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Keyword:'H3757'
Showing 31-60 of 73 results for "H3757" within Papers
Jun Muto et al.
The Journal of clinical investigation, 124(3), 1309-1319 (2014-02-04)
The breakdown and release of hyaluronan (HA) from the extracellular matrix has been hypothesized to act as an endogenous signal of injury. To test this hypothesis, we generated mice that conditionally overexpressed human hyaluronidase 1 (HYAL1). Mice expressing HYAL1 in
Noomi Altgärde et al.
Acta biomaterialia, 9(9), 8158-8166 (2013-06-12)
Molecular interactions involving glycosaminoglycans (GAGs) are important for biological processes in the extracellular matrix (ECM) and at cell surfaces, and also in biotechnological applications. Enzymes in the ECM constantly modulate the molecular structure and the amount of GAGs in our
Hiroyuki Yoshida et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(14), 5612-5617 (2013-03-20)
Hyaluronan (HA) has an extraordinarily high turnover in physiological tissues, and HA degradation is accelerated in inflammatory and neoplastic diseases. CD44 (a cell surface receptor) and two hyaluronidases (HYAL1 and HYAL2) are thought to be responsible for HA binding and
O Shpilberg et al.
British journal of cancer, 109(6), 1556-1561 (2013-09-05)
Rituximab and trastuzumab were the first therapeutic monoclonal antibodies (mAbs) approved in oncology. Both antibodies are delivered by the intravenous (IV) route, but recently subcutaneous (SC) formulations have been developed. Subcutaneous administration of mAbs can offer substantial patient and resource
Eugenia Girda et al.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 27(8), 1701-1707 (2017-07-07)
Patient-derived organoids (PDOs), used in multiple tumor types, have allowed evaluation of tumor characteristics from individual patients. This study aimed to assess the feasibility of applying PDO in vitro culture for endocrine-based and drug sensitivity testing in endometrial cancer. Endometrial
Brandon Buckway et al.
International journal of pharmaceutics, 456(1), 202-211 (2013-08-13)
Delivery of macromolecules to pancreatic cancer is inhibited by a dense extracellular matrix composed of hyaluronic acid, smooth muscle actin and collagen fibers. Hyaluronic acid causes a high intratumoral fluidic pressure which prevents diffusion and penetration into the pancreatic tumor.
Débora Laís Justo Jacomini et al.
Toxicon : official journal of the International Society on Toxinology, 64, 70-80 (2013-01-12)
In this study, we describe the cDNA cloning, sequencing, and 3-D structure of the allergen hyaluronidase from Polybia paulista venom (Pp-Hyal). Using a proteomic approach, the native form of Pp-Hyal was purified to homogeneity and used to produce a Pp-specific
Yan Jiang et al.
Journal of assisted reproduction and genetics, 30(9), 1175-1179 (2013-08-31)
To study the efficacy of percutaneous epididymal sperm aspiration (PESA) in combination with short time insemination to treat infertile men with obstructive azoospermia (OA). Paired randomized controlled trial in which each couple's cohort of oocytes was divided into two equal
Neelesh Kumar Nema et al.
Pharmaceutical biology, 51(9), 1182-1187 (2013-06-15)
Centella asiatica (L.) Urban (Apiaceae), a valuable herb described in Ayurveda, is used in the indigenous system of medicine as a tonic to treat skin diseases. Centella asiatica methanol extract and its ethyl acetate, n-butanol and aqueous fraction, were subjected
Olga N Uchakina et al.
Clinical immunology (Orlando, Fla.), 146(1), 56-69 (2012-12-19)
We investigated the role of the extracellular matrix component, hyaluronic acid (HA) in SEB-induced ALI/ARDS. Intranasal exposure of mice to SEB led to a significant increase in the level of soluble hyaluronic acid in the lungs. Similarly, in an endothelial
Timothy Corcoran Flynn et al.
Plastic and reconstructive surgery, 132(4 Suppl 2), 22S-32S (2013-10-01)
In this study, the authors sought to determine the molecular weight distribution of three hyaluronic acids-Belotero Balance, Restylane, and Juvéderm Ultra-and their rates of degradation following exposure to hyaluronidase. Lot consistency of Belotero Balance also was analyzed. Three lots of
Lisa A Gurski et al.
PloS one, 7(11), e50075-e50075 (2012-11-21)
To study the individual functions of hyaluronan interacting proteins in prostate cancer (PCa) motility through connective tissues, we developed a novel three-dimensional (3D) hyaluronic acid (HA) hydrogel assay that provides a flexible, quantifiable, and physiologically relevant alternative to current methods.
Vadim Cherezov et al.
Structure (London, England : 1993), 16(9), 1378-1388 (2008-09-13)
The crystal structures of the cytoplasmic domain of the putative zinc transporter CzrB in the apo and zinc-bound forms reported herein are consistent with the protein functioning in vivo as a homodimer. NMR, X-ray scattering, and size-exclusion chromatography provide support
Tegginamath Gireesh et al.
Archiv der Pharmazie, 346(9), 645-653 (2013-08-03)
A novel series of Biginelli 2-3 (a and b) and Biginelli-like compounds 4-7 (a and b) were synthesized from 3-aryl-4-formylsydnone 1 (a and b). Since the crystal structure of hyaluronidase was unavailable, the human hyaluronidase protein structure was used as
Erdenechimeg Selenge et al.
Journal of natural medicines, 67(4), 867-875 (2013-02-12)
Activity-guided isolation of the n-butanol fraction of Chamaerhodos erecta and water soluble fraction of C. altaica resulted in the isolation of 39 compounds, including new compounds identified as 4,5-dihydroxybenzaldehyde-3-O-β-D-glucopyranoside (1) from C. erecta and quercetin-3-O-β-D-glucuronopyranosyl-4'-O-β-D-glucopyranoside (2) from C. altaica. A
Casper B Foldager et al.
Acta orthopaedica, 82(2), 234-240 (2011-03-26)
In vitro expansion of autologous chondrocytes is an essential part of many clinically used cartilage repair treatments. Native chondrocytes reside in a 3-dimensional (3D) network and are exposed to low levels of oxygen. We compared monolayer culture to combined 3D
Fei Gao et al.
The Journal of biological chemistry, 283(10), 6058-6066 (2008-01-01)
Extracellular superoxide dismutase (EC-SOD) is expressed at high levels in lungs. EC-SOD has a polycationic matrix-binding domain that binds to polyanionic constituents in the matrix. Previous studies indicate that EC-SOD protects the lung in both bleomycin- and asbestos-induced models of
Ema Ruszová et al.
General physiology and biophysics, 32(3), 347-359 (2013-07-03)
Stress-induced fibroblast senescence is thought to contribute to skin aging. Ultraviolet light (UV) radiation is the most potent environmental risk factor in these processes. An Epilobium angustifolium (EA) extract was evaluated for its capacity to reverse the senescent response of
Luciano Alves Favorito et al.
International braz j urol : official journal of the Brazilian Society of Urology, 38(6), 802-808 (2013-01-11)
To evaluate histological alterations in prepuce of patients with phimosis submitted to topic treatment with betamethasone in association with hyaluronidase. We studied sixty patients (mean age 4.5), presenting true phimosis and treated with a topical treatment with betamethasone cream (0.2%)
Tomoyuki Kaneiwa et al.
The Journal of biological chemistry, 287(50), 42119-42128 (2012-10-23)
Human hyaluronidase-4 (hHYAL4), a member of the hyaluronidase family, has no hyaluronidase activity, but is a chondroitin sulfate (CS)-specific endo-β-N-acetylgalactosaminidase. The expression of hHYAL4 is not ubiquitous but restricted to placenta, skeletal muscle, and testis, suggesting that hHYAL4 is not
Kate E Keller et al.
PloS one, 7(11), e48523-e48523 (2012-11-10)
Hyaluronan (HA) is a major component of the extracellular matrix (ECM) and is synthesized by three HA synthases (HAS). Similarities between the HAS2 knockout mouse and the hdf mutant mouse, which has a mutation in the versican gene, suggest that
Chris J Wynne et al.
Cancer chemotherapy and pharmacology, 72(5), 1079-1087 (2013-09-24)
To demonstrate pharmacokinetic (PK) comparability for a single dose of 600 mg subcutaneous (SC) trastuzumab, administered via a novel single-use injection device (SID) or handheld syringe in 119 randomized healthy male subjects. The co-primary PK endpoints area under the time-concentration
Chun-I Lee et al.
Taiwanese journal of obstetrics & gynecology, 55(4), 558-562 (2016-09-04)
This study established a simple criterion for improving the pregnancy and delivery rates of Day 3 embryo transfer for in vitro fertilization (IVF) by assessing the early cleavage of two-cell stage embryos. In total, 258 cycle patients undergoing an IVF and
Aziz Fennouri et al.
Analytical chemistry, 85(18), 8488-8492 (2013-09-03)
The enzymatic degradation of long polysaccharide chains is monitored by nanopore detection. It follows a Michaelis-Menten mechanism. We measure the corresponding kinetic constants at the single molecule level. The simulation results of the degradation process allowed one to account for
Matthew D Dean et al.
Evolution; international journal of organic evolution, 63(1), 20-28 (2008-08-30)
Barriers to gene flow can arise at any stage in the reproductive sequence. Most studies of reproductive isolation focus on premating or postzygotic phenotypes, leaving the importance of differences in fertilization rate overlooked. Two closely related species of house mice
Bart J M Eskens et al.
PloS one, 8(1), e55399-e55399 (2013-02-06)
It has been demonstrated that insulin-mediated recruitment of microvascular blood volume is associated with insulin sensitivity. We hypothesize that insulin rapidly stimulates penetration of red blood cells (RBC) and plasma into the glycocalyx and thereby promotes insulin-mediated glucose uptake by
Sarah L Lawson et al.
The American journal of emergency medicine, 31(5), 886-886 (2013-04-23)
Treatment for significant hypoglycemia includes administration of dextrose containing agents, including 50% dextrose (D50%W) intravenously. Significant extravasation of D50%W can lead to complications, including skin and soft tissue injury, loss of limb, or death. The aim of this case report
Sarie Yamada et al.
Arteriosclerosis, thrombosis, and vascular biology, 38(5), 994-1006 (2018-03-03)
Macrophages play a central role in various stages of atherosclerotic plaque formation and progression. The local macrophages reportedly proliferate during atherosclerosis, but the pathophysiological significance of macrophage proliferation in this context remains unclear. Here, we investigated the involvement of local
Marnie Preston et al.
Annals of neurology, 73(2), 266-280 (2013-03-07)
Oligodendrocyte progenitor cells (OPCs) recruited to demyelinating lesions often fail to mature into oligodendrocytes (OLs) that remyelinate spared axons. The glycosaminoglycan hyaluronan (HA) accumulates in demyelinating lesions and has been implicated in the failure of OPC maturation and remyelination. We
Ryan M Rich et al.
Journal of photochemistry and photobiology. B, Biology, 116, 7-12 (2012-09-29)
The over-expression of hyaluronidase has been observed in many types of cancer, suggesting that it may have utility for diagnosis. Here we present a technique for the detection of hyaluronidase using Fluorescence Correlation Spectroscopy (FCS). Hyaluronan macromolecules (HAs) have been
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