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Showing 1-30 of 188 results for "H3884" within Papers
Jorge Ojeda et al.
Frontiers in cellular neuroscience, 14, 225-225 (2020-08-28)
The neuromuscular junction (NMJ) is the peripheral synapse that controls the coordinated movement of many organisms. The NMJ is also an archetypical model to study synaptic morphology and function. As the NMJ is the primary target of neuromuscular diseases and
Lin-Wei Guo et al.
Clinical and translational medicine, 11(11), e589-e589 (2021-11-30)
Few studies have discussed the contradictory roles of mutated-PI3Kα in HER2-positive (HER2+) breast cancer. Thus, we characterised the adaptive roles of PI3Kα mutations among HER2+ tumour progression. We conducted prospective clinical sequencing of 1923 Chinese breast cancer patients and illustrated
Nathan V Welham et al.
Journal of speech, language, and hearing research : JSLHR, 52(4), 1008-1020 (2009-07-31)
To develop and evaluate a rat excised larynx model for the measurement of acoustic, aerodynamic, and vocal fold vibratory changes resulting from vocal fold scar. Twenty-four 4-month-old male Sprague-Dawley rats were assigned to 1 of 4 experimental groups: chronic vocal
Vanesa Y Rawe et al.
Methods in molecular biology (Clifton, N.J.), 518, 189-206 (2008-12-17)
Understanding the cellular events during fertilization in mammals is a major challenge that can contribute to the improvement of future infertility treatments in humans and reproductive performance in farm animals. Of special interest is the role of the oocyte and
Transcriptome analysis reveals differences in cell cycle, growth and migration related genes that distinguish fibroblasts derived from pre-invasive and invasive breast cancer.
Fang, et al.
Frontiers in Oncology, 13, 1130911-1130911 (2023)
C Kolliopoulos et al.
Journal of pharmaceutical and biomedical analysis, 83, 299-304 (2013-06-20)
Colorectal cancer is the third most commonly diagnosed type of cancer. Hyaluronan is involved in this malignancy. Moreover, hyaluronidases - its degrading enzymes - display controversial roles regarding their involvement in tumor development. HYAL-1 is the major tumor derived hyaluronidase.
Lindsay K McGuire et al.
Journal of drugs in dermatology : JDD, 12(10), 1181-1183 (2013-10-03)
We report a case of a 36-year-old female who experienced significant vascular occlusion after injection with hyaluronic acid into the nasolabial folds. The patient experienced immediate pain after the injection, however, the vascular compromise was not diagnosed and treated until
Gry Hulsart-Billström et al.
Biomacromolecules, 14(9), 3055-3063 (2013-08-21)
Regeneration of bone by delivery of bone morphogenetic proteins (BMPs) from implantable scaffolds is a promising alternative to the existing autologous bone grafting procedures. Hydrogels are used extensively in biomaterials as delivery systems for different growth factors. However, a controlled
Mohammad Amin Fayaz et al.
Andrology, 8(5), 1332-1346 (2020-02-08)
Subcutaneous grafting/implantation of neonatal testis tissue/cells from diverse donor species into recipient mice can be used as an in vivo model to study testis development, spermatogenesis, and steroidogenesis. Ultrasound biomicroscopy (UBM) allows obtaining high definition cross-sectional images of tissues at
Maengjo Kim et al.
Journal of molecular and cellular cardiology, 45(2), 270-280 (2008-07-04)
Cardiovascular sequelae including diabetic cardiomyopathy constitute the major cause of death in diabetic patients. Although several factors may contribute to the development of this cardiomyopathy, the underlying molecular/cellular mechanisms leading to cardiac dysfunction are still partially understood. Recently, a novel
Prashanth Srinivas et al.
Indian journal of biochemistry & biophysics, 49(4), 228-235 (2012-10-20)
Hyaluronan (HA) is a component of extracellular matrix that influences cell-proliferation, migration, development, regeneration, normal tissue remodeling, tissues undergoing malignancy and tumor cell interaction. The widespread occurrence of HA binding proteins, their involvement in tissue organization and the control of
Chenzhuo Feng et al.
Biochemical and biophysical research communications, 386(4), 715-717 (2009-06-30)
The biological function of regulatory factor X1 (RFX1), the prototype member of the transcription factor RFX family, is not clear. We have used gene trap technique to disrupt the expression of RFX1 in mice. Although, heterozygous RFX1(+/-) mice appear normal
O Shpilberg et al.
British journal of cancer, 109(6), 1556-1561 (2013-09-05)
Rituximab and trastuzumab were the first therapeutic monoclonal antibodies (mAbs) approved in oncology. Both antibodies are delivered by the intravenous (IV) route, but recently subcutaneous (SC) formulations have been developed. Subcutaneous administration of mAbs can offer substantial patient and resource
Hiroyuki Yoshida et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(14), 5612-5617 (2013-03-20)
Hyaluronan (HA) has an extraordinarily high turnover in physiological tissues, and HA degradation is accelerated in inflammatory and neoplastic diseases. CD44 (a cell surface receptor) and two hyaluronidases (HYAL1 and HYAL2) are thought to be responsible for HA binding and
Russell M L Simpson et al.
The American journal of pathology, 176(3), 1215-1228 (2010-01-23)
Fibroblast differentiation into myofibroblasts is a key event during normal wound repair. We have previously demonstrated an age-related defect in this process associated with impaired synthesis of hyaluronan (HA) synthase (HAS) 2 but failed to prescribe its role in a
Sharon Gerecht et al.
Methods in molecular biology (Clifton, N.J.), 584, 333-354 (2009-11-13)
The vascularization of tissue constructs remains a major challenge in regenerative medicine, as the diffusional supply of oxygen can support only 100-200 mum thick layers of viable tissue. The formation of a mature and functional vascular network requires communication between
Wendy Leskova et al.
Experimental eye research, 179, 125-131 (2018-11-18)
We sought to investigate the effects of diabetes and hyaluronidase on the thickness of the endothelial glycocalyx layer in the mouse retina. In our study, the retinal circulation of diabetic Ins2(Akita) mice and their nondiabetic littermates were observed via intravital
Patricia Diaz-Rodriguez et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 107(6), 2019-2029 (2018-12-15)
Synovium-derived mesenchymal stem cells (SMSCs) are an emerging cell source for regenerative medicine applications, including osteochondral defect (OCD) repair. However, in contrast to bone marrow MSCs, scaffold compositions which promote SMSC chondrogenesis/osteogenesis are still being identified. In the present manuscript
Eline A E van der Hagen et al.
Pflugers Archiv : European journal of physiology, 466(11), 2077-2087 (2014-02-22)
Fine-tuning of renal calcium ion (Ca(2+)) reabsorption takes place in the distal convoluted and connecting tubules (distal convolution) of the kidney via transcellular Ca(2+) transport, a process controlled by the epithelial Ca(2+) channel Transient Receptor Potential Vanilloid 5 (TRPV5). Studies
D Scarlet et al.
Domestic animal endocrinology, 59, 11-22 (2016-11-21)
The objective of this study was to determine whether (1) systemic and intrafollicular cortisol concentrations in horses are directly related and (2) supraphysiological levels of glucocorticoids affect in vitro maturation (IVM) rates of oocytes. Specifically, we studied the (1) changes in
Kaneez Fatima et al.
Frontiers in nutrition, 9, 857256-857256 (2022-04-26)
Carvacrol, a monoterpene known for its pharmacological activities, is present in the essential oil of Origanum majorana, Origanum vulgare, Thymus vulgaris, and Lippia graveolens. It is used in food as a flavoring and preservative agent in cosmetics and medicines because
The pathogenesis of common Gjb2 mutations associated with human hereditary deafness in mice.
Li, et al.
Cellular and Molecular Life Sciences, 80, 148-148 (2023)
Christophe Heinrich et al.
Nature protocols, 6(2), 214-228 (2011-02-05)
Instructing glial cells to generate neurons may prove to be a strategy to replace neurons that have degenerated. Here, we describe a robust protocol for the efficient in vitro conversion of postnatal astroglia from the mouse cerebral cortex into functional
Yining Li et al.
Reproduction (Cambridge, England), 161(3), 289-294 (2020-12-11)
Ovarian follicle development is regulated by locally produced TGFβ superfamily members. The TGFβ type III receptor (TGFBR3, or betaglycan), which regulates the actions of diverse TGFβ ligands, including inhibins, is expressed in different ovarian cell types. However, its functional roles
Steven H Bailey et al.
Plastic and reconstructive surgery, 133(2), 127e-132e (2014-01-29)
Soft-tissue augmentation has become an increasingly popular option for facial rejuvenation. Hyaluronic acid fillers are part of the most rapidly expanding segment of this market, largely because of their safe drug profile and temporary nature. Despite their good safety profile
Genevieve B Wortzman et al.
Methods in molecular biology (Clifton, N.J.), 341, 89-101 (2006-06-27)
The interactions between egg and sperm are among the most fascinating in cell biology. These interactions include cell-cell adhesion and then membrane fusion between the two gametes. This chapter details the experimental methods used to for gamete culture and in
T K Cooper et al.
Veterinary pathology, 52(2), 388-392 (2014-06-11)
Chordomas are uncommon neoplasms arising from notochord remnants, most commonly occurring in the axial skeleton. Extraskeletal soft tissue chordomas are rare primary tumors, and primary alimentary tract chordomas have not been reported. Herein we report 24 cases of spontaneous primary
Aishwarya Korgaonkar et al.
Current biology : CB, 31(9), 1836-1849 (2021-03-04)
In an elaborate form of inter-species exploitation, many insects hijack plant development to induce novel plant organs called galls that provide the insect with a source of nutrition and a temporary home. Galls result from dramatic reprogramming of plant cell
Mauro Pavan et al.
Carbohydrate polymers, 97(2), 321-326 (2013-08-06)
Five amide derivatives of Hyaluronic Acid (HA) were synthesized with C8, C12, C15, C16 and C18 linear alkyl-amines. These polymers (Hyadd) were tested against thermal, oxidative and hyaluronidase degradation by means of rheological experiments and SEC analysis and compared to
Yining Li et al.
The Journal of biological chemistry, 292(6), 2301-2314 (2016-12-21)
Pituitary follicle-stimulating hormone (FSH) is an essential regulator of fertility in females and of quantitatively normal spermatogenesis in males. Pituitary-derived activins are thought to act as major stimulators of FSH synthesis by gonadotrope cells.
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