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Showing 1-30 of 1323 results for "G3893" within Papers
Laura Fernández-Sánchez et al.
Frontiers in neuroanatomy, 16, 858073-858073 (2022-05-03)
Retinitis pigmentosa is primarily characterized by a massive photoreceptor loss. But a global retinal remodeling occurs in later stages of the disease. At that phase, glial cells and retinal vasculature are also strongly affected. The main aim of the present
Juan Bernal et al.
Methods in molecular biology (Clifton, N.J.), 1801, 17-28 (2018-06-13)
The actions of thyroid hormones on brain development and function are due primarily to regulation of gene expression. Identification of direct transcriptional responses requires cell culture approaches given the difficulty of in vivo studies. Here, we describe the use of
Elian da Silva Francisco et al.
Frontiers in neuroscience, 13, 981-981 (2019-10-18)
This study aimed to evaluate the possible protective role of taurine on anxiety-like behavior, brain electrical activity and glial cell immunoreactivity in well-nourished and malnourished rats that were treated with a subconvulsing dose of pilocarpine. Newborn Wistar rats were subjected
Sergei Chuikov et al.
Nature cell biology, 12(10), 999-1006 (2010-09-14)
To better understand the mechanisms that regulate stem cell identity and function, we sought to identify genes that are preferentially expressed by stem cells and critical for their function in multiple tissues. Prdm16 is a transcription factor that regulates leukaemogenesis
Aurore Quirié et al.
The European journal of neuroscience, 37(7), 1193-1202 (2013-01-15)
Because arginase and nitric oxide (NO) synthases (NOS) compete to degrade l-arginine, arginase plays a crucial role in the modulation of NO production. Moreover, the arginase 1 isoform is a marker of M2 phenotype macrophages that play a key role
Christine J Fontaine et al.
Learning & memory (Cold Spring Harbor, N.Y.), 27(9), 380-389 (2020-08-21)
Cannabinoid receptors are widely expressed throughout the hippocampal formation, but are particularly dense in the dentate gyrus (DG) subregion. We, and others, have shown in mice that cannabinoid type 1 receptors (CB1Rs) are involved in a long-term depression (LTD) that
Michele Bellesi et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(36), 14288-14300 (2013-09-06)
Previous studies of differential gene expression in sleep and wake pooled transcripts from all brain cells and showed that several genes expressed at higher levels during sleep are involved in the synthesis/maintenance of membranes in general and of myelin in
Maxime Wc Rousseaux et al.
eLife, 7 (2018-06-05)
Alzheimer's and Parkinson's disease are late onset neurodegenerative diseases that will require therapy over decades to mitigate the effects of disease-driving proteins such tau and α-synuclein (α-Syn). Previously we found that TRIM28 regulates the levels and toxicity of α-Syn and
Matthew Grove et al.
eLife, 6 (2017-01-27)
Nuclear exclusion of the transcriptional regulators and potent oncoproteins, YAP/TAZ, is considered necessary for adult tissue homeostasis. Here we show that nuclear YAP/TAZ are essential regulators of peripheral nerve development and myelin maintenance. To proliferate, developing Schwann cells (SCs) require
Zhongfu Shen et al.
Cell reports, 34(11), 108853-108853 (2021-03-18)
Radial glial progenitors (RGPs) give rise to the vast majority of neurons and glia in the neocortex. Although RGP behavior and progressive generation of neocortical neurons have been delineated, the exact process of neocortical gliogenesis remains elusive. Here, we report
Qiyan Fan et al.
Glia, 71(3), 667-681 (2022-11-23)
The unfolded protein response (UPR) is a signal transduction network that responds to endoplasmic reticulum (ER) stress by coordinating protein homeostasis to maintain cell viability. The UPR can also trigger cell death when adaptive responses fail to improve protein homeostasis.
Yang Zhang et al.
eNeuro, 8(2) (2021-01-24)
Experiments in primary culture have helped advance our understanding of the curious phenomenon of cell cycle-related neuronal death. In a differentiated postmitotic cell such as a neuron, aberrant cell cycle reentry is strongly associated with apoptosis. Indeed, in many pathologic
Shu-Zhen Zhang et al.
BMC medicine, 17(1), 204-204 (2019-11-16)
Brain innate immunity is vital for maintaining normal brain functions. Immune homeostatic imbalances play pivotal roles in the pathogenesis of neurological diseases including Parkinson's disease (PD). However, the molecular and cellular mechanisms underlying the regulation of brain innate immunity and
Michele Bellesi et al.
BMC biology, 13, 66-66 (2015-08-26)
Astrocytes can mediate neurovascular coupling, modulate neuronal excitability, and promote synaptic maturation and remodeling. All these functions are likely to be modulated by the sleep/wake cycle, because brain metabolism, neuronal activity and synaptic turnover change as a function of behavioral
Kouya Uchino et al.
iScience, 25(8), 104762-104762 (2022-08-10)
Although astrocytes are involved in the pathogenesis of CNS diseases, how they induce synaptic abnormalities is unclear. Currently, in vitro pathological astrocyte cultures or animal models do not reproduce human disease phenotypes accurately. Induced pluripotent stem cells (iPSCs) are replacing animal
Jasdeep Saini et al.
Journal of clinical medicine, 9(10) (2020-10-15)
In many neurodegenerative and muscular disorders, and loss of innervation in sarcopenia, improper reinnervation of muscle and dysfunction of the motor unit (MU) are key pathogenic features. In vivo studies of MUs are constrained due to difficulties isolating and extracting
Matteo Moschetta et al.
Advanced biology, 5(1), e2000177-e2000177 (2021-03-17)
Graphene is regarded as a viable bio-interface for neuroscience due to its biocompatibility and electrical conductivity, which would contribute to efficient neuronal network signaling. Here, monolayer graphene grown via chemical vapor deposition is treated with remote hydrogen plasma to demonstrate
Cathleen Pfefferkorn et al.
Journal of virology, 90(4), 2031-2038 (2015-12-15)
Interferon beta (IFN-β) is a key component of cellular innate immunity in mammals, and it constitutes the first line of defense during viral infection. Studies with cultured cells previously showed that almost all nucleated cells are able to produce IFN-β
M F Poitras et al.
Neuroscience, 148(1), 198-211 (2007-07-21)
Poly(ADP-ribose) polymerases (PARPs) are members of a family of enzymes that utilize nicotinamide adenine dinucleotide (NAD(+)) as substrate to form large ADP-ribose polymers (PAR) in the nucleus. PAR has a very short half-life due to its rapid degradation by poly(ADP-ribose)
Deletion of Calhm2 alleviates MPTP-induced Parkinson's disease pathology by inhibiting EFHD2-STAT3 signaling in microglia.
Bo, et al.
Theranostics, 13, 1809-1822 (2023)
Leila Ghanbari et al.
Nature communications, 10(1), 1500-1500 (2019-04-04)
Neural computations occurring simultaneously in multiple cerebral cortical regions are critical for mediating behaviors. Progress has been made in understanding how neural activity in specific cortical regions contributes to behavior. However, there is a lack of tools that allow simultaneous
Anne Enzbrenner et al.
International journal of molecular sciences, 22(17) (2021-09-11)
Age-related macular degeneration (AMD), one of the leading causes of blindness worldwide, causes personal suffering and high socioeconomic costs. While there has been progress in the treatments for the neovascular form of AMD, no therapy is yet available for the
Yoshio Shinozaki et al.
Brain structure & function, 224(1), 57-72 (2018-09-27)
The diaphragm is driven by phrenic motoneurons that are located in the cervical spinal cord. Although the anatomical location of the phrenic nucleus and the function of phrenic motoneurons at a single cellular level have been extensively analyzed, the spatiotemporal
Takayuki Matsushita et al.
Arthritis research & therapy, 23(1), 273-273 (2021-10-31)
Central nervous system (CNS)-mediated symptoms, such as fatigue, depression, and hyperalgesia, are common complications among patients with rheumatoid arthritis (RA). However, it remains unclear how the peripheral pathology of RA spreads to the brain. Accumulated evidence showing an association between
Francesca Viganò et al.
Glia, 64(2), 287-299 (2015-10-16)
In the adult brain NG2-glia continuously generate mature, myelinating oligodendrocytes. To which extent the differentiation process is common to all NG2-glia and whether distinct pools are recruited for repair under physiological and pathological conditions still needs clarification. Here, we aimed
Nicholas E Albrecht et al.
Cell reports methods, 2(7), 100253-100253 (2022-07-27)
Fine-scale molecular architecture is critical for nervous system and other biological functions. Methods to visualize these nanoscale structures would benefit from enhanced accessibility, throughput, and tissue compatibility. Here, we report RAIN-STORM, a rapid and scalable nanoscopic imaging optimization approach that
Free fatty acids support oligodendrocyte survival in a mouse model of amyotrophic lateral sclerosis.
Maruyama, et al.
Frontiers in Cellular Neuroscience, 17, 1081190-1081190 (2023)
Hisaaki Takahashi et al.
Brain structure & function, 214(2-3), 145-160 (2010-03-10)
Hippocampal atrophy and neuron loss are commonly found in Alzheimer's disease (AD). However, the underlying molecular mechanisms and the fate in the AD hippocampus of subpopulations of interneurons that express the calcium-binding proteins parvalbumin (PV) and calretinin (CR) has not
Jacob Kjell et al.
Cell stem cell, 26(2), 277-293 (2020-02-08)
The mammalian brain contains few niches for neural stem cells (NSCs) capable of generating new neurons, whereas other regions are primarily gliogenic. Here we leverage the spatial separation of the sub-ependymal zone NSC niche and the olfactory bulb, the region
Joanna Bouchat et al.
Neurotoxicity research, 36(1), 144-162 (2019-05-03)
A murine model used to investigate the osmotic demyelination syndrome (ODS) demonstrated ultrastructural damages in thalamus nuclei. Following chronic hyponatremia, significant myelinolysis was merely detected 48 h after the rapid reinstatement of normonatremia (ODS 48 h). In ODS samples, oligodendrocytes and astrocytes
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