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Showing 1-30 of 148 results for "g2539" within Papers
Zhiwei Cai et al.
American journal of physiology. Cell physiology, 305(8), C817-C828 (2013-06-21)
The chemical structures of the thyroid hormones triiodothyronine (T3) and thyroxine (T4) resemble those of small-molecules that inhibit the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel. We therefore tested the acute effects of T3, T4 and reverse T3 (rT3)
Ruchira M Jha et al.
Journal of neurotrauma, 38(5), 628-645 (2020-11-19)
Glibenclamide (GLY) is the sixth drug tested by the Operation Brain Trauma Therapy (OBTT) consortium based on substantial pre-clinical evidence of benefit in traumatic brain injury (TBI). Adult Sprague-Dawley rats underwent fluid percussion injury (FPI; n = 45), controlled cortical impact (CCI;
Ayesha Rashid et al.
Pakistan journal of pharmaceutical sciences, 27(1), 153-159 (2014-01-01)
The study was aimed to evaluate various pharmacokinetic parameters of a commercially available fixed dose combination of oral antidiabetics (Metformin/Glibenclamide 500/5mg tablets) in plasma sample of normal healthy adult male volunteers by applying an accurate, selective, and reproducible HPLC-UV analytical
Nir Melamed et al.
Women's health (London, England), 5(6), 649-658 (2009-10-30)
Until the last decade, oral hypoglycemic agents have not been recommended in pregnancy owing to fear of their potential adverse fetal effects, including teratogenicity and neonatal hypoglycemia. However, the evidence in support of these recommendations is weak and is principally
Brice-Loïc Renard et al.
European journal of medicinal chemistry, 46(5), 1935-1941 (2011-03-15)
In the study of previously reported modulators of CFTR chloride channels that are cyclic methylglyoxal (MG) diadducts (CMGD) to aromatic α-aminoazaheterocycles, we optimized a new expeditious one pot route for preparing in water novel aromatic polycyclic azaheterocycles and described 5-pyrimidinols
Shuwen Jiang et al.
Drug metabolism and pharmacokinetics, 30(3), 240-246 (2015-04-22)
Accumulating evidences have shown that diabetes is often accompanied with depression, thus it is possible that oral antidiabetic agent glyburide and antidepressive agent paroxetine are co-administered in diabetic patients. The aim of this study was to assess interactions between glyburide
Vijay Ramani et al.
Journal of leukocyte biology, 98(6), 1037-1048 (2015-08-09)
Inflammation is induced because of interplay among multiple signaling pathways and molecules during infectious and noninfectious tissue injuries. Crosstalk between Toll-like receptor-4 signaling and the neuronal apoptosis inhibitor protein, major histocompatibility class 2 transcription activator, incompatibility locus protein from Podospora
Wenbo Zhang et al.
PloS one, 9(9), e107639-e107639 (2014-09-13)
Myocardial contractile dysfunction in sepsis is associated with the increased morbidity and mortality. Although the underlying mechanisms of the cardiac depression have not been fully elucidated, an exaggerated inflammatory response is believed to be responsible. Nucleotide-binding oligomerization domain-like receptor containing
Montserrat Balsells et al.
BMJ (Clinical research ed.), 350, h102-h102 (2015-01-23)
To summarize short term outcomes in randomized controlled trials comparing glibenclamide or metformin versus insulin or versus each other in women with gestational diabetes requiring drug treatment. Systematic review and meta-analysis. Randomized controlled trials that fulfilled all the following: (1)
Poonam Shukla et al.
Bioorganic & medicinal chemistry letters, 17(3), 799-802 (2006-11-11)
A series of chalcone based aryloxypropanolamines were synthesized and evaluated for their antihyperglycemic activity in SLM and STZ rat models. Most of the compounds exhibited moderate to good activity ranging from 6.5% to 31.1% in SLM and 8.3% to 22.6%
Marilia Trindade de Santana et al.
Pharmaceutical biology, 51(9), 1144-1149 (2013-06-26)
Citronellal is a monoterpene present in the oil of many species, including Cymbopogon winterianus Jowitt (Poaceae). The present study investigated the effect of citronellal on inflammatory nociception induced by different stimuli and examined the involvement of the NO-cGMP-ATP-sensitive K⁺ channel
Shilpa Raut et al.
Journal of pharmaceutical and biomedical analysis, 109, 121-127 (2015-03-15)
We are reporting a new methodology of using Raman spectroscopy for studying the drug surfactant interactions in self-emulsifying drug delivery systems (SEDDS). The physicochemical properties of surfactants could affect the performance of drugs from lipid delivery systems. Thus the purpose
Shay Eliahu et al.
Journal of medicinal chemistry, 53(6), 2472-2481 (2010-02-24)
Dinucleoside polyphosphates exert their physiological effects via P2 receptors (P2Rs). They are attractive drug candidates, as they offer better stability and specificity compared to nucleotides, the most common P2 receptor ligands. The activation of pancreatic P2Y receptors by nucleotides increases
Faiyaz Shakeel et al.
Pharmaceutical development and technology, 19(7), 799-805 (2013-08-24)
The present study was undertaken to evaluate the impact of various combinations of nonionic surfactants on self-nanoemulsifying performance of two grades of Lauroglycol (Lauroglycol-90 and Lauroglycol-FCC) in glibenclamide (GBN) nanoemulsion. Formulations (L1-L30) were prepared by spontaneous emulsification method. Prepared formulations
Charles E Norton et al.
American journal of physiology. Lung cellular and molecular physiology, 315(2), L212-L226 (2018-03-16)
The sensory neurotransmitter calcitonin gene-related peptide (CGRP) is associated with vasodilation of systemic arteries through activation of ATP-sensitive K+ (KATP) channels in smooth muscle cells (SMCs); however, its effects on endothelial cell (EC) membrane potential ( Vm) are unresolved. In
Gaetano Santulli et al.
The Journal of clinical investigation, 125(5), 1968-1978 (2015-04-07)
The type 2 ryanodine receptor (RyR2) is a Ca2+ release channel on the endoplasmic reticulum (ER) of several types of cells, including cardiomyocytes and pancreatic β cells. In cardiomyocytes, RyR2-dependent Ca2+ release is critical for excitation-contraction coupling; however, a functional
Ihab T Abdel-Raheem et al.
Basic & clinical pharmacology & toxicology, 113(3), 158-166 (2013-04-30)
Doxorubicin is a chemotherapeutic drug used to treat solid and haematopoietic tumours. Its use is limited by a major side effect of cardiotoxicity. It was reported that doxorubicin-induced cardiotoxicity is mediated through oxidative stress coupled with impaired NO bioavailability and
Rajanbabu Venugopal et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 36(5), 2012-2024 (2015-07-24)
Neuregulin (NRG)-1-human epidermal receptor (HER)-2 signaling pathway is a key regulator of IL-1β-mediated pulmonary inflammation and epithelial permeability. The inflammasome is a newly discovered molecular platform required for caspase-1 activation and maturation of IL-1β. However, the role of the inflammasome
Nagaraj Kerur et al.
Investigative ophthalmology & visual science, 54(12), 7395-7401 (2013-10-12)
Accumulation of Alu RNA transcripts due to DICER1 deficiency in the retinal pigmented epithelium (RPE) promotes geographic atrophy. Recently we showed that Alu RNA activated the NLRP3 inflammasome, leading to RPE cell death via interleukin-18 (IL-18)-mediated MyD88 signaling. However, the
Diana L Shuster et al.
Biochemical pharmacology, 92(4), 690-700 (2014-12-03)
Glyburide is commonly prescribed for the treatment of gestational diabetes mellitus; however, fetal exposure to glyburide is not well understood and may have short- and long-term consequences for the health of the child. Glyburide can cross the placenta; fetal concentrations
Carlos A Aguilar-Salinas et al.
Metabolism: clinical and experimental, 62(5), 638-641 (2013-01-01)
To test the hypothesis that persons with the R230C allele of ABCA1 show a decreased glycemic response to glyburide. This polymorphism is exclusively found in Ameri-indian populations and is associated with type 2 diabetes. This is a single blind controlled
Vincenzo Calderone et al.
Bioorganic & medicinal chemistry, 17(15), 5426-5432 (2009-07-15)
Endothelial dysfunction and consequent reduction of biosynthesis of endogenous nitric oxide (NO) play an important pathogenetic role in the cardiovascular complications associated with type II diabetes. In this work, the hybrid drugs 3a and 3b, nitrooxymethylbenzoate-derivatives of 1 (which is
Z Wojnarowska et al.
Physical review. E, Statistical, nonlinear, and soft matter physics, 86(6 Pt 2), 067104-067104 (2013-02-02)
Rheological measurements have been applied to study the tautomerization of the pharmaceutically active compound glibenclamide. The rate constant and activation energy of the imidic-acid-amide transformation have been successfully determined by monitoring the evolution of shear viscosity. The kinetic parameters from
Simona Bo et al.
European journal of endocrinology, 169(1), 117-126 (2013-05-11)
Available data about mortality of type 2 diabetic patients treated with different sulphonylureas are scarce and contradictory. We evaluated the associations between all-cause and cause-specific mortality and treatments with different sulphonylureas in a retrospective cohort of type 2 diabetic patients
Glyburide-induced cholestatic hepatitis and liver failure. Case-report and review of the literature.
J P van Basten et al.
The Netherlands journal of medicine, 40(5-6), 305-307 (1992-06-01)
As sulphonylurea derivatives are used ubiquitously, the possibility that they may cause liver disease deserves attention. In contrast to the known pattern of reversible parenchymal liver disease due to sulphonylurea derivatives, we describe a fatal case of glyburide-induced cholestatic hepatitis
G Koren
Reproductive toxicology (Elmsford, N.Y.), 15(3), 227-229 (2001-06-08)
Oral hypoglycemics have been avoided in pregnancy due to their potential to cause fetal hyperinsulinemia/hypoglycemia. A recent human study has shown glyburide to minimally cross the placenta, allowing a safe new treatment for gestational diabetes. The mechanisms for the minimal
Mark C Wenlock et al.
Bioorganic & medicinal chemistry letters, 21(12), 3550-3556 (2011-05-24)
In drug discovery projects the ability to show a relationship between a compound's molecular structure and its pharmacokinetic, in vivo efficacy, or toxicity profile is paramount for the design of better analogues. To aid this understanding the measurement of distribution
Sammy W M Shiu et al.
Clinical science (London, England : 1979), 126(2), 175-181 (2013-08-03)
LDL (low-density lipoprotein) is subjected to pro-atherogenic modifications in the circulation. A novel uraemia-independent mechanism of carbamylation of lipoproteins mediated by MPO (myeloperoxidase) has recently been reported. We have investigated whether carbamylation of LDL was increased in patients with Type
Maryam Sharifi-Sanjani et al.
American journal of physiology. Heart and circulatory physiology, 304(10), H1294-H1301 (2013-03-26)
Myocardial metabolites such as adenosine mediate reactive hyperemia, in part, by activating ATP-dependent K(+) (K(ATP)) channels in coronary smooth muscle. In this study, we investigated the role of adenosine A(2A) and A(2B) receptors and their signaling mechanisms in reactive hyperemia.
J F Caro
The American journal of medicine, 89(2A), 17S-25S (1990-08-20)
Increased hepatic glucose production is responsible for fasting hyperglycemia in type II diabetes. Insulin resistance is the key in this process because of the inability of insulin to suppress hepatic glucose production, thereby allowing an unopposed glucagon effect. Glyburide, one
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