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Showing 1-30 of 88 results for "G1N70" within Papers
Christian Marinaccio et al.
Cancer discovery, 11(6), 1398-1410 (2021-02-14)
The myeloproliferative neoplasms (MPN) frequently progress to blast phase disease, an aggressive form of acute myeloid leukemia. To identify genes that suppress disease progression, we performed a focused CRISPR/Cas9 screen and discovered that depletion of LKB1/Stk11 led to enhanced in
Scott D Zawieja et al.
American journal of physiology. Heart and circulatory physiology, 302(3), H643-H653 (2011-12-14)
Numerous studies on metabolic syndrome (MetSyn), a cluster of metabolic abnormalities, have demonstrated its profound impact on cardiovascular and blood microvascular health; however, the effects of MetSyn on lymphatic function are not well understood. We hypothesized that MetSyn would modulate
J M Meredith et al.
Insect molecular biology, 17(2), 103-112 (2008-03-21)
cDNAs of Anopheles gambiae Defensin 2 (AgDef2), Defensin 3 (AgDef3) and Defensin 4 (AgDef4), identified in the genome sequence, have been characterized and their expression profiles investigated. In contrast to both typical defensins and insect antimicrobial peptides generally, the newly
Bing-Chuan Geng et al.
Acta pharmacologica Sinica, 41(11), 1427-1432 (2020-06-20)
Induced pluripotent stem cells (iPSCs) have become an essential research platform to study different human diseases once being discovered by Dr. Shinya Yamanaka in 2006. Another breakthrough in biomedical research is the application of CRISPR/Cas9 system for genome editing in
Ida Beate Ø Østhus et al.
PloS one, 7(12), e52769-e52769 (2013-01-10)
Telomeres are potential markers of mitotic cellular age and are associated with physical ageing process. Long-term endurance training and higher aerobic exercise capacity (VO(2max)) are associated with improved survival, and dynamic effects of exercise are evident with ageing. However, the
Nicolas Le May et al.
Molecular cell, 47(4), 622-632 (2012-07-10)
Nucleotide excision repair factors, initially characterized as part of DNA repair, have been shown to participate in the transcriptional process in the absence of genotoxic attack. However, their molecular function when recruited at the promoters of activated genes together with
Yurika Miyoshi et al.
Amino acids, 43(5), 1919-1931 (2012-09-20)
For elucidation of the regulation mechanisms of intrinsic amounts of D-serine (D-Ser) which modulates the neuro-transmission of N-methyl-D-aspartate receptors in the brain, mutant animals lacking serine racemase (SRR) and D-amino acid oxidase (DAO) were established, and the amounts of D-Ser
Bo He et al.
International journal of oncology, 59(5) (2021-09-25)
The expression of microRNA‑383 (miR‑383) is downregulated in a variety of tumor tissues, and it exhibits antiproliferative activity in non‑small cell lung cancer cells. In the present study, an association between the downregulation of miR‑383 expression and the deletion of
Matthew J Coussens et al.
Journal of visualized experiments : JoVE, (58)(58), doi:10-doi:10 (2012-01-05)
RNA interference (RNAi) is an intrinsic cellular mechanism for the regulation of gene expression. Harnessing the innate power of this system enables us to knockdown gene expression levels in loss of gene function studies. There are two main methods for
Hanieh Ghassabian et al.
Viruses, 13(5) (2021-06-03)
Human cytomegalovirus (HCMV) is a leading cause of severe diseases in immunocompromised individuals, including AIDS patients and transplant recipients, and in congenitally infected newborns. The utility of available drugs is limited by poor bioavailability, toxicity, and emergence of resistant strains.
Teresa P Raposo et al.
Journal of clinical pathology (2017-08-11)
Gene dosage can have a major impact on cell biology, although, hitherto, it has been difficult to study using in vitro models. We sought to refine and accelerate the development of 'gene dosage' models through using CRISPR/Cas9 (a gene editing
Magda Spella et al.
eLife, 8 (2019-05-30)
Lung cancer and chronic lung diseases impose major disease burdens worldwide and are caused by inhaled noxious agents including tobacco smoke. The cellular origins of environmental-induced lung tumors and of the dysfunctional airway and alveolar epithelial turnover observed with chronic
Qiaojuan Zhang et al.
Journal of neurochemistry, 151(2), 238-254 (2019-03-20)
Herpes simplex virus-type 1 (HSV-1) infection of sensory neurons may lead to a significant reduction in the expression of voltage-activated Na+ and Ca2+ channels, which can disrupt the transmission of pain information. Viral infection also results in the secretion of
Use of immunomagnetic separation technique and polymerase chain reaction for detection of verocytotoxin-producing Escherichia coli in cattle at slaughter.
S Bonardi et al.
Veterinary research communications, 29 Suppl 2, 323-326 (2005-10-26)
Mitochondrial metabolism directs stemness and differentiation in P19 embryonal carcinoma stem cells.
I Vega-Naredo et al.
Cell death and differentiation, 21(10), 1560-1574 (2014-05-17)
The relationship between mitochondrial metabolism and cell viability and differentiation in stem cells (SCs) remains poorly understood. In the present study, we compared mitochondrial physiology and metabolism between P19SCs before/after differentiation and present a unique fingerprint of the association between
Marianne de la Roche et al.
The Journal of cell biology, 217(10), 3560-3576 (2018-07-29)
Cellular lipids determine membrane integrity and fluidity and are being increasingly recognized to influence immune responses. Cellular cholesterol requirements are fulfilled through biosynthesis and uptake programs. In an intricate pathway involving the lysosomal cholesterol transporter NPC1, the sterol gets unequally
K Ordog et al.
Life sciences, 268, 118936-118936 (2021-01-10)
During oxidative stress mitochondria become the main source of endogenous reactive oxygen species (ROS) production. In the present study, we aimed to clarify the effects of pharmacological PARP-1 inhibition on mitochondrial function and quality control processes. L-2286, a quinazoline-derivative PARP
Matthew J Binnington et al.
Pharmacogenetics and genomics, 22(6), 429-440 (2012-05-10)
Alaska Native (AN) people have a high prevalence of tobacco use and associated morbidity and mortality when compared with the general USA population. Variations in the CYP2A6 and CYP2B6 genes, encoding enzymes responsible for nicotine metabolic inactivation and procarcinogen activation
Srilatha Nalluri et al.
Cancer biology & therapy, 16(2), 276-286 (2015-03-11)
The pediatric solid tumor neuroblastoma (NB) often depends on the anti-apoptotic protein, Mcl(-)1, for survival through Mcl(-)1 sequestration of pro-apoptotic Bim. High affinity Mcl(-)1 inhibitors currently do not exist such that novel methods to inhibit Mcl(-)1 clinically are in high
Ameer L Elaimy et al.
Journal of cell science, 132(15) (2019-07-03)
The ability to monitor changes in the expression and localization of integrins is essential for understanding their contribution to development, tissue homeostasis and disease. Here, we pioneered the use of Crispr/Cas9 genome editing to tag an allele of the β4
Martina Belli et al.
Endocrinology, 159(4), 1690-1703 (2018-02-23)
Germline knockout studies in female mice demonstrated an essential role for forkhead box L2 (FOXL2) in early follicle development, whereas an inducible granulosa cell (GC)-specific deletion of Foxl2 in adults has shown ovary-to-testis somatic sex reprogramming. In women, over 120
Melissa K Hypes et al.
Cancer letters, 282(2), 177-186 (2009-04-07)
Transforming growth factor-beta (TGF-beta) signaling is disrupted in many cancers, including cervical cancer, leading to TGF-beta resistance. Although initially sensitive, human papillomavirus type 16 (HPV16) immortalized human keratinocytes (HKc/HPV16) become increasingly resistant to the growth inhibitory effects of TGF-beta during
Yunhao Wu et al.
Acta pharmaceutica Sinica. B, 12(3), 1198-1212 (2022-05-10)
Pulmonary endothelial barrier dysfunction is a hallmark of clinical pulmonary edema and contributes to the development of acute lung injury (ALI). Here we reported that ruscogenin (RUS), an effective steroidal sapogenin of Radix Ophiopogon japonicus, attenuated lipopolysaccharides (LPS)-induced pulmonary endothelial
Vida Vafaizadeh et al.
Oncogene, 40(43), 6195-6209 (2021-09-22)
Canonical Wnt/β-catenin signaling is an established regulator of cellular state and its critical contributions to tumor initiation, malignant tumor progression and metastasis formation have been demonstrated in various cancer types. Here, we investigated how the binding of β-catenin to the
Michael L Litvack et al.
Molecular immunology, 48(1-3), 37-47 (2010-11-03)
Innate immune collectin surfactant protein D (SP-D) and natural immunoglobulin M (IgM) are two soluble proteins. These opsonic proteins are good candidates for enhancing late apoptotic cell clearance. However, effects of these proteins on late apoptotic cell clearance in the
Li Liu et al.
Cancer research, 69(17), 6871-6878 (2009-08-13)
HER2-directed therapies, such as trastuzumab and lapatinib, are important treatments for breast cancer. However, some tumors do not respond or develop resistance to these agents. We isolated and characterized multiple lapatinib-resistant, HER2-positive, estrogen receptor (ER)-positive breast cancer clones derived from
Wang-Yong Yang et al.
Journal of medicinal chemistry, 54(24), 8501-8516 (2011-11-05)
We describe a family of hybrid compounds for the most efficient light-activated double-strand (ds) DNA cleavage known to date. This family represents the second generation of "switchable" molecular systems for pH-gated ds DNA-cleavage which combine a potent DNA-photocleaver and a
Chiara Riganti et al.
Neuro-oncology, 15(11), 1502-1517 (2013-07-31)
Glioblastoma multiforme stem cells display a highly chemoresistant phenotype, whose molecular basis is poorly known. We aim to clarify this issue and to investigate the effects of temozolomide on chemoresistant stem cells. A panel of human glioblastoma cultures, grown as
David G Belair et al.
Scientific reports, 10(1), 2864-2864 (2020-02-20)
Exposure to thalidomide during a critical window of development results in limb defects in humans and non-human primates while mice and rats are refractory to these effects. Thalidomide-induced teratogenicity is dependent on its binding to cereblon (CRBN), the substrate receptor
Christopher Gilfillan et al.
PloS one, 11(10), e0163824-e0163824 (2016-10-14)
Telomeres undergo shortening with cell division, accelerated by increased oxidative stress. We aimed to demonstrate shortened telomeres in the offspring of mothers who have diabetes as a consequence of exposure to increased oxidative stress during intrauterine development. We examined the
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