H2779

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Showing 1-28 of 28 results for "H2779" within Papers

FIS1 encodes a GA2-oxidase that regulates fruit firmness in tomato.

Ren Li et al.

Nature communications, 11(1), 5844-5844 (2020-11-19)

Fruit firmness is a target trait in tomato breeding because it facilitates transportation and storage. However, it is also a complex trait and uncovering the molecular genetic mechanisms controlling fruit firmness has proven challenging. Here, we report the map-based cloning

Defective Kernel 39 encodes a PPR protein required for seed development in maize.

Xiaojie Li et al.

Journal of integrative plant biology, 60(1), 45-64 (2017-10-06)

RNA editing is a posttranscriptional process that is important in mitochondria and plastids of higher plants. All RNA editing-specific trans-factors reported so far belong to PLS-class of pentatricopeptide repeat (PPR) proteins. Here, we report the map-based cloning and molecular characterization

Recombinant TSR1 of ADAMTS5 Suppresses Melanoma Growth in Mice via an Anti-angiogenic Mechanism.

Bhuvanasundar Renganathan et al.

Cancers, 10(6) (2018-06-13)

Inhibiting tumor angiogenesis is a well-established approach for anticancer therapeutic development. A Disintegrin-like and Metalloproteinase with ThromboSpondin Motifs 5 (ADAMTS5) is a secreted matrix metalloproteinase in the ADAMTS family that also functions as an anti-angiogenic/anti-tumorigenic molecule. Its anti-angiogenic/anti-tumorigenic function is

Platelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokines.

Carol de la Motte et al.

The American journal of pathology, 174(6), 2254-2264 (2009-05-16)

Hyaluronan (HA) occurs in the body as a large, hydrating, space-filling, carbohydrate polymer in the extracellular matrix; it has both anti-angiogenic and immunosuppressive properties. Cleavage of HA results in the generation of variably sized fragments that stimulate multiple angiogenic and

Transgenic expression of tgfb1a induces hepatic inflammation, fibrosis and metastasis in zebrafish.

Chuan Yan et al.

Biochemical and biophysical research communications, 509(1), 175-181 (2018-12-26)

TGFB signaling pathway plays a key role on liver disease progression. In our previous study, we have demonstrated the oncogenic ability of Tgfb signaling pathway as a chronic induction of tgfb1a specifically in hepatocytes led to both hepatocellular carcinoma (HCC)

Selective restoration of male fertility in mice lacking angiotensin-converting enzymes by sperm-specific expression of the testicular isozyme.

P Ramaraj et al.

The Journal of clinical investigation, 102(2), 371-378 (1998-07-17)

Although angiotensin-converting enzyme (ACE) has been studied primarily in the context of its role in blood pressure regulation, this widely distributed enzyme has many other physiological functions. The ACE gene encodes two isozymes. The somatic isozyme is expressed in many

Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer.

Aitziber Buqué et al.

Nature communications, 11(1), 3819-3819 (2020-08-01)

Hormone receptor (HR)+ breast cancer (BC) causes most BC-related deaths, calling for improved therapeutic approaches. Despite expectations, immune checkpoint blockers (ICBs) are poorly active in patients with HR+ BC, in part reflecting the lack of preclinical models that recapitulate disease

Syncoilin modulates peripherin filament networks and is necessary for large-calibre motor neurons.

W Thomas Clarke et al.

Journal of cell science, 123(Pt 15), 2543-2552 (2010-07-01)

Syncoilin is an atypical type III intermediate filament (IF) protein, which is expressed in muscle and is associated with the dystrophin-associated protein complex. Here, we show that syncoilin is expressed in both the central and peripheral nervous systems. Isoform Sync1

Kaposi's sarcoma-associated herpesvirus upregulates angiogenin during infection of human dermal microvascular endothelial cells, which induces 45S rRNA synthesis, antiapoptosis, cell proliferation, migration, and angiogenesis.

Sathish Sadagopan et al.

Journal of virology, 83(7), 3342-3364 (2009-01-23)

Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) is associated with the angioproliferative KS lesions characterized by spindle-shaped endothelial cells, inflammatory cells, cytokines, growth factors, and angiogenic factors. De novo KSHV infection of human microvascular dermal endothelial cells results in increased secretion of

Exposure profiles and human papillomavirus infection in skin cancer: an analysis of 25 genus beta-types in a population-based study.

Anita S Patel et al.

The Journal of investigative dermatology, 128(12), 2888-2893 (2008-06-13)

An increasing number of studies report that genus beta human papillomaviruses (HPVs) are associated with skin cancer, with suggestions of specificity for squamous cell carcinoma (SCC) of the skin. We have conducted a systematic examination of HPV DNA in tumors

R-Spondin 1 (RSPO1) Increases Mouse Intestinal Organoid Unit Size and Survival in vitro and Improves Tissue-Engineered Small Intestine Formation in vivo.

Gabriel Levin et al.

Frontiers in bioengineering and biotechnology, 8, 476-476 (2020-06-26)

Introduction: Cell therapy and tissue engineering has recently emerged as a new option for short bowel syndrome (SBS) treatment, generating tissue engineered small intestine (TESI) from organoid units (OU) and biodegradable scaffolds. The recombinant human R-Spondin 1 (rhRSPO1) protein may

Conditional expression demonstrates the role of the homeodomain transcription factor Pdx1 in maintenance and regeneration of beta-cells in the adult pancreas.

Andrew M Holland et al.

Diabetes, 54(9), 2586-2595 (2005-08-27)

The homeodomain transcription factor Pdx1 is essential for pancreas development. To investigate the role of Pdx1 in the adult pancreas, we employed a mouse model in which transcription of Pdx1 could be reversibly repressed by administration of doxycycline. Repression of

The use of Histochoice for histological examination of articular and growth plate cartilages, intervertebral disc and meniscus.

J Melrose et al.

Biotechnic & histochemistry : official publication of the Biological Stain Commission, 83(1), 47-53 (2008-06-24)

Histochoice is a proprietary nontoxic, non-cross-linking fixative designed by the manufacturer to replace formaldehyde based fixation protocols. We compared Histochoice and formalin fixation for several cartilaginous tissues including, articular and growth plate cartilage, meniscus and intervertebral disc. The tissues were

Telomere shortening produces an inflammatory environment that increases tumor incidence in zebrafish.

Kirsten Lex et al.

Proceedings of the National Academy of Sciences of the United States of America, 117(26), 15066-15074 (2020-06-20)

Cancer incidence increases exponentially with age when human telomeres are shorter. Similarly, telomerase reverse transcriptase (tert) mutant zebrafish have premature short telomeres and anticipate cancer incidence to younger ages. However, because short telomeres constitute a road block to cell proliferation

Synchrotron Time-Lapse Imaging of Lignocellulosic Biomass Hydrolysis: Tracking Enzyme Localization by Protein Autofluorescence and Biochemical Modification of Cell Walls by Microfluidic Infrared Microspectroscopy

Devaux, et al.

Frontiers in Plant Science (2018)

A simplified method for combined immunohistochemistry and in-situ hybridization in fresh-frozen, cryocut mouse brain sections.

Sathyanesan Samuel Newton et al.

Brain research. Brain research protocols, 9(3), 214-219 (2002-07-13)

A method is described to perform combined immunohistochemistry and in situ hybridization in mouse brain sections. The protocol is specific to sections mounted on glass slides. In contrast to earlier methods that require either paraffin embedding or perfusion of the

Distinct temporal patterns of macrophage-inflammatory protein-2 and KC chemokine gene expression in surgical injury.

Brian Endlich et al.

Journal of immunology (Baltimore, Md. : 1950), 168(7), 3586-3594 (2002-03-22)

In the present study the regulation of CXC chemokine expression was evaluated in full-thickness abdominal wounds in mice. During the first 24 h after injury, IL-1alphabeta, KC, macrophage-inflammatory protein (MIP)-2, and monocyte chemoattractant protein-1 were the predominant cytokines and chemokines

The Combination of Metformin and Valproic Acid Has a Greater Anti-tumoral Effect on Prostate Cancer Growth In Vivo than Either Drug Alone.

Linh N K Tran et al.

In vivo (Athens, Greece), 33(1), 99-108 (2018-12-28)

The hypoglycemic drug metformin (MET) and the anti-epileptic drug valproic acid (VPA) have individually shown anti-tumor effects in prostate cancer in vitro. The present study intended to investigate the efficacy of the combination of MET and VPA in prostate cancer

Identification of xylem occlusions occurring in cut clematis (Clematis L., fam. Ranunculaceae Juss.) stems during their vase life.

Agata Jedrzejuk et al.

TheScientificWorldJournal, 2012, 749281-749281 (2012-08-25)

During the vase life of cut stems obstruction of xylem vessels occurs due to microbial growth, formation of tyloses, deposition of materials in the lumen of xylem vessels and the presence of air emboli in the vascular system. Such obstructions

Nuclear factor-kappaB activation and postischemic inflammation are suppressed in CD36-null mice after middle cerebral artery occlusion.

Alexander Kunz et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(7), 1649-1658 (2008-02-15)

CD36, a class-B scavenger receptor involved in multiple functions, including inflammatory signaling, may also contribute to ischemic brain injury through yet unidentified mechanisms. We investigated whether CD36 participates in the molecular events underlying the inflammatory reaction that accompanies cerebral ischemia

Cytoplasmic ADP-ribosylation levels correlate with markers of patient outcome in distinct human cancers

Aimi, et al.

Modern Pathology (2021)

Carcinogen exposure and gene promoter hypermethylation in bladder cancer.

Carmen J Marsit et al.

Carcinogenesis, 27(1), 112-116 (2005-07-01)

Tobacco smoking, certain occupational exposures, and exposure to inorganic arsenic in drinking water have been associated with the occurrence of bladder cancer. However, in these tumors the exposure-associated pattern of somatic alterations in genes in the causal pathway for disease

Circulating Levels of Epirubicin Cause Endothelial Senescence While Compromising Metabolic Activity and Vascular Function.

Amanda J Eakin et al.

Frontiers in cell and developmental biology, 8, 799-799 (2020-09-26)

Anthracycline-based chemotherapy is a common treatment for cancer patients. Because it is delivered intravenously, endothelial cells are exposed first and to the highest concentrations, prior to diffusion to target cells. Not surprisingly, vascular dysfunction is a consequence of anthracycline therapy.

Whole mount in situ localization of miRNAs and target mRNA transcripts in plants.

Vibhav Gautam et al.

3 Biotech, 9(5), 193-193 (2019-05-09)

The functional characterization of miRNAs often involves understanding of their spatiotemporal expression, which mostly relies on reporter-based or in situ hybridization studies. The available in situ localization methods follow separate protocols for pre-hybridization, hybridization, post-hybridization, and detection steps for both miRNA and mRNA transcripts

Immunogenicity and contraceptive potential of three infertility-relevant zona pellucida 2 epitopes in the marsupial brushtail possum (Trichosurus vulpecula).

Janine A Duckworth et al.

Reproduction (Cambridge, England), 133(1), 177-186 (2007-01-25)

In a previous study, three infertility-relevant epitopes of possum ZP2 (Pep12 (amino acids 111-125), Pep31 (amino acids 301-315), and Pep44 (amino acids 431-445)) were identified using sera from possums (Trichosurus vulpecula) immunized with recombinant possum zona pellucida 2 (ZP2) constructs

A roadmap for zinc trafficking in the developing barley grain based on laser capture microdissection and gene expression profiling.

Birgitte Tauris et al.

Journal of experimental botany, 60(4), 1333-1347 (2009-03-20)

Nutrients destined for the developing cereal grain encounter several restricting barriers on their path towards their final storage sites in the grain. In order to identify transporters and chelating agents that may be involved in transport and deposition of zinc

Ontogeny in terminal buds of Abies nordmanniana (Pinaceae) characterized by ubiquitin.

Bjarke Veierskov et al.

American journal of botany, 95(6), 766-771 (2008-06-01)

Meristematic activity in the bud meristem of Abies nordmanniana was visualized by ubiquitin immunohistochemical localization from before bud break and throughout shoot expansion. Ubiquitin was detected in meristematic cells either in the cytosol or nucleus, or both, depending on tissue

Heavy metal-induced toxicity in the Indian green frog: Biochemical and histopathological alterations.

Uthpala Apekshani Jayawardena et al.

Environmental toxicology and chemistry, 36(10), 2855-2867 (2017-05-06)

Heavy metal contamination may have adverse effects on wetland biota, particularly on amphibians. Severe immunotoxic effects elicited in Euphlyctis hexadactylus (Indian green frog) because of metal exposure (Cd, Cr, Cu, Pb, and Zn) in the Bellanwila-Attidiya Sanctuary, a polluted urban

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