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Showing 1-30 of 1510 results for "G7651" within Papers
Clemens Tscheka et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 95(Pt A), 151-155 (2015-03-18)
Cylindrical particles offer the opportunity to develop controlled and sustained release systems for the respiratory tract. One reason is that macrophages can phagocyte such particles only from either of the two ends. We investigated the uptake behaviour of murine alveolar
Reina N Fuji et al.
Science translational medicine, 7(273), 273ra15-273ra15 (2015-02-06)
Inhibition of the kinase activity of leucine-rich repeat kinase 2 (LRRK2) is under investigation as a possible treatment for Parkinson's disease. However, there is no clinical validation as yet, and the safety implications of targeting LRRK2 kinase activity are not
Alain C Burette et al.
The Journal of comparative neurology, 523(13), 1913-1924 (2015-03-11)
Tumor necrosis factor receptor-associated factor 2 (TRAF2)- and noncatalytic region of tyrosine kinase (NCK)-interacting kinase (TNIK) has been identified as an interactor in the psychiatric risk factor, Disrupted in Schizophrenia 1 (DISC1). As a step toward deciphering its function in
C M Sosa et al.
Molecular human reproduction, 21(3), 244-254 (2014-12-03)
The acrosome reaction is a unique event in the lifespan of sperm characterized by the exocytosis of the acrosomal content and the release of hybrid vesicles formed by patches of the outer acrosomal membrane and the plasma membrane. This unique
João F Requicha et al.
Tissue engineering. Part A, 20(17-18), 2483-2492 (2014-03-01)
Human and canine periodontium are often affected by an inflammatory pathology called periodontitis, which is associated with severe damages across tissues, namely, in the periodontal ligament, cementum, and alveolar bone. However, the therapies used in the routine dental practice, often
Susu Mao et al.
Protein & cell, 6(7), 529-540 (2015-06-21)
MicroRNAs (miRNAs) are a class of noncoding RNAs that regulates target gene expression at posttranscriptional level, leading to further biological functions. We have demonstrated that microvesicles (MVs) can deliver miRNAs into target cells as a novel way of intercellular communication.
Secil Koseoglu et al.
Blood, 126(5), 651-660 (2015-05-23)
Platelet activation results in profound morphologic changes accompanied by release of granule contents. Recent evidence indicates that fusion of granules with the plasma membrane during activation provides auxiliary membrane to cover growing actin structures. Yet little is known about how
Jing-Zhou Yang et al.
Biomedical materials (Bristol, England), 10(4), 045006-045006 (2015-07-15)
Bioceramic scaffolds with desired bone regeneration functions have the potential to become real alternatives to autologous bone grafts for reconstruction of load-bearing and critical-sized segmental bone defects. The aim of this paper was to develop a layered scaffold structure that
Kristin Derlig et al.
Cell and tissue research, 362(2), 281-294 (2015-05-28)
Chromatin organization and the management of transcription and splicing are fundamental to the correct functioning of every cell but, in particular, for highly active cells such as photoreceptors, the sensory neurons of the retina. Rod photoreceptor cells of nocturnal animals
Ye Yao et al.
European journal of medical research, 20, 8-8 (2015-01-30)
Exosomes secreted by tumor cells contain specific antigens that may have immunotherapeutic purposes. The aim of this study was to characterize the proteomic content of lymphoma cell-derived exosomes (LCEXs). In this study, exosomes derived from Raji cells (EXO(Raji)) were purified
Violeta Velikova et al.
Plant physiology, 168(3), 859-870 (2015-05-16)
Isoprene is a small lipophilic molecule with important functions in plant protection against abiotic stresses. Here, we studied the lipid composition of thylakoid membranes and chloroplast ultrastructure in isoprene-emitting (IE) and nonisoprene-emitting (NE) poplar (Populus × canescens). We demonstrated that
Karpagavalli Ramji et al.
Journal of biomaterials applications, 29(3), 411-422 (2014-04-09)
Electrospun fibers with an average fiber diameter in the nanometer range were prepared from soy protein isolate to develop scaffolds for tissue engineering applications. Poly(ethylene oxide) was added to facilitate fiber formation. The influence of processing parameters such as applied
Julien Ramier et al.
Journal of materials science. Materials in medicine, 25(6), 1563-1575 (2014-03-04)
Electrospinning coupled with electrospraying provides a straightforward and robust route toward promising electrospun biocomposite scaffolds for bone tissue engineering. In this comparative investigation, four types of poly(3-hydroxybutyrate) (PHB)-based nanofibrous scaffolds were produced by electrospinning a PHB solution, a PHB/gelatin (GEL)
Alžběta Filipová et al.
Cell biology international, 39(8), 943-953 (2015-03-27)
Primary cilia act as physical-chemical sensors and their functions include the perception of the extracellular milieu, regulation of organogenesis, and cell polarity. In general, these cells are monociliated and the single cilium possesses diverse receptors and channels which are involved
Alexander Fehr et al.
Emerging microbes & infections, 4(5), e29-e29 (2015-06-11)
Bacteria belonging to the genus Cronobacter spp. have been recognized as causative agents of life-threatening systemic infections, primarily in premature, low-birth weight and/or immune-compromised neonates. Knowledge remains scarce regarding the underlying molecular mechanisms of disease development. In this study, we
Yoon Young Kim et al.
Yonsei medical journal, 49(5), 819-827 (2008-10-31)
Human embryonic stem cells (hESCs) can proliferate for a prolonged period and differentiate into cardiomyocytes in vitro. Recent studies used bone morphogenetic protein 2 (BMP2) to generate cardiomyocytes from hESCs, however, all those studies used early embryoid bodies (EBs) and
Lorraine B Ferreira et al.
Journal of biomaterials applications, 29(7), 965-976 (2014-09-12)
Statins are hypolipemiant drugs with osteoinductive effect. We evaluated the potential of simvastatin loaded into poly(lactic-co-glycolic acid) (PLGA) microspheres to heal critical size defects in rat calvaria. PLGA scaffolds (50:50 ratio) were synthesized as pure membranes or as microspheres loaded
Yu Shomura et al.
The Annals of thoracic surgery, 95(6), 2000-2005 (2013-04-30)
Mitral valve repair is an established surgical procedure for treating severe organic mitral regurgitation. The mechanisms of mitral regurgitation due to infective endocarditis include rheumatic disease and congenital diseases such as a lack of leaflet tissue, and thus additional material
Subir Kumar Mandal et al.
Environmental monitoring and assessment, 187(9), 597-597 (2015-09-01)
Discosphaera tubifer, a coccolithophore has been first time reported as a bloom-forming organism from an over-crowded fishing harbour at Veraval, west coast of India. Physiochemical and optical parameters were measured following standard protocols. Average concentration of inorganic nutrients, such as
Jingyu Yao et al.
Autophagy, 11(6), 939-953 (2015-06-16)
Autophagy regulates cellular homeostasis and response to environmental stress. Within the retinal pigment epithelium (RPE) of the eye, the level of autophagy can change with both age and disease. The purpose of this study is to determine the relationship between
L F P Gondim et al.
Veterinary parasitology, 210(3-4), 131-140 (2015-04-19)
Hammondia heydorni was in vitro isolated from oocysts shed by three dogs using a finite cell line from embryonal bovine heart (KH-R). The oocysts were purified and suspended in 2% potassium dichromate or 2% sulphuric acid for sporulation for 2-5
Julia C Meier et al.
Cancer medicine, 4(2), 253-267 (2014-12-11)
Molecular mechanisms underlying the development of resistance to platinum-based treatment in patients with ovarian cancer remain poorly understood. This is mainly due to the lack of appropriate in vivo models allowing the identification of resistance-related factors. In this study, we
Soo-Yeon Park et al.
Cancer letters, 357(1), 419-427 (2014-12-17)
Programmed cell death 5 (PDCD5) positively regulates p53-mediated apoptosis and rapidly accumulates upon DNA damage. However, the underlying mechanism of PDCD5 upregulation during the DNA damage response remains unknown. Here, we found that OTU deubiquitinase 5 (OTUD5) was bound to
Jantipa Jobsri et al.
PloS one, 10(2), e0118096-e0118096 (2015-02-19)
Induction of potent antibody is the goal of many vaccines targeted against infections or cancer. Modern vaccine designs that use virus-like particles (VLP) have shown efficacy for prophylactic vaccination against virus-associated cancer in the clinic. Here we used plant viral
Briana R Flaherty et al.
PloS one, 10(5), e0129239-e0129239 (2015-05-27)
Drug resistance poses a significant threat to ongoing malaria control efforts. Coupled with lack of a malaria vaccine, there is an urgent need for the development of new antimalarials with novel mechanisms of action and low susceptibility to parasite drug
Enrica Calleri et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 968, 79-86 (2014-01-28)
We described the development of a biochromatographic system which uses a purine nucleoside phosphorylase from Aeromonas hydrophila (AhPNP) for the evaluation of the substrate specificity on nucleoside libraries. AhPNP has been covalently immobilized on a fused silica Open Tubular Capillary
Feng Zhang et al.
Journal of tissue engineering and regenerative medicine, 9(1), 77-84 (2012-11-21)
To regenerate articular cartilage tissue from degeneration and trauma, synovial mesenchymal stem cells (SMSCs) were used in this study as therapeutic progenitor cells to induce therapeutic chondrogenesis. To accomplish this, chondrocytes pre-transduced with adenoviral vectors carrying the transforming growth factor
Yen Pei-Wen et al.
Biosensors & bioelectronics, 61, 112-118 (2014-05-28)
For on-site clinical diagnosis of biomolecules, the detection performances of most point-of-care (POC) biosensor devices are limited by undesired cross-detection of other non-analyte proteins in patient serum samples and other complex samples. To conquer this obstacle, this work presents a
Malgorzata Kotula-Balak et al.
Toxicology in vitro : an international journal published in association with BIBRA, 29(3), 529-537 (2015-01-03)
Our previous studies revealed that in bank vole testicular cells octylphenol (OP) action is related either to its binding to estrogen receptors or increasing cAMP level that modulates spermatozoa motility and acrosome reaction (AR), (Kotula-Balak et al., 2011, 2014). To
Susmita Kaushik et al.
Nature cell biology, 17(6), 759-770 (2015-05-12)
Chaperone-mediated autophagy (CMA) selectively degrades a subset of cytosolic proteins in lysosomes. A potent physiological activator of CMA is nutrient deprivation, a condition in which intracellular triglyceride stores or lipid droplets (LDs) also undergo hydrolysis (lipolysis) to generate free fatty
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