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Showing 1-30 of 2408 results for "h6167" within Papers
Han Seok Choi et al.
Yonsei medical journal, 56(4), 951-960 (2015-06-13)
In epidemiologic and animal studies, a high fat diet (HFD) has been shown to be associated with lower bone mineral density (BMD) and a higher risk of osteoporotic fractures. Meanwhile, consuming a HFD containing diacylglycerol (DAG) instead of triacylglycerol (TAG)
Ri Ryu et al.
Journal of medicinal food, 18(7), 715-723 (2015-06-11)
The leaves of the persimmon tree (PL) are known to have beneficial effects on hyperglycemia, dyslipidemia, and nonalcoholic fatty liver disease. We recently demonstrated that PL had antithrombotic properties in vitro. However, little is known about the antiplatelet and anticoagulant
Rui Ran et al.
International journal of pharmaceutics, 477(1-2), 590-600 (2014-12-03)
RNA interference is an effective method to achieve highly specific gene regulation. However, the commonly used cationic liposomes have poor biocompatibility, which may lead to systematic siRNA delivery of no avail. PEGylation is a good strategy in shielding the positive
Lai Wang et al.
PloS one, 10(6), e0125961-e0125961 (2015-06-04)
Extramedullary hematopoiesis has been shown to contribute to the pathogenesis of a variety of diseases including cardiovascular diseases. In this process, the spleen is seeded with mobilized bone marrow cells that augment its hematopoietic ability. It is unclear whether these
Vincent Forster et al.
Science translational medicine, 6(258), 258ra141-258ra141 (2014-10-17)
Peritoneal dialysis confers therapeutic advantages in patients with renal insufficiency and has proven beneficial in other indications, such as removal of excess metabolites or overdosed drugs. However, it is used in only about 10% of the dialyzed population worldwide, partly
Celine I L Justino et al.
Bioanalysis, 6(11), 1459-1470 (2014-07-22)
Disposable immunosensors based on field effect transistors with single-walled carbon nanotubes (NTFET) were applied for the first time to clinical samples of undiluted blood serum and saliva for the determination of C-reactive protein (CRP), and validated by comparison with ELISA.
Maidina Tuohetahuntila et al.
Biochimica et biophysica acta, 1851(2), 220-230 (2014-12-17)
Hepatic stellate cell (HSC) activation is a critical step in the development of chronic liver disease. We previously observed that the levels of triacylglycerol (TAG) species containing long polyunsaturated fatty acids (PUFAs) are increased in in vitro activated HSCs. Here
Mitsunobu Kubota et al.
Journal of atherosclerosis and thrombosis, 21(10), 1087-1097 (2014-06-20)
Serum cholesterol efflux has been suggested to be a key anti-atherogenic function of reverse cholesterol transport. Meanwhile, the quantitative and qualitative alteration of the levels of lipoproteins in the serum has been reported in patients with diabetes, although it remains
John O Younge et al.
Psychosomatic medicine, 77(7), 775-783 (2015-07-18)
The increased popularity of mind-body practices highlights the need to explore their potential effects. We determined the cross-sectional association between mind-body practices and cardiometabolic risk factors. We used data from 2579 participants free of cardiovascular disease from the Rotterdam Study
Jong Hee Park et al.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 19(3), 269-274 (2015-05-09)
Chronic inflammation has been proposed as one of the main molecular mechanisms of aging and age-related diseases. Although evidence in humans is limited, short-term calorie restriction (CR) has been shown to have anti-inflammatory effects in aged experimental animals. We reported
Ali Akal et al.
Indian journal of ophthalmology, 62(6), 671-674 (2014-07-10)
Resistive index (RI) is an indirect measurement of blood flow resistance that can be used to evaluate vascular damage in ophthalmologic disease. The purpose of this study was to evaluate the association between RI values of orbital arteries using the
Hanna Johnsson et al.
Annals of the rheumatic diseases, 73(8), 1495-1499 (2013-05-30)
Raised total cholesterol (TC) and reduced high-density lipoprotein (HDL) cholesterol levels are established cardiovascular disease (CVD) risk factors. However, in autoimmune conditions the lipid-CVD association appears paradoxical, with inflammation as a potential confounding factor. We therefore sought to model the
Revathi Sekar et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(8), 3494-3505 (2014-04-29)
Secretin, a classical gastrointestinal hormone released from S cells in response to acid and dietary lipid, regulates pleiotropic physiological functions, such as exocrine pancreatic secretion and gastric motility. Subsequent to recently proposed revisit on secretin's metabolic effects, we have confirmed
Jéssica Aguiar de Souza et al.
Clinical biochemistry, 48(16-17), 1039-1044 (2015-06-17)
PON1 plays an important role in inhibiting LDL-C oxidation, which reduces atherosclerosis and cardiovascular disease. Elevated PON1 activity or levels may contribute to increased HDL-C levels, but controversy exists over the hypothesis that genetic variation in the PON1 gene locus
Anders E Hansen et al.
ACS nano, 9(7), 6985-6995 (2015-05-30)
Since the first report of the enhanced permeability and retention (EPR) effect, the research in nanocarrier based antitumor drugs has been intense. The field has been devoted to treatment of cancer by exploiting EPR-based accumulation of nanocarriers in solid tumors
Wenhua He et al.
Drug design, development and therapy, 9, 3989-4104 (2015-09-09)
NADPH oxidases (NOXs) are a predominant mediator of redox homeostasis in hepatic stellate cells (HSCs), and oxidative stress plays an important role in the pathogenesis of liver fibrosis. Ursolic acid (UA) is a pentacyclic triterpenoid with various pharmacological activities, but
Huazhi Han et al.
The Journal of physiology, 592(18), 4025-4038 (2014-07-20)
A growing number of studies show that different types of ion channels localize in caveolae and are regulated by the level of membrane cholesterol. Furthermore, it has been proposed that cholesterol-induced regulation of ion channels might be attributed to partitioning
Varun U Ektare et al.
The American journal of managed care, 20(10 Suppl), S204-S215 (2014-12-17)
To compare 1-year clinical outcomes and cost efficiency of treating adults with type 2 diabetes mellitus (T2DM) with canagliflozin (300 mg/day) or sitagliptin (100 mg/day), both added on a background of metformin and sulfonylurea. An economic model integrated data from
Ousseynou Sarr et al.
PloS one, 9(6), e98433-e98433 (2014-06-14)
Uteroplacental insufficiency (UPI)-induced intrauterine growth restriction (IUGR) predisposes individuals to adult visceral obesity. We postulated that low birth weight (LBW) offspring, from UPI-induced IUGR pregnancies, would display a visceral adipose lipogenic molecular signature involving altered gene expression, phosphorylation status of
Dilek Yonar et al.
Biochimica et biophysica acta, 1838(10), 2369-2379 (2014-06-21)
The interaction of antidepressant drug trazodone hydrochloride (TRZ) with dipalmitoyl phosphatidylcholine (DPPC) multilamellar liposomes (MLVs) in the presence and absence of cholesterol (CHO) was investigated as a function of temperature by using Electron Paramagnetic Resonance (EPR) spin labeling, Fourier Transform
Yoshiyuki Hattori et al.
Journal of liposome research, 25(2), 131-140 (2014-09-10)
In this study, we investigated the possibility of whether depletion of tumor-associated macrophages (TAMs) by zoledronic acid (ZOL) entrapped in folate-linked liposome could inhibit tumor angiogenesis and consequently tumor growth. Abundant expression of folate receptor β (FRβ) mRNA was detected
W Zhao et al.
Gene therapy, 22(8), 645-652 (2015-04-15)
Interleukin-5 (IL-5) increases the secretion of natural T15/EO6 IgM antibodies that inhibit the uptake of oxidized low-density lipoprotein (LDL) by macrophages. This study aimed to determine whether macrophage-specific expression of IL-5 in LDL receptor-deficient mice (Ldlr(-/-)) could improve cholesterol metabolism
Lucas H Hofmeister et al.
ACS nano, 9(4), 4435-4446 (2015-03-15)
In regions of the circulation where vessels are straight and unbranched, blood flow is laminar and unidirectional. In contrast, at sites of curvature, branch points, and regions distal to stenoses, blood flow becomes disturbed. Atherosclerosis preferentially develops in these regions
Hye-Ja Lee et al.
Clinica chimica acta; international journal of clinical chemistry, 450, 155-161 (2015-08-21)
Glucokinase regulator (GCKR) plays important roles in the regulation of glucokinase (GK) activity and the metabolism of glucose and lipids. We investigated whether the association between GCKR genetic variants with serum lipids in Korean adults is replicated in children, and
Miaoying Yun et al.
Journal of hypertension, 33(2), 266-274 (2014-11-08)
The study assessed the hypothesis that smoking strengthens the association of adult arterial stiffness with long-term cumulative burden of blood pressure (BP) from childhood to adulthood. Tobacco smoking and elevated BPs are important risk factors of vascular stiffness. However, the
Xiao-Na Wang et al.
Journal of clinical hypertension (Greenwich, Conn.), 17(8), 594-600 (2015-04-22)
The authors investigated whether plasma total homocysteine (tHcy) is a predictive factor for arterial stiffness (carotid-femoral pulse wave velocity [cf-PWV] and carotid-radial PWV) in 1447 patients from a 4.8-year prospective study in Beijing, People's Republic of China. Baseline tHcy showed
Eung Ju Kim et al.
PloS one, 9(6), e97841-e97841 (2014-06-06)
Although triglyceride accumulation in the liver causes non-alcoholic fatty liver disease (NAFLD), hypercholesterolemia is also a main cause of NAFLD as well as atherosclerosis. However, NAFLD and atherosclerosis have not been investigated simultaneously in animal models fed a high-cholesterol diet.
S Maynard et al.
Acta physiologica (Oxford, England), 213(1), 156-170 (2014-04-08)
To examine associations of DNA damage, cardiovascular risk factors and physical performance with vitality, in middle-aged men. We also sought to elucidate underlying factors of physical performance by comparing physical performance parameters to DNA damage parameters and cardiovascular risk factors.
Lili Ding et al.
The Journal of pharmacology and experimental therapeutics, 351(2), 474-483 (2014-09-11)
Sterol regulatory element-binding proteins (SREBPs) are major transcription factors regulating the expression of genes involved in biosynthesis of cholesterol, fatty acids, and triglycerides. We investigated the effect of the specific SREBP suppressor andrographolide, a natural compound isolated from Andrographis paniculata
Jun Zhou et al.
Carbohydrate polymers, 121, 199-206 (2015-02-11)
The present study was designed to investigate the hypoglycemic activity and the potential mechanisms of Misgurnus anguillicaudatus polysaccharide (MAP) in streptozotocin-induced diabetic mice. MAP oral administration significantly decreased the blood levels of glucose, TC, TG, LDL-C, and increased the blood
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