H3136

Applied Filters:

Keyword:'H3136'

Showing 1-30 of 2413 results for "H3136" within Papers

Fascin1 expression in high-grade serous ovarian carcinoma is a prognostic marker and knockdown of fascin1 suppresses the proliferation of ovarian cancer cells.

Sae Hyun Park et al.

International journal of oncology, 44(3), 637-646 (2014-01-01)

Fascin1 (FSCN1) involved in cell motility and filopodia assembly plays important roles in biological processes such as cancer invasion and metastasis of multiple epithelial tumors. High-grade serous ovarian carcinoma (HGSOC) is aggressive and metastatic by acquiring an invasive phenotype and

A carboxy terminal BMP/TGF-β binding site in secreted phosphoprotein 24 kD independently affects BMP-2 activity.

Haijun Tian et al.

Journal of cellular biochemistry, 116(4), 667-676 (2014-11-25)

Secreted phosphoprotein 24 kD (spp24) is a bone matrix protein isolated during attempts to identify osteogenic proteins. It is not osteogenic but performs other important roles in the regulation of bone metabolism, at least in part, by binding to and affecting

Imaging mass spectrometry increased resolution using 2-mercaptobenzothiazole and 2,5-diaminonaphtalene matrices: application to lipid distribution in human colon.

Jone Garate et al.

Analytical and bioanalytical chemistry, 407(16), 4697-4708 (2015-04-24)

Imaging mass spectrometry is becoming a reference technique in the field of lipidomics, due to its ability to map the distribution of hundreds of species in a single run, along a tissue section. The next frontier is now achieving increasing

Identification of Site-Specific Stroke Biomarker Candidates by Laser Capture Microdissection and Labeled Reference Peptide.

Tingting Lian et al.

International journal of molecular sciences, 16(6), 13427-13441 (2015-06-26)

The search to date for accurate protein biomarkers in acute ischemic stroke has taken into consideration the stage and/or the size of infarction, but has not accounted for the site of stroke. In the present study, multiple reaction monitoring using

The bidirectional tumor--mesenchymal stromal cell interaction promotes the progression of head and neck cancer.

Benjamin A Kansy et al.

Stem cell research & therapy, 5(4), 95-95 (2014-08-15)

Mesenchymal stromal cells (MSC) are an integral cellular component of the tumor microenvironment. Nevertheless, very little is known about MSC originating from human malignant tissue and modulation of these cells by tumor-derived factors. The aim of this study was to

Sustained BMP signaling in osteoblasts stimulates bone formation by promoting angiogenesis and osteoblast differentiation.

Fengjie Zhang et al.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 24(7), 1224-1233 (2009-03-05)

Angiogenesis and bone formation are tightly coupled during the formation of the skeleton. Bone morphogenetic protein (BMP) signaling is required for both bone development and angiogenesis. We recently identified endosome-associated FYVE-domain protein (endofin) as a Smad anchor for BMP receptor

Sleeve Gastrectomy Reduces Hepatic Steatosis by Improving the Coordinated Regulation of Aquaglyceroporins in Adipose Tissue and Liver in Obese Rats.

Leire Méndez-Giménez et al.

Obesity surgery, 25(9), 1723-1734 (2015-03-05)

Glycerol constitutes an important metabolite for the control of lipid accumulation and glucose homeostasis. Our aim was to investigate the potential role of aquaglyceroporins, which are glycerol channels mediating glycerol efflux in adipocytes (AQP3 and AQP7) and glycerol influx (AQP9)

Brain-derived neurotrophic factor alleviates the oxidative stress induced by oxygen and glucose deprivation in an ex vivo brain slice model.

Paloma González-Rodríguez et al.

Journal of cellular physiology, 234(6), 9592-9604 (2018-10-15)

Brain-derived neurotrophic factor (BDNF) is considered as a putative therapeutic agent against stroke. Since BDNF role on oxidative stress is uncertain, we have studied this role in a rat brain slice ischemia model, which allows BDNF reaching the neural parenchyma.

Full-length TDP-43 forms toxic amyloid oligomers that are present in frontotemporal lobar dementia-TDP patients.

Yu-Sheng Fang et al.

Nature communications, 5, 4824-4824 (2014-09-13)

Proteinaceous inclusions are common hallmarks of many neurodegenerative diseases. TDP-43 proteinopathies, consisting of several neurodegenerative diseases, including frontotemporal lobar dementia (FTLD) and amyotrophic lateral sclerosis (ALS), are characterized by inclusion bodies formed by polyubiquitinated and hyperphosphorylated full-length and truncated TDP-43.

Neonatal exposure to low doses of endosulfan induces implantation failure and disrupts uterine functional differentiation at the pre-implantation period in rats.

María M Milesi et al.

Molecular and cellular endocrinology, 401, 248-259 (2014-12-09)

We investigated whether neonatal exposure to low doses of endosulfan affects fertility and uterine functional differentiation at pre-implantation in rats. Newborn female rats received the vehicle, 0.2 µg/kg/d of diethylstilbestrol (DES), 6 µg/kg/d of endosulfan (Endo6) or 600 µg/kg/d of endosulfan (Endo600) on

Presence of intramucosal neuroglial cells in normal and aganglionic human colon.

Kamran Badizadegan et al.

American journal of physiology. Gastrointestinal and liver physiology, 307(10), G1002-G1012 (2014-09-13)

The enteric nervous system (ENS) is composed of neural crest-derived neurons (also known as ganglion cells) the cell bodies of which are located in the submucosal and myenteric plexuses of the intestinal wall. Intramucosal ganglion cells are known to exist

Active hexose correlated compound potentiates the antitumor effects of low-dose 5-fluorouracil through modulation of immune function in hepatoma 22 tumor-bearing mice.

Zhiyun Cao et al.

Nutrition research and practice, 9(2), 129-136 (2015-04-11)

A variety of immunomodulators can improve the efficacy of low-dose chemotherapeutics. Active hexose correlated compound (AHCC), a mushroom mycelia extract, has been shown to be a strong immunomodulator. Whether AHCC could enhance the antitumor effect of low-dose 5-fluorouracil (5-FU) via

Gonadotropin-releasing hormone regulates human trophoblastic cell invasion via TWIST-induced N-cadherin expression.

Bo Peng et al.

The Journal of clinical endocrinology and metabolism, 100(1), E19-E29 (2014-10-15)

GnRH and its receptor, GnRHR, were shown to promote trophoblastic cell invasion. Detection of elevated early development-related transcription factor TWIST and adhesion molecule N-cadherin in the invasive trophoblastic cells could suggest that GnRH promotes trophoblastic cell invasion through TWIST-regulated N-cadherin

Modulating the expression of survivin and other basal epidermal proteins protects human skin from UVB damage and oxidative stress.

Florian Labarrade et al.

Journal of cosmetic dermatology, 14(3), 191-203 (2015-07-17)

The chromosomal passenger complex (CPC) is an assembly made of four interacting proteins: survivin, borealin, INCENP, and aurora kinase B. CPC is the key regulatory complex responsible for the correct development of cellular mitosis, accompanying each step of the chromosomal

Leptin administration activates irisin-induced myogenesis via nitric oxide-dependent mechanisms, but reduces its effect on subcutaneous fat browning in mice.

A Rodríguez et al.

International journal of obesity (2005), 39(3), 397-407 (2014-09-10)

BACKGROUND/OBJETIVES: Obese leptin-deficient ob/ob mice exhibit high adiposity and reduced muscle mass with leptin replacement promoting weight loss and inducing muscle accretion through PGC-1α-dependent mechanisms. Our aim was to analyze in vivo and in vitro the effect of leptin on

ER Stress During the Pubertal Growth Spurt Results in Impaired Long-Bone Growth in Chondrocyte-Specific ERp57 Knockout Mice.

Andrea Linz et al.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(8), 1481-1493 (2015-02-24)

Long-bone growth by endochondral ossification is cooperatively accomplished by chondrocyte proliferation, hypertrophic differentiation, and appropriate secretion of collagens, glycoproteins, and proteoglycans into the extracellular matrix (ECM). Before folding and entering the secretory pathway, ECM macromolecules in general are subject to

Sperm-associated antigen 16 is a novel target of the humoral autoimmune response in multiple sclerosis.

Laura de Bock et al.

Journal of immunology (Baltimore, Md. : 1950), 193(5), 2147-2156 (2014-08-03)

We have previously identified eight novel autoantibody targets in the cerebrospinal fluid of multiple sclerosis (MS) patients, including sperm-associated Ag 16 (SPAG16). In the current study, we further investigated the autoantibody response against SPAG16-a protein with unknown function in the

Moesin and stress-induced phosphoprotein-1 are possible sero-diagnostic markers of psoriasis.

Hideki Maejima et al.

PloS one, 9(7), e101773-e101773 (2014-07-11)

To identify diagnostic markers for psoriasis vulgaris and psoriatic arthritis, autoantibodies in sera from psoriasis vulgaris and psoriatic arthritis patients were screened by two-dimensional immunoblotting (2D-IB). Based on 2D-IB and MADLI TOF/TOF-MS analyses, eleven proteins each in psoriasis vulgaris and

EG-VEGF, BV8, and their receptor expression in human bronchi and their modification in cystic fibrosis: Impact of CFTR mutation (delF508).

Sylvain Chauvet et al.

American journal of physiology. Lung cellular and molecular physiology, 309(3), L314-L322 (2015-06-07)

Enhanced lung angiogenesis has been reported in cystic fibrosis (CF). Recently, two highly homologous ligands, endocrine gland vascular endothelial growth factor (EG-VEGF) and mammalian Bv8, have been described as new angiogenic factors. Both ligands bind and activate two closely related

Low expression of phosphatase and tensin homolog in clear‑cell renal cell carcinoma contributes to chemoresistance through activating the Akt/HDM2 signaling pathway.

Jun Chen et al.

Molecular medicine reports, 12(2), 2622-2628 (2015-05-09)

Clear-cell renal cell carcinoma (CCRCC) is the most frequent primary malignancy in the adult kidney. Most patients with advanced CCRCC have poor prognosis as CCRCC remains resistant to chemotherapy. The present study explored the possible mechanism underlying CCRCC resistance to

Immunomodulatory Role of Adipose-Derived Stem Cells on Equine Endometriosis.

Maria Elena Falomo et al.

BioMed research international, 2015, 141485-141485 (2015-07-17)

Endometriosis is a degenerative process due to a chronic inflammatory damage leading to extracellular matrix components deposition and glandular fibrosis. It is known that mesenchymal stem cells secrete a wide range of bioactive molecules, some of them modulating the immune

LMP1-deficient Epstein-Barr virus mutant requires T cells for lymphomagenesis.

Shi-Dong Ma et al.

The Journal of clinical investigation, 125(1), 304-315 (2014-12-09)

Epstein-Barr virus (EBV) infection transforms B cells in vitro and is associated with human B cell lymphomas. The major EBV oncoprotein, latent membrane protein 1 (LMP1), mimics constitutively active CD40 and is essential for outgrowth of EBV-transformed B cells in

Characterization of Cerebral Damage in a Monkey Model of Alzheimer's Disease Induced by Intracerebroventricular Injection of Streptozotocin.

Hyeon-Gu Yeo et al.

Journal of Alzheimer's disease : JAD, 46(4), 989-1005 (2015-04-18)

In line with recent findings showing Alzheimer's disease (AD) as an insulin-resistant brain state, a non-transgenic animal model with intracerebroventricular streptozotocin (icv-STZ) administration has been proposed as a representative experimental model of AD. Although icv-STZ rodent models of AD have

Gravity, a regulation factor in the differentiation of rat bone marrow mesenchymal stem cells.

Yan Huang et al.

Journal of biomedical science, 16, 87-87 (2009-09-24)

Stem cell therapy has emerged as a potential therapeutic option for tissue engineering and regenerative medicine, but many issues remain to be resolved, such as the amount of seed cells, committed differentiation and the efficiency. Several previous studies have focused

Eosinophilic inflammation of chronic rhinosinusitis with nasal polyps is related to OX40 ligand expression.

Monica Boita et al.

Innate immunity, 21(2), 167-174 (2014-03-04)

The aims of this study were to investigate OX40 ligand expression in sinus tissue from patients with nasal polyposis compared with patients with chronic rhinosinusitis without nasal polyps (NPs), and to determine if OX40 ligand expression is related to eosinophilic

Efficient endodermal induction of human adipose stem cells using various concentrations of Activin A for hepatic differentiation.

Sang Woo Lee et al.

Biochemical and biophysical research communications, 464(4), 1178-1184 (2015-07-26)

Activin A, which is a signaling molecule similar to Nodal, rapidly promotes endoderm induction of both embryonic stem (ES) cells and MSCs. Protocols for hepatic induction exhibit differences in efficiency and reproducibility depending on the specific methods or sources of

Clinical significance of hepatocyte growth factor/c-Met expression in the assessment of gastric cancer progression.

Eiichiro Noguchi et al.

Molecular medicine reports, 11(5), 3423-3431 (2015-01-17)

Among the mechanisms that control cancer progression, cell mobility is a significant factor required for cellular liberation from the primary focus and infiltration. Hepatocyte growth factor (HGF) has been shown to facilitate cell mobility. In the present study, the clinical

Integrated analysis of miRNA/mRNA network in placenta identifies key factors associated with labor onset of Large White and Qingping sows.

Huanan Li et al.

Scientific reports, 5, 13074-13074 (2015-08-15)

Labour onset is a very complex physiological process, and its mechanism is poorly understood. Here, we obtained the mRNA and miRNA expression profiles from the placentas of four groups of sows: Qingping sows 112 days after insemination with signs of

Increasing expression of substance P and calcitonin gene-related peptide in synovial tissue and fluid contribute to the progress of arthritis in developmental dysplasia of the hip.

Hui Wang et al.

Arthritis research & therapy, 17, 4-4 (2015-01-13)

Developmental dysplasia of the hip (DDH) is a common musculoskeletal disorder that has pain and loss of joint function as major pathological features. In the present study, we explored the mechanisms of possible involvement and regulation of substance P (SP)

Changes in cell-cycle kinetics responsible for limiting somatic growth in mice.

Maria Chang et al.

Pediatric research, 64(3), 240-245 (2008-06-07)

In mammals, the rate of somatic growth is rapid in early postnatal life but then slows with age, approaching zero as the animal approaches adult body size. To investigate the underlying changes in cell-cycle kinetics, [methyl-H]thymidine and 5'-bromo-2'deoxyuridine were used

Page 1 of 81