CN
Search Within
G7526
Applied Filters:
Keyword:'G7526'
Showing 1-30 of 1452 results for "G7526" within Papers
Kyung Mi Lim et al.
Molecular medicine reports, 12(2), 2650-2660 (2015-05-09)
Dermal papilla (DP) cells function as important regulators of the hair growth cycle. The loss of these cells is a primary cause of diseases characterized by hair loss, including alopecia, and evidence has revealed significantly increased levels of reactive oxygen
Benjamin L Farah et al.
PloS one, 9(6), e98155-e98155 (2014-06-21)
Autophagy recently has been shown to be involved in normal hepatic function and in pathological conditions such as non-alcoholic fatty liver disease. Adrenergic signalling also is an important regulator of hepatic metabolism and function. However, currently little is known about
Ai-Li Sun
The Analyst, 140(23), 7948-7954 (2015-10-27)
A new electrochemical immunosensor with signal enhancement was designed for sensitive detection of disease-related protein (human carbohydrate antigen 19-9, CA 19-9 used in this case). The assay was carried out on a capture antibody-modified screen-printed carbon electrode with a sandwich-type
Peace Mabeta et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 69, 186-190 (2015-02-11)
Herein, we describe the effects of Taxol on endothelioma cell growth and migration in vitro and on vascular tumor growth in vivo. The effects of Taxol on endothelioma cell growth were determined using the crystal violet assay, while cell migration
Esther Roselló-Lletí et al.
PloS one, 9(11), e112971-e112971 (2014-11-15)
Dilated cardiomyopathy (DCM) is a public health problem with no available curative treatment, and mitochondrial dysfunction plays a critical role in its development. The present study is the first to analyze the mitochondrial proteome in cardiac tissue of patients with
Lei Wu et al.
Small (Weinheim an der Bergstrasse, Germany), 11(23), 2798-2806 (2015-02-18)
A surface enhanced Raman scattering (SERS)-assisted 3D barcode chip has been developed for high-throughput biosensing. The 3D barcode is realized through joint 2D spatial encoding with the Raman spectroscopic encoding, which stores the SERS fingerprint information in the format of
Ailing Teo et al.
Journal of biomechanics, 48(10), 1777-1781 (2015-06-09)
Embryonic stem cells (ESCs) grow into three-dimensional (3D) spheroid structures en-route to tissue growth. In vitro spheroids can be controllably induced on a two-dimensional (2D) substrate with high viability. Here we use a method for inducing pluripotent embryoid body (EB)
Aurelie Vivares et al.
Xenobiotica; the fate of foreign compounds in biological systems, 45(1), 29-44 (2014-07-30)
1. The quantitative prediction of the pharmacokinetic parameters of a drug from data obtained using human in vitro systems remains a significant challenge i.e. prediction of metabolic clearance in humans and estimation of the relative contribution of enzymes involved in
Jamie Hinks et al.
Applied and environmental microbiology, 81(6), 1949-1958 (2015-01-13)
The modification of microbial membranes to achieve biotechnological strain improvement with exogenous small molecules, such as oligopolyphenylenevinylene-conjugated oligoelectrolyte (OPV-COE) membrane insertion molecules (MIMs), is an emerging biotechnological field. Little is known about the interactions of OPV-COEs with their target, the
Fotis Ioakeimidis et al.
PloS one, 9(8), e104237-e104237 (2014-08-12)
Mitochondrial structure and function is emerging as a major contributor to neuromuscular disease, highlighting the need for the complete elucidation of the underlying molecular and pathophysiological mechanisms. Following a forward genetics approach with N-ethyl-N-nitrosourea (ENU)-mediated random mutagenesis, we identified a
Manuel Valero et al.
Nature neuroscience, 18(9), 1281-1290 (2015-07-28)
Sharp-wave ripples represent a prominent synchronous activity pattern in the mammalian hippocampus during sleep and immobility. GABAergic interneuronal types are silenced or fire during these events, but the mechanism of pyramidal cell (PC) participation remains elusive. We found opposite membrane
Ying-Qin Li et al.
Molecular medicine reports, 12(1), 913-920 (2015-03-31)
Although studies have been undertaken on gadolinium labeling-based molecular imaging in magnetic resonance imaging (MRI), the use of non-ionic gadolinium in the tracking of stem cells remains uncommon. To investigate the efficiency in tracking of stem cells with non-ionic gadolinium
Federica Maccarinelli et al.
Journal of molecular medicine (Berlin, Germany), 92(8), 859-869 (2014-04-15)
Mitochondrial ferritin is a functional ferritin that localizes in the mitochondria. It is expressed in the testis, heart, brain, and cells with active respiratory activity. Its overexpression in cultured cells protected against oxidative damage and reduced cytosolic iron availability. However
Robert H J Bandsma et al.
American journal of physiology. Endocrinology and metabolism, 309(5), E466-E473 (2015-07-15)
Severe malnutrition is a leading cause of global childhood mortality, and infection and hypoglycemia or hyperglycemia are commonly present. The etiology behind the changes in glucose homeostasis is poorly understood. Here, we generated an animal model of severe malnutrition with
Jian Han et al.
Microbiology (Reading, England), 161(Pt 1), 57-66 (2014-11-02)
Staphylococcus aureus is a prominent human pathogen and is known to form L-forms in vitro and in vivo during infection. However, the conditions of L-form formation are not optimal and the mechanisms of L-form formation in this organism are unknown.
Oscar Rodríguez-Espinosa et al.
Immunology, 145(2), 213-224 (2014-12-30)
As part of the innate immune response, neutrophils are at the forefront of defence against infection, resolution of inflammation and wound healing. They are the most abundant leucocytes in the peripheral blood, have a short lifespan and an estimated turnover
Pai-Wei Su et al.
Molecules (Basel, Switzerland), 20(6), 11119-11130 (2015-06-19)
Recently, drug resistance due to the extensive abuse and over-use of antibiotics has become an increasingly serious problem, making the development of alternative antibiotics a very urgent issue. In this study, the Chinese herbal medicine, Polygonum cuspidatum, was extracted with
Tamara Muñoz-Caro et al.
Parasitology research, 113(11), 4189-4197 (2014-09-07)
Extracellular trap (ET) formation has been demonstrated as an important novel effector mechanism of polymorphonuclear neutrophils (PMN), eosinophils, mast cells and macrophages acting extracellularly against pathogens. In the present study, we show that tachyzoites of the emerging apicomplexan parasite Besnoitia
Visesato Mor et al.
mBio, 6(3), e00647-e00647 (2015-06-25)
Recent estimates suggest that >300 million people are afflicted by serious fungal infections worldwide. Current antifungal drugs are static and toxic and/or have a narrow spectrum of activity. Thus, there is an urgent need for the development of new antifungal
Robert Silasi-Mansat et al.
Journal of cellular and molecular medicine, 19(11), 2549-2563 (2015-09-05)
Acute respiratory distress syndrome (ARDS) induced by severe sepsis can trigger persistent inflammation and fibrosis. We have shown that experimental sepsis in baboons recapitulates ARDS progression in humans, including chronic inflammation and long-lasting fibrosis in the lung. Complement activation products
Wenting Zou et al.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 151(6), 1020-1027 (2014-09-27)
To study the osteogenesis and ototoxicity of autogenous bone cement. A randomized, prospective, controlled animal study. University laboratory. We created a critical defect on the bulla wall of guinea pigs. Fifty-three guinea pigs were divided into 3 groups. The defects
Janeesh Plakkal Ayyappan et al.
Chemical biology & drug design, 84(3), 292-299 (2014-03-05)
Poly-L-Lysine (PLL) nanocapsules are the emerging drug-delivery vehicle for the therapeutics of targeted diseases. The study was designed for the synthesis and characterization of PLL nanocapsules and to know its immunocompatibility and toxicity behavior for in vivo drug-delivery applications. Alteration
Megan Melland-Smith et al.
Autophagy, 11(4), 653-669 (2015-04-09)
Bioactive sphingolipids including ceramides are involved in a variety of pathophysiological processes by regulating cell death and survival. The objective of the current study was to examine ceramide metabolism in preeclampsia, a serious disorder of pregnancy characterized by oxidative stress
Tina C Roeske et al.
PloS one, 9(11), e111722-e111722 (2014-11-14)
All-trans retinoic acid (ATRA), the main active metabolite of vitamin A, is a powerful signaling molecule that regulates large-scale morphogenetic processes during vertebrate embryonic development, but is also involved post-natally in regulating neural plasticity and cognition. In songbirds, it plays
Urosh Vilimanovich et al.
European journal of pharmacology, 765, 415-428 (2015-09-12)
Statins exhibit anti-leukemic properties due to suppression of the mevalonate pathway by the inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase, and subsequent depletion of cholesterol, farnesylpyrophosphate, and geranylgeranylpyrophosphate. We investigated the role of autophagy, a controlled intracellular self-digestion, in the anti-leukemic
Min-Jun Huang et al.
Annals of the rheumatic diseases, 73(9), 1719-1727 (2013-07-16)
An exogenous supplement of n-3 polyunsaturated fatty acids (PUFAs) has been reported to prevent osteoarthritis (OA) through undefined mechanisms. This study investigated the effect of alterations in the composition of endogenous PUFAs on OA, and associations of PUFAs with mammalian
Jennifer A Bennett et al.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, 34(4), 340-350 (2015-04-09)
Giant cell tumors, a well-recognized neoplasm of bone, can rarely be found in the uterus. Such tumors are characterized by a dual population of mononuclear and osteoclast-like giant cells that lack epithelial and specific mesenchymal differentiation. In this study, the
Shahnaz Razavi et al.
Journal of biomedical materials research. Part A, 103(8), 2628-2634 (2015-01-24)
The transdifferentiation of human adipose-derived stem cells (ADSCs) into Schwann-like cells on biocomposite scaffolds may be a critical issue in nerve regeneration medicine. In this study, tissue-engineered scaffold with chitosan (CS) nanopowders and poly(lactide-co-glycolide) (PLGA) was investigated for its potential
Luisa Fiandra et al.
Nanomedicine : nanotechnology, biology, and medicine, 11(6), 1387-1397 (2015-04-04)
Eradication of virus by sanctuary sites is a main goal in HIV management. The central nervous system (CNS) is a classic model of sanctuary where viral replication occurs despite a complete viral suppression in peripheral blood. In recent years, nanotechnologies
Jie Yuan et al.
Stem cell research & therapy, 6, 217-217 (2015-11-07)
Adult stem cell-derived hepatocytes transplantation holds considerable promise for future clinical individualized therapy of liver failure or dysfunction. However, the low engraftment of the available hepatocytes in the liver disease microenvironment has been a major obstacle. Acellular human amniotic membrane
Page 1 of 49