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Showing 31-60 of 73 results for "H3757" within Papers
R N Tsepilov et al.
Zhurnal mikrobiologii, epidemiologii, i immunobiologii, (2)(2), 12-20 (2013-06-29)
Selection of high-mucoid morphotype of Streptococcus equi subsp. zooepidemicus (Streptococcus zooepidemicus) and study of its morphological, physiological, biochemical and technological characteristics for providing increased secretion of hyaluronic acid (HA). Submerged cultivation was performed in 100 ml glass flasks without baffles
Kuo-Chung Lan et al.
Journal of assisted reproduction and genetics, 36(2), 325-334 (2018-11-12)
Reactive oxygen species (ROS) are thought to play a critical role in the success of IVF. The relationships between oxidative stress parameters in culture media and IVF outcomes have not been extensively investigated. The objective of this study is to
Takayuki Yamochi et al.
The Journal of reproduction and development, 63(6), 591-595 (2017-10-13)
To determine the optimum culture duration for porcine growing oocytes (GOs) to attain maturation competence, we examined the meiotic competence, chromatin configuration, and fertilization ability of porcine oocytes obtained from early antral follicles and cultured for 10-16 days. The survival
Biswajit Chowdhury et al.
The Journal of biological chemistry, 288(1), 520-528 (2012-11-23)
Hyaluronidase (HYAL) 2 is a membrane-anchored protein that is proposed to hydrolyze hyaluronan (HA) to smaller fragments that are internalized for breakdown. Initial studies of a Hyal2 knock-out (KO) mouse revealed a mild phenotype with high serum HA, supporting a
Chenzhuo Feng et al.
Biochemical and biophysical research communications, 386(4), 715-717 (2009-06-30)
The biological function of regulatory factor X1 (RFX1), the prototype member of the transcription factor RFX family, is not clear. We have used gene trap technique to disrupt the expression of RFX1 in mice. Although, heterozygous RFX1(+/-) mice appear normal
Chaemoon Lim et al.
Journal of cancer prevention, 27(2), 122-128 (2022-07-23)
Osteosarcoma is the most frequent primary malignant bone tumor with higher incidences in children and adolescents. Despite clinical evolutions, patients with osteosacoma have had a poor prognosis. There has been increasing evidence that cancer is a stem cell disease. This
Jing-hong Chen et al.
Journal of Zhejiang University. Science. B, 9(6), 455-463 (2008-06-11)
To investigate the effects of T-2 toxin on expressions of Fas, p53, Bcl-xL, Bcl-2, Bax and caspase-3 on human chondrocytes. Human chondrocytes were treated with T-2 toxin (1-20 ng/ml) for 5 d. Fas, p53 and other apoptosis-related proteins such as
Inhibition of Local Macrophage Growth Ameliorates Focal Inflammation and Suppresses Atherosclerosis.
Sarie Yamada et al.
Arteriosclerosis, thrombosis, and vascular biology, 38(5), 994-1006 (2018-03-03)
Macrophages play a central role in various stages of atherosclerotic plaque formation and progression. The local macrophages reportedly proliferate during atherosclerosis, but the pathophysiological significance of macrophage proliferation in this context remains unclear. Here, we investigated the involvement of local
Bart J M Eskens et al.
PloS one, 8(1), e55399-e55399 (2013-02-06)
It has been demonstrated that insulin-mediated recruitment of microvascular blood volume is associated with insulin sensitivity. We hypothesize that insulin rapidly stimulates penetration of red blood cells (RBC) and plasma into the glycocalyx and thereby promotes insulin-mediated glucose uptake by
Luciano Alves Favorito et al.
International braz j urol : official journal of the Brazilian Society of Urology, 38(6), 802-808 (2013-01-11)
To evaluate histological alterations in prepuce of patients with phimosis submitted to topic treatment with betamethasone in association with hyaluronidase. We studied sixty patients (mean age 4.5), presenting true phimosis and treated with a topical treatment with betamethasone cream (0.2%)
Tomoyuki Kaneiwa et al.
The Journal of biological chemistry, 287(50), 42119-42128 (2012-10-23)
Human hyaluronidase-4 (hHYAL4), a member of the hyaluronidase family, has no hyaluronidase activity, but is a chondroitin sulfate (CS)-specific endo-β-N-acetylgalactosaminidase. The expression of hHYAL4 is not ubiquitous but restricted to placenta, skeletal muscle, and testis, suggesting that hHYAL4 is not
Chris J Wynne et al.
Cancer chemotherapy and pharmacology, 72(5), 1079-1087 (2013-09-24)
To demonstrate pharmacokinetic (PK) comparability for a single dose of 600 mg subcutaneous (SC) trastuzumab, administered via a novel single-use injection device (SID) or handheld syringe in 119 randomized healthy male subjects. The co-primary PK endpoints area under the time-concentration
Ema Ruszová et al.
General physiology and biophysics, 32(3), 347-359 (2013-07-03)
Stress-induced fibroblast senescence is thought to contribute to skin aging. Ultraviolet light (UV) radiation is the most potent environmental risk factor in these processes. An Epilobium angustifolium (EA) extract was evaluated for its capacity to reverse the senescent response of
The transglycosylative action of testicular hyaluronidase.
B WEISSMANN
The Journal of biological chemistry, 216(2), 783-794 (1955-10-01)
Kate E Keller et al.
PloS one, 7(11), e48523-e48523 (2012-11-10)
Hyaluronan (HA) is a major component of the extracellular matrix (ECM) and is synthesized by three HA synthases (HAS). Similarities between the HAS2 knockout mouse and the hdf mutant mouse, which has a mutation in the versican gene, suggest that
P Scodeller et al.
Nanoscale, 5(20), 9690-9698 (2013-08-24)
We report the first nanoformulation of Hyaluronidase (Hyal) and its enhanced adjuvant effect over the free enzyme. Hyaluronic acid (HA) degrading enzyme Hyal was immobilized on 250 nm silica nanoparticles (SiNP) maintaining specific activity of the enzyme via the layer-by-layer
Ryan M Rich et al.
Journal of photochemistry and photobiology. B, Biology, 116, 7-12 (2012-09-29)
The over-expression of hyaluronidase has been observed in many types of cancer, suggesting that it may have utility for diagnosis. Here we present a technique for the detection of hyaluronidase using Fluorescence Correlation Spectroscopy (FCS). Hyaluronan macromolecules (HAs) have been
M Nazarul Islam et al.
Journal of the Indian Medical Association, 110(1), 29-30 (2012-10-04)
It has been reported that alkalinisation of an anaesthetic medication enhances the rate of onset of regional anaesthesia. The purpose of this study therefore was to find out whether alkalinisation really hastened peribulbar anaesthesia as given prior to routine cataract
Marnie Preston et al.
Annals of neurology, 73(2), 266-280 (2013-03-07)
Oligodendrocyte progenitor cells (OPCs) recruited to demyelinating lesions often fail to mature into oligodendrocytes (OLs) that remyelinate spared axons. The glycosaminoglycan hyaluronan (HA) accumulates in demyelinating lesions and has been implicated in the failure of OPC maturation and remyelination. We
Matthew D Dean et al.
Evolution; international journal of organic evolution, 63(1), 20-28 (2008-08-30)
Barriers to gene flow can arise at any stage in the reproductive sequence. Most studies of reproductive isolation focus on premating or postzygotic phenotypes, leaving the importance of differences in fertilization rate overlooked. Two closely related species of house mice
Sarah L Lawson et al.
The American journal of emergency medicine, 31(5), 886-886 (2013-04-23)
Treatment for significant hypoglycemia includes administration of dextrose containing agents, including 50% dextrose (D50%W) intravenously. Significant extravasation of D50%W can lead to complications, including skin and soft tissue injury, loss of limb, or death. The aim of this case report
Chun-I Lee et al.
Taiwanese journal of obstetrics & gynecology, 55(4), 558-562 (2016-09-04)
This study established a simple criterion for improving the pregnancy and delivery rates of Day 3 embryo transfer for in vitro fertilization (IVF) by assessing the early cleavage of two-cell stage embryos. In total, 258 cycle patients undergoing an IVF and
Aziz Fennouri et al.
Analytical chemistry, 85(18), 8488-8492 (2013-09-03)
The enzymatic degradation of long polysaccharide chains is monitored by nanopore detection. It follows a Michaelis-Menten mechanism. We measure the corresponding kinetic constants at the single molecule level. The simulation results of the degradation process allowed one to account for
Youngnam Cho et al.
Chemical communications (Cambridge, England), 49(12), 1202-1204 (2013-01-04)
The development of a target-activatable "smart" platform with high-affinity and specificity is of great importance for a wide range of biomedical applications. Here, we attempted to develop a new enzyme-activatable graphene oxide-photosensitizer complex as a biologically tunable theranostic agent, making
Pu Liu et al.
Journal of immunotherapy (Hagerstown, Md. : 1997), 33(1), 53-59 (2009-12-03)
Cyclophosphamide (CTX) is often used to create a "window" for more effective therapeutic tumor vaccination. According to a commonly applied protocol, we injected 2 mg CTX intraperitoneally to mice with small (2 to 3 mm diameter) or large (5 to
Casper B Foldager et al.
Acta orthopaedica, 82(2), 234-240 (2011-03-26)
In vitro expansion of autologous chondrocytes is an essential part of many clinically used cartilage repair treatments. Native chondrocytes reside in a 3-dimensional (3D) network and are exposed to low levels of oxygen. We compared monolayer culture to combined 3D
Fei Gao et al.
The Journal of biological chemistry, 283(10), 6058-6066 (2008-01-01)
Extracellular superoxide dismutase (EC-SOD) is expressed at high levels in lungs. EC-SOD has a polycationic matrix-binding domain that binds to polyanionic constituents in the matrix. Previous studies indicate that EC-SOD protects the lung in both bleomycin- and asbestos-induced models of
Brandon Buckway et al.
International journal of pharmaceutics, 456(1), 202-211 (2013-08-13)
Delivery of macromolecules to pancreatic cancer is inhibited by a dense extracellular matrix composed of hyaluronic acid, smooth muscle actin and collagen fibers. Hyaluronic acid causes a high intratumoral fluidic pressure which prevents diffusion and penetration into the pancreatic tumor.
Olga N Uchakina et al.
Clinical immunology (Orlando, Fla.), 146(1), 56-69 (2012-12-19)
We investigated the role of the extracellular matrix component, hyaluronic acid (HA) in SEB-induced ALI/ARDS. Intranasal exposure of mice to SEB led to a significant increase in the level of soluble hyaluronic acid in the lungs. Similarly, in an endothelial
Lisa A Gurski et al.
PloS one, 7(11), e50075-e50075 (2012-11-21)
To study the individual functions of hyaluronan interacting proteins in prostate cancer (PCa) motility through connective tissues, we developed a novel three-dimensional (3D) hyaluronic acid (HA) hydrogel assay that provides a flexible, quantifiable, and physiologically relevant alternative to current methods.
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