G5417

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Showing 1-30 of 1230 results for "G5417" within Papers

Targeting cystalysin, a virulence factor of treponema denticola-supported periodontitis.

Francesca Spyrakis et al.

ChemMedChem, 9(7), 1501-1511 (2014-03-13)

Cystalysin from Treponema denticola is a pyridoxal 5'-phosphate dependent lyase that catalyzes the formation of pyruvate, ammonia, and sulfide from cysteine. It is a virulence factor in adult periodontitis because its reaction contributes to hemolysis, which sustains the pathogen. Therefore

SOCS3 silencing attenuates eosinophil functions in asthma patients.

Ma Paz Zafra et al.

International journal of molecular sciences, 16(3), 5434-5451 (2015-03-13)

Eosinophils are one of the key inflammatory cells in asthma. Eosinophils can exert a wide variety of actions through expression and secretion of multiple molecules. Previously, we have demonstrated that eosinophils purified from peripheral blood from asthma patients express high

Interactions between glycine transporter type 1 (GlyT-1) and some inhibitor molecules - glycine transporter type 1 and its inhibitors (review).

Laszlo G Harsing et al.

Acta physiologica Hungarica, 99(1), 1-17 (2012-03-20)

Glycine is a mandatory positive allosteric modulator of N-methyl-D-aspartate (NMDA)-type ionotropic glutamate receptors in the central nervous system. Elevation of glycine concentrations by inhibition of its reuptake in the vicinity of NMDA receptors may positively influence receptor functions as glycine

Development of a stable low-dose aglycosylated antibody formulation to minimize protein loss during intravenous administration.

Sorina Morar-Mitrica et al.

mAbs, 7(4), 792-803 (2015-06-16)

The physical and chemical integrity of a biopharmaceutical must be maintained not only during long-term storage but also during administration. Specifically for the intravenous (i.v.) delivery of a protein drug, loss of stability can occur when the protein formulation is

EZH2 is highly expressed in pituitary adenomas and associated with proliferation.

David Schult et al.

Scientific reports, 5, 16965-16965 (2015-11-26)

Enhancer of zeste homolog 2 (EZH2) is a core epigenetic regulator, playing a crucial role in cell cycle regulation. The protein is known to be associated with proliferation and worse outcome in several tumor entities. In this study, we immunohistochemically

A review of methods for the analysis of orphan and difficult pesticides: glyphosate, glufosinate, quaternary ammonium and phenoxy acid herbicides, and dithiocarbamate and phthalimide fungicides.

Renata Raina-Fulton

Journal of AOAC International, 97(4), 965-977 (2014-08-26)

This article reviews the chromatography/MS methodologies for analysis of pesticide residues of orphan and difficult chemical classes in a variety of sample matrixes including water, urine, blood, and food. The review focuses on pesticide classes that are not commonly included

Regulation of copper transport crossing brain barrier systems by Cu-ATPases: effect of manganese exposure.

Xue Fu et al.

Toxicological sciences : an official journal of the Society of Toxicology, 139(2), 432-451 (2014-03-13)

Regulation of cellular copper (Cu) homeostasis involves Cu-transporting ATPases (Cu-ATPases), i.e., ATP7A and ATP7B. The question as to how these Cu-ATPases in brain barrier systems transport Cu, i.e., toward brain parenchyma, cerebrospinal fluid (CSF), or blood, remained unanswered. This study

Contributions of photosynthetic and non-photosynthetic cell types to leaf respiration in Vicia faba L. and their responses to growth temperature.

Benedict M Long et al.

Plant, cell & environment, 38(11), 2263-2276 (2015-04-02)

In intact leaves, mitochondrial populations are highly heterogeneous among contrasting cell types; how such contrasting populations respond to sustained changes in the environment remains, however, unclear. Here, we examined respiratory rates, mitochondrial protein composition and response to growth temperature in

The Signaling Mechanism of Contraction Induced by ATP and UTP in Feline Esophageal Smooth Muscle Cells.

Tae Hoon Kwon et al.

Molecules and cells, 38(7), 616-623 (2015-05-28)

P2 receptors are membrane-bound receptors for extracellular nucleotides such as ATP and UTP. P2 receptors have been classified as ligand-gated ion channels or P2X receptors and G protein-coupled P2Y receptors. Recently, purinergic signaling has begun to attract attention as a

Batf2/Irf1 induces inflammatory responses in classically activated macrophages, lipopolysaccharides, and mycobacterial infection.

Sugata Roy et al.

Journal of immunology (Baltimore, Md. : 1950), 194(12), 6035-6044 (2015-05-10)

Basic leucine zipper transcription factor Batf2 is poorly described, whereas Batf and Batf3 have been shown to play essential roles in dendritic cell, T cell, and B cell development and regulation. Batf2 was drastically induced in IFN-γ-activated classical macrophages (M1)

Conditioned medium as a strategy for human stem cells chondrogenic differentiation.

M L Alves da Silva et al.

Journal of tissue engineering and regenerative medicine, 9(6), 714-723 (2013-10-25)

Paracrine signalling from chondrocytes has been reported to increase the synthesis and expression of cartilage extracellular matrix (ECM) by stem cells. The use of conditioned medium obtained from chondrocytes for stimulating stem cells chondrogenic differentiation may be a very interesting

Rg1 exhibits neuroprotective effects by inhibiting the endoplasmic reticulum stress-mediated c-Jun N-terminal protein kinase apoptotic pathway in a rat model of Alzheimer's disease.

Jun-Shan Mu et al.

Molecular medicine reports, 12(3), 3862-3868 (2015-05-29)

The neuroprotective agents currently used to treat Alzheimer's disease (AD) often only target one aspect of the disease process. Therefore, identifying effective drug targets associated with the pathogenesis of AD is critical for the production of novel AD therapeutic strategies.

Sirtuin inhibitors, EX527 and AGK2, suppress cell migration by inhibiting HSF1 protein stability.

Hyun-Woo Kim et al.

Oncology reports, 35(1), 235-242 (2015-11-05)

The histone deacetylases (HDACs), Sirtuin 1 (Sirt1) and Sirt2, play crucial roles in many biological processes, including cell proliferation, differentiation and apoptosis. HDAC inhibitors have been considered as a potential therapeutic approach for various types of cancers. Here, we demonstrated

Benzoate treatment and the glycine index in nonketotic hyperglycinaemia.

J L K Van Hove et al.

Journal of inherited metabolic disease, 28(5), 651-663 (2005-09-10)

High-dose benzoate treatment aimed at reducing plasma glycine levels to normal reduces seizures and increases wakefulness in patients with nonketotic hyperglycinaemia (NKH). Since benzoate metabolism is dependent on the available glycine pool, and since the glycine pool is variably affected

3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds.

Maria Luisa Gelmi et al.

Journal of medicinal chemistry, 49(18), 5571-5577 (2006-09-01)

A novel class of 3-demethoxy-3-glycosylaminothiocolchicines (7) was prepared and tested for muscle relaxant activity. The syntheses were performed starting from the new 3-amino-3-demethoxythiocolchicine (5) prepared in good yield from 3-O-demethylthiocolchicine (1c) using the Buchwald-Hartwig reaction. The condensation of 5 with

VEGF can protect against blood brain barrier dysfunction, dendritic spine loss and spatial memory impairment in an experimental model of diabetes.

Stephanie L Taylor et al.

Neurobiology of disease, 78, 1-11 (2015-04-02)

Clinical and experimental studies have shown a clear link between diabetes, vascular dysfunction and cognitive impairment. However, the molecular underpinnings of this association remain unclear. Since vascular endothelial growth factor (VEGF) signaling is important for maintaining vascular integrity and function

High-affinity nitrate/nitrite transporter genes (Nrt2) in Tisochrysis lutea: identification and expression analyses reveal some interesting specificities of Haptophyta microalgae.

Aurélie Charrier et al.

Physiologia plantarum, 154(4), 572-590 (2015-02-03)

Microalgae have a diversity of industrial applications such as feed, food ingredients, depuration processes and energy. However, microalgal production costs could be substantially improved by controlling nutrient intake. Accordingly, a better understanding of microalgal nitrogen metabolism is essential. Using in

In vivo detection of brain glycine with echo-time-averaged (1)H magnetic resonance spectroscopy at 4.0 T.

Andrew P Prescot et al.

Magnetic resonance in medicine, 55(3), 681-686 (2006-02-03)

A single-voxel proton magnetic resonance spectroscopy ((1)H-MRS) method is described that enables the in vivo measurement of endogenous brain glycine (Gly) levels in human subjects. At 4.0 T, TE-averaging (1)H-MRS dramatically attenuates the overlapping myo-inositol (mI) resonances at 3.52 ppm

Polysaccharide nanofibers with variable compliance for directing cell fate.

Xu Jiang et al.

Journal of biomedical materials research. Part A, 103(3), 959-968 (2014-05-24)

Cells perceive their microenvironment through physical and mechanical cues, such as extracellular matrix topography or stiffness. In this study, we developed a polysaccharide scaffold that can provide combined substrate topography and matrix compliance signals to direct cell fate. Pullulan/dextran (P/D)

HIV infection and antiretroviral therapy lead to unfolded protein response activation.

Mariana Borsa et al.

Virology journal, 12, 77-77 (2015-05-16)

The unfolded protein response (UPR) is one of the pathways triggered to ensure quality control of the proteins assembled in the endoplasmic reticulum (ER) when cell homeostasis is compromised. This mechanism is primarily composed of three transmembrane proteins serving as

RNA binding protein HuR regulates the expression of ABCA1.

Cristina M Ramírez et al.

Journal of lipid research, 55(6), 1066-1076 (2014-04-15)

ABCA1 is a major regulator of cellular cholesterol efflux and plasma HDL biogenesis. Even though the transcriptional activation of ABCA1 is well established, the posttranscriptional regulation of ABCA1 expression is poorly understood. Here, we investigate the potential contribution of the

Calcineurin mediates synaptic scaling via synaptic trafficking of Ca2+-permeable AMPA receptors.

Seonil Kim et al.

PLoS biology, 12(7), e1001900-e1001900 (2014-07-02)

Homeostatic synaptic plasticity is a negative-feedback mechanism for compensating excessive excitation or inhibition of neuronal activity. When neuronal activity is chronically suppressed, neurons increase synaptic strength across all affected synapses via synaptic scaling. One mechanism for this change is alteration

Assessment of heat shock protein 70 induction by heat in alfalfa varieties and constitutive overexpression in transgenic plants.

Nicoletta Ferradini et al.

PloS one, 10(5), e0126051-e0126051 (2015-05-08)

Heat shock proteins (HSPs) are molecular chaperones involved in many cellular functions. It has been shown that mammalian cytosolic HSP70 binds antigenic peptides mediating the activation of the immune system, and that it plays a determining role in tumour immunogenicity.

The 15-lipoxygenase inhibitory, antioxidant, antimycobacterial activity and cytotoxicity of fourteen ethnomedicinally used African spices and culinary herbs.

Jean Paul Dzoyem et al.

Journal of ethnopharmacology, 156, 1-8 (2014-08-26)

Culinary herbs and spices are widely used ethnomedically across Africa. They are traditionally employed in the treatment of several ailments including inflammation disorders, pain alleviation and infectious diseases. Pharmacological studies are necessary to provide a scientific basis to substantiate their

Chemical forces and water holding capacity study of heat-induced myofibrillar protein gel as affected by high pressure.

Ziye Zhang et al.

Food chemistry, 188, 111-118 (2015-06-05)

The effects of high pressure (100-500 MPa) on chemical forces and water holding capacity of heat-induced myofibrillar protein (MP) gel were investigated. As pressure increased, total sulfhydryl (SH) group content decreased and absolute value of zeta potential increased, which suggested

Urinary and plasma organic acids and amino acids in chronic fatigue syndrome.

Mark G Jones et al.

Clinica chimica acta; international journal of clinical chemistry, 361(1-2), 150-158 (2005-07-05)

Previous work by others have suggested the occurrence of one or more chemical or metabolic 'markers' for ME/CFS including specific amino acids and organic acids and a number of unidentified compounds (CFSUM1, CFSUM2). We have shown elsewhere that CFSUM1 is

Candida albicans erythroascorbate peroxidase regulates intracellular methylglyoxal and reactive oxygen species independently of D-erythroascorbic acid.

Min-Kyu Kwak et al.

FEBS letters, 589(15), 1863-1871 (2015-05-11)

Candida albicans D-erythroascorbate peroxidase (EAPX1), which can catalyze the oxidation of D-erythroascorbic acid (EASC) to water, was observed to be inducible in EAPX1-deficient and EAPX1-overexpressing cells via activity staining. EAPX1-deficient cells have remarkably increased intracellular reactive oxygen species and methylglyoxal

Silencing ECHS1 attenuates the proliferation and induces the autophagy of hepatocellular carcinoma via impairing cell metabolism and activating AMPK.

W J Xu et al.

Neoplasma, 62(6), 872-880 (2015-10-16)

Hepatocellular carcinoma (HCC) is among the most common cancers in the world with a low survival rate. Our previous study showed Short chain enoyl-CoA hydratase (ECHS1) could bind to HBsAg (HBs) and that ECHS1's localization in mitochondria induced HepG2 cell apoptosis.

A Sertoli cell-specific connexin43 knockout leads to altered interstitial connexin expression and increased Leydig cell numbers.

Joanna Noelke et al.

Cell and tissue research, 361(2), 633-644 (2015-02-20)

The Sertoli cell (SC)-specific knockout (KO) of connexin43 (Cx43) results in spermatogenic arrest at the level of spermatogonia and/or SC-only syndrome. Histology of the interstitial compartment suggests Leydig cell (LC) hyperplasia. Our aim has been to investigate possible effects of

Alendronate-induced atypical bone fracture: evidence that the drug inhibits osteogenesis.

S Patntirapong et al.

Journal of clinical pharmacy and therapeutics, 39(4), 349-353 (2014-03-26)

Alendronate (ALN) is used for the treatment of post-menopausal osteoporosis. By reducing bone turnover, it increases bone mineral density. However, recent reports suggest an increased risk of atypical bone fractures after long-term ALN administration. Despite its well-known anti-osteoclastic activity, it

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