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Showing 1-30 of 82 results for "G3278" within Papers
Maiko Mitake et al.
Biomedical research (Tokyo, Japan), 33(1), 15-24 (2012-03-01)
Geranylgeranoic acid (GGA), a 20-carbon acyclic polyprenoic acid (all-trans 3,7,11,15-tetramethyl- 2,4,6,10,14-hexadecatetraenoic acid) and its derivatives were developed as synthetic "acyclic retinoids" for cancer chemoprevention. Previously, we have shown the natural occurrence of GGA in various medicinal herbs and reported enzymatic
Jiaxi Ding et al.
BMC developmental biology, 8, 120-120 (2009-01-02)
Primordial germ cells (PGCs) are the embryonic precursors of the sperm and eggs. Environmental or genetic defects that alter PGC development can impair fertility or cause formation of germ cell tumors. We demonstrate a novel role for cholesterol during germ
Ban H Edani et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(34), 20794-20802 (2020-08-21)
Cis-prenyltransferase (cis-PTase) catalyzes the rate-limiting step in the synthesis of glycosyl carrier lipids required for protein glycosylation in the lumen of endoplasmic reticulum. Here, we report the crystal structure of the human NgBR/DHDDS complex, which represents an atomic resolution structure
Behnaz Nowrouzi et al.
Microbial cell factories, 19(1), 200-200 (2020-11-04)
Cost-effective production of the highly effective anti-cancer drug, paclitaxel (Taxol®), remains limited despite growing global demands. Low yields of the critical taxadiene precursor remains a key bottleneck in microbial production. In this study, the key challenge of poor taxadiene synthase
Mathieu Blanc et al.
Immunity, 38(1), 106-118 (2013-01-01)
Recent studies suggest that the sterol metabolic network participates in the interferon (IFN) antiviral response. However, the molecular mechanisms linking IFN with the sterol network and the identity of sterol mediators remain unknown. Here we report a cellular antiviral role
Jong Hyun Lee et al.
Cancer letters, 360(2), 280-293 (2015-02-24)
Aberrant activation of signal transducer and activator of transcription 3 (STAT3) is frequently observed in multiple myeloma (MM) cancer and can upregulate the expression of several genes involved in proliferation, survival, metastasis, and angiogenesis. The effect of farnesol (FOH) on
Sen Wang et al.
Frontiers in cell and developmental biology, 8, 247-247 (2020-05-16)
Babesia microti, the main pathogen causing human babesiosis, has been reported to exhibit resistance to the traditional treatment of azithromycin + atovaquone and clindamycin + quinine, suggesting the necessity of developing new drugs. The methylerythritol 4-phosphate (MEP) pathway, a unique
T Minegaki et al.
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 29(6), 656-662 (2015-04-22)
Esophageal squamous cell carcinoma (ESCC) is one of the most malignant cancers in Japan. Anticancer chemotherapy has been useful for ESCC treatment. However, therapeutic options are limited. Recently, bisphosphonates (BPs), which are osteoporosis drugs, have shown anticancer effects in several
Fatty acid isoprenoid alcohol ester synthesis in fruits of the African Oil Palm (Elaeis guineensis).
Philipp Gutbrod et al.
Phytochemistry, 185, 112684-112684 (2021-02-14)
The African Oil Palm (Elaeis guineensis; family Arecaceae) represents the most important oil crop for food and feed production and for biotechnological applications. Two types of oil can be extracted from palm fruits, the mesocarp oil which is rich in
Yuchi Feng et al.
Frontiers in plant science, 11, 589-589 (2020-06-12)
Cyanobacteria are photosynthetic prokaryotes that perform oxygenic photosynthesis. Due to their ability to use the photon energy of sunlight to fix carbon dioxide into biomass, cyanobacteria are promising hosts for the sustainable production of terpenoids, also known as isoprenoids, a
Takayuki Nakagawa et al.
Archives of oral biology, 60(4), 557-565 (2015-01-21)
Bisphosphonates (BPs) are widely used in the prevention of skeletal-related events (SRE), including osteoporosis, skeletal metastases of malignant tumours, and multiple myeloma. Osteonecrosis of the jaw (ONJ) is frequently reported as a major adverse effect induced by BP treatment. The
E L Scheller et al.
Journal of dental research, 90(7), 894-899 (2011-05-10)
Osteonecrosis of the jaw (ONJ), a side-effect of bisphosphonate therapy, is characterized by exposed bone that fails to heal within eight weeks. Healing time of oral epithelial wounds is decreased in the presence of amino-bisphosphonates; however, the mechanism remains unknown.
Tetsuya Minegaki et al.
The Journal of pharmacy and pharmacology, 70(8), 1040-1047 (2018-05-16)
Tumour hypoxia is a major obstacle in cancer therapy that leads to poor prognosis. Therefore, the development of cancer treatments that are effective in hypoxia is necessary. Nitrogen-containing bisphosphonates (N-BPs), which are used to treat bone disease, are cytotoxic to
Gareth D Healey et al.
Journal of immunology (Baltimore, Md. : 1950), 196(2), 823-831 (2015-12-18)
Metabolic changes can influence inflammatory responses to bacteria. To examine whether localized manipulation of the mevalonate pathway impacts innate immunity, we exploited a unique mucosal disease model, endometritis, where inflammation is a consequence of innate immunity. IL responses to pathogenic
Bingyin Peng et al.
Metabolic engineering, 39, 209-219 (2016-12-13)
Sesquiterpenes are C15 isoprenoids with utility as fragrances, flavours, pharmaceuticals, and potential biofuels. Microbial fermentation is being examined as a competitive approach for bulk production of these compounds. Competition for carbon allocation between synthesis of endogenous sterols and production of
Tiffany Mailman et al.
Journal of neurochemistry, 119(5), 1002-1015 (2011-09-09)
Cholesterol is highly enriched in the brain, and plays a key role in synapse formation and function. The brain does not derive cholesterol from the circulation; instead, the majority of cholesterol is made in glia and secreted in form of
Fraser P Coxon et al.
Bone, 49(1), 111-121 (2011-03-23)
The described ability of phosphonocarboxylate analogues of bisphosphonates (BPs) to inhibit Rab geranylgeranyl transferase (RGGT) is thought to be the mechanism underlying their cellular effects, including their ability to reduce macrophage cell viability and to inhibit osteoclast-mediated resorption. However, until
Fu-Cai Tang et al.
Molecular medicine reports, 16(6), 8123-8129 (2017-10-07)
Reactive oxygen species‑induced cyclophilin A (CyPA) release from vascular smooth muscle cells (VSMCs) may be inhibited by simvastatin in vitro. The present study aimed to further examine the effect of simvastatin on serum CyPA levels and the basigin (CD147)‑extracellular signal‑regulated kinase
Ying-Ying Li et al.
Anti-cancer drugs, 22(1), 89-98 (2010-10-12)
Zoledronic acid (ZOL) was shown earlier to prolong survival in animal models of lung cancer. The aim of this study was to examine whether alteration of intracellular cyclins, cyclin-dependent kinases, cyclin-dependent kinase inhibitors, retinoblastoma, and Ras protein expression and E2F
Lan He et al.
Parasites & vectors, 11(1), 452-452 (2018-08-08)
The apicomplexan parasite Babesia orientalis, the causative agent of water buffalo babesiosis in China, is widespread in central and south China, resulting in a huge economic loss annually. Currently, there is no effective vaccine or drug against this disease. Babesia
S Zafar et al.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 43(9), 711-721 (2014-04-26)
The mevalonate pathway (MVP) and the anti-angiogenic effect of bisphosphonates have been shown to play a role in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw (BRONJ). This study determined the effect of the bisphosphonate, zoledronic acid and the replenishment
Comments on ''Geranylgeraniol--a new potential therapeutic approach to bisphosphonate associated osteonecrosis of the jaw" by Ziebart T et al. (2011).
Annalisa Marcuzzi et al.
Oral oncology, 47(5), 436-437 (2011-03-18)
Oh Sasaki et al.
Journal of immunology (Baltimore, Md. : 1950), 191(6), 2879-2889 (2013-08-13)
Bisphosphonates (BPs) have been widely used to treat osteoporosis. They act by inhibiting farnesyl diphosphate synthase in the mevalonate pathway. This resembles the action of statins, whose immune-modulating effect has recently been highlighted. In contrast, the effect of BPs on
Juhi Misra et al.
Stem cells (Dayton, Ohio), 34(3), 756-767 (2015-12-19)
Mesenchymal stem cells (MSCs) undergo a decline in function following ex vivo expansion and exposure to irradiation. This has been associated with accumulation of DNA damage and has important implications for tissue engineering approaches or in patients receiving radiotherapy. Therefore
Identification and Characterization of Daurichromenic Acid Synthase Active in Anti-HIV Biosynthesis.
Miu Iijima et al.
Plant physiology, 174(4), 2213-2230 (2017-07-07)
Daurichromenic acid (DCA) synthase catalyzes the oxidative cyclization of grifolic acid to produce DCA, an anti-HIV meroterpenoid isolated from
Muhammad Novrizal Abdi Sahid et al.
European journal of pharmacology, 814, 255-263 (2017-09-03)
Statins are well-known inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, which block the mevalonate pathway. The activity of statins not only decreases cholesterol levels but also ameliorates inflammation and modulates the immune system. In this study, we investigated the effects of
Humberto M Spindola et al.
European journal of pharmacology, 656(1-3), 45-51 (2011-02-08)
The crude alcoholic extracts obtained from Pterodon pubescens Benth. seeds are widely used in Brazilian folk medicine as anti-inflammatory, analgesic, anti-rheumatic tonics and depurative preparations. We previously demonstrated the antinociceptive activity on writhing capsaicin, glutamate, and hot-plate tests of two
Kenro Tokuhiro et al.
Applied and environmental microbiology, 75(17), 5536-5543 (2009-07-14)
(E, E, E)-Geranylgeraniol (GGOH) is a valuable starting material for perfumes and pharmaceutical products. In the yeast Saccharomyces cerevisiae, GGOH is synthesized from the end products of the mevalonate pathway through the sequential reactions of farnesyl diphosphate synthetase (encoded by
Nikolas H Kazmers et al.
Bone, 45(1), 52-60 (2009-04-14)
Cytoskeletal elements are critical for cell morphology and signal transduction, and are involved in many cellular processes including motility, intracellular transport, and differentiation. Small GTP-binding proteins (G proteins) of the Ras family, such as RhoA, influence various elements of the
Annalisa Marcuzzi et al.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 30(6), 451-456 (2012-07-05)
Mevalonic aciduria (MA), the most severe form of mevalonate kinase deficiency (MKD), is still an orphan drug disease and the pathogenetic mechanisms underlying neuronal dysfunction is still poorly understood. In our study we have investigated the apoptotic mechanism mediated by
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