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Showing 1-30 of 32 results for "G4546" within Papers
Badrah Alghamdi et al.
Frontiers in neuroanatomy, 9, 49-49 (2015-06-25)
The extent to which NG-2(+) cells form a distinct population separate from astrocytes is central to understanding whether this important cell class is wholly an oligodendrocyte precursor cell (OPC) or has additional functions akin to those classically ascribed to astrocytes.
Wai Ping Yew et al.
Journal of neuroinflammation, 16(1), 6-6 (2019-01-11)
Altered neuronal connectivity in peri-infarct tissue is an important contributor to both the spontaneous recovery of neurological function that commonly develops after stroke and improvements in recovery that have been induced by experimental treatments in animal models. Microglia and astrocytes
Spyros Sideromenos et al.
Translational psychiatry, 12(1), 497-497 (2022-12-01)
Epidemiological studies indicate a bidirectional association between metabolic disturbances, including obesity and related pathological states, and mood disorders, most prominently major depression. However, the biological mechanisms mediating the comorbid relationship between the deranged metabolic and mood states remain incompletely understood.
Sonali N Reisinger et al.
Molecular psychiatry, 26(7), 2886-2899 (2020-10-14)
The signal transducer and activator of transcription 3 (STAT3) signalling pathway is activated through phosphorylation by Janus kinases in response to a diverse set of immunogenic and non-immunogenic triggers. Several distinct lines of evidence propose an intricate involvement of STAT3
Elzbieta Janda et al.
Autophagy, 11(7), 1063-1080 (2015-06-06)
Oxidative stress (OS) stimulates autophagy in different cellular systems, but it remains controversial if this rule can be generalized. We have analyzed the effect of chronic OS induced by the parkinsonian toxin paraquat (PQ) on autophagy in astrocytoma cells and
Yasuhito Tokumoto et al.
Scientific reports, 7(1), 1019-1019 (2017-04-23)
The adult mammalian central nervous system (CNS) contains a population of slowly dividing oligodendrocyte precursor cells (OPCs), i.e., adult OPCs, which supply new oligodendrocytes throughout the life of animal. While adult OPCs develop from rapidly dividing perinatal OPCs, the mechanisms
Hsiao-Han Wang et al.
American journal of translational research, 9(11), 4785-4806 (2017-12-09)
Glioblastoma multiforme (GBM) is one of the most malignant and aggressive brain tumors with great amount of hyaluronan (HA) secretion and CD44 overexpression (HA receptor). CD44 has been suggested as a cancer stem cells (CSCs) marker. However, several clinical studies
Christopher G Dengler et al.
Scientific reports, 7, 42090-42090 (2017-02-22)
In a mouse model of temporal lobe epilepsy, multicellular calcium imaging revealed that disease emergence was accompanied by massive amplification in the normally sparse, afferent stimulation-induced activation of hippocampal dentate granule cells. Patch recordings demonstrated reductions in local inhibitory function
Jesús Agulla et al.
Theranostics, 4(1), 90-105 (2014-01-08)
The use of theranostics in neurosciences has been rare to date because of the limitations imposed on the free delivery of substances to the brain by the blood-brain barrier. Here we report the development of a theranostic system for the
Jiacheng Chen et al.
Frontiers in aging neuroscience, 15, 1105095-1105095 (2023-02-07)
Alzheimer's disease (AD) is characterized by amyloid β (Aβ) aggregation and neuroinflammation. This study aimed to investigate the therapeutic effect of isoniazid (INH) against AD. The APP/PS1 transgenic mouse model of AD was adopted. The APP/PS1 mice received oral INH
Wai Ping Yew et al.
Journal of neuroinflammation, 18(1), 168-168 (2021-08-02)
Following stroke, changes in neuronal connectivity in tissue surrounding the infarct play an important role in both spontaneous recovery of neurological function and in treatment-induced improvements in function. Microglia and astrocytes influence this process through direct interactions with the neurons
Silvia Ravera et al.
Journal of neurochemistry, 151(3), 336-350 (2019-07-10)
Amyotrophic lateral sclerosis is an adult-onset neurodegenerative disease that develops because of motor neuron death. Several mechanisms occur supporting neurodegeneration, including mitochondrial dysfunction. Recently, we demonstrated that the synaptosomes from the spinal cord of SOD1G93A mice, an in vitro model
Natalia Jermakow et al.
International journal of molecular sciences, 24(18) (2023-09-28)
Parasitic helminths induce a transient, short-term inflammation at the beginning of infection, but in persistent infection may suppress the systemic immune response by enhancing the activity of regulatory M2 macrophages. The aim of the study was to determine how nematode
Myungsik Yoo et al.
Journal of neurotrauma, 31(6), 553-564 (2013-10-16)
Cell replacement therapy is one potential avenue for central nervous system (CNS) repair. However, transplanted stem cells may not contribute to long-term recovery of the damaged CNS unless they are engineered for functional advantage. To fine tune regenerative capabilities, we
Haleh Mokabber et al.
Journal of cellular physiology, 234(6), 8941-8950 (2018-11-13)
Hair follicle stem cells (HFSCs) are able to differentiate into neurons and glial cells. Distinct microRNAs (miRNAs) regulate the proliferation and differentiation of HFSCs. However, the exact role of miR-124 in the neural differentiation of HFSCs has not been elucidated.
Maha Saber et al.
Journal of neurotrauma, 34(2), 423-435 (2016-03-16)
Traumatic brain injury (TBI) affects 1.7 million persons annually in the United States (Centers for Disease Control and Prevention). There is increasing evidence that persons exposed to TBI have increased risk of the development of multiple neurodegenerative conditions, including Alzheimer
Dorota Lubanska et al.
Oncoscience, 1(5), 336-348 (2015-01-17)
Neuroblastoma is an aggressive pediatric cancer originating embryonically from the neural crest. The heterogeneity of the disease, as most solid tumors, complicates diagnosis and treatment. In neuroblastoma this heterogeneity is well represented in both primary tumours and derived cell lines
Yanli Zhu et al.
Molecular vision, 19, 2360-2372 (2013-12-10)
We recently demonstrated in a mouse model of glaucoma that endogenous epigenetic mechanisms can be activated by a repetitive hypoxic preconditioning (RHP) stimulus to provide robust retinal ganglion cell (RGC) protection. Although we also provided evidence that RHP prevents or
Micheli M Pillat et al.
Journal of cell science, 129(18), 3437-3448 (2016-08-17)
During brain development, cells proliferate, migrate and differentiate in highly accurate patterns. In this context, published results indicate that bradykinin functions in neural fate determination, favoring neurogenesis and migration. However, mechanisms underlying bradykinin function are yet to be explored. Our
Wai Ping Yew et al.
Cell transplantation, 30, 963689720984437-963689720984437 (2021-01-13)
Dental pulp contains multipotent mesenchymal stem cells that improve outcomes when administered early after temporary middle cerebral artery occlusion in rats. To further assess the therapeutic potential of these cells, we tested whether functional recovery following stroke induced by photothrombosis
Smriti M Agrawal et al.
Brain : a journal of neurology, 136(Pt 6), 1760-1777 (2013-05-21)
Inflammatory perivascular cuffs are comprised of leucocytes that accumulate in the perivascular space around post-capillary venules before their infiltration into the parenchyma of the central nervous system. Inflammatory perivascular cuffs are commonly found in the central nervous system of patients
Walaa Yehia Abdelzaher et al.
Frontiers in pharmacology, 12, 715354-715354 (2021-10-12)
Depression is a common mental illness leading to upset or anxiety, with a high incidence rate in the world. Depression can lead to suicidal thoughts and behavior. The present study aimed to evaluate the effect of the direct oral anticoagulant
Eva M Jimenez-Mateos et al.
Scientific reports, 5, 17486-17486 (2015-12-04)
The ATP-gated ionotropic P2X7 receptor (P2X7R) modulates glial activation, cytokine production and neurotransmitter release following brain injury. Levels of the P2X7R are increased in experimental and human epilepsy but the mechanisms controlling P2X7R expression remain poorly understood. Here we investigated
Aline M Thomas et al.
Integrative biology : quantitative biosciences from nano to macro, 6(7), 694-705 (2014-05-31)
Spinal cord injury (SCI) results in loss of sensory and motor function below the level of injury and has limited available therapies. Multiple channel bridges have been investigated as a means to create a permissive environment for regeneration, with channels
Myungsik Yoo et al.
PloS one, 8(3), e57415-e57415 (2013-03-23)
Bacterial chondroitinase ABC (ChaseABC) has been used to remove the inhibitory chondroitin sulfate chains from chondroitin sulfate proteoglycans to improve regeneration after rodent spinal cord injury. We hypothesized that the mammalian enzyme arylsulfatase B (ARSB) would also enhance recovery after
Francesca Provenzano et al.
Cells, 11(23) (2022-12-12)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with no effective cure. Astrocytes display a toxic phenotype in ALS and contribute to motoneuron (MN) degeneration. Modulating astrocytes' neurotoxicity can reduce MN death. Our previous studies showed the beneficial effect of
Sushanta Kumar Mishra et al.
The European journal of neuroscience (2021-05-02)
Cellular transplantation of stem cells can be a beneficial treatment approach for neurodegenerative diseases such as traumatic brain injury (TBI). In this study, we investigated the proliferation and differentiation potential of infused mesenchymal stem cells (MSCs) after localisation at the
G F Hamilton et al.
Neuroscience, 265, 274-290 (2014-02-12)
Neonatal alcohol exposure impairs cognition and learning in adulthood and permanently damages the hippocampus. Wheel running (WR) improves hippocampus-associated learning and memory and increases the genesis and survival of newly generated neurons in the hippocampal dentate gyrus. WR significantly increases
Han-Xiang Deng et al.
Communications biology, 4(1), 396-396 (2021-03-27)
CRISPR/Cas9-mediated genome editing provides potential for therapeutic development. Efficacy and long-term safety represent major concerns that remain to be adequately addressed in preclinical studies. Here we show that CRISPR/Cas9-mediated genome editing in two distinct SOD1-amyotrophic lateral sclerosis (ALS) transgenic mouse
Arpita Konar et al.
Evidence-based complementary and alternative medicine : eCAM, 2015, 837012-837012 (2015-09-29)
Preclinical studies on animal models have discerned the antiamnesic and memory-enhancing potential of Bacopa monniera (Brahmi) crude extract and standardized extracts. These studies primarily focus on behavioral consequences. However, lack of information on molecular underpinnings has limited the clinical trials
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