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Showing 31-60 of 2860 results for "H1758" within Papers
Tom Zhao et al.
Journal of neuroinflammation, 12, 121-121 (2015-06-25)
The membrane attack complex (MAC) is a key player in the pathogenesis of age-related macular degeneration (AMD) and is a putative activator of the NLRP3 inflammasome. Amyloid beta (Aβ), a component of drusen deposits, has also been implicated in inflammasome
Georgette E Shields et al.
Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association, 56(5), 466-473 (2015-04-29)
Injuries involving the femoral third trochanter are an uncommon but important source of equine lameness; however, clinical localization can be challenging. The purpose of this retrospective study was to describe ultrasonographic and scintigraphic findings in a group of horses with
Suresh B Lakshminarayana et al.
Antimicrobial agents and chemotherapy, 59(2), 1200-1210 (2014-12-10)
Limited information is available on the pharmacokinetic (PK) and pharmacodynamic (PD) parameters driving the efficacy of antimalarial drugs. Our objective in this study was to determine dose-response relationships of a panel of related spiroindolone analogs and identify the PK-PD index
Roya Ravarian et al.
Journal of biomedical materials research. Part A, 103(9), 2898-2908 (2015-02-19)
A nonuniform degradation of physical mixture of organic-inorganic biomaterials increases their risk of failure. In this study a chemical bonding between chitosan and bioglass was used as an alternative product to address this issue. To prepare a homogenous composite, chitosan
Nozomi Hirose et al.
Biochemical and biophysical research communications, 460(2), 464-468 (2015-03-23)
Clarification of the mechanism of the sense of taste in chickens will provide information useful for creating and improving new feedstuffs for chickens, because the character of the taste receptors in oral tissues affects feeding behavior in animals. In this
Shu Zhang et al.
PloS one, 10(7), e0131833-e0131833 (2015-07-07)
Cyclin-dependent kinase 5 (CDK5) is a cytoplasmic serine/ threonine kinase. Knockdown of CDK5 enhances paclitaxel sensitivity in human ovarian cancer cells. This study explores the mechanisms by which CDK5 regulates paclitaxel sensitivity in human ovarian cancers. Multiple ovarian cancer cell
Katherine M Serafine et al.
The Journal of pharmacology and experimental therapeutics, 355(3), 381-385 (2015-09-19)
(1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine (lorcaserin) is approved by the United States Food and Drug Administration for treating obesity, and its therapeutic effects are thought to result from agonist activity at serotonin (5-HT)2C receptors. Lorcaserin has affinity for other 5-HT receptor subtypes, although its
Katrin Holst et al.
Journal of cell science, 128(15), 2866-2880 (2015-06-21)
Dendritic cells are potent antigen-presenting cells endowed with the unique ability to initiate adaptive immune responses upon inflammation. Inflammatory processes are often associated with an increased production of serotonin, which operates by activating specific receptors. However, the functional role of
Yun Yang et al.
mAbs, 7(2), 440-450 (2015-02-14)
Panitumumab, as a commercially available antibody, is an effective anticancer therapeutic against epidermal growth factor receptor (EGFR), although it exerts weak antibody-dependent cell-mediated cytotoxicity (ADCC) activity owing to its IgG2 nature. Here, we firstly engineered panitumumab by grafting its variable
Daniel Kring Rasmussen Guldager et al.
Journal of immunological methods, 425, 62-68 (2015-06-17)
To establish and validate a rapid, cost-effective and accurate screening assay for the simultaneous testing of human naturally occurring anti-cytokine autoantibodies (c-aAb) targeting interleukin-1α (IL-1α), interleukin-6 (IL-6), interleukin-10 (IL-10), granulocyte-macrophage colony-stimulating factor (GM-CSF), and interferon α (IFNα). Because the c-aAbs
Jonathan D Dubue et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(31), 11118-11124 (2015-08-08)
New memories are thought to be solidified (consolidated) by de novo synthesis of proteins in the period subsequent to learning. This view stems from the observation that protein synthesis inhibitors, such as anisomycin (ANI), administered during this consolidation period cause
Tianzhu Qin et al.
Journal of contaminant hydrology, 230, 103598-103598 (2020-01-04)
This study presents a pore-scale investigation of two-phase flow dynamics during nanofluid flooding in subsurface formations containing non-aqueous phase liquids (NAPLs) such as crude oils. The goal was to gain fundamental understanding of the dominant displacement mechanisms of NAPL at
Youn Hee Nam et al.
Journal of agricultural and food chemistry, 63(23), 5612-5621 (2015-05-21)
Pancreatic islets (PIs) are damaged under diabetic conditions, resulting in decreased PI size. This study examined the regenerative effects of coffee and its components (caffeine, CFI; trigonelline, TRG; chlorogenic acid, CGA) on zebrafish larval PIs and β-cells damaged by administration
Yanfen Fu et al.
Applied microbiology and biotechnology, 99(10), 4397-4408 (2015-01-27)
Systems metabolic engineering has made the renewable production of industrial chemicals a feasible alternative to modern operations. One major example of a renewable process is the production of carboxylic acids, such as octanoic acid (C8), from Escherichia coli, engineered to
Rand Arafeh et al.
Nature genetics, 47(12), 1408-1410 (2015-10-27)
Analysis of 501 melanoma exomes identified RASA2, encoding a RasGAP, as a tumor-suppressor gene mutated in 5% of melanomas. Recurrent loss-of-function mutations in RASA2 were found to increase RAS activation, melanoma cell growth and migration. RASA2 expression was lost in
Menglin Liu et al.
Nature communications, 10(1), 2126-2126 (2019-05-11)
Repair of the endothelial cell barrier after inflammatory injury is essential for tissue fluid homeostasis and normalizing leukocyte transmigration. However, the mechanisms of endothelial regeneration remain poorly understood. Here we show that the endothelial and hematopoietic developmental transcription factor Sox17
Jason M Dwyer et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(19), 6188-6193 (2015-04-29)
Current treatments for major depressive disorder (MDD) have a time lag and are ineffective for a large number of patients. Development of novel pharmacological therapies requires a comprehensive understanding of the molecular events that contribute to MDD pathophysiology. Recent evidence
Morse Faria et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1001, 156-168 (2015-08-19)
Human osteopontin (hOPN) is a secreted plasma protein which is elevated in various cancers and is indicative of poor prognosis. Here we describe investigations involving an extended peptide internal standard to track an unstable signature peptide followed by further method
Georg Wultsch et al.
Mutagenesis, 30(5), 701-709 (2015-05-11)
Wood dust was classified by the IARC as a human carcinogen which causes sinonasal tumours. However, the exposure in different industries varies strongly and the risks of workers depend on the specific situation which can be assessed by the use
Érika Cosset et al.
Biomaterials, 53, 296-308 (2015-04-22)
Human cytomegalovirus (HCMV) is the most common cause of congenital infection of the central nervous system (CNS). To overcome the limited access to human neural tissue and stringent species specificity of HCMV, we used engineered neural tissues to: (i) provide
Shan Lu et al.
Molecular pharmaceutics, 12(2), 621-629 (2015-01-16)
In this study, we formulated polyplexes with different compositions for codelivery of DNA and small-interfering RNA (siRNA). Since DNA and siRNA have distinctive and complementary morphological characteristics (DNA is long and winding and siRNA is short and rigid), we hypothesized
Seshadri Reddy Ankireddy et al.
International journal of nanomedicine, 10 Spec Iss, 113-119 (2015-09-09)
Dopamine is a neurotransmitter of the catecholamine family and has many important roles, especially in human brain. Several diseases of the nervous system, such as Parkinson's disease, attention deficit hyperactivity disorder, restless legs syndrome, are believed to be related to
Kibaek Choe et al.
The Journal of clinical investigation, 125(11), 4042-4052 (2015-10-06)
Lacteals are lymphatic vessels located at the center of each intestinal villus and provide essential transport routes for lipids and other lipophilic molecules. However, it is unclear how absorbed molecules are transported through the lacteal. Here, we used reporter mice
Rosalind V Silverman-Gavrila et al.
Cytoskeleton (Hoboken, N.J.), 72(4), 157-170 (2015-04-24)
Directed migration of smooth muscle cells (SMCs) from the media to the intima and their subsequent proliferation are key events in atherosclerosis as these cells contribute to the bulk and stability of atheromatous plaques. We showed previously that two cytoskeleton-associated
Hiroshi Nogawa et al.
Dental materials journal, 34(2), 219-226 (2015-03-06)
The purpose of this study was to evaluate the shear bond strength and durability of 4-META/MMA-TBB resin to human enamel. A self-etching primer that contained 4-META (Teeth Primer, TP) and 35-45% or 60-65% concentrations of phosphoric acid (K-Etchant Gel, KE
Sheila López-Cobo et al.
Immunology, 146(1), 70-80 (2015-05-20)
After immune interactions, membrane fragments can be transferred between cells. This fast transfer of molecules is transient and shows selectivity for certain proteins; however, the constraints underlying acquisition of a protein are unknown. To characterize the mechanism and functional consequences
Chun Kiang Chua et al.
Small (Weinheim an der Bergstrasse, Germany), 11(11), 1266-1272 (2014-10-22)
Graphite oxide (GiO) and graphene oxide (GeO) possess wide applicability in technological devices. The exact chemical compositions, structures, and properties of these materials remain vague to the graphene community despite being heavily researched. As metastable materials, the properties of GiO
K F Chan et al.
Materials science & engineering. C, Materials for biological applications, 58, 666-674 (2015-10-20)
Immunosensors based on gold nanoparticles and reduced graphene oxide (AuNPs/rGO)-modified screen-printed electrodes (SPEs) were successfully synthesized using an electrochemical deposition method. The modified SPEs were characterized using a field emission scanning electron microscope (FESEM) and Raman spectroscopy to analyze the
Constantin Lapa et al.
EJNMMI research, 4, 46-46 (2014-01-01)
Peptide receptor radionuclide therapy (PRRT) is routinely used for advanced or metastasized neuroendocrine tumours (NET). To prevent nephrotoxicity, positively charged amino acids (AA) are co-infused. The aim of this study was to correlate the risk for therapy-related hyperkalaemia with the
Miroslav Skorna et al.
Muscle & nerve, 52(1), 28-33 (2014-10-14)
Small-fiber pathology can develop in the acute phase of critical illness and may explain chronic sensory impairment and pain in critical care survivors. Eleven adult ischemic stroke patients in a neurocritical care unit were enrolled in an observational cohort study.
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