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Showing 1-30 of 188 results for "H3884" within Papers
Silvia Monteagudo et al.
Nature communications, 8, 15889-15889 (2017-06-20)
Osteoarthritis is the most prevalent and crippling joint disease, and lacks curative treatment, as the underlying molecular basis is unclear. Here, we show that DOT1L, an enzyme involved in histone methylation, is a master protector of cartilage health. Loss of
Yunxia O'Malley et al.
Advances in redox research : an official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe, 5 (2022-07-30)
Cystic fibrosis-related diabetes (CFRD) is one the most common comorbidities in cystic fibrosis (CF). Pancreatic oxidative stress has been postulated in the pathogenesis of CFRD, but no studies have been done to show an association. The main obstacle is the
Jun Muto et al.
The Journal of clinical investigation, 124(3), 1309-1319 (2014-02-04)
The breakdown and release of hyaluronan (HA) from the extracellular matrix has been hypothesized to act as an endogenous signal of injury. To test this hypothesis, we generated mice that conditionally overexpressed human hyaluronidase 1 (HYAL1). Mice expressing HYAL1 in
Nina Bertaux-Skeirik et al.
Methods in molecular biology (Clifton, N.J.), 1576, 205-213 (2016-08-20)
The culture of organoids has represented a significant advancement in the gastrointestinal research field. Previous research studies have described the oncogenic transformation of human intestinal and mouse gastric organoids. Here we detail the protocol for the oncogenic transformation and orthotopic
K D Kuhn et al.
Molecular and cellular neurosciences, 103, 103467-103467 (2020-02-01)
During neural development, complex organisms rely on progressive and regressive events whereby axons, synapses, and neurons are overproduced followed by selective elimination of a portion of these components. Tumor necrosis factor α (TNFα) together with its cognate receptor (Tumor necrosis
Xusheng Wang et al.
Nature protocols, 8(2), 302-309 (2013-01-19)
The mouse excisional wound healing model has been used extensively to study wound healing and cutaneous regeneration. However, as mouse skin is mobile, contraction accounts for a large part of wound closure. In the mouse excisional wound splinting model, a
Karina Frankowski et al.
Frontiers in zoology, 19(1), 14-14 (2022-04-02)
Pycnogonida (sea spiders) is the sister group of all other extant chelicerates (spiders, scorpions and relatives) and thus represents an important taxon to inform early chelicerate evolution. Notably, phylogenetic analyses have challenged traditional hypotheses on the relationships of the major
Base editing-mediated one-step inactivation of the Dnmt gene family reveals critical roles of DNA methylation during mouse gastrulation.
Li, et al.
Nature Communications, 14, 2922-2922 (2023)
Annalisa La Gatta et al.
Polymers, 13(19) (2021-10-14)
In this research work, viscosupplements based on linear, derivatized, crosslinked and complexed HA forms were extensively examined, providing data on the hydrodynamic parameters for the water-soluble-HA-fraction, rheology, sensitivity to enzymatic hydrolysis and capacity to modulate specific biomarkers' expression in human
Ji-Hyun Lee et al.
Clinical proteomics, 17, 20-20 (2020-06-11)
Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease affecting the axial skeleton and peripheral joints. The etiology of this disease remains poorly understood, but interactions between genetic and environmental factors have been implicated. The present study identified differentially expressed
Carmen A Vlahu et al.
Journal of the American Society of Nephrology : JASN, 23(11), 1900-1908 (2012-10-23)
Damage to the endothelial glycocalyx, which helps maintain vascular homeostasis, heightens the sensitivity of the vasculature to atherogenic stimuli. Patients with renal failure have endothelial dysfunction and increased risk for cardiovascular morbidity and mortality, but the state of the endothelial
S Schwarz et al.
Scientific reports, 10(1), 5380-5380 (2020-03-28)
Dogs share many chronic morbidities with humans and thus represent a powerful model for translational research. In comparison to rodents, the canine ganglioside metabolism more closely resembles the human one. Gangliosides are components of the cell plasma membrane playing a
Guangqin Wang et al.
Development (Cambridge, England), 148(5) (2021-02-10)
CRISPR-stop converts protein-coding sequences into stop codons, which, in the appropriate location, results in a null allele. CRISPR-stop induction in one-cell-stage zygotes generates Founder 0 (F0) mice that are homozygous mutants; this avoids mouse breeding and serves as a rapid
Alasdair MacKenzie
Methods in molecular biology (Clifton, N.J.), 349, 139-150 (2006-10-31)
The generation of transgenic animals has become an important tool in helping to understand the roles of genes in maintaining health and the roles of human gene variants in contributing to disease susceptibility. In order to model the subtleties of
Philip R Spandorfer et al.
Clinical therapeutics, 34(11), 2232-2245 (2012-10-16)
Alternative treatment of dehydration is needed when intravenous (IV) or oral rehydration therapy fails. Subcutaneous (SC) hydration facilitated by recombinant human hyaluronidase offers an alternative treatment for dehydration. This clinical trial is the first to compare recombinant human hyaluronidase-facilitated SC
Ana Domingo-Muelas et al.
Nature communications, 14(1), 373-373 (2023-01-24)
Neural stem cells (NSCs) in the adult murine subependymal zone balance their self-renewal capacity and glial identity with the potential to generate neurons during the lifetime. Adult NSCs exhibit lineage priming via pro-neurogenic fate determinants. However, the protein levels of
Jakob Georgi et al.
Magnetic resonance in medicine, 81(2), 1265-1279 (2018-10-03)
Water mobility in tissues is related to the microstructure that modulates diffusion and spin relaxation. Previous work has shown that the extracellular matrix (ECM) impacts water diffusion in cartilage. To investigate if similar contributions to image contrast exist for brain
A Hatziri et al.
European review for medical and pharmacological sciences, 17(2), 247-252 (2013-02-05)
Nasal polyps are benign lesions originating from the nasal mucosa or paranasal sinuses. The most important etiological factor seems to be increased hydration of epithelium and hyperplasia of the extracellular matrix, which may involve hyaluronan, a high molecular mass extracellular
Bhavana Gupta et al.
Cell reports, 36(8), 109588-109588 (2021-08-26)
Radial glia-like (RGL) stem cells persist in the adult mammalian hippocampus, where they generate new neurons and astrocytes throughout life. The process of adult neurogenesis is well documented, but cell-autonomous factors regulating neuronal and astroglial differentiation are incompletely understood. Here
Marilina Mascaró et al.
Histochemistry and cell biology, 148(2), 173-187 (2017-04-04)
Hyaluronan (HA) is the major glycosaminoglycan present in the extracellular matrix. It is produced by some tumours and promotes proliferation, differentiation and migration among others cellular processes. Gestational trophoblastic disease (GTD) is composed by non-tumour entities, such as hydatidiform mole
Pasquale Sacco et al.
Carbohydrate polymers, 136, 418-426 (2015-11-18)
In this study we present a novel silver complex of hyaluronan-lipoate (SHLS12) in a gel-state form. NMR analysis, conductometry and elemental analysis demonstrated stable non-covalent interactions between silver ions and the polysaccharide-lipoate backbone, whereas rheological investigations confirmed its gel-like physical-chemical
Lindsey Seldin et al.
Developmental cell, 55(5), 558-573 (2020-10-16)
DNA crosslinking agents are commonly used in cancer chemotherapy; however, responses of normal tissues to these agents have not been widely investigated. We reveal in mouse interfollicular epidermal, mammary and hair follicle epithelia that genotoxicity does not promote apoptosis but
Damian B Yap et al.
PloS one, 6(11), e27127-e27127 (2011-11-10)
Mll5 is currently a member of the Mll family of SET domain histone methyltransferase proteins but studies have also showed that it could be part of the SET3 branch of proteins. Recently, constitutive knock out animal studies have shown that
Alexandra A Tsitrina et al.
Glycobiology, 31(8), 959-974 (2021-05-13)
Elevated plasma levels of hyaluronic acid (HA) is a disease marker in liver pathology and other inflammatory disorders. Inhibition of HA synthesis with coumarin 4-methylumbelliferone (4MU) has a beneficial effect in animal models of fibrosis, inflammation, cancer and metabolic syndrome.
Saida Farah Issa et al.
Clinical and experimental rheumatology, 38(1), 122-128 (2019-09-10)
To study circulating MFAP4 in rheumatoid arthritis (RA) and its associations with clinical phenotype. Early RA (ERA): 47 patients with newly diagnosed, treatment naïve RA were included. Serum MFAP4, clinical and laboratory disease variables were recorded serially during 12 months
Cell labeling and gene misexpression by electroporation.
Terence J Van Raay et al.
Methods in molecular biology (Clifton, N.J.), 198, 223-232 (2002-04-16)
Pietro Lo Riso et al.
Genome medicine, 12(1), 94-94 (2020-10-31)
High-grade serous ovarian cancer (HGSOC) is a major unmet need in oncology. The remaining uncertainty on its originating tissue has hampered the discovery of molecular oncogenic pathways and the development of effective therapies. We used an approach based on the
Maxim A Vodyanik et al.
Methods in molecular biology (Clifton, N.J.), 407, 275-293 (2008-05-06)
Embryonic stem cells represent a pluripotent population of cells capable of self-renewal, large-scale expansion, and differentiation in various cell lineages including cells of hematopoietic lineage. In this chapter, we describe a three-step cell culture method for directed differentiation of human
Noomi Altgärde et al.
Acta biomaterialia, 9(9), 8158-8166 (2013-06-12)
Molecular interactions involving glycosaminoglycans (GAGs) are important for biological processes in the extracellular matrix (ECM) and at cell surfaces, and also in biotechnological applications. Enzymes in the ECM constantly modulate the molecular structure and the amount of GAGs in our
Structure of the transmembrane protein 2 (TMEM2) ectodomain and its apparent lack of hyaluronidase activity.
Niu, et al.
Wellcome open research, 8, 76-76 (2023)
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