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Showing 1-30 of 5187 results for "G5792" within Papers
Nathella P Kumar et al.
Immunology, 144(4), 677-686 (2014-11-05)
Type 2 diabetes mellitus (DM) is associated with expanded frequencies of mycobacterial antigen-specific CD4(+) T helper type 1 (Th1) and Th17 cells in individuals with active pulmonary tuberculosis (TB). No data are available on the role of CD8(+) T and
Sumayah Salie et al.
The Journal of antimicrobial chemotherapy, 69(6), 1551-1558 (2014-02-27)
Phenothiazines are a commercially available class of psychotropic drugs known to show antituberculosis activity. At clinically relevant bactericidal doses, however, the psychotropic drugs produce undesirable side effects in addition to their neuroleptic properties. This study aimed to evaluate rationally designed
Barbara Adinolfi et al.
Anticancer research, 35(7), 3781-3786 (2015-07-01)
The current study was designed to characterize the anticancer effects of clotrimazole on human cutaneous melanoma cells. The v-raf murine sarcoma viral oncogene homolog B1 V600E mutant melanoma cell line A375 was used as an in vitro model. Characterization tools
Xingbo Xu et al.
Nature communications, 6, 6008-6008 (2015-01-24)
Reprogramming of mouse somatic cells into induced pluripotent stem cells (iPSCs) often generates partially reprogrammed iPSCs (pre-iPSCs), low-grade chimera forming iPSCs (lg-iPSCs) and fully reprogrammed, high-grade chimera production competent iPSCs (hg-iPSCs). Lg-iPSC transcriptome analysis revealed misregulated Dlk1-Dio3 cluster gene expression
Nicholas R Meyerson et al.
Journal of virology, 89(16), 8611-8622 (2015-06-13)
Most HIV-1 variants isolated from early-stage human infections do not use nonhuman primate versions of the CD4 receptor for cellular entry, or they do so poorly. We and others have previously shown that CD4 has experienced strong natural selection over
Han-Joo Maeng et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 62, 189-196 (2014-06-10)
It is apparent that lung cancer is associated with inflammation, with accompanying hallmark elevations of cyclooxygenase 2 (COX-2) and prostaglandin E2 (PGE2) levels. However, the effects of these changes on MRP efflux transporters have not been thoroughly investigated before. Here
Chenghai Wang et al.
Development, growth & differentiation, 57(6), 466-473 (2015-06-23)
Long noncoding RNAs (LncRNAs) are longer than 200 nucleotide noncoding RNAs without apparent functional coding capacity that function as regulators of cell growth and development. In recent years, increasing evidence implicates the involvement of LncRNAs in erythropoiesis. shlnc-EC6 is a
A S Menko et al.
Molecular biology of the cell, 25(6), 776-790 (2014-01-31)
Mock cataract surgery provides a unique ex vivo model for studying wound repair in a clinically relevant setting. Here wound healing involves a classical collective migration of the lens epithelium, directed at the leading edge by an innate mesenchymal subpopulation
Guihua Jiang et al.
Tissue engineering. Part C, Methods, 20(9), 731-740 (2014-01-23)
The reliable derivation of induced pluripotent stem cells (iPSCs) from a noninvasive autologous source at birth would facilitate the study of patient-specific in vitro modeling of congenital diseases and would enhance ongoing efforts aimed at developing novel cell-based treatments for
Takashi Kotera et al.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 67(10), 499-507 (2015-07-26)
Malignant fibrous histiocytomas (MFHs) show a storiform growth pattern consisting of fibroblastic, histiocytic and undifferentiated mesenchymal cells with possible multipotency. Because MFH-like tumors are induced experimentally by some chemicals and materials, it is important to know the histogenesis of MFHs.
Sami Ventelä et al.
Oncotarget, 6(1), 144-158 (2014-12-05)
Radiotherapy is a mainstay for treatment of many human cancer types, including head and neck squamous cell carcinoma (HNSCC). Thereby, it is clinically very relevant to understand the mechanisms determining radioresistance. Here, we identify CIP2A as an Oct4 target gene
Meike Schneider et al.
Urologic oncology, 32(6), 877-884 (2014-06-16)
Novel personalized therapeutic approaches are urgently needed for patients with metastatic clear cell renal cell carcinoma (ccRCC). We combined the development of a primary patient-derived ccRCC cell line with a phenotypic drug screen consisting of 101 approved anticancer compounds. We
Sung Min Son et al.
Neurobiology of aging, 36(12), 3214-3227 (2015-10-11)
Alzheimer's disease (AD) is characterized by impaired cognitive function and memory loss, which are often the result of synaptic pathology. Thrombospondin (TSP) is an astrocyte-secreted protein, well known for its function as a modulator of synaptogenesis and neurogenesis. Here, we
Shuai Gao et al.
Nature communications, 6, 6318-6318 (2015-02-19)
Although viable mice can be generated from induced pluripotent stem cells (iPSCs), the impact of accumulated mutations on the developmental potential of the resulting iPSCs remains to be determined. Here, we demonstrate that all-iPSC mice generated through tetraploid blastocysts complementation
Nu Ry Song et al.
International journal of molecular sciences, 16(3), 4453-4470 (2015-02-25)
Licorice is a traditional botanical medicine, and has historically been commonly prescribed in Asia to treat various diseases. Glycyrrhizin (Gc), a triterpene compound, is the most abundant phytochemical constituent of licorice. However, high intake or long-term consumption of Gc has
IL-4 specific-response in whole blood associates with human Cystic Echinococcosis and cyst activity.
Linda Petrone et al.
The Journal of infection, 70(3), 299-306 (2014-12-03)
Human Cystic Echinococcosis (CE) is estimated in 2-3 million global cases. CE diagnosis and clinical management are based on imaging and serology, which lacks sensitivity and does not provide cyst stage information. This study aimed to evaluate tools for improving
Georg F Weber et al.
The Journal of experimental medicine, 211(6), 1243-1256 (2014-05-14)
Pneumonia is a major cause of mortality worldwide and a serious problem in critical care medicine, but the immunophysiological processes that confer either protection or morbidity are not completely understood. We show that in response to lung infection, B1a B
Weidong Zhou et al.
Cancer letters, 356(2 Pt A), 176-183 (2013-11-23)
Cancer metabolism has been extensively investigated by various tools, and the fact of diverse metabolic reprogramming in cancer cells has been gradually unveiled. In this review, we discuss some contributions in cancer metabolism by general proteomic analysis and post-translational modification
Allison Chalupa et al.
The Journal of investigative dermatology, 135(1), 202-211 (2014-07-24)
Galectin-3 is a family member of the carbohydrate-binding proteins widely expressed by many cell types and exhibits multiple cellular functions. We demonstrate that melanocytes express galectin-3, which is predominantly localized to the cell body peripherally along the Golgi zone. Downregulation
Fang-Ming Hung et al.
Environmental toxicology, 30(11), 1343-1353 (2014-06-04)
Diallyl trisulfide (DATS), a chemopreventive dietary constituent and extracted from garlic, has been shown to against cultured many types of human cancer cell liens but the fate of apoptosis in murine leukemia cells in vitro and immune responses in leukemic
Stephen L Ball et al.
The Annals of otology, rhinology, and laryngology, 124(6), 437-442 (2014-12-30)
Well-characterized cell lines represent useful scientific tools to study the pathophysiology of human disease. Chronic rhinosinusitis (CRS) is a very common condition, though the number of CRS cell lines is limited, as are data showing how closely they resemble primary
Maria E Cuevas et al.
International journal of oncology, 47(2), 650-656 (2015-06-06)
Endometrial cancer is the most common female reproductive cancer in the United States and is associated with deregulated tight junction protein expression. Given the highly estrogen-responsive nature of this tissue, we investigated the effects of estrogen and its agonist, 4-OH
Laura Hakanpaa et al.
Nature communications, 6, 5962-5962 (2015-01-31)
Angiopoietins regulate vascular homeostasis via the endothelial Tie receptor tyrosine kinases. Angiopoietin-1 (Ang1) supports endothelial stabilization via Tie2 activation. Angiopoietin-2 (Ang2) functions as a context-dependent Tie2 agonist/antagonist promoting pathological angiogenesis, vascular permeability and inflammation. Elucidating Ang2-dependent mechanisms of vascular destablization
Xiefan Fang et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 307(12), R1471-R1487 (2014-10-31)
Previous studies demonstrated that in utero caffeine treatment at embryonic day (E) 8.5 alters DNA methylation patterns, gene expression, and cardiac function in adult mice. To provide insight into the mechanisms, we examined cardiac gene and microRNA (miRNA) expression in
Odysseus Zis et al.
Molecular neurobiology, 51(1), 155-167 (2014-05-16)
The macrophage migration inhibitory factor (MIF) is a multifaceted cytokine involved in many processes, including cellular responses to ischemia/reperfusion injury in the heart and brain. This study was undertaken to determine whether human MIF expression is induced following cerebral ischemia
Xuan Guo et al.
Rejuvenation research, 18(3), 211-224 (2015-01-06)
Pluripotent human hepatic stem cells have broad research and clinical applications, which are, however, restricted by both limited resources and technical difficulties with respect to isolation of stem cells from the adult or fetal liver. In this study, we developed
Qyana Griffith et al.
Experimental parasitology, 153, 139-150 (2015-03-31)
Many chronic inflammatory diseases can be improved by helminth infection, but the mechanisms are poorly understood. Allergy and helminthiasis are both associated with Th2-like immune responses; thus, defining how infection with parasites leads to reduced allergy has been particularly challenging.
Rongqing Pang et al.
Cellular & molecular biology letters, 20(3), 404-417 (2015-07-26)
Multipotent stem cells have potential therapeutic roles in the treatment of Duchenne muscular dystrophy (DMD). However, the limited access to stem cell sources restricts their clinical application. To address this issue, we established a simple in vitro epigenetic reprogramming technique
Christine Freimüller et al.
Cytotherapy, 17(7), 989-1007 (2015-04-14)
Despite antiviral drug therapies, human adenovirus (HAdV), cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infections still contribute substantially to transplant-related death of patients after hematopoietic stem cell transplantation. Earlier clinical studies demonstrated successful adoptive transfer of magnetically selected CMV-specific T cells
Elena I Kovalenko et al.
Oncotarget, 5(23), 11800-11812 (2014-12-17)
ROS production and intracellular HSP70 levels were measured in human neutrophils for three age groups: young (20-59 years), elders (60-89 years) and nonagenarians (90 years and older). Elders showed higher levels of spontaneous intracellular ROS content compared with young and
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