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Showing 1-30 of 51 results for "H0879" within Papers
Alexandre Kanashiro et al.
Basic & clinical pharmacology & toxicology, 119(5), 453-457 (2016-04-22)
The cholinergic anti-inflammatory pathway (CAP) is a complex neuroimmune mechanism triggered by the central nervous system to regulate peripheral inflammatory responses. Understanding the role of CAP in the pathogenesis of rheumatoid arthritis (RA) could help develop new therapeutic strategies for
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the
Petteri Rinne et al.
Peptides, 38(1), 150-158 (2012-09-18)
α-Melanocyte-stimulating hormone (α-MSH) regulates important physiological functions including energy homeostasis and inflammation. Potent analogs of α-MSH, [Nle(4), D-Phe(7)]-α-MSH (NDP-α-MSH) and melanotan-II (MT-II), are widely used in pharmacological studies, but the hemodynamic effects associated with their systemic administration have not been
Sean H White et al.
Journal of neurophysiology, 112(2), 446-462 (2014-04-18)
Nicotinic receptors form a diverse group of ligand-gated ionotropic receptors with roles in both synaptic transmission and the control of excitability. In the bag cell neurons of Aplysia, acetylcholine activates an ionotropic receptor, which passes inward current to produce a
H-Z Sun et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 63(6), 623-629 (2013-02-08)
This study aims to investigate whether exogenous nitric oxide (NO) plays a role in controlling gastric motility within the nucleus ambiguus (NA). Experiments were performed on male Wistar rats anaesthetized with chloral hydrate. A latex balloon, connected to a pressure
Jaime Pei Pei Foong et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(18), 7106-7115 (2015-05-08)
Acetylcholine-activating pentameric nicotinic receptors (nAChRs) are an essential mode of neurotransmission in the enteric nervous system (ENS). In this study, we examined the functional development of specific nAChR subtypes in myenteric neurons using Wnt1-Cre;R26R-GCaMP3 mice, where all enteric neurons and
Masanobu Mori et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 887-888, 1-7 (2012-02-04)
A combination of polyvinyl alcohol chemically coated capillary (PVA capillary) and background electrolyte (BGE) with ion-pair reagent (hexamethonium dichloride, HMC) was used on capillary ion electrophoresis-UV detection (CIE-UV) for analysis of Br⁻, I⁻, NO₂⁻, NO₃⁻, SCN⁻ and uric acid in
Chiaki Nakamori et al.
Life sciences, 90(13-14), 495-501 (2012-01-31)
Replacement of smooth muscles by striated muscles occurs in the esophagus during the early postnatal period. The aim of this study was to clarify postnatal changes in vagal control of esophageal muscle contractions in rats. An isolated segment of the
Mercedes Perusquía et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 309(2), R189-R195 (2015-05-08)
Testosterone (TES) and other androgens exert a direct vasorelaxing action on the vasculature in vitro that is structurally specific and independent of cytosolic androgen receptor (AR). The effects of intravenous androgen infusions on mean arterial blood pressure (BP) and heart
James T Heaton et al.
Neuroscience, 265, 9-20 (2014-02-01)
Vibrissal whisking is often employed to track facial nerve regeneration in rats; however, we have observed similar degrees of whisking recovery after facial nerve transection with or without repair. We hypothesized that the source of non-facial nerve-mediated whisker movement after
Yasuhiro Nishida et al.
The journal of physiological sciences : JPS, 62(3), 147-161 (2012-02-04)
Mean arterial pressure fluctuates depending on physical or psychological activity, but should be stable at rest at around 100 mmHg throughout an entire life in human. The causes of hypertension and the blood pressure regulation mechanisms have been discussed for
R C Palheta et al.
Life sciences, 92(10), 569-575 (2013-01-29)
We previously reported that mechanical atrial stretch (AS) by balloon distention increased gastric tonus in anesthetized rats. The present study evaluated the effect of AS on the gastric emptying of a liquid test meal in awake rats and its underlying
Rui Tao et al.
Psychopharmacology, 232(7), 1245-1260 (2014-10-11)
Illicit use of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) may cause a mild or severe form of the serotonin syndrome. The syndrome intensity is not just influenced by drug doses but also by environmental factors. Warm environmental temperatures and physical activity are features
Maximilian Tischer et al.
Bioorganic & medicinal chemistry, 18(9), 2998-3003 (2010-04-13)
The bisquaternary bisnaphthalimides are a versatile class of compounds being active against the malaria parasite Plasmodium falciparum in the lower nanomolar range of concentration combined with no cytotoxicity. The series of compounds is designed as choline analogues and interfering agents
Taiming Liu et al.
American journal of physiology. Heart and circulatory physiology, 307(7), H976-H986 (2014-08-12)
Recent evidence from humans and rats indicates that nitrite is a vasodilator under hypoxic conditions by reacting with metal-containing proteins to produce nitric oxide (NO). We tested the hypothesis that near-physiological concentrations of nitrite would produce vasodilation in a hypoxia-
M Mendel et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 19(7), 591-595 (2012-04-03)
The dry extract of Hedra helix leaves and its main active compounds, predominantly α-hederin and hederacoside C, has been traditionally believed to act spasmolytic. However, it has been recently proved that both, the extract of ivy and triterpenoid saponins, exhibit
Mariusz Sikora et al.
Pharmacological reports : PR, 66(5), 751-758 (2014-08-26)
Increasing evidence suggests that disturbances in H2S homeostasis may participate in the development of hypertension. In this study we compared hemodynamic responses to intracerebroventricular (ICV) infusions of sodium hydrosulfide (NaHS), a H2S donor, between normotensive rats (WKY), spontaneously hypertensive rats
Jasna Twynstra et al.
Microvascular research, 84(2), 133-139 (2012-06-21)
We hypothesized that neuropeptide Y (NPY) exerts vasoconstrictor properties in sciatic nerve blood supply by a Y1 receptor (Y1R) mechanism. Using Doppler ultrasound (40MHz), we measured blood flow velocity through a sciatic nerve supply artery during infusions of NPY and/or
Monalisa W Pereira et al.
Clinical and experimental pharmacology & physiology, 39(10), 869-877 (2012-09-28)
1. The 2 Hz train-of-four ratio (TOF(ratio)) is used to monitor the degree of patient curarization. Using a rat phrenic nerve-hemidiaphragm preparation, we showed that antinicotinic agents, such as hexamethonium, d-tubocurarine and pancuronium, but not cisatracurium, decreased contractions produced by
Colin S Cunningham et al.
Behavioural pharmacology, 25(4), 296-305 (2014-07-01)
The extent to which chronic nicotine treatment can alter the effects of the nicotinic acetylcholine receptor antagonist mecamylamine, and whether those effects can be attenuated by nicotine have not been clearly established in the literature. Here, the discriminative stimulus effects
P G Dinning et al.
American journal of physiology. Gastrointestinal and liver physiology, 303(1), G83-G92 (2012-05-05)
The rabbit colon consists of four distinct regions. The motility of each region is controlled by myogenic and neurogenic mechanisms. Associating these mechanisms with specific motor patterns throughout all regions of the colon has not previously been achieved. Three sections
Bart G Borghuis et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(18), 6128-6139 (2014-05-03)
A fundamental question in sensory neuroscience is how parallel processing is implemented at the level of molecular and circuit mechanisms. In the retina, it has been proposed that distinct OFF cone bipolar cell types generate fast/transient and slow/sustained pathways by
Yi-Fan Li et al.
Autonomic neuroscience : basic & clinical, 154(1-2), 14-19 (2009-11-06)
Nicotinic cholinergic receptors mediate autonomic transmission at ganglia. However, whether different subtypes of nicotinic cholinergic receptors expressed in autonomic ganglia elicit distinct roles in mediating sympathetic and parasympathetic regulations remain to be defined. In this study, we observed that different
Bapi Gorain et al.
SpringerPlus, 3, 666-666 (2014-01-01)
Telescopium telescopium, a marine mollusc collected from Sundarban mangrove, belongs to the largest mollusca phylum in the world and exudes a blue secretion when stimulated mechanically. The blue secretion was found to metabolize (preferentially) para-amino benzoic acid, a substrate for
W J Lavery et al.
Experimental eye research, 111, 88-94 (2013-04-10)
In humans, changing from upright to supine elicits an approximately 10 mmHg increase in cephalic venous pressure caused by the hydrostatic column effect, but episcleral venous pressure (EVP) and intraocular pressure (IOP) rise by only a few mmHg. The dissociation
Edward S Schelegle et al.
Respiratory physiology & neurobiology, 181(3), 277-285 (2012-04-25)
Brown-Norway rats (n=113) sensitized and challenged with nDer f 1 allergen were used to examine the contribution of lung sensory nerves to ozone (O(3)) exacerbation of asthma. Prior to their third challenge rats inhaled 1.0ppm O(3) for 8h. There were
Lalah M Niane et al.
Experimental physiology, 97(8), 981-993 (2012-04-13)
We hypothesized that the combined blockade of peripheral cholinergic and purinergic receptors alters the baseline breathing pattern and respiratory responses to carotid body stimuli (hypoxia, hyperoxia and hypercapnia). Rat pups at 4 (P4) and 12 days of postnatal age (P12)
M Mastropaolo et al.
Acta physiologica (Oxford, England), 215(1), 37-45 (2015-06-09)
To analyse the effects of angiotensin II (Ang II) on the contractility of human sigmoid colon, and to characterize the subtype(s) of receptor(s) involved and the related action mechanism. The contractility of sigmoid colon circular muscle strips was recorded isometrically.
Hsin-Kuo Ko et al.
Journal of cellular physiology, 230(8), 1781-1793 (2014-12-17)
Inhaled cigarette smoke (CS) causes persistent lung inflammation in smokers. Interleukin 8 (IL-8) released from macrophages is a key chemokine during initiation and progression of CS-induced lung inflammation, yet its regulation is largely unknown. AMP-activated protein kinase (AMPK), a crucial
T C Sia et al.
American journal of physiology. Gastrointestinal and liver physiology, 305(12), G933-G939 (2013-10-12)
We recently identified hexamethonium-resistant peristalsis in the guinea pig colon. We showed that, following acute blockade of nicotinic receptors, peristalsis recovers, leading to normal propagation velocities of fecal pellets along the colon. This raises the fundamental question: what mechanisms underlie
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