G11950

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Showing 1-30 of 228 results for "G11950" within Papers

Plumbagin elicits differential proteomic responses mainly involving cell cycle, apoptosis, autophagy, and epithelial-to-mesenchymal transition pathways in human prostate cancer PC-3 and DU145 cells.

Jia-Xuan Qiu et al.

Drug design, development and therapy, 9, 349-417 (2015-01-23)

Plumbagin (PLB) has exhibited a potent anticancer effect in preclinical studies, but the molecular interactome remains elusive. This study aimed to compare the quantitative proteomic responses to PLB treatment in human prostate cancer PC-3 and DU145 cells using the approach

Formation of 8-nitroguanine by the reaction of guanine with peroxynitrite in vitro.

V Yermilov et al.

Carcinogenesis, 16(9), 2045-2050 (1995-09-01)

Nitric oxide and superoxide anion, both formed in inflamed tissues, react rapidly to form the peroxynitrite anion (ONOO-), a strong oxidant which can initiate reactions characteristic of hydroxyl radical (HO.), nitronium ion (NO2+) and nitrogen dioxide radical (NO2.). Peroxynitrite, therefore

ROCK1 and 2 differentially regulate actomyosin organization to drive cell and synaptic polarity.

Karen A Newell-Litwa et al.

The Journal of cell biology, 210(2), 225-242 (2015-07-15)

RhoGTPases organize the actin cytoskeleton to generate diverse polarities, from front-back polarity in migrating cells to dendritic spine morphology in neurons. For example, RhoA through its effector kinase, RhoA kinase (ROCK), activates myosin II to form actomyosin filament bundles and

[Efficacy of first-line afatinib versus chemotherapy in EGFR mutation positive pulmonary adenocarcinoma].

Veronika Sárosi et al.

Magyar onkologia, 58(4), 325-329 (2014-12-18)

Therapy of patients with advanced NSCLC has lately changed due to the algorithm based on the presence or absence of oncogenic mutations. There is an agreement nowadays that in the presence of activating EGFR mutations, the administration of EGFR TKI

Oxygen as a friend and enemy: How to combat the mutational potential of 8-oxo-guanine.

Barbara van Loon et al.

DNA repair, 9(6), 604-616 (2010-04-20)

The maintenance of genetic stability is of crucial importance for any form of life. Prior to cell division in each mammalian cell, the process of DNA replication must faithfully duplicate the three billion bases with an absolute minimum of mistakes.

M. leprae components induce nerve damage by complement activation: identification of lipoarabinomannan as the dominant complement activator.

Nawal Bahia El Idrissi et al.

Acta neuropathologica, 129(5), 653-667 (2015-03-17)

Peripheral nerve damage is the hallmark of leprosy pathology but its etiology is unclear. We previously identified the membrane attack complex (MAC) of the complement system as a key determinant of post-traumatic nerve damage and demonstrated that its inhibition is

Cyclic di-GMP riboswitch-regulated type IV pili contribute to aggregation of Clostridium difficile.

Eric Bordeleau et al.

Journal of bacteriology, 197(5), 819-832 (2014-12-17)

Clostridium difficile is an anaerobic Gram-positive bacterium that causes intestinal infections with symptoms ranging from mild diarrhea to fulminant colitis. Cyclic diguanosine monophosphate (c-di-GMP) is a bacterial second messenger that typically regulates the switch from motile, free-living to sessile and

Phase II study of pemetrexed in combination with cisplatin in patients with advanced urothelial cancer: the PECULIAR study (KCSG 10-17).

Y J Choi et al.

British journal of cancer, 112(2), 260-265 (2014-11-28)

Pemetrexed has shown a favourable response rate of about 30% with minimal toxicity when used as a single agent for treatment of advanced urothelial carcinoma. This phase II study evaluated the efficacy and safety of pemetrexed plus cisplatin in advanced

Annexin A4 is a novel direct regulator of adenylyl cyclase type 5.

Alexander Heinick et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(9), 3773-3787 (2015-05-30)

Annexin A4 (AnxA4), a Ca(2+)- and phospholipid-binding protein, is up-regulated in the human failing heart. In this study, we examined the impact of AnxA4 on β-adrenoceptor (β-AR)/cAMP-dependent signal transduction. Expression of murine AnxA4 in human embryonic kidney (HEK)293 cells dose-dependently

Immunohistochemical analysis of the natural killer cell cytotoxicity pathway in human abdominal aortic aneurysms.

Irene Hinterseher et al.

International journal of molecular sciences, 16(5), 11196-11212 (2015-05-21)

Our previous analysis using genome-wide microarray expression data revealed extreme overrepresentation of immune related genes belonging the Natural Killer (NK) Cell Mediated Cytotoxicity pathway (hsa04650) in human abdominal aortic aneurysm (AAA). We followed up the microarray studies by immunohistochemical analyses

Peroxynitrite-induced oxidation and nitration products of guanine and 8-oxoguanine: structures and mechanisms of product formation.

Jacquin C Niles et al.

Nitric oxide : biology and chemistry, 14(2), 109-121 (2005-12-15)

Peroxynitrite induces DNA base damage predominantly at guanine (G) and 8-oxoguanine (8-oxoG) nucleobases via oxidation reactions. Nitration products are also observed, consistent with the generation of radical intermediates that can recombine with the (.)NO(2) formed during peroxynitrite degradation. The neutral

[Critical role of nitrated cyclic guanine nucleotide signaling via protein S-guanylation in the antioxidant adaptive response].

Shigemoto Fujii et al.

Seikagaku. The Journal of Japanese Biochemical Society, 84(2), 124-128 (2012-05-04)

Use of individual retention modeling for gradient optimization in hydrophilic interaction chromatography: separation of nucleobases and nucleosides.

Eva Tyteca et al.

Journal of chromatography. A, 1368, 125-131 (2014-12-03)

In this study, the separation of twelve nucleobases and nucleosides was optimized via chromatogram simulation (i.e., prediction of individual retention times and estimation of the peak widths) with the use of an empirical (reversed-phase) non-linear model proposed by Neue and

Proteomic analysis of the mouse brain after repetitive exposure to hypoxia.

Can Cui et al.

Chemico-biological interactions, 236, 57-66 (2015-05-06)

Hypoxic preconditioning (HPC) is known to have a protective effect against hypoxic damage; however, the precise mechanisms involved remain unknown. In this study, an acute and repetitive hypoxia mouse model, two-dimensional fluorescence difference gel electrophoresis (2D-DIGE) coupled with matrix-assisted laser

Glycogen synthase kinase 3β sustains invasion of glioblastoma via the focal adhesion kinase, Rac1, and c-Jun N-terminal kinase-mediated pathway.

Yuri Chikano et al.

Molecular cancer therapeutics, 14(2), 564-574 (2014-12-17)

The failure of current treatment options for glioblastoma stems from their inability to control tumor cell proliferation and invasion. Biologically targeted therapies offer great hope and one promising target is glycogen synthase kinase-3β (GSK3β), implicated in various diseases, including cancer.

Is antiviral prophylaxis necessary to prevent hepatitis B virus (HBV) reactivation in patients with HBV-resolved infection receiving rituximab-containing chemotherapy?

Shigeru Kusumoto et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(35), 4480-4480 (2013-11-14)

Whether Alzheimer's diseases related genes also differently express in the hippocampus of Ts65Dn mice?

Bin Zhang et al.

International journal of clinical and experimental pathology, 8(4), 4120-4125 (2015-06-23)

Down syndrome is a condition which extra genetic material causes delays in child development, both mentally and physically. Strengthening the study of the neural defects of DS is of great significance. Ts65Dn mice were used in this study. We removed

Base excision repair of oxidative DNA damage coupled with removal of a CAG repeat hairpin attenuates trinucleotide repeat expansion.

Meng Xu et al.

Nucleic acids research, 42(6), 3675-3691 (2014-01-16)

Trinucleotide repeat (TNR) expansion is responsible for numerous human neurodegenerative diseases. However, the underlying mechanisms remain unclear. Recent studies have shown that DNA base excision repair (BER) can mediate TNR expansion and deletion by removing base lesions in different locations

In vivo NCL targeting affects breast cancer aggressiveness through miRNA regulation.

Flavia Pichiorri et al.

The Journal of experimental medicine, 210(5), 951-968 (2013-04-24)

Numerous studies have described the altered expression and the causal role of microRNAs (miRNAs) in human cancer. However, to date, efforts to modulate miRNA levels for therapeutic purposes have been challenging to implement. Here we find that nucleolin (NCL), a

Modulation of Glucagon-like Peptide-1 (GLP-1) Potency by Endocannabinoid-like Lipids Represents a Novel Mode of Regulating GLP-1 Receptor Signaling.

Yu-Hong Cheng et al.

The Journal of biological chemistry, 290(23), 14302-14313 (2015-04-24)

Glucagon-like peptide-1 (GLP-1) analogs are approved for treatment of type 2 diabetes and are in clinical trials for disorders including neurodegenerative diseases. GLP-1 receptor (GLP-1R) is expressed in many peripheral and neuronal tissues and is activated by circulating GLP-1. Other

Does long-term entecavir treatment really reduce hepatocellular carcinoma incidence in patients with hepatitis B virus infection?

Gin-Ho Lo

Hepatology (Baltimore, Md.), 59(5), 2053-2053 (2013-10-15)

Transcriptome networks in the mouse retina: An exon level BXD RI database.

Rebecca King et al.

Molecular vision, 21, 1235-1251 (2015-11-26)

Differences in gene expression provide diverse retina phenotypes and may also contribute to susceptibility to injury and disease. The present study defines the transcriptome of the retina in the BXD RI strain set, using the Affymetrix Mouse Gene 2.0 ST

Lead compounds for antimalarial chemotherapy: purine base analogs discriminate between human and P. falciparum 6-oxopurine phosphoribosyltransferases.

Dianne T Keough et al.

Journal of medicinal chemistry, 49(25), 7479-7486 (2006-12-08)

The malarial parasite Plasmodium falciparum depends on the purine salvage enzyme hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT) to convert purine bases from the host to nucleotides needed for DNA and RNA synthesis. An approach to developing antimalarial drugs is to use HGXPRT to

Phase II trial of carboplatin and pemetrexed as first-line chemotherapy for non-squamous non-small cell lung cancer, and correlation between the efficacy/toxicity and genetic polymorphisms associated with pemetrexed metabolism: Hokkaido Lung Cancer Clinical Study Group Trial (HOT) 0902.

Kenya Kanazawa et al.

Cancer chemotherapy and pharmacology, 74(6), 1149-1157 (2014-10-09)

This phase II study evaluated the response rate (RR) and safety of combination therapy with carboplatin (CBDCA) and pemetrexed (PEM) in Japanese patients with non-squamous non-small cell lung cancer (non-sq NSCLC). Further, the relationship between therapy efficacy/toxicity and genetic polymorphisms

Identification and expression analysis of the LRR-RLK gene family in tomato (Solanum lycopersicum) Heinz 1706.

Zhirong Wei et al.

Genome, 58(4), 121-134 (2015-07-25)

As the largest subfamily of receptor-like kinases (RLKs), leucine-rich repeat receptor-like kinases (LRR-RLKs) regulate the growth, development, and stress responses of plants. Through a reiterative process of sequence analysis and re-annotation, 234 LRR-RLK genes were identified in the genome of

Eukaryotic translation initiation factor 5A inhibition alters physiopathology and immune responses in a "humanized" transgenic mouse model of type 1 diabetes.

Shahnawaz Imam et al.

American journal of physiology. Endocrinology and metabolism, 306(7), E791-E798 (2014-02-06)

Therapeutic options for treatment of type 1 diabetes (T1D) are still missing. New avenues for immune modulation need to be developed. Here we attempted at altering the diabetes outcome of our humanized model of T1D by inhibiting translation-initiation factor eIF5A

Optimal antiviral prophylaxis against hepatitis B reactivation in patients receiving rituximab-based chemotherapy for lymphoma.

Jeremy S Abramson et al.

JAMA, 312(23), 2505-2507 (2014-12-17)

Kif20a inhibition reduces migration and invasion of pancreatic cancer cells.

Daniela Stangel et al.

The Journal of surgical research, 197(1), 91-100 (2015-05-09)

The Translational Genome Research Network in Pancreatic Cancer performed a meta-analysis of publicly available various high-throughput gene analysis panels to identify drugable targets. There, the most differentially expressed gene between normal and cancerous pancreas was Kif20a. The aim of the

The DNA methylation signature of human TCRαβ+CD4-CD8- double negative T cells reveals CG demethylation and a unique epigenetic architecture permissive to a broad stimulatory immune response.

Paul A Renauer et al.

Clinical immunology (Orlando, Fla.), 156(1), 19-27 (2014-12-03)

T cell receptor (TCR) αβ+CD4-CD8- double negative T cells represent a rare T cell subset implicated in the pathogenesis of several autoimmune diseases. We investigated the DNA methylation signature of double negative T cells to gain insight into the epigenetic

Adherence to medication is a more important contributor to viral breakthrough in chronic hepatitis B patients treated with entecavir than in those with Lamivudine.

Hidehiro Kamezaki et al.

International journal of medical sciences, 10(5), 567-574 (2013-03-28)

Viral breakthrough is related to poor adherence to medication in some chronic hepatitis B patients treated with nucleos(t)ide analogues (NAs). Our study aimed to examine how adherence to medication is associated with viral breakthrough in patients treated with NAs. A

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