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Keyword:'H4272'
Showing 1-30 of 194 results for "H4272" within Papers
Kailiang Li et al.
Biology of reproduction, 105(4), 859-875 (2021-06-10)
Basigin (BSG) is a transmembrane glycoprotein involved in cell proliferation, angiogenesis, and tissue remodeling. BSG has been shown to be essential for male and female reproduction although little is known about its role in normal uterine function. To study the
Baolu Shi et al.
Human reproduction open, 2023(3), hoad022-hoad022 (2023-06-16)
What are some pathogenic mutations for non-obstructive azoospermia (NOA) and their effects on spermatogenesis? Biallelic missense and frameshift mutations in ADAD2 disrupt the differentiation of round spermatids to spermatozoa causing azoospermia in humans and mice. NOA is the most severe
Lingyan Wang et al.
Cell biology international, 33(12), 1274-1279 (2009-09-08)
To establish experimental protocols for cloning golden hamsters, optimal concentrations of colchicine and demecolcine were determined for inducing cytoplasmic protrusion (containing chromosomes) and assisting enucleation of their oocytes. Denuded oocytes at different ages were treated with 2.5-10 microg/ml of colchicine
Jun Muto et al.
The Journal of clinical investigation, 124(3), 1309-1319 (2014-02-04)
The breakdown and release of hyaluronan (HA) from the extracellular matrix has been hypothesized to act as an endogenous signal of injury. To test this hypothesis, we generated mice that conditionally overexpressed human hyaluronidase 1 (HYAL1). Mice expressing HYAL1 in
Natalie M Hohos et al.
Reproduction (Cambridge, England), 161(3), 307-317 (2021-01-12)
High-fat diet (HFD) consumption in female rodents causes impaired estrous cyclicity, fewer pups per litter, and dysregulation of key ovulatory genes suggesting that HFD-induced subfertility may be due to ovulatory dysfunction. To test this hypothesis female mice were fed chow
Alina Osychenko et al.
Experimental cell research, 389(1), 111887-111887 (2020-02-07)
The cell fusion is a widespread process, which takes place in many systems in vivo and in vitro. Fusion of cells is frequently related to tetraploidy, which can be found within natural physiological conditions, e.g., placentation, and in pathophysiological conditions
Mattia Quattrocelli et al.
The American journal of pathology, 187(11), 2520-2535 (2017-08-22)
The muscular dystrophies are genetically diverse. Shared pathological features among muscular dystrophies include breakdown, or loss of muscle, and accompanying fibrotic replacement. Novel strategies are needed to enhance muscle repair and function and to slow this pathological remodeling. Glucocorticoid steroids
Benedikt Wefers et al.
Nature protocols, 8(12), 2355-2379 (2013-11-02)
Genetically engineered mice are instrumental for the analysis of mammalian gene function in health and disease. As classical gene targeting, which is performed in embryonic stem (ES) cell cultures and generates chimeric mice, is a time-consuming and labor-intensive procedure, we
Hagen Körschgen et al.
Molecular human reproduction, 23(9), 607-616 (2017-09-16)
How and where is pro-ovastacin activated and how does active ovastacin regulate zona pellucida hardening (ZPH) and successful fertilization? Ovastacin is partially active before exocytosis and pre-hardens the zona pellucida (ZP) before fertilization. The metalloproteinase ovastacin is stored in cortical
Wan Kin Au Yeung et al.
Cell reports, 27(1), 282-293 (2019-04-04)
Mammalian histone methyltransferase G9a (also called EHMT2) deposits H3K9me2 on chromatin and is essential for postimplantation development. However, its role in oogenesis and preimplantation development remains poorly understood. We show that H3K9me2-enriched chromatin domains in mouse oocytes are generally depleted
O Shpilberg et al.
British journal of cancer, 109(6), 1556-1561 (2013-09-05)
Rituximab and trastuzumab were the first therapeutic monoclonal antibodies (mAbs) approved in oncology. Both antibodies are delivered by the intravenous (IV) route, but recently subcutaneous (SC) formulations have been developed. Subcutaneous administration of mAbs can offer substantial patient and resource
Lindsay K McGuire et al.
Journal of drugs in dermatology : JDD, 12(10), 1181-1183 (2013-10-03)
We report a case of a 36-year-old female who experienced significant vascular occlusion after injection with hyaluronic acid into the nasolabial folds. The patient experienced immediate pain after the injection, however, the vascular compromise was not diagnosed and treated until
Alexander Meissner et al.
Methods in molecular biology (Clifton, N.J.), 482, 3-19 (2008-12-18)
Pluripotent embryonic stem (ES) cell lines were first isolated over 25 years ago and remain an essential tool in molecular and developmental biology to this day. In particular, the use of homologous recombination and subsequent generation of ES-derived mice has
Hiroyuki Yoshida et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(14), 5612-5617 (2013-03-20)
Hyaluronan (HA) has an extraordinarily high turnover in physiological tissues, and HA degradation is accelerated in inflammatory and neoplastic diseases. CD44 (a cell surface receptor) and two hyaluronidases (HYAL1 and HYAL2) are thought to be responsible for HA binding and
Ji Liao et al.
Scientific reports, 10(1), 20636-20636 (2020-11-28)
A battery of chromatin modifying enzymes play essential roles in remodeling the epigenome in the zygote and cleavage stage embryos, when the maternal genome is the sole contributor. Here we identify an exemption. DOT1L methylates lysine 79 in the globular
Yu Shi et al.
Nature communications, 8(1), 2043-2043 (2017-12-13)
Bone formation in mammals requires continuous production of osteoblasts throughout life. A common molecular marker for all osteogenic mesenchymal progenitors has not been identified. Here, by lineage-tracing experiments in fetal or postnatal mice, we discover that Gli1+ cells progressively produce
Sofia Lamas et al.
Animals : an open access journal from MDPI, 10(8) (2020-08-23)
Embryo transfer (ET) is a common procedure in rodent facilities. Optimizing this technique may help to reduce the number of animals, but little information is available regarding wild type strains and the conditions that affect embryo transfer. To explore this
Yulong Liu et al.
eLife, 11 (2022-05-20)
Zebrafish are an established research organism that has made many contributions to our understanding of vertebrate tissue and organ development, yet there are still significant gaps in our understanding of the genes that regulate gonad development, sex, and reproduction. Unlike
Yixiong Wang et al.
Nature communications, 13(1), 3794-3794 (2022-07-02)
The DEAD box protein DDX1, previously associated with 3'-end RNA processing and DNA repair, forms large aggregates in the cytoplasm of early mouse embryos. Ddx1 knockout causes stalling of embryos at the 2-4 cell stages. Here, we identify a DDX1-containing
Özge Özgüç et al.
PLoS biology, 20(3), e3001593-e3001593 (2022-03-25)
Actomyosin contractility is a major engine of preimplantation morphogenesis, which starts at the 8-cell stage during mouse embryonic development. Contractility becomes first visible with the appearance of periodic cortical waves of contraction (PeCoWaCo), which travel around blastomeres in an oscillatory
A Hatziri et al.
European review for medical and pharmacological sciences, 17(2), 247-252 (2013-02-05)
Nasal polyps are benign lesions originating from the nasal mucosa or paranasal sinuses. The most important etiological factor seems to be increased hydration of epithelium and hyperplasia of the extracellular matrix, which may involve hyaluronan, a high molecular mass extracellular
Graeme A Pollock et al.
Clinical & experimental ophthalmology, 31(6), 517-521 (2003-12-03)
The use of topical fluoroquinolones to treat microbial keratitis is associated with an increased incidence of corneal perforation compared to other standard treatments. This study examined the effects of topical fluoro-quinolones on corneal collagen and keratocytes in intact rabbit corneas
Michelle Percharde et al.
STAR protocols, 2(3), 100726-100726 (2021-08-20)
LINE1 is the most active and abundant family of retrotransposons; it is implicated in a number of pathologies, as well as in early embryo development. We present a protocol to specifically knockdown LINE1 in mouse embryonic stem cells and embryos
John Heath et al.
EMBO reports, 23(1), e51041-e51041 (2021-11-11)
The heterochromatin protein HP1 plays a central role in the maintenance of genome stability but little is known about how HP1 is controlled. Here, we show that the zinc finger protein POGZ promotes the presence of HP1 at DNA double-strand
T Peter Lopez et al.
Acta neuropathologica communications, 5(1), 84-84 (2017-11-22)
The larger brain of the rat enables a much greater repertoire of complex behaviors than mice, likely making rats preferential for investigating neurodegeneration. Because molecular tools for specific expression of transgenes in the rat brain are sparse, we chose Prnp
Carmen A Vlahu et al.
Journal of the American Society of Nephrology : JASN, 23(11), 1900-1908 (2012-10-23)
Damage to the endothelial glycocalyx, which helps maintain vascular homeostasis, heightens the sensitivity of the vasculature to atherogenic stimuli. Patients with renal failure have endothelial dysfunction and increased risk for cardiovascular morbidity and mortality, but the state of the endothelial
Henning T Langer et al.
Journal of cachexia, sarcopenia and muscle, 11(5), 1364-1376 (2020-09-08)
Desminopathy is a clinically heterogeneous muscle disease caused by over 60 different mutations in desmin. The most common mutation with a clinical phenotype in humans is an exchange of arginine to proline at position 350 of desmin leading to p.R350P.
Sharmistha Mitra et al.
Disease models & mechanisms, 16(1) (2022-12-14)
Glycogen is the largest cytosolic macromolecule and is kept in solution through a regular system of short branches allowing hydration. This structure was thought to solely require balanced glycogen synthase and branching enzyme activities. Deposition of overlong branched glycogen in
Zhi Yong Sun et al.
Hippocampus, 28(1), 42-52 (2017-09-19)
Hippocampal sharp wave ripples (SWRs) represent irregularly occurring synchronous neuronal population events that are observed during phases of rest and slow wave sleep. SWR activity that follows learning involves sequential replay of training-associated neuronal assemblies and is critical for systems
Philip R Spandorfer et al.
Clinical therapeutics, 34(11), 2232-2245 (2012-10-16)
Alternative treatment of dehydration is needed when intravenous (IV) or oral rehydration therapy fails. Subcutaneous (SC) hydration facilitated by recombinant human hyaluronidase offers an alternative treatment for dehydration. This clinical trial is the first to compare recombinant human hyaluronidase-facilitated SC
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