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Showing 1-30 of 1427 results for "G3893" within Papers
Mona Abdelhamid et al.
Journal of Alzheimer's disease : JAD, 85(4), 1555-1571 (2021-12-28)
Probiotic supplementation reestablishes microbiome diversity and improves brain function in Alzheimer's disease (AD); their molecular mechanisms, however, have not yet been fully illustrated. We investigated the effects of orally supplemented Bifidobacterium breve MCC1274 on cognitive function and AD-like pathologies in
H Saleh et al.
Bratislavske lekarske listy, 120(2), 148-154 (2019-02-23)
Alzheimer's disease (AD) is an advanced neurodegenerative disorder greatly accompanied by acetylcholinesterase (AChE) activation and amyloid plaque deposition. Tetrahydrodeoxycorticosterone (THDOC) is an endogenous neurosteroid that is reduced in AD patient according to previous results. It has neuroprotective effects and plays
Inesa Lelyte et al.
Scientific reports, 14(1), 14325-14325 (2024-06-22)
Diabetic retinopathy (DR) is a multifactorial disease displaying vascular-associated pathologies, including vascular leakage and neovascularization, ultimately leading to visual impairment. However, animal models accurately reflecting these pathologies are lacking. Vascular endothelial growth factor A (VEGF-A) is an important factor in
Alan Y L Jiang et al.
Biomicrofluidics, 13(6), 064111-064111 (2019-11-19)
We created an integrated microfluidic cell separation system that incorporates hydrophoresis and dielectrophoresis modules to facilitate high-throughput continuous cell separation. The hydrophoresis module consists of a serpentine channel with ridges and trenches to generate a diverging fluid flow that focuses
Blanca Arango-Gonzalez et al.
PloS one, 7(4), e35687-e35687 (2012-05-05)
To explore the effect of ketamine-xylazine anesthesia on light-induced retinal degeneration in rats. Rats were anesthetized with ketamine and xylazine (100 and 5 mg, respectively) for 1 h, followed by a recovery phase of 2 h before exposure to 16,000
Kathryn M Lenz et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(37), 8044-8059 (2018-08-11)
Many sex differences in brain and behavior are programmed during development by gonadal hormones, but the cellular mechanisms are incompletely understood. We found that immune-system-derived mast cells are a primary target for the masculinizing hormone estradiol and that mast cells
Jing Tong et al.
Journal of neurotrauma, 30(4), 247-258 (2012-09-13)
Central nervous system (CNS) axons recover poorly following injury because of the expression of myelin-derived inhibitors of axonal outgrowth such as Nogo, myelin-associated glycoprotein (MAG), and oligodendrocyte-myelin glycoprotein (OMgp), all of which bind to the Nogo-66 receptor 1 (NgR1). Herein
Kazuhide Adachi et al.
Stem cells (Dayton, Ohio), 25(11), 2827-2836 (2007-08-04)
The subventricular zone (SVZ) is the largest germinal zone in the mature rodent brain, and it continuously produces young neurons that migrate to the olfactory bulb. Neural stem cells in this region generate migratory neuroblasts via highly proliferative transit-amplifying cells.
Aurore Quirié et al.
The European journal of neuroscience, 37(7), 1193-1202 (2013-01-15)
Because arginase and nitric oxide (NO) synthases (NOS) compete to degrade l-arginine, arginase plays a crucial role in the modulation of NO production. Moreover, the arginase 1 isoform is a marker of M2 phenotype macrophages that play a key role
Laura Fernández-Sánchez et al.
Frontiers in neuroanatomy, 16, 858073-858073 (2022-05-03)
Retinitis pigmentosa is primarily characterized by a massive photoreceptor loss. But a global retinal remodeling occurs in later stages of the disease. At that phase, glial cells and retinal vasculature are also strongly affected. The main aim of the present
Ana A Baburamani et al.
Acta neuropathologica communications, 8(1), 141-141 (2020-08-21)
Down syndrome (DS) occurs with triplication of human chromosome 21 and is associated with deviations in cortical development evidenced by simplified gyral appearance and reduced cortical surface area. Radial glia are neuronal and glial progenitors that also create a scaffolding
Anna Elizabeth Laird et al.
NeuroImmune pharmacology and therapeutics, 3(2), 113-128 (2024-08-23)
People with HIV (PWH) have high rates of depression and neurocognitive impairment (NCI) despite viral suppression on antiretroviral therapy (ART). Mounting evidence suggests that immunometabolic disruptions may contribute to these conditions in some PWH. We hypothesized that metabolic dysfunction in
Shuai Gao et al.
Heliyon, 10(6), e26911-e26911 (2024-03-18)
N6-methyladenosine (m6A) modification is a common RNA modification in the central nervous system and has been linked to various neurological disorders, including Alzheimer's disease (AD). However, the dynamic of mRNA m6A modification and m6A enzymes during the development of AD
Erica de Sousa et al.
Cell death & disease, 13(4), 393-393 (2022-04-23)
The voltage-dependent anion channel 1 (VDAC1) was first described as a mitochondrial porin that mediates the flux of metabolites and ions, thereby integrating both cell survival and death signals. In the nervous system, the functional roles of VDAC1 remain poorly
Rajender K Motiani et al.
Pflugers Archiv : European journal of physiology, 465(9), 1249-1260 (2013-03-22)
The Ca(2+) sensor stromal interacting molecule 1 (STIM1) and the Ca(2+) channel Orai1 mediate the ubiquitous store-operated Ca(2+) entry (SOCE) pathway activated by depletion of internal Ca(2+) stores and mediated through the highly Ca(2+)-selective, Ca(2+) release-activated Ca(2+) (CRAC) current. Furthermore
Jasbir S Dalal et al.
Frontiers in molecular neuroscience, 10, 9-9 (2017-02-14)
Studies on regulation of gene expression have contributed substantially to understanding mechanisms for the long-term activity-dependent alterations in neural connectivity that are thought to mediate learning and memory. Most of these studies, however, have focused on the regulation of mRNA
Yuka Nakazawa et al.
Cell, 180(6), 1228-1244 (2020-03-07)
Transcription-coupled nucleotide excision repair (TC-NER) is initiated by the stalling of elongating RNA polymerase II (RNAPIIo) at DNA lesions. The ubiquitination of RNAPIIo in response to DNA damage is an evolutionarily conserved event, but its function in mammals is unknown.
Francesca Viganò et al.
Glia, 64(2), 287-299 (2015-10-16)
In the adult brain NG2-glia continuously generate mature, myelinating oligodendrocytes. To which extent the differentiation process is common to all NG2-glia and whether distinct pools are recruited for repair under physiological and pathological conditions still needs clarification. Here, we aimed
Yuchen Pan et al.
Neuroscience bulletin, 35(5), 802-814 (2019-04-28)
The correct differentiation of oligodendrocyte precursor cells (OPCs) is essential for the myelination and remyelination processes in the central nervous system. Determining the regulatory mechanism is fundamental to the treatment of demyelinating diseases. By analyzing the RNA sequencing data of
María Elena Quintanilla et al.
Translational psychiatry, 12(1), 462-462 (2022-11-06)
The present study investigates the possible therapeutic effects of human mesenchymal stem cell-derived secretome on morphine dependence and relapse. This was studied in a new model of chronic voluntary morphine intake in Wistar rats which shows classic signs of morphine
Shaffi Manchanda et al.
Molecular and cellular biochemistry, 449(1-2), 63-72 (2018-03-20)
Chronic sleep loss/fragmentation prevalent in the current 24/7 society is associated with irreversible consequences on health and overall wellbeing. Various studies have well documented the ill effects of acute sleep loss on cognitive functions of individuals; however, the underlying mechanism
Kerstin Ure et al.
eLife, 5 (2016-06-22)
The postnatal neurodevelopmental disorder Rett syndrome, caused by mutations in MECP2, produces a diverse array of symptoms, including loss of language, motor, and social skills and the development of hand stereotypies, anxiety, tremor, ataxia, respiratory dysrhythmias, and seizures. Surprisingly, despite
J Kempf et al.
Cell reports, 36(3), 109409-109409 (2021-07-22)
Astrocytes are a viable source for generating new neurons via direct conversion. However, little is known about the neurogenic cascades triggered in astrocytes from different regions of the CNS. Here, we examine the transcriptome induced by the proneural factors Ascl1
Patricia Paez-Gonzalez et al.
Nature neuroscience, 17(7), 934-942 (2014-06-02)
Postnatal and adult subventricular zone (SVZ) neurogenesis is believed to be primarily controlled by neural stem cell (NSC)-intrinsic mechanisms, interacting with extracellular and niche-driven cues. Although behavioral experiments and disease states have suggested possibilities for higher level inputs, it is
Patrick S McQuillen et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 23(8), 3308-3315 (2003-04-30)
Neonatal hypoxia-ischemia in the preterm human leads to selective injury to the subcortical developing white matter, which results in periventricular leukomalacia (PVL), a condition associated with abnormal neurodevelopment. Maturation-dependent vulnerability of late oligodendrocyte progenitors is thought to account for the
Virpi Alarautalahti et al.
Investigative ophthalmology & visual science, 60(6), 1914-1927 (2019-05-03)
Retinal explant cultures provide simplified systems where the functions of the retina and the effects of ocular therapies can be studied in an isolated environment. The purpose of this study was to provide insight into long-term preservation of retinal tissue
Prisca S Leferink et al.
Annals of neurology, 86(5), 780-792 (2019-08-23)
Astrocytes have gained attention as important players in neurological disease. In line with their heterogeneous character, defects in specific astrocyte subtypes have been identified. Leukodystrophy vanishing white matter (VWM) shows selective vulnerability in white matter astrocytes, but the underlying mechanisms
Wenze Niu et al.
Nature cell biology, 15(10), 1164-1175 (2013-09-24)
Adult differentiated cells can be reprogrammed into pluripotent stem cells or lineage-restricted proliferating precursors in culture; however, this has not been demonstrated in vivo. Here, we show that the single transcription factor SOX2 is sufficient to reprogram resident astrocytes into
Ravi Kumar et al.
Cerebral cortex communications, 1(1), tgaa053-tgaa053 (2021-07-24)
Synchronous bursting (SB) is ubiquitous in neuronal networks and independent of network structure. Although it is known to be driven by glutamatergic neurotransmissions, its underlying mechanism remains unclear. Recent studies show that local glutamate recycle by astrocytes affects nearby neuronal
Jelena Platisa et al.
Nature methods, 20(7), 1095-1103 (2023-03-28)
Monitoring spiking activity across large neuronal populations at behaviorally relevant timescales is critical for understanding neural circuit function. Unlike calcium imaging, voltage imaging requires kilohertz sampling rates that reduce fluorescence detection to near shot-noise levels. High-photon flux excitation can overcome
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