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Showing 1-30 of 75 results for "G3407" within Papers
X-ray studies on crystalline complexes involving amino acids and peptides. XXXVII. Novel aggregation patterns and effect of chirality in the complexes of DL-and L-lysine with glutaric acid.
Saraswathi NT, et al.
Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials, 53(1), 366-371 (2001)
Agnieszka Kozak et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 133, 59-68 (2019-03-27)
Cocrystal formation may affect manufacturability (flow, compaction and processability) as well as solubility/dissolution, hygroscopicity and stability properties of drugs. Therefore, cocrystallization could be used to improve the pharmaceutical properties of low-soluble drugs such as ethenzamide. In this project, solid-state nuclear
Primiano Pio Di Mauro et al.
International journal of pharmaceutics, 553(1-2), 169-185 (2018-10-16)
A dual-targeting drug delivery system for paclitaxel (PTX) was developed by functionalizing novel polyester-based nanoparticles (NPs) with peptides possessing special affinity for low-density lipoprotein receptor (LDLR), overcoming the limitations of the current chemotherapeutics, to transport drug from blood to brain
Arun Sreekumar et al.
Nature, 457(7231), 910-914 (2009-02-13)
Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the identification of critical biomarkers for cancer invasion and disease aggressiveness. Although gene and protein expression have
Sambhav R Kumbhani et al.
Rapid communications in mass spectrometry : RCM, 31(19), 1659-1668 (2017-08-07)
Ambient ionization mass spectrometry methods are convenient, sensitive and require little sample preparation. However, they are susceptible to species present in air surrounding the mass spectrometer. This study identifies some challenges associated with the potential impacts of indoor air contaminants
Yun-Gi Hong et al.
Biotechnology and bioengineering, 116(2), 333-341 (2018-11-20)
Glutaric acid is a promising alternative chemical to phthalate plasticizer since it can be produced by the bioconversion of lysine. Though, recent studies have enabled the high-yield production of its precursor, 5-aminovaleric acid (AMV), glutaric acid production via the AMV
C Mühlhausen et al.
Journal of inherited metabolic disease, 31(2), 188-193 (2008-04-12)
The neurodegenerative disorder glutaric aciduria type I (GA I) is characterized by increased levels of cytotoxic metabolites such as glutaric acid (GA) and 3-hydroxyglutaric (3OHGA). The present report summarizes recent investigations providing insights into mechanisms of intra- and intercellular translocation
Julia Roeder et al.
Applied and environmental microbiology, 75(14), 4821-4828 (2009-05-26)
A novel, strictly anaerobic, cadaverine-oxidizing, defined coculture was isolated from an anoxic freshwater sediment sample. The coculture oxidized cadaverine (1,5-diaminopentane) with sulfate as the electron acceptor. The sulfate-reducing partner could be replaced by a hydrogenotrophic methanogenic partner. The defined coculture
I Höliner et al.
Klinische Padiatrie, 222(1), 35-37 (2010-01-20)
We report on a 4.5-year-old patient diagnosed with Glutaric aciduria type I (GAI), an autosomal recessive inborn error of lysine, hydroxylysine and tryptophan metabolism. Enzymatic assay in cultivated skin fibroblasts revealed complete absence of glutaryl-CoA dehydrogenase activity. All 11 Exons
ENDOR Studies in Molecular Crystals. I. Glutaric Acid at 4.2? K.
Kwiram AL.
J. Chem. Phys. , 55(5), 2484-2495 (1971)
Mohamed El Amine Benmalti et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 74(1), 58-66 (2009-06-16)
A full quantum theoretical model is proposed to study the nu(O-H) experimental IR line shapes of polarized crystalline glutaric and 1-naphthoic acid dimer crystals at room and liquid nitrogen temperatures. This work is an application of a previous model [M.
Danieli Valnes Magni et al.
Epilepsy research, 93(2-3), 138-148 (2010-12-25)
Glutaric acidemia type I (GA-I) is an inherited metabolic disease characterized by accumulation of glutaric acid (GA) and seizures. Considering that seizures are precipitated by common infections in children with GA-I, we investigated whether lipopolysaccharide (LPS) modifies GA-induced electrographic and
Electron spin resonance of (CO2H) CH2CH2CH (CO2H) in irradiated glutaric acid.
Horsfield A, et al.
Molecular Physics, 4(2), 169-175 (1961)
Yosuke Shigematsu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 823(1), 7-12 (2005-08-02)
We developed a simple and sensitive stable-isotope dilution method for the quantification of 3-hydroxyglutaric acid (3HGA) and glutaric acid (GA) in body fluids. In our method, tert-butyldimethylsilyl (tBDMS) derivatives of 3HGA and GA were measured with a conventional electron-impact ionization
Daniel P McNamara et al.
Pharmaceutical research, 23(8), 1888-1897 (2006-07-13)
The bioavailability of a development candidate active pharmaceutical ingredient (API) was very low after oral dosing in dogs. In order to improve bioavailability, we sought to increase the dissolution rate of the solid form of the API. When traditional methods
Sven W Sauer et al.
Biochimica et biophysica acta, 1802(6), 552-560 (2010-03-23)
Intracerebral accumulation of neurotoxic dicarboxylic acids (DCAs) plays an important pathophysiological role in glutaric aciduria type I and methylmalonic aciduria. Therefore, we investigated the transport characteristics of accumulating DCAs - glutaric (GA), 3-hydroxyglutaric (3-OH-GA) and methylmalonic acid (MMA) - across
C Jakobs et al.
European journal of pediatrics, 141(3), 153-157 (1984-01-01)
A method for the measurement of dicarboxylic acids in amniotic fluid was developed that utilizes isolation of the acids by liquid partition chromatography and quantification by ammonia chemical ionization selected ion monitoring, gas chromatography-mass spectrometry. The concentrations of dicarboxylic acids
D H Morton et al.
American journal of medical genetics, 41(1), 89-95 (1991-10-01)
We have diagnosed type I glutaric aciduria (GA-I) in 14 children from 7 Old Order Amish families in Lancaster County, Pennsylvania. An otherwise rare disorder, GA-I appears to be a common cause of acute encephalopathy and cerebral palsy among the
G F Hoffmann et al.
Journal of inherited metabolic disease, 16(4), 648-669 (1993-01-01)
Concentrations of organic acids in cerebrospinal fluid (CSF) appear to be directly dependent upon their rate of production in the brain. There is evidence that the net release of short-chain monocarboxylic acids from the brain is a major route for
B Riscob et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 78(1), 543-548 (2010-12-18)
Glycine glutaric acid, a new organic compound has been synthesized and good quality single crystals were grown by slow evaporation technique. The structure of the grown crystal was elucidated by using single crystal XRD. The presence of the functional groups
Boris A Zakharov et al.
Acta crystallographica. Section B, Structural science, 68(Pt 3), 287-296 (2012-05-23)
The occurrence of a first-order reversible phase transition in glycine-glutaric acid co-crystals at 220-230 K has been confirmed by three different techniques - single-crystal X-ray diffraction, polarized Raman spectroscopy and differential scanning calorimetry. The most interesting feature of this phase
Yoshiaki Miyamoto et al.
The international journal of neuropsychopharmacology, 17(8), 1283-1294 (2014-02-25)
A novel N-acetyltransferase, Shati/Nat8l, was identified in the nucleus accumbens (NAc) of mice with methamphetamine (METH) treatment. Previously we reported that suppression of Shati/Nat8l enhanced METH-induced behavioral alterations via dopaminergic neuronal regulation. However, the physiological mechanisms of Shati/Nat8l on the
Bart Claeys et al.
International journal of pharmaceutics, 477(1-2), 244-250 (2014-12-03)
The influence of several dicarboxylic acids on the release characteristics of polyurethane tablets with a high drug load was investigated. Mixtures of diprophylline (Dyph) and thermoplastic polyurethane (TPUR) (ratio: 50/50, 65/35 and 75/25 wt.%) were hot-melt extruded and injection molded
Danieli Valnes Magni et al.
Journal of neuroscience research, 90(9), 1723-1731 (2012-04-27)
Glutaric acidemia type I (GA-I) is an inherited metabolic disease characterized by accumulation of glutaric acid (GA) and seizures. The intrastriatal GA administration in rats has been used as an animal model to mimic seizures presented by glutaric acidemic patients.
Marisa C Gaspar et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 96, 65-75 (2015-07-21)
The aim of this work was the development of innovative levofloxacin-loaded swellable microspheres (MS) for the dry aerosol therapy of pulmonary chronicPseudomonas aeruginosainfections in Cystic Fibrosis patients. In a first step, a factorial design was applied to optimize formulations of
Primiano Pio Di Mauro et al.
Pharmaceutical research, 31(12), 3461-3477 (2014-06-19)
The objective of this study was to develop a custom-tailored polymeric drug delivery system for paclitaxel, employing a novel biodegradable block co-polymer (P), intended to be intravenously administered, capable of improving therapeutic index of the drug and devoid of the
Basem Kanawati et al.
Rapid communications in mass spectrometry : RCM, 24(8), 1198-1206 (2010-03-20)
Glutaric acid, a common short-chain aliphatic dicarboxylic acid, was investigated in the negative ion mode by subjecting its [M-H](-) ion to collision-induced dissociation (CID) experiments in an infinity ion cyclotron resonance (ICR) cell coupled to a hexapole-quadrupole-hexapole ion guide. A
Cornelia von Baeckmann et al.
Journal of colloid and interface science, 589, 453-461 (2021-01-24)
The typical method for minimizing serum protein adsorption in biological settings and prolonging blood circulation time of nanoparticles, is to anchor hydrophilic polymers (e.g., poly(ethylene glycol), PEG) on the particle surface, which is most often done by covalent attachment (PEGylation).
Management of outpatient anesthesia in an unusually case with glutaric aciduria type-1.
Ugur Goktas et al.
Paediatric anaesthesia, 19(6), 632-633 (2009-08-04)
Jessica Lamp et al.
The Journal of biological chemistry, 286(20), 17777-17784 (2011-04-02)
The inherited neurodegenerative disorder glutaric aciduria type 1 (GA1) results from mutations in the gene for the mitochondrial matrix enzyme glutaryl-CoA dehydrogenase (GCDH), which leads to elevations of the dicarboxylates glutaric acid (GA) and 3-hydroxyglutaric acid (3OHGA) in brain and
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