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Showing 1-30 of 88 results for "G1N70" within Papers
Christopher Gilfillan et al.
PloS one, 11(10), e0163824-e0163824 (2016-10-14)
Telomeres undergo shortening with cell division, accelerated by increased oxidative stress. We aimed to demonstrate shortened telomeres in the offspring of mothers who have diabetes as a consequence of exposure to increased oxidative stress during intrauterine development. We examined the
David G Belair et al.
Scientific reports, 10(1), 2864-2864 (2020-02-20)
Exposure to thalidomide during a critical window of development results in limb defects in humans and non-human primates while mice and rats are refractory to these effects. Thalidomide-induced teratogenicity is dependent on its binding to cereblon (CRBN), the substrate receptor
Zenita Adhireksan et al.
Nature communications, 5, 3462-3462 (2014-03-19)
Ruthenium compounds have become promising alternatives to platinum drugs by displaying specific activities against different cancers and favourable toxicity and clearance properties. Nonetheless, their molecular targeting and mechanism of action are poorly understood. Here we study two prototypical ruthenium-arene agents-the
Chiara Riganti et al.
Neuro-oncology, 15(11), 1502-1517 (2013-07-31)
Glioblastoma multiforme stem cells display a highly chemoresistant phenotype, whose molecular basis is poorly known. We aim to clarify this issue and to investigate the effects of temozolomide on chemoresistant stem cells. A panel of human glioblastoma cultures, grown as
Vida Vafaizadeh et al.
Oncogene, 40(43), 6195-6209 (2021-09-22)
Canonical Wnt/β-catenin signaling is an established regulator of cellular state and its critical contributions to tumor initiation, malignant tumor progression and metastasis formation have been demonstrated in various cancer types. Here, we investigated how the binding of β-catenin to the
Melissa K Hypes et al.
Cancer letters, 282(2), 177-186 (2009-04-07)
Transforming growth factor-beta (TGF-beta) signaling is disrupted in many cancers, including cervical cancer, leading to TGF-beta resistance. Although initially sensitive, human papillomavirus type 16 (HPV16) immortalized human keratinocytes (HKc/HPV16) become increasingly resistant to the growth inhibitory effects of TGF-beta during
Justin Tan et al.
Hearing research, 268(1-2), 46-59 (2010-05-15)
In the adult rodent inner ear, p75NTR is weakly expressed in primary auditory neurons (PANs) and cochlear Schwann cells. When the organ of Corti is damaged during trauma, its expression dramatically increases. It is unclear what role p75NTR plays under
Alison G Greene et al.
Experimental eye research, 201, 108349-108349 (2020-11-15)
Pseudoexfoliation syndrome (PXF) is the most common cause of secondary open angle glaucoma worldwide. Single nucleotide polymorphisms (SNPs) in the gene Lysyl oxidase like 1 (LOXL1) are strongly associated with the development of pseudoexfoliation glaucoma (PXFG). However, these SNPs are
Yunhao Wu et al.
Acta pharmaceutica Sinica. B, 12(3), 1198-1212 (2022-05-10)
Pulmonary endothelial barrier dysfunction is a hallmark of clinical pulmonary edema and contributes to the development of acute lung injury (ALI). Here we reported that ruscogenin (RUS), an effective steroidal sapogenin of Radix Ophiopogon japonicus, attenuated lipopolysaccharides (LPS)-induced pulmonary endothelial
Clara Morral et al.
Cell stem cell, 26(6), 845-861 (2020-05-13)
Colorectal cancers (CRCs) are composed of an amalgam of cells with distinct genotypes and phenotypes. Here, we reveal a previously unappreciated heterogeneity in the biosynthetic capacities of CRC cells. We discover that the majority of ribosomal DNA transcription and protein
Li Liu et al.
Cancer research, 69(17), 6871-6878 (2009-08-13)
HER2-directed therapies, such as trastuzumab and lapatinib, are important treatments for breast cancer. However, some tumors do not respond or develop resistance to these agents. We isolated and characterized multiple lapatinib-resistant, HER2-positive, estrogen receptor (ER)-positive breast cancer clones derived from
Michael L Litvack et al.
Molecular immunology, 48(1-3), 37-47 (2010-11-03)
Innate immune collectin surfactant protein D (SP-D) and natural immunoglobulin M (IgM) are two soluble proteins. These opsonic proteins are good candidates for enhancing late apoptotic cell clearance. However, effects of these proteins on late apoptotic cell clearance in the
Malgorzata Marta Drozd et al.
Frontiers in genetics, 12, 792218-792218 (2022-01-04)
Early-Onset Schizophrenia (EOS) is a very rare mental disorder that is a form of schizophrenia occurring before the age of 18. EOS is a brain disease marked by an early onset of positive and negative symptoms of psychosis that impact
Elahu G Sustarsic et al.
Cell metabolism, 28(1), 159-174 (2018-06-05)
Activation of energy expenditure in thermogenic fat is a promising strategy to improve metabolic health, yet the dynamic processes that evoke this response are poorly understood. Here we show that synthesis of the mitochondrial phospholipid cardiolipin is indispensable for stimulating
Sherilyn Grill et al.
Cell reports, 27(12), 3511-3521 (2019-06-20)
Telomerase replicates chromosome ends in germ and somatic stem cells to facilitate their continued proliferation. Telomerase action depends on the telomeric protein TPP1, which recruits telomerase to telomeres and facilitates processive DNA synthesis. Here, we identify separation-of-function long (TPP1-L) and
Wang-Yong Yang et al.
Journal of medicinal chemistry, 54(24), 8501-8516 (2011-11-05)
We describe a family of hybrid compounds for the most efficient light-activated double-strand (ds) DNA cleavage known to date. This family represents the second generation of "switchable" molecular systems for pH-gated ds DNA-cleavage which combine a potent DNA-photocleaver and a
Martina Belli et al.
Endocrinology, 159(4), 1690-1703 (2018-02-23)
Germline knockout studies in female mice demonstrated an essential role for forkhead box L2 (FOXL2) in early follicle development, whereas an inducible granulosa cell (GC)-specific deletion of Foxl2 in adults has shown ovary-to-testis somatic sex reprogramming. In women, over 120
Matthew J Coussens et al.
Journal of visualized experiments : JoVE, (58)(58), doi:10-doi:10 (2012-01-05)
RNA interference (RNAi) is an intrinsic cellular mechanism for the regulation of gene expression. Harnessing the innate power of this system enables us to knockdown gene expression levels in loss of gene function studies. There are two main methods for
Helen S Mueller et al.
Proceedings of the National Academy of Sciences of the United States of America, 118(34) (2021-08-20)
Epigenetic regulators play key roles in cancer and are increasingly being targeted for treatment. However, for many, little is known about mechanisms of resistance to the inhibition of these regulators. We have generated a model of resistance to inhibitors of
Inés Sanchez-Roman et al.
Biogerontology, 13(4), 399-411 (2012-05-15)
It is known that a global decrease in food ingestion (dietary restriction, DR) lowers mitochondrial ROS generation (mitROS) and oxidative stress in young immature rats. This seems to be caused by the decreased methionine ingestion of DR animals. This is
Puleng Matatiele et al.
Journal of biomedical science, 22, 34-34 (2015-05-20)
Systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) are systemic autoimmune connective tissue diseases that share overlapping clinico-pathological features. It is highly probable that there is an overlap in epigenetic landscapes of both diseases. This study aimed to identify similarities
K Ordog et al.
Life sciences, 268, 118936-118936 (2021-01-10)
During oxidative stress mitochondria become the main source of endogenous reactive oxygen species (ROS) production. In the present study, we aimed to clarify the effects of pharmacological PARP-1 inhibition on mitochondrial function and quality control processes. L-2286, a quinazoline-derivative PARP
Matthew J Binnington et al.
Pharmacogenetics and genomics, 22(6), 429-440 (2012-05-10)
Alaska Native (AN) people have a high prevalence of tobacco use and associated morbidity and mortality when compared with the general USA population. Variations in the CYP2A6 and CYP2B6 genes, encoding enzymes responsible for nicotine metabolic inactivation and procarcinogen activation
Christian Marinaccio et al.
Cancer discovery, 11(6), 1398-1410 (2021-02-14)
The myeloproliferative neoplasms (MPN) frequently progress to blast phase disease, an aggressive form of acute myeloid leukemia. To identify genes that suppress disease progression, we performed a focused CRISPR/Cas9 screen and discovered that depletion of LKB1/Stk11 led to enhanced in
Scott D Zawieja et al.
American journal of physiology. Heart and circulatory physiology, 302(3), H643-H653 (2011-12-14)
Numerous studies on metabolic syndrome (MetSyn), a cluster of metabolic abnormalities, have demonstrated its profound impact on cardiovascular and blood microvascular health; however, the effects of MetSyn on lymphatic function are not well understood. We hypothesized that MetSyn would modulate
Bing-Chuan Geng et al.
Acta pharmacologica Sinica, 41(11), 1427-1432 (2020-06-20)
Induced pluripotent stem cells (iPSCs) have become an essential research platform to study different human diseases once being discovered by Dr. Shinya Yamanaka in 2006. Another breakthrough in biomedical research is the application of CRISPR/Cas9 system for genome editing in
Ida Beate Ø Østhus et al.
PloS one, 7(12), e52769-e52769 (2013-01-10)
Telomeres are potential markers of mitotic cellular age and are associated with physical ageing process. Long-term endurance training and higher aerobic exercise capacity (VO(2max)) are associated with improved survival, and dynamic effects of exercise are evident with ageing. However, the
Magda Spella et al.
eLife, 8 (2019-05-30)
Lung cancer and chronic lung diseases impose major disease burdens worldwide and are caused by inhaled noxious agents including tobacco smoke. The cellular origins of environmental-induced lung tumors and of the dysfunctional airway and alveolar epithelial turnover observed with chronic
Qiaojuan Zhang et al.
Journal of neurochemistry, 151(2), 238-254 (2019-03-20)
Herpes simplex virus-type 1 (HSV-1) infection of sensory neurons may lead to a significant reduction in the expression of voltage-activated Na+ and Ca2+ channels, which can disrupt the transmission of pain information. Viral infection also results in the secretion of
Teresa P Raposo et al.
Journal of clinical pathology (2017-08-11)
Gene dosage can have a major impact on cell biology, although, hitherto, it has been difficult to study using in vitro models. We sought to refine and accelerate the development of 'gene dosage' models through using CRISPR/Cas9 (a gene editing
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