hypoglycemia, and is administrated by subcutaneous injection. Oral administration is the most preferred route for lifelong treatment of diabetes, but oral delivery of peptide drug
Luz Alejandra Castillo-Alanis et al.
Journal of medical entomology, 57(5), 1421-1431 (2020-05-23)
One of the problems faced by entomotoxicological studies is the large variability of experimental set-ups and the absence of harmonized protocols to compare the data and results obtained by different research groups. Among the wide range of influencing factors on
Jiasheng Wu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1153, 122269-122269 (2020-08-03)
Natural bear bile powder (NBBP) is a famous traditional medicine and has been widely used in clinic. However, access to the sources of bear bile is restricted; hence, it is essential to discover new substitutes for NBBP. Cultured bear bile
Irina Vyazunova et al.
PloS one, 9(11), e113489-e113489 (2014-11-26)
Genomic studies of human high-grade gliomas have discovered known and candidate tumor drivers. Studies in both cell culture and mouse models have complemented these approaches and have identified additional genes and processes important for gliomagenesis. Previously, we found that mobilization
Tingting Yang et al.
The Journal of steroid biochemistry and molecular biology, 172, 69-78 (2017-06-07)
Bile acid homeostasis is maintained by liver synthesis, bile duct secretion, microbial metabolism and intestinal reabsorption into the blood. When drug insults result in liver damage, the variances of bile acids (BAs) are related to the physiological status of the
Xiao Chen et al.
Clinica chimica acta; international journal of clinical chemistry, 497, 67-75 (2019-07-06)
Asymptomatic hypercholanemia of pregnancy (AHP) is a controversial hypercholanemia, which is difficult to distinguish from intrahepatic cholestasis of pregnancy (ICP). Our aim is to elucidate the characteristics of urinary bile acid (BA) profiling of women with AHP and to find
Ujjal Sarkar et al.
Drug metabolism and disposition: the biological fate of chemicals, 45(7), 855-866 (2017-04-30)
In vitro hepatocyte culture systems have inherent limitations in capturing known human drug toxicities that arise from complex immune responses. Therefore, we established and characterized a liver immunocompetent coculture model and evaluated diclofenac (DCF) metabolic profiles, in vitro-in vivo clearance
Dongying Zhao et al.
BMC pediatrics, 20(1), 255-255 (2020-05-29)
Early distinguishing biliary atresia from other causes of infantile cholestasis remains a major challenge. We aimed to develop and validate a scoring system based on bile acid for identification of biliary atresia. In a prospective study, a total of 141
Simone Hanna Brütsch et al.
Antioxidants & redox signaling, 22(4), 281-293 (2014-10-15)
Glutathione peroxidases (Gpx) and lipoxygenases (Alox) are functional counterplayers in the metabolism of hydroperoxy lipids that regulate cellular redox homeostasis. Gpx4 is a moonlighting protein that has been implicated not only as an enzyme in anti-oxidative defense, gene expression regulation
Mona Hommada et al.
Autoimmunity reviews, 16(11), 1131-1137 (2017-09-16)
To assess the detection rate of aortitis in giant cell arteritis (GCA) with fluorodeoxyglucose positron emission tomography/computed tomography (PET) and to compare the findings with CT angiography (CTA). Fifty-two GCA patients and 27 controls were included. GCA patients had a
Julia Jehn et al.
RNA (New York, N.Y.), 26(6), 694-707 (2020-03-08)
Fragments of mature tRNAs have long been considered as mere degradation products without physiological function. However, recent reports show that tRNA-derived small RNAs (tsRNAs) play prominent roles in diverse cellular processes across a wide spectrum of species. Contrasting the situation
Yaofeng Cheng et al.
The Journal of pharmacology and experimental therapeutics, 362(3), 385-394 (2017-06-25)
The interference of bile acid secretion through bile salt export pump (BSEP) inhibition is one of the mechanisms for troglitazone (TGZ)-induced hepatotoxicity. Here, we investigated the impact of single or repeated oral doses of TGZ (200 mg/kg/day, 7 days) on
Snehal N Chaudhari et al.
Cell host & microbe, 29(3), 408-424 (2021-01-13)
Bariatric surgery is the most effective treatment for type 2 diabetes and is associated with changes in gut metabolites. Previous work uncovered a gut-restricted TGR5 agonist with anti-diabetic properties-cholic acid-7-sulfate (CA7S)-that is elevated following sleeve gastrectomy (SG). Here, we elucidate
ERK8 is a negative regulator of O-GalNAc glycosylation and cell migration.
Chia J, et al.
eLife, 3(6), e01828-e01828 (2014)
Heng Li et al.
Nature methods, 15(8), 595-597 (2018-07-18)
Existing benchmark datasets for use in evaluating variant-calling accuracy are constructed from a consensus of known short-variant callers, and they are thus biased toward easy regions that are accessible by these algorithms. We derived a new benchmark dataset from the
Juan Wang et al.
Cancer biomarkers : section A of Disease markers, 23(2), 193-203 (2018-09-11)
Circulating microRNAs (miRNAs) have been implicated as novel biomarkers for various types of cancers. The aim of the study is to identify serum miRNAs with potential in detecting gastric cardia adenocarcinoma (GCA). A three-phase study was designed with 102 GCA
Anthony M Sammel et al.
International journal of rheumatic diseases, 23(4), 582-588 (2020-02-27)
Positron emission tomography/computed tomography (PET/CT) can detect cranial and large vessel inflammation in giant cell arteritis (GCA). We aimed to determine the change and significance of vascular activity at diagnosis and 6 months. Newly diagnosed GCA patients underwent time-of-flight fluorine-18-fluoro-2-deoxyglucose PET/CT
Luca Ambrosino et al.
Developmental biology, 448(2), 101-110 (2018-12-24)
Non-coding regions with dozens to several hundred base pairs of extreme conservation have been found in all metazoan genomes. The distribution of these conserved non-coding elements (CNE) within and across genomes has suggested that many of them may have roles
Katherine J Picott et al.
MedChemComm, 10(3), 478-483 (2019-04-25)
Tambjamines are natural products that consist of a conserved bipyrrole core functionalized with different imines giving rise to many derivatives. The core structure of tambjamines allows ion coordination through the nitrogen atoms, which is a key aspect in many of
Yuhao Jiang et al.
Scientific reports, 9(1), 5927-5927 (2019-04-13)
There is growing evidence that the amygdala serves as the base for dealing with complex human social communication and emotion. Although amygdalar networks plays a central role in these functions, causality connectivity during the human lifespan between amygdalar subregions and
G Maugars et al.
General and comparative endocrinology, 287, 113350-113350 (2019-12-04)
Since its discovery in birds, gonadotropin-inhibitory hormone (GnIH) has triggered investigation in the other groups of vertebrates. In the present study, we have identified a single gnih gene in the European eel (Anguilla anguilla), a representative species of a basal
Yan Dong et al.
Oncology reports, 34(2), 936-942 (2015-06-13)
Ovarian cancer is one of the most common types of cancer in females and is the leading cause of death among gynaecological cancers in women worldwide. In the present study, we identified insulin-like growth factor 2 (IGF2) as a differentially
Xiaoyan Chu et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(6), 851-863 (2015-03-31)
Inhibition of hepatic transporters such as organic anion transporting polypeptides (OATPs) 1B can cause drug-drug interactions (DDIs). Determining the impact of perpetrator drugs on the plasma exposure of endogenous substrates for OATP1B could be valuable to assess the risk for
Qi Zhao et al.
Scientific reports, 7(1), 9967-9967 (2017-09-01)
Intrahepatic cholestasis induced by drug toxicity, bile salt export pump (BSEP) deficiency, or pregnancy frequently causes cholestatic liver damage, which ultimately may lead to liver fibrosis and cirrhosis. Here, the preventive and therapeutic effects of peroxisome proliferator-activated receptor α (PPARα)
Ayane Shikano et al.
Food research international (Ottawa, Ont.), 121, 817-824 (2019-05-22)
To clarify the effect of loofah Luffa cylindrica and fermented loofah on hyperlipidemia, the in vitro bile acid lowering capacity and blood lipid levels of ddY mice fed high-fat diet supplemented with loofah were determined. Furthermore, the caecal microbiomes patterns
Anna-Marie Finger et al.
Science advances, 7(30) (2021-07-25)
Coupling between cell-autonomous circadian oscillators is crucial to prevent desynchronization of cellular networks and disruption of circadian tissue functions. While neuronal oscillators within the mammalian central clock, the suprachiasmatic nucleus, couple intercellularly, coupling among peripheral oscillators is controversial and the
Jiyong Liang et al.
Nature communications, 6, 7926-7926 (2015-08-15)
AMP-activated protein kinase (AMPK) plays a central role in cellular energy sensing and bioenergetics. However, the role of AMPK in surveillance of mitochondrial damage and induction of mitophagy remains unclear. We demonstrate herein that AMPK is required for efficient mitophagy.
Kyungsil Yoon et al.
Cells, 8(3) (2019-03-15)
Chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI) is an orphan receptor and member of the nuclear receptor superfamily. Among a series of methylene substituted diindolylmethanes (C-DIMs) containing substituted phenyl and heteroaromatic groups, we identified 1,1-bis(3'-indolyl)-1-(4-pyridyl)-methane (DIM-C-Pyr-4) as an activator of
Sonja Vanderhaeghen et al.
FEMS microbiology letters, 362(13), fnv092-fnv092 (2015-05-31)
Hydrogenotrophic methanogens live in a synthrophic relationship with the human gut microbiota as the terminal part of the anaerobic food chain. Methanobrevibacter smithii of the Methanobacteriales is the prevailing archaeal species. Recently, methylotrophic archaea of the novel order Methanomassiliicoccales were
Rafael Plana Simões et al.
Molecular genetics and genomics : MGG, 296(2), 289-298 (2020-12-01)
The lack of consensus concerning the biological meaning of entropy and complexity of genomes and the different ways to assess these data hamper conclusions concerning what are the causes of genomic entropy variation among species. This study aims to evaluate
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