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Showing 1-17 of 17 results for "H1115000" within Papers
Xiaojiao Wang et al.
Signal transduction and targeted therapy, 5(1), 35-35 (2020-04-17)
The inhibitory receptor signal regulatory protein-α (Sirpα) is a myeloid-specific immune checkpoint that engages the "don't eat me" signal CD47, which is expressed on tumor and normal tissue cells. However, the profile and regulatory mechanism of Sirpα expression in tumor-associated
Wei Xiang et al.
Nature communications, 9(1), 2574-2574 (2018-07-04)
Metabolic reprogramming greatly contributes to the regulation of macrophage activation. However, the mechanism of lipid accumulation and the corresponding function in tumor-associated macrophages (TAMs) remain unclear. With primary investigation in colon cancer and confirmation in other cancer models, here we
Hui-Fang Zhu et al.
Cancer biology & therapy, 20(7), 967-978 (2019-03-22)
Nontumour cells in the tumour microenvironment, especially fibroblasts, contribute to tumour progression and metastasis. The occurrence and evolution of colorectal cancer (CRC) is closely related to cancer-associated fibroblasts (CAFs). The aim of this work was to evaluate the effects of
Marie-Ming Aynaud et al.
Cell reports, 30(6), 1767-1779 (2020-02-13)
EWSR1-FLI1, the chimeric oncogene specific for Ewing sarcoma (EwS), induces a cascade of signaling events leading to cell transformation. However, it remains elusive how genetically homogeneous EwS cells can drive the heterogeneity of transcriptional programs. Here, we combine independent component
Lin Shi et al.
Clinical and translational medicine, 12(7), e989-e989 (2022-07-21)
Cancer-associated fibroblasts (CAFs) contributes to overall tumor progression. In the current survey, we explored the ability of microRNA-20a (miR-20a) within these CAF-derived exosomes to influence non-small-cell lung cancer (NSCLC) progression. Normal tissue-associated fibroblasts (NAFs) and CAFs were collected from samples
Frederik J Hansen et al.
International journal of molecular sciences, 23(9) (2022-05-15)
Immunotherapy has become increasingly important in the treatment of colorectal cancer (CRC). Currently, CD73, also known as ecto-5'-nucleotidase (NT5E), has gained considerable interest as a potential therapeutic target. CD73 is one of the key enzymes catalyzing the conversion of extracellular
Ling-Fang Gao et al.
Journal of experimental & clinical cancer research : CR, 41(1), 81-81 (2022-03-05)
Tumor budding is included in the routine diagnosis of colorectal cancer (CRC) and is considered a tumor prognostic factor independent of TNM staging. This study aimed to identify the fibroblast-mediated effect of tumor bud-derived C-C chemokine ligand 5 (CCL5) on
Na Liu et al.
The Journal of clinical investigation, 129(2), 631-646 (2018-11-16)
Macrophages perform key functions in tissue homeostasis that are influenced by the local tissue environment. Within the tumor microenvironment, tumor-associated macrophages can be altered to acquire properties that enhance tumor growth. Here, we found that lactate, a metabolite found in
Ruiqi Liu et al.
iScience, 25(3), 103982-103982 (2022-03-22)
The Mammary gland undergoes complicated epithelial remodeling to form lobuloalveoli during pregnancy, in which basal epithelial cells remarkably increase to form a basket-like architecture. However, it remains largely unknown how dormant mammary basal stem/progenitor cells involve in lobuloalveolar development. Here
Junyan Sun et al.
Cell cycle (Georgetown, Tex.), 17(13), 1591-1601 (2018-06-19)
Psychological stress, which exerts detrimental effects on human reproduction, may compromise the meiotic competence of oocytes. Meiotic resumption, germinal vesicle breakdown (GVBD), is the first milestone to confer meiotic competence to oocytes. In the practice of assisted reproductive technology (ART)
Sara Darbandi et al.
Turkish journal of urology, 45(3), 164-170 (2019-03-01)
Studies showed a decrease of the semen analysis parameters and an increase in the average age of first-time fathers over the past several decades. The aim of the present study was to assess the influence of paternal age on semen
Seyed Mojtaba Hosseini et al.
Asian journal of neurosurgery, 13(4), 1101-1107 (2018-11-22)
Spinal cord injury (SCI) as one of the most important diseases of central nervous system (CNS) without any definite treatment is still growing in incidence. In addition to trauma, some surgeries such as cardiac and thoracic aorta surgery may result
Erratum to: Isolation and Characterization of Aortic Dendritic Cells and Lymphocytes in Atherosclerosis.
Tae Jin Yun et al.
Methods in molecular biology (Clifton, N.J.), 1559, E1-E1 (2017-10-19)
Hui-Fang Zhu et al.
Cancer biology & therapy, 20(7), 967-978 (2019-03-22)
Nontumour cells in the tumour microenvironment, especially fibroblasts, contribute to tumour progression and metastasis. The occurrence and evolution of colorectal cancer (CRC) is closely related to cancer-associated fibroblasts (CAFs). The aim of this work was to evaluate the effects of
Wei Xiang et al.
Signal transduction and targeted therapy, 5(1), 239-239 (2020-10-17)
Peritoneal carcinomatosis (PC) of colorectal cancer (CRC) is a terminal phase of malignancy with no effective strategies for the prevention of this condition. Here we established PC models in mice by intraperitoneal engraftment of CRC cells and revealed an unexpected
Tae Jin Yun et al.
Methods in molecular biology (Clifton, N.J.), 1559, 419-437 (2017-01-08)
Dendritic cells (DCs) are central to initiate antigen-specific immunity and tolerance. The in vivo development and distribution of DCs are now better understood even in nonlymphoid tissues [1]. Atherosclerosis is a chronic inflammatory disease of blood vessels and DCs are
Tao Wang et al.
International journal of molecular medicine, 46(1), 340-350 (2020-07-07)
The present study aimed to investigate the protective effects exerted by astragaloside‑IV (AIV) on retinal pigment epithelial (RPE) cells of rats with diabetes mellitus (DM), and to explore the underlying molecular mechanisms. For this purpose, a rat model of DM
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