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Showing 1-30 of 217 results for "G6779" within Papers
Kenya Kanazawa et al.
Cancer chemotherapy and pharmacology, 74(6), 1149-1157 (2014-10-09)
This phase II study evaluated the response rate (RR) and safety of combination therapy with carboplatin (CBDCA) and pemetrexed (PEM) in Japanese patients with non-squamous non-small cell lung cancer (non-sq NSCLC). Further, the relationship between therapy efficacy/toxicity and genetic polymorphisms
Hongwei Qin et al.
Analytical biochemistry, 462, 60-66 (2014-06-29)
An in situ electrochemical method was used to assess the cytotoxicity of chlorophenols using human breast cancer (MCF-7) and cervical carcinoma (HeLa) cells as models. On treatment with different chlorophenols, the electrochemical responses of the selected cells, resulting from the
Mathieu Chauleau et al.
RNA (New York, N.Y.), 19(12), 1840-1847 (2013-10-26)
T4 RNA ligase 2 (Rnl2) repairs 3'-OH/5'-PO4 nicks in duplex nucleic acids in which the broken 3'-OH strand is RNA. Ligation entails three chemical steps: reaction of Rnl2 with ATP to form a covalent Rnl2-(lysyl-Nζ)-AMP intermediate (step 1); transfer of
Barbara van Loon et al.
DNA repair, 9(6), 604-616 (2010-04-20)
The maintenance of genetic stability is of crucial importance for any form of life. Prior to cell division in each mammalian cell, the process of DNA replication must faithfully duplicate the three billion bases with an absolute minimum of mistakes.
Nawal Bahia El Idrissi et al.
Acta neuropathologica, 129(5), 653-667 (2015-03-17)
Peripheral nerve damage is the hallmark of leprosy pathology but its etiology is unclear. We previously identified the membrane attack complex (MAC) of the complement system as a key determinant of post-traumatic nerve damage and demonstrated that its inhibition is
Daniela Stangel et al.
The Journal of surgical research, 197(1), 91-100 (2015-05-09)
The Translational Genome Research Network in Pancreatic Cancer performed a meta-analysis of publicly available various high-throughput gene analysis panels to identify drugable targets. There, the most differentially expressed gene between normal and cancerous pancreas was Kif20a. The aim of the
Paul A Renauer et al.
Clinical immunology (Orlando, Fla.), 156(1), 19-27 (2014-12-03)
T cell receptor (TCR) αβ+CD4-CD8- double negative T cells represent a rare T cell subset implicated in the pathogenesis of several autoimmune diseases. We investigated the DNA methylation signature of double negative T cells to gain insight into the epigenetic
Hidehiro Kamezaki et al.
International journal of medical sciences, 10(5), 567-574 (2013-03-28)
Viral breakthrough is related to poor adherence to medication in some chronic hepatitis B patients treated with nucleos(t)ide analogues (NAs). Our study aimed to examine how adherence to medication is associated with viral breakthrough in patients treated with NAs. A
Jia-Xuan Qiu et al.
Drug design, development and therapy, 9, 349-417 (2015-01-23)
Plumbagin (PLB) has exhibited a potent anticancer effect in preclinical studies, but the molecular interactome remains elusive. This study aimed to compare the quantitative proteomic responses to PLB treatment in human prostate cancer PC-3 and DU145 cells using the approach
Flavia Pichiorri et al.
The Journal of experimental medicine, 210(5), 951-968 (2013-04-24)
Numerous studies have described the altered expression and the causal role of microRNAs (miRNAs) in human cancer. However, to date, efforts to modulate miRNA levels for therapeutic purposes have been challenging to implement. Here we find that nucleolin (NCL), a
Daishi Kasai et al.
Anticancer research, 33(5), 1935-1940 (2013-05-07)
Pemetrexed is a key drug for therapy of non-small cell lung cancer (NSCLC). In a search for biomarkers for study of the efficacy of pemetrexed treatment, we examined the thymidylate synthase (TYMS) copy number in NSCLC cell lines and in
Karen A Newell-Litwa et al.
The Journal of cell biology, 210(2), 225-242 (2015-07-15)
RhoGTPases organize the actin cytoskeleton to generate diverse polarities, from front-back polarity in migrating cells to dendritic spine morphology in neurons. For example, RhoA through its effector kinase, RhoA kinase (ROCK), activates myosin II to form actomyosin filament bundles and
Hepatitis B virus reactivation associated with ruxolitinib.
Chien-Heng Shen et al.
Annals of hematology, 93(6), 1075-1076 (2013-11-01)
Zhirong Wei et al.
Genome, 58(4), 121-134 (2015-07-25)
As the largest subfamily of receptor-like kinases (RLKs), leucine-rich repeat receptor-like kinases (LRR-RLKs) regulate the growth, development, and stress responses of plants. Through a reiterative process of sequence analysis and re-annotation, 234 LRR-RLK genes were identified in the genome of
Shahnawaz Imam et al.
American journal of physiology. Endocrinology and metabolism, 306(7), E791-E798 (2014-02-06)
Therapeutic options for treatment of type 1 diabetes (T1D) are still missing. New avenues for immune modulation need to be developed. Here we attempted at altering the diabetes outcome of our humanized model of T1D by inhibiting translation-initiation factor eIF5A
Optimal antiviral prophylaxis against hepatitis B reactivation in patients receiving rituximab-based chemotherapy for lymphoma.
Jeremy S Abramson et al.
JAMA, 312(23), 2505-2507 (2014-12-17)
Rubí Viedma-Rodríguez et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36(9), 6991-7005 (2015-04-12)
Majority of women with estrogen receptor (ER)-positive breast cancers initially respond to hormone therapies such as tamoxifen (TAM; antagonist of estrogen). However, many tumors eventually become resistant to TAM. Therefore, understanding the various cellular components involved in causing resistance to
Nikhil Thiruvengadam et al.
Clinical and translational gastroenterology, 6, e88-e88 (2015-06-13)
There is significant research interest in developing and validating novel pancreatic cyst-fluid biomarkers given the increasing recognition of the prevalence of pancreatic cysts and their associated malignant potential. Although current international consensus guidelines are helpful, they fail to diagnose with
Alexander Heinick et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(9), 3773-3787 (2015-05-30)
Annexin A4 (AnxA4), a Ca(2+)- and phospholipid-binding protein, is up-regulated in the human failing heart. In this study, we examined the impact of AnxA4 on β-adrenoceptor (β-AR)/cAMP-dependent signal transduction. Expression of murine AnxA4 in human embryonic kidney (HEK)293 cells dose-dependently
Y J Choi et al.
British journal of cancer, 112(2), 260-265 (2014-11-28)
Pemetrexed has shown a favourable response rate of about 30% with minimal toxicity when used as a single agent for treatment of advanced urothelial carcinoma. This phase II study evaluated the efficacy and safety of pemetrexed plus cisplatin in advanced
Yuri Chikano et al.
Molecular cancer therapeutics, 14(2), 564-574 (2014-12-17)
The failure of current treatment options for glioblastoma stems from their inability to control tumor cell proliferation and invasion. Biologically targeted therapies offer great hope and one promising target is glycogen synthase kinase-3β (GSK3β), implicated in various diseases, including cancer.
Carmela Protano et al.
The Science of the total environment, 500-501, 44-51 (2014-09-14)
The aims of the present study were to establish the background levels of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo), 8-oxo-7,8-dihydroguanosine (8-oxoGuo), 8-oxo-7,8-dihydroguanine (8-oxoGua) among a group of healthy Italian children, and to evaluate the contribution of some potential interfering/confounding factors to the urinary (u)
T Nikopensius et al.
Journal of dental research, 92(6), 507-511 (2013-04-23)
Mutations in the ectodysplasin-A (EDA) gene have been generally associated with X-linked hypohidrotic ectodermal dysplasia (XLHED). Recently, missense mutations in EDA have been reported to cause familial non-syndromic tooth agenesis. In this study, we report a novel EDA mutation in
Satoshi Kambayashi et al.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 79(3), 201-209 (2015-07-02)
The DNA repair protein O (6)-methylguanine-DNA methyltransferase (MGMT) causes resistance to nitrosoureas in various human cancers. In this study, we analyzed the correlation between canine lymphomas and MGMT in vitro. Two of five canine lymphoma cell lines required higher concentrations
Rafael Gozalbes et al.
Bioorganic & medicinal chemistry, 18(19), 7078-7084 (2010-09-03)
Solubility plays a very important role in the selection of compounds for drug screening. In this context, a QSAR model was developed for predicting water solubility of drug-like compounds. First, a set of relevant parameters for establishing a drug-like chemical
Yu Mao et al.
Sensors (Basel, Switzerland), 15(11), 28244-28256 (2015-11-17)
A novel biosensing platform was developed by integrating an aptamer-based DNA biosensor with graphene oxide (GO) for rapid and facile detection of adenosine triphosphate (ATP, as a model target). The DNA biosensor, which is locked by GO, is designed to
Origin of life. From hell on Earth, life's building blocks.
Sid Perkins
Science (New York, N.Y.), 346(6215), 1279-1279 (2014-12-17)
Veronika Sárosi et al.
Magyar onkologia, 58(4), 325-329 (2014-12-18)
Therapy of patients with advanced NSCLC has lately changed due to the algorithm based on the presence or absence of oncogenic mutations. There is an agreement nowadays that in the presence of activating EGFR mutations, the administration of EGFR TKI
Yuqi Liu et al.
BMC medical genetics, 15, 84-84 (2014-07-25)
Hypertension is a very common cardiovascular disease influenced by multiple genetic and environmental factors. More recently, there are some studies showed that mutations in mitochondrial DNA have been involved in its pathogenesis. In this study we did further investigations on
Jianfeng Li et al.
Antioxidants & redox signaling, 18(18), 2429-2443 (2013-01-15)
Appropriately controlled epigenetic regulation is critical for the normal development and health of an organism. Misregulation of epigenetic control via deoxyribonucleic acid (DNA) methylation or histone methylation has been associated with cancer and chromosomal instability syndromes. The main function of
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