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Showing 1-30 of 37 results for "G4546" within Papers
Yi-Xin Wang et al.
Neural regeneration research, 17(6), 1318-1323 (2021-11-17)
Oscillating field stimulation (OFS) is a potential method for treating spinal cord injury. Although it has been used in spinal cord injury (SCI) therapy in basic and clinical studies, its underlying mechanism and the correlation between its duration and nerve
Myungsik Yoo et al.
PloS one, 8(3), e57415-e57415 (2013-03-23)
Bacterial chondroitinase ABC (ChaseABC) has been used to remove the inhibitory chondroitin sulfate chains from chondroitin sulfate proteoglycans to improve regeneration after rodent spinal cord injury. We hypothesized that the mammalian enzyme arylsulfatase B (ARSB) would also enhance recovery after
Han-Xiang Deng et al.
Communications biology, 4(1), 396-396 (2021-03-27)
CRISPR/Cas9-mediated genome editing provides potential for therapeutic development. Efficacy and long-term safety represent major concerns that remain to be adequately addressed in preclinical studies. Here we show that CRISPR/Cas9-mediated genome editing in two distinct SOD1-amyotrophic lateral sclerosis (ALS) transgenic mouse
G F Hamilton et al.
Neuroscience, 265, 274-290 (2014-02-12)
Neonatal alcohol exposure impairs cognition and learning in adulthood and permanently damages the hippocampus. Wheel running (WR) improves hippocampus-associated learning and memory and increases the genesis and survival of newly generated neurons in the hippocampal dentate gyrus. WR significantly increases
Aline M Thomas et al.
Integrative biology : quantitative biosciences from nano to macro, 6(7), 694-705 (2014-05-31)
Spinal cord injury (SCI) results in loss of sensory and motor function below the level of injury and has limited available therapies. Multiple channel bridges have been investigated as a means to create a permissive environment for regeneration, with channels
Ivan Merdzo et al.
American journal of physiology. Heart and circulatory physiology, 310(7), H830-H838 (2016-02-14)
Little is known about mitochondrial functioning in the cerebral vasculature during insulin resistance (IR). We examined mitochondrial respiration in isolated cerebral arteries of male Zucker obese (ZO) rats and phenotypically normal Zucker lean (ZL) rats using the Seahorse XFe24 analyzer.
Sushanta Kumar Mishra et al.
The European journal of neuroscience (2021-05-02)
Cellular transplantation of stem cells can be a beneficial treatment approach for neurodegenerative diseases such as traumatic brain injury (TBI). In this study, we investigated the proliferation and differentiation potential of infused mesenchymal stem cells (MSCs) after localisation at the
Micheli M Pillat et al.
Journal of cell science, 129(18), 3437-3448 (2016-08-17)
During brain development, cells proliferate, migrate and differentiate in highly accurate patterns. In this context, published results indicate that bradykinin functions in neural fate determination, favoring neurogenesis and migration. However, mechanisms underlying bradykinin function are yet to be explored. Our
Jose E Perez et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 10(27), e2302411-e2302411 (2023-08-07)
Engineered 3D brain-like models have advanced the understanding of neurological mechanisms and disease, yet their mechanical signature, while fundamental for brain function, remains understudied. The surface tension for instance controls brain development and is a marker of cell-cell interactions. Here
Federica Pilotto et al.
STAR protocols, 5(2), 102936-102936 (2024-05-12)
GABAergic interneurons are inhibitory neurons of the CNS, playing a fundamental role in neural circuitry and activity. Here, we provide a robust protocol for the successful enrichment of human cerebellar GABAergic interneurons from human induced pluripotent stem cells (iPSCs) and
Walaa Yehia Abdelzaher et al.
Frontiers in pharmacology, 12, 715354-715354 (2021-10-12)
Depression is a common mental illness leading to upset or anxiety, with a high incidence rate in the world. Depression can lead to suicidal thoughts and behavior. The present study aimed to evaluate the effect of the direct oral anticoagulant
Wai Ping Yew et al.
Cell transplantation, 30, 963689720984437-963689720984437 (2021-01-13)
Dental pulp contains multipotent mesenchymal stem cells that improve outcomes when administered early after temporary middle cerebral artery occlusion in rats. To further assess the therapeutic potential of these cells, we tested whether functional recovery following stroke induced by photothrombosis
Eva M Jimenez-Mateos et al.
Scientific reports, 5, 17486-17486 (2015-12-04)
The ATP-gated ionotropic P2X7 receptor (P2X7R) modulates glial activation, cytokine production and neurotransmitter release following brain injury. Levels of the P2X7R are increased in experimental and human epilepsy but the mechanisms controlling P2X7R expression remain poorly understood. Here we investigated
Smriti M Agrawal et al.
Brain : a journal of neurology, 136(Pt 6), 1760-1777 (2013-05-21)
Inflammatory perivascular cuffs are comprised of leucocytes that accumulate in the perivascular space around post-capillary venules before their infiltration into the parenchyma of the central nervous system. Inflammatory perivascular cuffs are commonly found in the central nervous system of patients
Yanli Zhu et al.
Molecular vision, 19, 2360-2372 (2013-12-10)
We recently demonstrated in a mouse model of glaucoma that endogenous epigenetic mechanisms can be activated by a repetitive hypoxic preconditioning (RHP) stimulus to provide robust retinal ganglion cell (RGC) protection. Although we also provided evidence that RHP prevents or
Arpita Konar et al.
Evidence-based complementary and alternative medicine : eCAM, 2015, 837012-837012 (2015-09-29)
Preclinical studies on animal models have discerned the antiamnesic and memory-enhancing potential of Bacopa monniera (Brahmi) crude extract and standardized extracts. These studies primarily focus on behavioral consequences. However, lack of information on molecular underpinnings has limited the clinical trials
Francesca Provenzano et al.
Cells, 11(23) (2022-12-12)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with no effective cure. Astrocytes display a toxic phenotype in ALS and contribute to motoneuron (MN) degeneration. Modulating astrocytes' neurotoxicity can reduce MN death. Our previous studies showed the beneficial effect of
Silvia Ravera et al.
Journal of neurochemistry, 151(3), 336-350 (2019-07-10)
Amyotrophic lateral sclerosis is an adult-onset neurodegenerative disease that develops because of motor neuron death. Several mechanisms occur supporting neurodegeneration, including mitochondrial dysfunction. Recently, we demonstrated that the synaptosomes from the spinal cord of SOD1G93A mice, an in vitro model
Wai Ping Yew et al.
Journal of neuroinflammation, 18(1), 168-168 (2021-08-02)
Following stroke, changes in neuronal connectivity in tissue surrounding the infarct play an important role in both spontaneous recovery of neurological function and in treatment-induced improvements in function. Microglia and astrocytes influence this process through direct interactions with the neurons
Myungsik Yoo et al.
Journal of neurotrauma, 31(6), 553-564 (2013-10-16)
Cell replacement therapy is one potential avenue for central nervous system (CNS) repair. However, transplanted stem cells may not contribute to long-term recovery of the damaged CNS unless they are engineered for functional advantage. To fine tune regenerative capabilities, we
Natalia Jermakow et al.
International journal of molecular sciences, 24(18) (2023-09-28)
Parasitic helminths induce a transient, short-term inflammation at the beginning of infection, but in persistent infection may suppress the systemic immune response by enhancing the activity of regulatory M2 macrophages. The aim of the study was to determine how nematode
Haleh Mokabber et al.
Journal of cellular physiology, 234(6), 8941-8950 (2018-11-13)
Hair follicle stem cells (HFSCs) are able to differentiate into neurons and glial cells. Distinct microRNAs (miRNAs) regulate the proliferation and differentiation of HFSCs. However, the exact role of miR-124 in the neural differentiation of HFSCs has not been elucidated.
Maha Saber et al.
Journal of neurotrauma, 34(2), 423-435 (2016-03-16)
Traumatic brain injury (TBI) affects 1.7 million persons annually in the United States (Centers for Disease Control and Prevention). There is increasing evidence that persons exposed to TBI have increased risk of the development of multiple neurodegenerative conditions, including Alzheimer
Dorota Lubanska et al.
Oncoscience, 1(5), 336-348 (2015-01-17)
Neuroblastoma is an aggressive pediatric cancer originating embryonically from the neural crest. The heterogeneity of the disease, as most solid tumors, complicates diagnosis and treatment. In neuroblastoma this heterogeneity is well represented in both primary tumours and derived cell lines
Jesús Agulla et al.
Theranostics, 4(1), 90-105 (2014-01-08)
The use of theranostics in neurosciences has been rare to date because of the limitations imposed on the free delivery of substances to the brain by the blood-brain barrier. Here we report the development of a theranostic system for the
Daniel Radford-Smith et al.
Journal of proteome research, 23(8), 3383-3392 (2024-06-29)
Tumor necrosis factor (TNF) has well-established roles in neuroinflammatory disorders, but the effect of TNF on the biochemistry of brain cells remains poorly understood. Here, we microinjected TNF into the brain to study its impact on glial and neuronal metabolism
Christopher G Dengler et al.
Scientific reports, 7, 42090-42090 (2017-02-22)
In a mouse model of temporal lobe epilepsy, multicellular calcium imaging revealed that disease emergence was accompanied by massive amplification in the normally sparse, afferent stimulation-induced activation of hippocampal dentate granule cells. Patch recordings demonstrated reductions in local inhibitory function
Jiacheng Chen et al.
Frontiers in aging neuroscience, 15, 1105095-1105095 (2023-02-07)
Alzheimer's disease (AD) is characterized by amyloid β (Aβ) aggregation and neuroinflammation. This study aimed to investigate the therapeutic effect of isoniazid (INH) against AD. The APP/PS1 transgenic mouse model of AD was adopted. The APP/PS1 mice received oral INH
Yasuhito Tokumoto et al.
Scientific reports, 7(1), 1019-1019 (2017-04-23)
The adult mammalian central nervous system (CNS) contains a population of slowly dividing oligodendrocyte precursor cells (OPCs), i.e., adult OPCs, which supply new oligodendrocytes throughout the life of animal. While adult OPCs develop from rapidly dividing perinatal OPCs, the mechanisms
Alfredo González-Gil et al.
BMC veterinary research, 20(1), 372-372 (2024-08-20)
Neural stem and progenitor cells (NSPCs) from extra-neural origin represent a valuable tool for autologous cell therapy and research in neurogenesis. Identification of proneurogenic biomolecules on NSPCs would improve the success of cell therapies for neurodegenerative diseases. Preliminary data suggested
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