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Showing 31-60 of 194 results for "H4272" within Papers
Lindsay K McGuire et al.
Journal of drugs in dermatology : JDD, 12(10), 1181-1183 (2013-10-03)
We report a case of a 36-year-old female who experienced significant vascular occlusion after injection with hyaluronic acid into the nasolabial folds. The patient experienced immediate pain after the injection, however, the vascular compromise was not diagnosed and treated until
Prashanth Srinivas et al.
Indian journal of biochemistry & biophysics, 49(4), 228-235 (2012-10-20)
Hyaluronan (HA) is a component of extracellular matrix that influences cell-proliferation, migration, development, regeneration, normal tissue remodeling, tissues undergoing malignancy and tumor cell interaction. The widespread occurrence of HA binding proteins, their involvement in tissue organization and the control of
Maengjo Kim et al.
Journal of molecular and cellular cardiology, 45(2), 270-280 (2008-07-04)
Cardiovascular sequelae including diabetic cardiomyopathy constitute the major cause of death in diabetic patients. Although several factors may contribute to the development of this cardiomyopathy, the underlying molecular/cellular mechanisms leading to cardiac dysfunction are still partially understood. Recently, a novel
Gry Hulsart-Billström et al.
Biomacromolecules, 14(9), 3055-3063 (2013-08-21)
Regeneration of bone by delivery of bone morphogenetic proteins (BMPs) from implantable scaffolds is a promising alternative to the existing autologous bone grafting procedures. Hydrogels are used extensively in biomaterials as delivery systems for different growth factors. However, a controlled
Carmen A Vlahu et al.
Journal of the American Society of Nephrology : JASN, 23(11), 1900-1908 (2012-10-23)
Damage to the endothelial glycocalyx, which helps maintain vascular homeostasis, heightens the sensitivity of the vasculature to atherogenic stimuli. Patients with renal failure have endothelial dysfunction and increased risk for cardiovascular morbidity and mortality, but the state of the endothelial
Michael Prater et al.
Methods in molecular biology (Clifton, N.J.), 946, 395-409 (2012-11-28)
Evidence is emerging that the mouse mammary epithelium is arranged as a hierarchy that spans from stem cells to lineage-restricted progenitor cells to differentiated luminal and myoepithelial cells. The use of fluorescence-activated cell sorting (FACS) in combination with quantitative functional
Lei Yan et al.
Cell biochemistry and function, 38(3), 257-265 (2019-11-22)
The aim of this study was to investigate the regulatory mechanism of cancer-associated fibroblasts (CAFs) exosome in bladder cancer (BC) cell proliferation and invasion. CAFs and normal fibroblasts (NFs) were isolated from tumor tissues and adjacent normal tissues of BC
Emanuel Rognoni et al.
eLife, 10 (2021-12-24)
Solar ultraviolet radiation (UVR) is a major source of skin damage, resulting in inflammation, premature ageing, and cancer. While several UVR-induced changes, including extracellular matrix reorganisation and epidermal DNA damage, have been documented, the role of different fibroblast lineages and
Guruprasad Nayak et al.
Journal of assisted reproduction and genetics, 37(5), 1227-1238 (2020-04-27)
Metformin is the most commonly prescribed drug in the management of metabolic disorders such as polycystic ovarian syndrome (PCOS) and gestational diabetes in women of reproductive age. Insulin-sensitizing effect of metformin helps in improving from PCOS features such as hyperandrogenism
Systemic Delivery of mPEG-Masked Trispecific T-Cell Nanoengagers in Synergy with STING Agonists Overcomes Immunotherapy Resistance in TNBC and Generates a Vaccination Effect.
Shen, et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 9, e2203523-e2203523 (2022)
L Gabriel Sanchez-Partida et al.
PloS one, 6(6), e21597-e21597 (2011-07-09)
Oocyte cryopreservation is extremely beneficial for assisted reproductive technologies, the treatment of infertility and biotechnology and offers a viable alternative to embryo freezing and ovarian grafting approaches for the generation of embryonic stem cells and live offspring. It also offers
Waleed F A Marei et al.
Molecular human reproduction, 19(9), 590-599 (2013-04-30)
Biological functions of hyaluronan (HA) depend on its molecular size. Small size HAs are known to regulate cell proliferation; however, the expression of HA synthases (HASs) and hyaluronidase-2 (HYAL2) and their role during early embryo development have not been previously
Biswajit Chowdhury et al.
The Journal of biological chemistry, 288(1), 520-528 (2012-11-23)
Hyaluronidase (HYAL) 2 is a membrane-anchored protein that is proposed to hydrolyze hyaluronan (HA) to smaller fragments that are internalized for breakdown. Initial studies of a Hyal2 knock-out (KO) mouse revealed a mild phenotype with high serum HA, supporting a
Tyl H Taylor et al.
Fertility and sterility, 85(5), 1544-1546 (2006-05-02)
The objective of the present study was to compare a traditionally used bovine-derived hyaluronidase (Hyase) with the newly developed recombinant human-derived enzyme product (Cumulase) in intracytoplasmic sperm injection (ICSI) procedures using a sibling oocyte model in a prospective randomized design.
Jean-Philippe Hugnot
Methods in molecular biology (Clifton, N.J.), 1059, 53-63 (2013-08-13)
Whereas neural stem cells and their niches have been extensively studied in the brain, little is known on these cells, their environment and their function in the adult spinal cord. Adult spinal cord neural stem cells are located in a
R N Tsepilov et al.
Zhurnal mikrobiologii, epidemiologii, i immunobiologii, (2)(2), 12-20 (2013-06-29)
Selection of high-mucoid morphotype of Streptococcus equi subsp. zooepidemicus (Streptococcus zooepidemicus) and study of its morphological, physiological, biochemical and technological characteristics for providing increased secretion of hyaluronic acid (HA). Submerged cultivation was performed in 100 ml glass flasks without baffles
Tianyang Lan et al.
International journal of molecular sciences, 23(15) (2022-08-13)
Oocyte vitrification has been widely used in the treatment of infertility and fertility preservation. However, vitrification-induced mitochondrial damage adversely affects oocyte development. Several studies have reported that mitochondrial calcium uptake protein 1 (MICU1) regulates the uptake of mitochondrial calcium by
Lucia von Mengden et al.
Journal of assisted reproduction and genetics, 39(6), 1277-1295 (2022-04-27)
To study whether the cumulus cell antioxidant system varies accordingly to patients clinical characteristics' as age, infertility diagnosis, BMI, and stimulation protocol applied and if the antioxidant profile of cumulus cells could be used as a predictor of embryo development.
Lingyan Wang et al.
Cell biology international, 33(12), 1274-1279 (2009-09-08)
To establish experimental protocols for cloning golden hamsters, optimal concentrations of colchicine and demecolcine were determined for inducing cytoplasmic protrusion (containing chromosomes) and assisting enucleation of their oocytes. Denuded oocytes at different ages were treated with 2.5-10 microg/ml of colchicine
Hagen Körschgen et al.
Molecular human reproduction, 23(9), 607-616 (2017-09-16)
How and where is pro-ovastacin activated and how does active ovastacin regulate zona pellucida hardening (ZPH) and successful fertilization? Ovastacin is partially active before exocytosis and pre-hardens the zona pellucida (ZP) before fertilization. The metalloproteinase ovastacin is stored in cortical
Alina Osychenko et al.
Experimental cell research, 389(1), 111887-111887 (2020-02-07)
The cell fusion is a widespread process, which takes place in many systems in vivo and in vitro. Fusion of cells is frequently related to tetraploidy, which can be found within natural physiological conditions, e.g., placentation, and in pathophysiological conditions
Mattia Quattrocelli et al.
The American journal of pathology, 187(11), 2520-2535 (2017-08-22)
The muscular dystrophies are genetically diverse. Shared pathological features among muscular dystrophies include breakdown, or loss of muscle, and accompanying fibrotic replacement. Novel strategies are needed to enhance muscle repair and function and to slow this pathological remodeling. Glucocorticoid steroids
Wan Kin Au Yeung et al.
Cell reports, 27(1), 282-293 (2019-04-04)
Mammalian histone methyltransferase G9a (also called EHMT2) deposits H3K9me2 on chromatin and is essential for postimplantation development. However, its role in oogenesis and preimplantation development remains poorly understood. We show that H3K9me2-enriched chromatin domains in mouse oocytes are generally depleted
Benedikt Wefers et al.
Nature protocols, 8(12), 2355-2379 (2013-11-02)
Genetically engineered mice are instrumental for the analysis of mammalian gene function in health and disease. As classical gene targeting, which is performed in embryonic stem (ES) cell cultures and generates chimeric mice, is a time-consuming and labor-intensive procedure, we
Jack A Supple et al.
Current biology : CB, 30(4), 645-656 (2020-01-21)
Akin to all damselflies, Calopteryx (family Calopterygidae), commonly known as jewel wings or demoiselles, possess dichoptic (separated) eyes with overlapping visual fields of view. In contrast, many dragonfly species possess holoptic (dorsally fused) eyes with limited binocular overlap. We have
A Hatziri et al.
European review for medical and pharmacological sciences, 17(2), 247-252 (2013-02-05)
Nasal polyps are benign lesions originating from the nasal mucosa or paranasal sinuses. The most important etiological factor seems to be increased hydration of epithelium and hyperplasia of the extracellular matrix, which may involve hyaluronan, a high molecular mass extracellular
Özge Özgüç et al.
PLoS biology, 20(3), e3001593-e3001593 (2022-03-25)
Actomyosin contractility is a major engine of preimplantation morphogenesis, which starts at the 8-cell stage during mouse embryonic development. Contractility becomes first visible with the appearance of periodic cortical waves of contraction (PeCoWaCo), which travel around blastomeres in an oscillatory
Graeme A Pollock et al.
Clinical & experimental ophthalmology, 31(6), 517-521 (2003-12-03)
The use of topical fluoroquinolones to treat microbial keratitis is associated with an increased incidence of corneal perforation compared to other standard treatments. This study examined the effects of topical fluoro-quinolones on corneal collagen and keratocytes in intact rabbit corneas
Zhongshuai Sun et al.
Cell death and differentiation, 25(9), 1686-1701 (2018-02-23)
TMCO1 (transmembrane and coiled-coil domains 1) is an endoplasmic reticulum (ER) transmembrane protein that actively prevents Ca2+ stores from overfilling. To characterize its physiological function(s), we generated Tmco1-/- knockout (KO) mice. In addition to the main clinical features of human
Christelle Bertrand-Gaday et al.
International journal of molecular sciences, 21(19) (2020-10-03)
Skeletal muscle has a remarkable plasticity, and its phenotype is strongly influenced by hormones, transcription factors, and physical activity. However, whether skeletal phenotype can be oriented or not during early embryonic stages has never been investigated. Here, we report that
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